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Soft Tissue and Bone Neoplasms

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Precision Molecular Pathology of Neoplastic Pediatric Diseases

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Abstract

Bone and soft tissue tumors are overall rare but are histologically complex and biologically diverse. Recurring molecular events help define benign and malignant entities as well as confirm the neoplastic nature of lesions previously considered to represent reactive proliferations. In the case of Ewing and Ewing-like sarcomas, molecular features have allowed the definition of distinct disease entities that could not be discriminated reliably based on histomorphology alone. In the future, a more granular classification of bone and soft tissue tumors based in part on their molecular profile may allow better risk stratification and a more personalized treatment approach.

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Authors and Affiliations

  1. Department of Pathology, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA

    Peter Pytel MD & Nicole A. Cipriani MD

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Correspondence to Nicole A. Cipriani MD .

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  1. Department of Pathology, University of Utah/ARUP Laboratories, Salt Lake City, Utah, USA

    Larissa V. Furtado

  2. Department of Pathology, University of Chicago, Chicago, Illinois, USA

    Aliya N. Husain

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Pytel, P., Cipriani, N.A. (2018). Soft Tissue and Bone Neoplasms. In: Furtado, L., Husain, A. (eds) Precision Molecular Pathology of Neoplastic Pediatric Diseases . Molecular Pathology Library. Springer, Cham. https://doi.org/10.1007/978-3-319-89626-7_9

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