Animal Models of Rheumatoid Arthritis

  • David R. WebbEmail author


Animal models of rheumatoid arthritis (RA) have been key to understanding the underlying pathology in RA. For over 50 years, the most common models have been based on the use of adjuvants that contain bacteria (mycobacteria) or that rely on the use of collagen type II to induce the disease. The role of microbes in the etiology of RA has long been hypothesized, and the existing data, while correlative and circumstantial, suggest this hypothesis is correct. The animal models, however, as valuable as they have been, are acute in their initiation, onset, and outcomes unlike the disease that occurs in humans. This chapter focuses on the major animal models of RA currently in use and their advantages and disadvantages and offers suggestions for future directions including the use of transgenic and/or humanized mice.


Animal models Germ-free Rheumatoid arthritis 





Anti-parietal cell antibodies


Bovine serum albumin


Collagen antibody-induced arthritis


Complete Freund’s adjuvant


Collagen-induced arthritis




Inflammatory bowel disease


RF-like immunoglobulin






Monoclonal antibody


Multiple sclerosis


Nonsteroidal anti-inflammatory drug


Polymorphonuclear cell


Rheumatoid arthritis


Rheumatoid factor


Severe combined immunodeficiency


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.The Department of Integrated Structural and Computational BiologyThe Scripps Research InstituteLa JollaUSA

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