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Gene Therapy in Tendon Repair and Regeneration

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Gene Therapy in Reconstructive and Regenerative Surgery

Abstract

Tendon and ligament injuries constitute one of the most common traumas to the human body, with tendon injuries to the hand and wrist occurring in hundreds of thousands of people annually in the USA alone. Gene therapy for the purpose of tendon healing is used to manipulate the healing environment. In this chapter, we will define the issues with tendon injuries, the model of gene therapy, and the clinical problems that may be addressed with gene intervention.

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Abbreviations

AAV:

Adeno-associated virus

bFGF:

Basic fibroblast growth factor

PDGF-B:

Platelet-derived growth factor-B

VEGF:

Vascular endothelial growth factor

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Authors and Affiliations

  1. Department of Plastic Surgery, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI, USA

    Raman Mehrzad, Xiao Tian Wang & Paul Y. Liu

  2. Department of Hand Surgery, The Hand Surgery Research Center, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China

    You Lang Zhou & Ya Fang Wu

Authors
  1. Raman Mehrzad
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  2. Xiao Tian Wang
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  3. You Lang Zhou
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  4. Ya Fang Wu
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  5. Paul Y. Liu
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Corresponding author

Correspondence to Paul Y. Liu .

Editor information

Editors and Affiliations

  1. Division of Plastic Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Giorgio Giatsidis

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Mehrzad, R., Wang, X.T., Zhou, Y.L., Wu, Y.F., Liu, P.Y. (2018). Gene Therapy in Tendon Repair and Regeneration. In: Giatsidis, G. (eds) Gene Therapy in Reconstructive and Regenerative Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-78957-6_6

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  • DOI: https://doi.org/10.1007/978-3-319-78957-6_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-78956-9

  • Online ISBN: 978-3-319-78957-6

  • eBook Packages: MedicineMedicine (R0)

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