Abstract
Pathology is one of the tools for reaching a diagnosis. Like all procedures in medicine, the analysis of biopsies has some limitations. The diagnostic yield can be increased by using good quality samples, by optimizing the number of samples and sections, by optimal preparation of the samples and by confronting the findings with appropriate clinical information. Numbers of samples needed depend on the indication for the endoscopic procedures. When reading a biopsy, analysis can be improved with a systematic approach. This implies a proper knowledge of the normal histology and of potential artifacts. The pathologists should take note of the origin, the number, and the size of the samples and subsequently evaluate the architecture and cytological aspects of the specimen. The analysis can be improved by using a checklist or pro forma report.
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Farmer M, Petras RE, Hunt LE, et al. The importance of diagnostic accuracy in colonic inflammatory bowel disease. Am J Gastroenterol. 2000;95:3184–8.
Bentley E, Jenkins D, Campbell F, Warren BF. How could pathologists improve the initial diagnosis of colitis? Evidence from an international workshop. J Clin Pathol. 2002;55:955–60.
Sandler RS, Cummings MS, Keku TO, et al. Disposable versus reusable forceps for colorectal epithelial cell proliferation in humans. Cancer Epidemiol Biomark Prev. 2000;9:1123–5.
Abreu MT, Harpaz N. Diagnosis of colitis: making the initial diagnosis. Clin Gastroenterol Hepatol. 2007;5:295–301.
Magro F, Langner C, Driessen A, et al. European consensus on the histopathology of inflammatory bowel disease. J Crohns Colitis. 2013;7:827–51.
Rosenstock E, Farmer RG, Petras R, et al. Surveillance for colonic carcinoma in ulcerative colitis. Gastroenterology. 1985;89:1342–6.
Rubin CE, Haggitt RC, et al. DNA-aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis. Gastroenterology. 1992;103:1611–20.
Kornbluth A, Sachar DB. Ulcerative colitis practice guidelines in adults. American College of Gastroenterology, Practice Parameters Committee. Am J Gastroenterol. 1997;2:204–11.
Seldenrijk CA, Morson BC, Meuwissen SGM, et al. Histopathological evaluation of colonic mucosal biopsy specimens in chronic inflammatory bowel disease: diagnostic implications. Gut. 1991;32:1514–20.
Theodossi A, Spiegelhalter DJ, Jass J, et al. Observer variation and discriminatory value of biopsy features in inflammatory bowel disease. Gut. 1994;35:961–8.
Surawicz CM. Serial sectioning of a portion of a rectal biopsy detects more focal abnormalities. A prospective study of patients with inflammatory bowel disease. Dig Dis Sci. 1982;27:434–6.
Jenkins D, Balsitis M, Gallivan S, et al. Guidelines for the initial biopsy diagnosis of suspected chronic idiopathic inflammatory bowel disease. The British Society of Gastroenterology Initiative. J Clin Pathol. 1997;50:93–105.
Terada T. Histopathological study of the rectum in 1,438 consecutive rectal specimens in a single Japanese hospital: 1. Benign lesions. Int J Clin Exp Pathol. 2013;26:349–57.
Burks ML, Kundrotas L. Unusual colon biopsy. Gastroenterology. 2013;145:e10–1.
Rashid A, Hamilton SR. Necrosis of the gastrointestinal tract in uremic patients as a result of sodium polystyrene sulfonate (Kayexalate) in sorbitol: an under-recognized condition. Am J Surg Pathol. 1997;21:60–9.
Koteish A, Kannangai R, Abrahma SC, et al. Colonic spirochetosis in children and adults. Am J Clin Pathol. 2003;120:828–32.
Swanson BJ, Limketkai BN, Liu TC, et al. Sevelamer crystals in the gastrointestinal tract (GIT): a new entity associated with mucosal injury. Am J Surg Pathol. 2013;37:1686–93.
Connor A, Tolan D, Hughes S, et al. Consensus guidelines for the safe prescription and administration of oral bowel-cleansing agents. Gut. 2012;61:1525–32.
Wexner SD, Beck DE, Baron TH, et al. A consensus document on bowel preparation before colonoscopy prepared by a task force from the American Society of Colon and Rectal Surgeons, the American Society for Gastrointestinal Endoscopy and the Society of American Gastrointestinal and Endoscopic Surgeons. Gastrointest Endosc. 2006;63(7):894–909.
Rejchrt S, Bures J, Siroky M, Kopacova M, Slezak L, Langr F. A prospective observational study of colonic mucosal abnormalities associated with orally administrated sodium phosphate for colon cleansing before colonoscopy. Gastrointest Endosc. 2004;59:651–4.
Croucher LJ, Bury JP, Williams EA, et al. Commonly used bowel preparations have significant and different effects upon cell proliferation in the colon: a pilot study. BMC Gastroenterol. 2008;8:54.
Snover DC, Sandstad J, Hutton S. Mucosal pseudolipomatosis of the colon. Am J Clin Pathol. 1985;84:575–80.
Kara M, Turan I, Polat Z, et al. Chemical colitis caused by peracetic acid or hydrogen peroxide: a challenging dilemma. Endoscopy. 2010;42:E3–4.
Caprilli R, Viscido A, Frieri G, Latella G. Acute colitis following colonoscopy. Endoscopy. 1998;30:428–31.
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Jouret-Mourin, A., Geboes, K. (2018). The Endoscopic Biopsy: How to Proceed and How to Look at a Biopsy. In: Jouret-Mourin, A., Faa, G., Geboes, K. (eds) Colitis. Springer, Cham. https://doi.org/10.1007/978-3-319-89503-1_5
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DOI: https://doi.org/10.1007/978-3-319-89503-1_5
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