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Management of Recurrent Varicocele

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Varicocele and Male Infertility

Abstract

Varicocele is defined as the dilation of the veins of the pampiniform plexus. It has been reported that at least 15% of adolescent males and more than 30% of infertile men suffer from varicocele. Although primary surgical intervention for varicocele is feasible, varicocele recurrence is not a rare complication of this procedure. The actual rates of varicocele recurrence are not clear as the probability of recurrence varies according to the studied population, indication of the initial surgery and severity of the varicocele. Moreover, different varicocele correction techniques are associated with varying recurrence rates. The higher rates of varicocele recurrence are observed with macroscopic inguinal or subinguinal varicocelectomy, which is theorized to be secondary to missed smaller internal spermatic veins that later dilate and cause recurrence. Recurrences after the open retroperitoneal or laparoscopic varicocele corrections are often attributed to the inability to ligate external gonadal (cremasteric) vessels or the external spermatic veins. Correction of varicocele recurrence is indicated for patients who remain infertile or symptomatic after the initial surgery. The best management for patients with recurrent varicocele is under debate. Surgical correction can be performed with open varicocelectomy, laparoscopic varicocelectomy, or embolization; however, the lack of randomized clinical trials comparing the outcomes of these different techniques hampers our ability to recognize the most effective treatment option.

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References

  1. Steeno O, Knops J, Declerck L, Adimoelja A, van de Voorde H. Prevention of fertility disorders by detection and treatment of varicocele at school and college age. Andrologia. 1976;8(1):47–53.

    Article  CAS  Google Scholar 

  2. Greenberg SH, Lipshultz LI, Wein AJ. Experience with 425 subfertile male patients. J Urol. 1978;119(4):507–10.

    Article  CAS  Google Scholar 

  3. World Health Organization. The influence of varicocele on parameters of fertility in a large group of men presenting to infertility clinics. Fertil Steril. 1992;57(6):1289–93.

    Article  Google Scholar 

  4. Kroese AC, de Lange NM, Collins J, Evers JL. Surgery or embolization for varicoceles in subfertile men. Cochrane Database Syst Rev. 2012;10:CD000479. https://doi.org/10.1002/14651858.CD000479.pub5.

    Article  PubMed  Google Scholar 

  5. Baazeem A, Belzile E, Ciampi A, Dohle G, Jarvi K, Salonia A, Weidner W, Zini A. Varicocele and male factor infertility treatment: a new meta-analysis and review of the role of varicocele repair. Eur Urol. 2011;60(4):796–808. https://doi.org/10.1016/j.eururo.2011.06.018.

    Article  PubMed  Google Scholar 

  6. Kohn TP, Kohn JR, Pastuszak AW. Varicocelectomy before assisted reproductive technology: are outcomes improved? Fertil Steril. 2017;108(3):385–91. https://doi.org/10.1016/j.fertnstert.2017.06.033.

    Article  PubMed  Google Scholar 

  7. Cayan S, Erdemir F, Ozbey I, Turek PJ, Kadioglu A, Tellaloglu S. Can varicocelectomy significantly change the way couples use assisted reproductive technologies? J Urol. 2002;167(4):1749–52.

    Article  Google Scholar 

  8. Kirby EW, Wiener LE, Rajanahally S, Crowell K, Coward RM. Undergoing varicocele repair before assisted reproduction improves pregnancy rate and live birth rate in azoospermic and oligospermic men with a varicocele: a systematic review and meta-analysis. Fertil Steril. 2016;106(6):1338–43. https://doi.org/10.1016/j.fertnstert.2016.07.1093.

    Article  PubMed  Google Scholar 

  9. Rotker K, Sigman M. Recurrent varicocele. Asian J Androl. 2016;18(2):229–33. https://doi.org/10.4103/1008-682X.171578.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Cayan S, Kadioglu TC, Tefekli A, Kadioglu A, Tellaloglu S. Comparison of results and complications of high ligation surgery and microsurgical high inguinal varicocelectomy in the treatment of varicocele. Urology. 2000;55(5):750–4.

    Article  CAS  Google Scholar 

  11. Watanabe M, Nagai A, Kusumi N, Tsuboi H, Nasu Y, Kumon H. Minimal invasiveness and effectivity of subinguinal microscopic varicocelectomy: a comparative study with retroperitoneal high and laparoscopic approaches. Int J Urol. 2005;12(10):892–8. https://doi.org/10.1111/j.1442-2042.2005.01142.x.

    Article  PubMed  Google Scholar 

  12. Ghanem H, Anis T, El-Nashar A, Shamloul R. Subinguinal microvaricocelectomy versus retroperitoneal varicocelectomy: comparative study of complications and surgical outcome. Urology. 2004;64(5):1005–9. https://doi.org/10.1016/j.urology.2004.06.060.

    Article  CAS  PubMed  Google Scholar 

  13. Yavetz H, Levy R, Papo J, Yogev L, Paz G, Jaffa AJ, Homonnai ZT. Efficacy of varicocele embolization versus ligation of the left internal spermatic vein for improvement of sperm quality. Int J Androl. 1992;15(4):338–44.

    Article  CAS  Google Scholar 

  14. Shiraishi K, Oka S, Ito H, Matsuyama H. Comparison of the results and complications of retroperitoneal, microsurgical subinguinal, and high inguinal approaches in the treatment of varicoceles. J Androl. 2012;33(6):1387–93. https://doi.org/10.2164/jandrol.112.016444.

    Article  PubMed  Google Scholar 

  15. Mehan DJ, Andrus CH, Parra RO. Laparoscopic internal spermatic vein ligation: report of a new technique. Fertil Steril. 1992;58(6):1263–6.

    Article  CAS  Google Scholar 

  16. Enquist E, Stein BS, Sigman M. Laparoscopic versus subinguinal varicocelectomy: a comparative study. Fertil Steril. 1994;61(6):1092–6.

    Article  CAS  Google Scholar 

  17. Jarow JP, Assimos DG, Pittaway DE. Effectiveness of laparoscopic varicocelectomy. Urology. 1993;42(5):544–7.

    Article  CAS  Google Scholar 

  18. Milad MF, Zein TA, Hussein EA, Ayyat FM, Schneider MP, Sant GR. Laparoscopic varicocelectomy for infertility. An initial report from Saudi Arabia. Eur Urol. 1996;29(4):462–5.

    Article  CAS  Google Scholar 

  19. Al-Kandari AM, Shabaan H, Ibrahim HM, Elshebiny YH, Shokeir AA. Comparison of outcomes of different varicocelectomy techniques: open inguinal, laparoscopic, and subinguinal microscopic varicocelectomy: a randomized clinical trial. Urology. 2007;69(3):417–20. https://doi.org/10.1016/j.urology.2007.01.057.

    Article  PubMed  Google Scholar 

  20. Al-Said S, Al-Naimi A, Al-Ansari A, Younis N, Shamsodini A, As K, Shokeir AA. Varicocelectomy for male infertility: a comparative study of open, laparoscopic and microsurgical approaches. J Urol. 2008;180(1):266–70. https://doi.org/10.1016/j.juro.2008.03.050.

    Article  PubMed  Google Scholar 

  21. Ding H, Tian J, Du W, Zhang L, Wang H, Wang Z. Open non-microsurgical, laparoscopic or open microsurgical varicocelectomy for male infertility: a meta-analysis of randomized controlled trials. BJU Int. 2012;110(10):1536–42. https://doi.org/10.1111/j.1464-410X.2012.11093.x.

    Article  PubMed  Google Scholar 

  22. Chung SD, Wu CC, Lin VC, Ho CH, Yang SS, Tsai YC. Minilaparoscopic varicocelectomy with preservation of testicular artery and lymphatic vessels by using intracorporeal knot-tying technique: five-year experience. World J Surg. 2011;35(8):1785–90. https://doi.org/10.1007/s00268-011-1115-6.

    Article  PubMed  Google Scholar 

  23. Ross LS, Ruppman N. Varicocele vein ligation in 565 patients under local anesthesia: a long-term review of technique, results and complications in light of proposed management by laparoscopy. J Urol. 1993;149(5 Pt 2):1361–3.

    Article  CAS  Google Scholar 

  24. Abdel-Maguid AF, Othman I. Microsurgical and nonmagnified subinguinal varicocelectomy for infertile men: a comparative study. Fertil Steril. 2010;94(7):2600–3. https://doi.org/10.1016/j.fertnstert.2010.03.063.

    Article  PubMed  Google Scholar 

  25. Goldstein M, Gilbert BR, Dicker AP, Dwosh J, Gnecco C. Microsurgical inguinal varicocelectomy with delivery of the testis: an artery and lymphatic sparing technique. J Urol. 1992;148(6):1808–11.

    Article  CAS  Google Scholar 

  26. Ito H, Kotake T, Hamano M, Yanagi S. Results obtained from microsurgical therapy of varicocele. Urol Int. 1993;51(4):225–7. https://doi.org/10.1159/000282549.

    Article  CAS  PubMed  Google Scholar 

  27. Jungwirth A, Gogus C, Hauser G, Gomahr A, Schmeller N, Aulitzky W, Frick J. Clinical outcome of microsurgical subinguinal varicocelectomy in infertile men. Andrologia. 2001;33(2):71–4.

    Article  CAS  Google Scholar 

  28. Kumar R, Gupta NP. Subinguinal microsurgical varicocelectomy: evaluation of the results. Urol Int. 2003;71(4):368–72. https://doi.org/10.1159/000074087.

    Article  PubMed  Google Scholar 

  29. Marmar JL, Kim Y. Subinguinal microsurgical varicocelectomy: a technical critique and statistical analysis of semen and pregnancy data. J Urol. 1994;152(4):1127–32.

    Article  CAS  Google Scholar 

  30. Orhan I, Onur R, Semercioz A, Firdolas F, Ardicoglu A, Koksal IT. Comparison of two different microsurgical methods in the treatment of varicocele. Arch Androl. 2005;51(3):213–20.

    Article  CAS  Google Scholar 

  31. Kim SO, Jung H, Park K. Outcomes of microsurgical subinguinal varicocelectomy for painful varicoceles. J Androl. 2012;33(5):872–5. https://doi.org/10.2164/jandrol.111.014993.

    Article  PubMed  Google Scholar 

  32. Nabi G, Asterlings S, Greene DR, Marsh RL. Percutaneous embolization of varicoceles: outcomes and correlation of semen improvement with pregnancy. Urology. 2004;63(2):359–63. https://doi.org/10.1016/j.urology.2003.09.026.

    Article  CAS  PubMed  Google Scholar 

  33. Gandini R, Konda D, Reale CA, Pampana E, Maresca L, Spinelli A, Stefanini M, Simonetti G. Male varicocele: transcatheter foam sclerotherapy with sodium tetradecyl sulfate–outcome in 244 patients. Radiology. 2008;246(2):612–8. https://doi.org/10.1148/radiol.2462061295.

    Article  PubMed  Google Scholar 

  34. Li L, Zeng XQ, Li YH. Safety and effectiveness of transcatheter foam sclerotherapy for testicular varicocele with a fluoroscopic tracing technique. J Vasc Interv Radiol. 2010;21(6):824–8. https://doi.org/10.1016/j.jvir.2010.02.026.

    Article  PubMed  Google Scholar 

  35. Galfano A, Novara G, Iafrate M, Fracalanza S, Novella G, Cavalleri S, Artibani W, Ficarra V. Surgical outcomes after modified antegrade scrotal sclerotherapy: a prospective analysis of 700 consecutive patients with idiopathic varicocele. J Urol. 2008;179(5):1933–7. https://doi.org/10.1016/j.juro.2008.01.042.

    Article  PubMed  Google Scholar 

  36. Cayan S, Shavakhabov S, Kadioglu A. Treatment of palpable varicocele in infertile men: a meta-analysis to define the best technique. J Androl. 2009;30(1):33–40. https://doi.org/10.2164/jandrol.108.005967.

    Article  PubMed  Google Scholar 

  37. Lund L, Roebuck DJ, Lee KH, Sorensen HT, Yeung CK. Clinical assessment after varicocelectomy. Scand J Urol Nephrol. 2000;34(2):119–22.

    Article  CAS  Google Scholar 

  38. Cil AS, Bozkurt M, Kara Bozkurt D, Gok M. Investigating the relationship between persistent reflux flow on the first postoperative day and recurrent varicocele in varicocelectomy patients. J Clin Med Res. 2015;7(1):29–32. https://doi.org/10.14740/jocmr1967w.

    Article  PubMed  Google Scholar 

  39. Goren MR, Erbay G, Ozer C, Kayra MV, Hasirci E. Can we predict the outcome of varicocelectomy based on the duration of venous reflux? Urology. 2016;88:81–6. https://doi.org/10.1016/j.urology.2015.11.032.

    Article  PubMed  Google Scholar 

  40. Gorur S, Candan Y, Helli A, Akcin S, Cekirge SD, Kaya YS, Cekic C, Kiper AN. Low body mass index might be a predisposing factor for varicocele recurrence: a prospective study. Andrologia. 2015;47(4):448–54. https://doi.org/10.1111/and.12287.

    Article  CAS  PubMed  Google Scholar 

  41. Sze DY, Kao JS, Frisoli JK, McCallum SW, Kennedy WA 2nd, Razavi MK. Persistent and recurrent postsurgical varicoceles: venographic anatomy and treatment with N-butyl cyanoacrylate embolization. J Vasc Interv Radiol. 2008;19(4):539–45. https://doi.org/10.1016/j.jvir.2007.11.009.

    Article  PubMed  Google Scholar 

  42. Sigmund G, Gall H, Bahren W. Stop-type and shunt-type varicoceles: venographic findings. Radiology. 1987;163(1):105–10. https://doi.org/10.1148/radiology.163.1.3547489.

    Article  CAS  PubMed  Google Scholar 

  43. Moon KH, Cho SJ, Kim KS, Park S, Park S. Recurrent varicoceles: causes and treatment using angiography and magnification assisted subinguinal varicocelectomy. Yonsei Med J. 2012;53(4):723–8. https://doi.org/10.3349/ymj.2012.53.4.723.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Misseri R, Gershbein AB, Horowitz M, Glassberg KI. The adolescent varicocele. II: the incidence of hydrocele and delayed recurrent varicocele after varicocelectomy in a long-term follow-up. BJU Int. 2001;87(6):494–8.

    Article  CAS  Google Scholar 

  45. Yan TZ, Wu XQ, Wang ZW. Treatment effect of TUSPLV on recurrent varicocele. Exp Ther Med. 2017;13(1):45–8. https://doi.org/10.3892/etm.2016.3931.

    Article  PubMed  Google Scholar 

  46. Chen SS. Predictive factors of successful redo varicocelectomy in infertile patients with recurrent varicocele. Andrologia. 2014;46(7):738–43. https://doi.org/10.1111/and.12142.

    Article  PubMed  Google Scholar 

  47. Grober ED, Chan PT, Zini A, Goldstein M. Microsurgical treatment of persistent or recurrent varicocele. Fertil Steril. 2004;82(3):718–22. https://doi.org/10.1016/j.fertnstert.2004.03.028.

    Article  PubMed  Google Scholar 

  48. Madjar S, Moskovitz B, Issaq E, Weinberger M, Nativ O. Low inguinal approach for correction of recurrent varicocele. Int Urol Nephrol. 1998;30(1):69–73.

    Article  CAS  Google Scholar 

  49. Kang DH, Lee JY, Chung JH, Jo JK, Lee SH, Ham WS, Cho KS, Lee KS, Kim TH, Lee SW. Laparoendoscopic single site varicocele ligation: comparison of testicular artery and lymphatic preservation versus complete testicular vessel ligation. J Urol. 2013;189(1):243–9. https://doi.org/10.1016/j.juro.2012.09.024.

    Article  PubMed  Google Scholar 

  50. Jargiello T, Drelich-Zbroja A, Falkowski A, Sojka M, Pyra K, Szczerbo-Trojanowska M. Endovascular transcatheter embolization of recurrent postsurgical varicocele: anatomic reasons for surgical failure. Acta Radiol. 2015;56(1):63–9. https://doi.org/10.1177/0284185113519624.

    Article  PubMed  Google Scholar 

  51. Makris GC, Efthymiou E, Little M, Boardman P, Anthony S, Uberoi R, Tapping C. Safety and effectiveness of the different types of embolic materials for the treatment of testicular varicoceles: a systematic review. Br J Radiol. 2018;91(1088):20170445. https://doi.org/10.1259/bjr.20170445.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Kovac JR, Fantus J, Lipshultz LI, Fischer MA, Klinghoffer Z. Cost-effectiveness analysis reveals microsurgical varicocele repair is superior to percutaneous embolization in the treatment of male infertility. Can Urol Assoc J. 2014;8(9–10):E619–25. https://doi.org/10.5489/cuaj.1873.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Mazzoni G, Minucci S, Gentile V. Recurrent varicocele: role of antegrade sclerotherapy as first choice treatment. Eur Urol. 2002;41(6):614–8. discussion 618.

    Article  CAS  Google Scholar 

  54. Kim J, Shin JH, Yoon HK, Ko GY, Gwon DI, Kim EY, Sung KB. Persistent or recurrent varicocoele after failed varicocoelectomy: outcome in patients treated using percutaneous transcatheter embolization. Clin Radiol. 2012;67(4):359–65. https://doi.org/10.1016/j.crad.2011.10.007.

    Article  CAS  PubMed  Google Scholar 

  55. Cayan S, Akbay E. Fate of recurrent or persistent varicocele in the era of assisted reproduction technology: microsurgical subinguinal redo varicocelectomy versus observation. Urology. 2018;117:64–9. https://doi.org/10.1016/j.urology.2018.03.046.

    Article  PubMed  Google Scholar 

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Russo, G.I., Serefoglu, E.C. (2019). Management of Recurrent Varicocele. In: Esteves, S., Cho, CL., Majzoub, A., Agarwal, A. (eds) Varicocele and Male Infertility. Springer, Cham. https://doi.org/10.1007/978-3-319-79102-9_27

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