Management of Autoimmune and Inflammatory Disorders in the Setting of Infection or Immunodeficiency

  • W. Winn ChathamEmail author


Host-microbiome symbiosis is contingent upon intact immune surveillance and competence. Compromised immunity with development of clinical infection may occur as a consequence of immunosuppressive therapy prescribed for treatment of inflammatory or autoimmune disease. Alternatively, autoimmune disorders not uncommonly develop in the context of underlying immune deficiency. In either setting, clinicians may need to develop strategies to suppress autoimmune-mediated inflammation in the setting of intercurrent infection. The optimal strategy is best informed by what host defenses are required to effect resolution of the infection, the current status of these defenses in a given patient, and recognition of how chosen therapies for managing autoimmunity and associated inflammation may (or may not) impact the ability of the needed defenses to eradicate specific pathogens.


Autoimmune diseases Immunosuppressive therapy Infection Immunodeficiency 



Adenosine deaminase deficiency


Activation-induced cytidine deaminase


Common variable immunodeficiency


Disease-modifying antirheumatic drug


Giant cell arteritis


Granulomatosis with polyangiitis




Interleukin 6 (17) receptor


Intravenous immunoglobulin


Mannose-binding lectin


Matrix metalloproteinase


Microscopic polyangiitis




Nonsteroidal anti-inflammatory drug


Polyarteritis nodosa


Primary immunodeficiency


Rheumatoid arthritis


Selective IgA deficiency


Systemic lupus erythematosus


Seronegative spondyloarthritis


Transmembrane activator, calcium-modulator, and cyclophilin ligand interactor


Toll-like receptor


Uracil nucleoside glycosylase


Wiskott-Aldrich syndrome


X-linked agammaglobulinemia


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.University of Alabama at Birmingham (UAB), Division of Clinical Immunology and RheumatologyBirminghamUSA

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