Rheumatic Complications of Streptococcus pyogenes

  • Guliz ErdemEmail author
  • Edward L. Kaplan


Acute rheumatic fever remains one of the major autoimmune disorders known to occur as a result of a specific pathogen, group A Streptococcus (Streptococcus pyogenes), even though the precise mechanism is incompletely understood. Post-streptococcal reactive arthritis and post-streptococcal glomerulonephritis similarly follow group A streptococcal infections. Group A streptococcus-induced autoimmunity via suspected molecular mimicry has ramifications for future microbiome research and management and prevention of rheumatologic diseases.


Acute rheumatic fever Rheumatic heart disease Microbiome Carditis Streptococcus pyogenes Acute post-streptococcal glomerulonephritis Streptococcal reactive arthritis 



Acute rheumatic fever


Group A streptococcus


Major histocompatibility complex


Post-streptococcal glomerulonephritis


Post-streptococcal reactive arthritis


Rheumatic heart disease


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Nationwide Children’s Hospital Medical Center, The Ohio State University, Infectious Diseases SectionColumbusUSA
  2. 2.University of Minnesota Medical School, Department of PediatricsMinneapolisUSA

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