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Scrotal Hyperthermia, Hormonal Disturbances, Testicular Hypoperfusion, and Backflow of Toxic Metabolites in Varicocele

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Varicocele and Male Infertility

Abstract

Numerous studies have explored the pathophysiology of varicocele as it is recognized as an important factor contributing to male infertility. The focus of these studies is to understand the impact of varicocele on testicular function. Among the most common investigated pathophysiologies in literature were testicular hyperthermia, hormonal disturbances, testicular hypoperfusion, and backflow of toxic metabolites. The focus of this chapter is to thoroughly assess the mechanisms linking varicocele to male infertility.

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Author information

Authors and Affiliations

  1. Department of Urology, Hamad Medical Corporation, Weill Cornell Medicine Qatar, Doha, Qatar

    Ahmad Majzoub

  2. S.H. Ho Urology Centre, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong

    Chak-Lam Cho

  3. American Center for Reproductive Medicine, Department of Urology, Cleveland Clinic, Cleveland, OH, USA

    Ashok Agarwal

  4. ANDROFERT, Andrology & Human Reproduction Clinic, Campinas, SP, Brazil

    Sandro C. Esteves

Authors
  1. Ahmad Majzoub
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  2. Chak-Lam Cho
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  3. Ashok Agarwal
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  4. Sandro C. Esteves
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Editor information

Editors and Affiliations

  1. ANDROFERT, Andrology & Human Reproduction Clinic, Campinas, São Paulo, Brazil

    Sandro C Esteves

  2. S.H. Ho Urology Centre, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong

    Chak-Lam Cho

  3. Department of Urology, Hamad Medical Corporation, Weill Cornell Medicine Qatar, Doha, Qatar

    Ahmad Majzoub

  4. Department of Urology, Cleveland Clinic, Cleveland, OH, USA

    Ashok Agarwal

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Majzoub, A., Cho, CL., Agarwal, A., Esteves, S.C. (2019). Scrotal Hyperthermia, Hormonal Disturbances, Testicular Hypoperfusion, and Backflow of Toxic Metabolites in Varicocele. In: Esteves, S., Cho, CL., Majzoub, A., Agarwal, A. (eds) Varicocele and Male Infertility. Springer, Cham. https://doi.org/10.1007/978-3-319-79102-9_3

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  • DOI: https://doi.org/10.1007/978-3-319-79102-9_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-79101-2

  • Online ISBN: 978-3-319-79102-9

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