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The Microbiome in Rheumatic Diseases and Infection pp 465–474Cite as

The Promise of Personalized Medicine

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Abstract

There is substantial potential for the human intestinal microbiota to be mined for its therapeutic potential. Absent exogenous perturbations, the intestinal microbiota tends to be highly stable throughout adult life, and it appears to be associated with a variety of rheumatic diseases. Furthermore, the microbiota can influence the metabolism of many medicines used to treat inflammatory diseases, thus potentially playing a role in the disease process even in the absence of specific abnormalities in its composition. We have multiple tools at hand to alter the microbiota, and the future may hold targeted approaches to remove specific bacteria associated with a particular condition. Finally, there is evidence that an individual’s baseline microbiota might predict his or her response to dietary therapy, thus ushering in an era of individualized medicine targeting the human intestinal microbiota.

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Abbreviations

AID:

Anti-inflammatory diet

CGR:

Cardiac glycoside reductase

EEN:

Exclusive enteral nutrition

FMT:

Fecal microbial transplantation

HMP:

Human Microbiome Project

IBD:

Inflammatory bowel disease

JIA:

Juvenile idiopathic arthritis

RA:

Rheumatoid arthritis

ReA:

Reactive arthritis

SCFA:

Short-chain fatty acids

SpA:

Spondyloarthritis

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Authors and Affiliations

  1. Department of Pediatrics, Division of Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA

    Matthew L. Stoll

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  1. Matthew L. Stoll
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Correspondence to Matthew L. Stoll .

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Editors and Affiliations

  1. Faculty of Medicine, Cairo University, Cairo, Egypt

    Gaafar Ragab

  2. University of Alabama, Birmingham, Alabama, USA

    T. Prescott Atkinson

  3. University of Alabama, Birmingham, Alabama, USA

    Matthew L. Stoll

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Stoll, M.L. (2018). The Promise of Personalized Medicine. In: Ragab, G., Atkinson, T., Stoll, M. (eds) The Microbiome in Rheumatic Diseases and Infection. Springer, Cham. https://doi.org/10.1007/978-3-319-79026-8_35

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