Abstract
The role of the melanocortin system in energy homeostasis, feeding behavior, and metabolism has been a focus of intense study since its discovery in 1979 (Crine et al. 1979; Hill and Faulkner 2016). The ability of melanocortins to suppress feeding and increase energy expenditure has made melanocortin receptors (MCRs) a major target of anti-obesity drugs in development (Fani et al. 2014). In addition, the melanocortin system’s influence on circulating glucose levels suggests it could also be targeted to treat obesity-related type 2 diabetes (Morgan et al. 2015; Parton et al. 2007). While very promising in theory, problematic side effects have plagued pharmaceutical trials for such medications, preventing FDA approval (Ericson et al. 2017). These adverse effects are due to other systemic and central functions of the melanocortin system. To understand and overcome these challenges, a more comprehensive understanding is needed of the role melanocortin peptides play and how they perform their diverse functions.
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Singhal, S., Hill, J.W. (2018). Obesity and Stress: The Melanocortin Connection. In: Nillni, E. (eds) Textbook of Energy Balance, Neuropeptide Hormones, and Neuroendocrine Function. Springer, Cham. https://doi.org/10.1007/978-3-319-89506-2_11
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