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Textbook of Energy Balance, Neuropeptide Hormones, and Neuroendocrine Function pp 321–344Cite as

Obesity and the Growth Hormone Axis

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Abstract

Growth hormone (GH), as its name implies, promotes growth and alters nutrient metabolism through direct activation of the GH receptor (GHR) on target tissues. GH also indirectly regulates growth and nutrient metabolism by altering production of additional factors. One of the most important secondary effects of GH action is insulin-like growth factor-1 (IGF-1). Many of the growth-promoting activities that result from GH occur via GH-stimulated IGF-1 production. Due to the strong link between GH and IGF-1, they are often referred to collectively as the GH/IGF-1 axis. The GH/IGF-1 axis has anabolic effects on most tissues, including the heart, liver, kidneys, and intestines; however, GH – but not IGF-1 – has a dramatic catabolic effect on adipose tissue (AT). This chapter will focus mainly on GH, describe the clinical conditions and mouse lines with alterations in this axis along with their adiposity phenotype, and conclude by considering the role and therapeutic use of GH in obesity.

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Authors and Affiliations

  1. The Diabetes Institute, Konneker Research Labs, Ohio University, Athens, OH, USA

    Brooke Henry, Edward O. List & Darlene E. Berryman

  2. Edison Biotechnology Institute, Konneker Research Labs, Ohio University, Athens, OH, USA

    Brooke Henry, Elizabeth A. Jensen, Edward O. List & Darlene E. Berryman

  3. Translational Biomedical Sciences, Graduate College, Ohio University, Athens, OH, USA

    Elizabeth A. Jensen

  4. Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA

    Darlene E. Berryman

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  1. Brooke Henry
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  1. Emeritus Professor of Medicine, Molecular Biology, Cell Biology & Biochemistry, Department of Medicine, Molecular Biology, Cell Biology & Biochemistry, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA

    Eduardo A. Nillni

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Henry, B., Jensen, E.A., List, E.O., Berryman, D.E. (2018). Obesity and the Growth Hormone Axis. In: Nillni, E. (eds) Textbook of Energy Balance, Neuropeptide Hormones, and Neuroendocrine Function. Springer, Cham. https://doi.org/10.1007/978-3-319-89506-2_12

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