Subacute Bacterial Endocarditis

  • Gaafar RagabEmail author
  • Hussien Rizk


Subacute bacterial endocarditis involves microbial infection of the endocardium, heart valves, or intravascular device. Many pathogens are incriminated. Added to the clinical picture attributed to direct infection, the disease is capable of displaying a constellation of immunological and rheumatological manifestations. The diagnostic work-up includes microbiological and imaging techniques. The main rheumatological manifestations include musculoskeletal, renal, and vasculitic presentations. ANCA positivity has been reported repeatedly. We conducted a PubMed search on ANCA positivity with SBE, the results of which are discussed in this section. Attention to the possibility of SBE diagnosis in high-risk patients will lead to early diagnosis, timely treatment, and avoidance of unnecessary or potentially harmful treatment.


Subacute bacterial endocarditis Pathogenesis Diagnosis Autoimmune phenomena Rheumatic manifestations Nephritis Vasculitis ANCA 



ANCA-associated vasculitis


Anticardiolipin antibodies


Antinuclear antibodies


Antineutrophil cytoplasmic antibodies


Acute renal failure


Community-acquired IE


cANCA/proteinase 3


Crescentic GN


Central nervous system


Chronic renal failure


Chronic sclerotic GN


Haemophilus species, Aggregatibacter actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella kingae


Healthcare-associated IE


Infective endocarditis


Mesangial GN


Perinuclear anti-neutrophil cytoplasmic antibodies




Polymerase chain reaction


Prosthetic valve endocarditis


Rapidly progressive glomerulonephritis


Subacute bacterial endocarditis


Segmental necrotizing GN


Terminal renal failure


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Internal Medicine, Faculty of MedicineCairo UniversityCairoEgypt
  2. 2.Department of Cardiology, Faculty of MedicineCairo UniversityCairoEgypt

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