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Varicocele and Male Infertility pp 603–614Cite as

Sperm DNA Fragmentation Testing and Varicocele

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Abstract

The role of sperm DNA fragmentation (SDF) in the pathophysiology of varicocele-associated male infertility has been increasingly recognized. The expanding utilization of SDF testing among andrology laboratories worldwide is made possible by the development of various SDF assays which allows the important genetic content of male gametes to be assessed. The application of SDF testing in patients with varicocele has been explored in an attempt to better select patients who will benefit from varicocele treatment. Current evidence supports the potential value of the test based on the association between clinical varicocele and high SDF and the reduction of SDF in the majority of patients after varicocelectomy. Recent guidelines have provided indications of SDF testing in patients with varicocele to whom the results may guide management decision.

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Author information

Authors and Affiliations

  1. S.H. Ho Urology Centre, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong

    Chak-Lam Cho

  2. American Center for Reproductive Medicine, Department of Urology, Cleveland Clinic, Cleveland, OH, USA

    Ashok Agarwal

  3. ANDROFERT, Andrology & Human Reproduction Clinic, Campinas, SP, Brazil

    Sandro C. Esteves

  4. Department of Urology, Hamad Medical Corporation, Weill Cornell Medicine Qatar, Doha, Qatar

    Ahmad Majzoub

Authors
  1. Chak-Lam Cho
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  2. Ashok Agarwal
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  3. Sandro C. Esteves
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  4. Ahmad Majzoub
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Editor information

Editors and Affiliations

  1. ANDROFERT, Andrology & Human Reproduction Clinic, Campinas, São Paulo, Brazil

    Sandro C Esteves

  2. S.H. Ho Urology Centre, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong

    Chak-Lam Cho

  3. Department of Urology, Hamad Medical Corporation, Weill Cornell Medicine Qatar, Doha, Qatar

    Ahmad Majzoub

  4. Department of Urology, Cleveland Clinic, Cleveland, OH, USA

    Ashok Agarwal

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Cho, CL., Agarwal, A., Esteves, S.C., Majzoub, A. (2019). Sperm DNA Fragmentation Testing and Varicocele. In: Esteves, S., Cho, CL., Majzoub, A., Agarwal, A. (eds) Varicocele and Male Infertility. Springer, Cham. https://doi.org/10.1007/978-3-319-79102-9_57

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  • DOI: https://doi.org/10.1007/978-3-319-79102-9_57

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-79101-2

  • Online ISBN: 978-3-319-79102-9

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