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Bioactive Polysaccharide Materials for Modern Wound Healing pp 87–94Cite as

Safety and Efficiency Testing

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Part of the book series: SpringerBriefs in Molecular Science ((BRIEFSBP))

Abstract

The biocompatibility/cytotoxicity of materials intended for biomedical applications are always of utter importance (Danoux et al. in Acta Mater 17:1–15, 2015 [1], Yan et al. in Acta Biomater 12:227–241, 2015 [2]) Although the main objective of such testing is mostly related to assessment of the respective material safety and efficiency, functional testing of materials in relation to their targeted use is also needed to be considered. The main objective of the approach towards such testing is, therefore, not only related to the assessment of the specific materials’ biocompatibility with desired cells, but also the execution of the test as similar to the physiological application as possible (Naranda et al. in Sci Rep 6:28695, 2016 [3], Finšgar et al. in Sci Rep 6:26653, 2016 [4]). Related to this, the effect of possibly released toxic degradation products that could hinder cell growth can be determined, as well as possible local overdoses of respective drugs, which are often part of tested formulations, could be assessed, since these could also potentially harm the growing cells (Finšgar et al. in Sci Rep 6:26653, 2016[4]). Another related testing approach is to determine the respective formulation influence on the cell growth in comparison with different control samples (Naranda et al. in Sci Rep 6:28695, 2016 [3], Gradisnik et al. in Global Spine J 6:WST014, 2016 [5], Velnar et al. in Global Spine J 6:WST019, 2016 [6]). The following chapter will, therefore, be composed of two main parts. The first will review briefly some of the most used testing approaches in general (mostly according to the related ISO Standard—ISO 10993), while the second part will review and describe some of possible modifications of such standard approaches to get the best possible overview of the respective materials’ safety and efficiency for a specific purpose.

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Authors and Affiliations

  1. Faculty of Mechanical Engineering, Laboratory for Characterization and Processing of Polymers, University of Maribor, Maribor, Slovenia

    Tina Maver, Tanja Pivec, Manja Kurečič, Zdenka Persin & Karin Stana Kleinschek

  2. Faculty of Medicine, Institute of Biomedical Sciences and Department of Pharmacology, University of Maribor, Maribor, Slovenia

    Uroš Maver

  3. Graz University of Technology, Graz, Austria

    Manja Kurečič & Karin Stana Kleinschek

Authors
  1. Tina Maver
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  2. Uroš Maver
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  3. Tanja Pivec
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Correspondence to Tina Maver .

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Maver, T., Maver, U., Pivec, T., Kurečič, M., Persin, Z., Stana Kleinschek, K. (2018). Safety and Efficiency Testing. In: Bioactive Polysaccharide Materials for Modern Wound Healing. SpringerBriefs in Molecular Science(). Springer, Cham. https://doi.org/10.1007/978-3-319-89608-3_7

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