Behçet Disease

  • Ahmet GülEmail author


Behçet disease (BD) is a multifactorial inflammatory disorder characterized by recurrent attacks affecting mucocutaneous and ocular tissues as well as joints, blood vessels, and central nervous and gastrointestinal systems. Although this distinct set of manifestations was first thought to be associated with a generalized viral infection, no specific causative agent could be isolated. But several microorganisms, including uncommon serotypes of streptococcal strains and herpes simplex virus, have been implicated as triggers of disease manifestations in genetically susceptible individuals, and a hypersensitivity to streptococcal antigens and a possible cross-reactivity with self-proteins have been suggested in the pathogenesis of BD. Genetic factors may play a role in susceptibility to certain microbial agents as well as in the hyper-reactive immune response to these pathogens and other dangerous insults. Identification of the genetic and immunologic basis of the disordered host—microbial interactions is expected to provide insights to reduce the impact of BD in the patients as well as in the high-risk populations.


Behçet disease Streptococcus sanguinis Herpes simplex virus Heat shock proteins Microbiota Hypersensitivity 



Behçet disease


Human leukocyte antigen


Heat shock protein 60-kDa


Heat shock protein 65-kDa


Institute of Cancer Research


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of RheumatologyIstanbulTurkey

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