Abstract
The human brain is a formidably complex and adaptable organ capable of rewiring itself or adjusting existing connections in order to learn and to maximize its survival edge. Studies using sensory substitution devices have had a big impact on the uncovering of the mechanisms subtending brain organization. Sensory substitution devices are capable of conveying information typically received through a specific sensory modality (e.g., vision) and transferring it to the user via a different sense (e.g., audition or touch). Experimental research exploring the perceptual learning of sensory substitution devices has revealed the ability of users to recognize movement and shapes, to navigate routes, to detect and avoid obstacles, and to perceive colors or depth via touch or sound, even in cases of full and congenital blindness. Using a combination of functional and anatomical neuroimaging techniques, the comparisons of performances between congenitally blind people and sighted people using sensory substitution devices in perceptual and sensory-motor tasks as well as in several recognition tasks uncovered the striking ability of the brain to rewire itself during perceptual learning and to learn to interpret novel sensory information even during adulthood. This review discusses the impact of invasive and noninvasive forms of artificial vision on brain organization with a special emphasis on sensory substitution devices and also discusses the implications of these findings for the visual rehabilitation of congenitally and late blind and partially sighted individuals while applying insights from neuroimaging and psychophysics.
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References
Heimler B, Baruffaldi F, Bonmassar C, Venturini M, Pavani F (2017) Multisensory interference in early deaf adults. J Deaf Stud Deaf Educ 22(4):422–433
Amedi A, Hofstetter S, Maidenbaum S, Heimler B (2017) Task selectivity as a comprehensive principle for brain organization. Trends Cogn Sci 21(5):307–310
Heimler B, Striem-Amit E, Amedi A (2015) Origins of task-specific sensory-independent organization in the visual and auditory brain: neuroscience evidence, open questions and clinical implications. Curr Opin Neurobiol 35:169–177
Kupers R, Ptito M (2011) Insights from darkness: what the study of blindness has taught us about brain structure and function. In: Progress in brain research, vol 192. Elsevier, Amsterdam, pp 17–31
Reich L, Maidenbaum S, Amedi A (2012) The brain as a flexible task machine: implications for visual rehabilitation using noninvasive vs. invasive approaches. Curr Opin Neurol 25(1):86–95
Cecchetti L, Kupers R, Ptito M, Pietrini P, Ricciardi E (2016) Are supramodality and cross-modal plasticity the yin and yang of brain development? From blindness to rehabilitation. Front Syst Neurosci 10:89
Ptito M, Chebat DR, Kupers R (2008a) The blind get a taste of vision. In: Human haptic perception: basics and applications. Birkhäuser, Basel, pp 481–489
Bach-y-Rita P, Kercel SW (2003) Sensory substitution and the human–machine interface. Trends Cogn Sci 7(12):541–546
Chebat DR, Harrar V, Kupers R, Maidenbaum S, Amedi A, Ptito M (2018) Sensory substitution and the neural correlates of navigation in blindness. In: Mobility of Visually Impaired People. Springer, Cham, pp 167–200
Proulx MJ, Ptito M, Amedi A (2014) Multisensory integration, sensory substitution and visual rehabilitation. Neurosci Biobehav Rev 41:1
Fine I, Boynton GM (2015) Pulse trains to percepts: the challenge of creating a perceptually intelligible world with sight recovery technologies. Philos Trans R Soc Lond B Biol Sci 370(1677):20140208
Fine I, Cepko CL, Landy MS (2015) Vision research special issue: sight restoration: prosthetics, optogenetics and gene therapy. Vis Res 111(Pt B):115
Arabi K, Sawan MA (1999) Electronic design of a multichannel programmable implant for neuromuscular electrical stimulation. J IEEE Trans Rehabil Eng 7:204–214
Sawan M, Hu Y, Coulombe J (2005) Wireless smart implants dedicated to multichannel monitoring and microstimulation. IEEE Circuits Syst Mag 5:21–39
Delbeke J, Pins D, Michaux G, Wanet-Defalque MC, Parrini S, Veraart C (2001) Electrical stimulation of anterior visual pathways in retinitis pigmentosa. Invest Ophthalmol Vis Sci 42(1):291–297
Dobelle WH (2000) Artificial vision for the blind by connecting a television camera to the visual cortex. ASAIO J 46(1):3–9
Dobelle WH, Quest DO, Antunes JL, Roberts TS, Girvin JP (1979) Artificial vision for the blind by electrical stimulation of the visual cortex. Neurosurgery 5(4):521–527
Veraart C, Raftopoulos C, Mortimer JT, Delbeke J, Pins D, Michaux G, Vanlierde A, Parrini S, Wanet-Defalque MC (1998) Visual sensations produced by optic nerve stimulation using an implanted self-sizing spiral cuff electrode. Brain Res 813(1):181–186
Merabet LB, Rizzo JF III, Pascual-Leone A, Fernandez E (2007) ‘Who is the ideal candidate?’: Decisions and issues relating to visual neuroprosthesis development, patient testing and neuroplasticity. J Neural Eng 4(1):S130
Neville H, Bavelier D (2002) Human brain plasticity: evidence from sensory deprivation and altered language experience. Prog Brain Res 138:177–188
Gekeler F, Messias A, Ottinger M, Bartz-Schmidt KU, Zrenner E (2006) Phosphenes electrically evoked with DTL electrodes: a study in patients with retinitis pigmentosa, glaucoma, and homonymous visual field loss and normal subjects. Invest Ophthalmol Vis Sci 47(11):4966–4974
Veraart C, Wanet-Defalque MC, Gerard B, Vanlierde A, Delbeke J (2003) Pattern recognition with the optic nerve visual prosthesis. Artif Organs 27(11):996–1004
Humayun MS, Dorn JD, Da Cruz L, Dagnelie G, Sahel JA, Stanga PE, Ho AC (2012) Interim results from the international trial of second Sight's visual prosthesis. Ophthalmology 119(4):779–788
Luo YHL, da Cruz L (2016) The Argus® II retinal prosthesis system. Prog Retin Eye Res 50:89–107
Matet A, Amar N, Mohand-Said S, Sahel JA, Barale PO (2016) Argus II retinal prosthesis implantation with scleral flap and autogenous temporalis fascia as alternative patch graft material: a 4-year follow-up. Clin Ophthalmol (Auckland, NZ) 10:1565
Dagnelie G, Christopher P, Arditi A, Cruz L, Duncan JL, Ho AC et al (2017) Performance of real-world functional vision tasks by blind subjects improves after implantation with the Argus® II retinal prosthesis system. Clin Experiment Ophthalmol 45(2):152–159
Barry MP, Dagnelie G, Argus IISG (2012) Use of the Argus II retinal prosthesis to improve visual guidance of fine hand movements. Invest Ophthalmol Vis Sci 53(9):5095±101. https://doi.org/10.1167/iovs.12-9536. PMID: 22661464; PubMed Central PMCID: PMCPMC3416020
Chader GJ, Weiland J, Humayun MS (2009) Artificial vision: needs, functioning, and testing of a retinal electronic prosthesis. Prog Brain Res 175:317±32. https://doi.org/10.1016/S0079-6123(09)17522-2. PMID: 19660665
da Cruz L, Coley BF, Dorn J, Merlini F, Filley E, Christopher P et al (2013) The Argus II epiretinal prosthesis system allows letter and word reading and long-term function in patients with profound vision loss. Br J Ophthalmol 97(5):632±6. https://doi.org/10.1136/bjophthalmol-2012-301525. PMID: 23426738; PubMed Central PMCID: PMCPMC3632967
Dorn JD, Ahuja AK, Caspi A, da Cruz L, Dagnelie G, Sahel JA et al (2013) The detection of motion by blind subjects with the Epiretinal 60-electrode (Argus II) retinal prosthesis. JAMA Ophthalmol 131(2):183±9. https://doi.org/10.1001/2013.jamaophthalmol.221. PMID: 23544203; PubMed Central PMCID: PMCPMC3924899
Rizzo S, Belting C, Cinelli L, Allegrini L, Genovesi-Ebert F, Barca F et al (2014) The Argus II retinal prosthesis: 12-month outcomes from a single-study center. Am J Ophthalmol 157(6):1282±90. https://doi.org/10.1016/j.ajo.2014.02.039. PMID: 24560994
Kotecha A, Zhong J, Stewart D, da Cruz L (2014) The Argus II prosthesis facilitates reaching and grasping tasks: a case series. BMC Ophthalmol 14(1):71
Luo YHL, Zhong JJ, Da Cruz L (2015) The use of Argus® II retinal prosthesis by blind subjects to achieve localisation and prehension of objects in 3-dimensional space. Graefes Arch Clin Exp Ophthalmol 253(11):1907–1914
Sabbah N, Authié CN, Sanda N, Mohand-Said S, Sahel JA, Safran AB (2014) Importance of eye position on spatial localization in blind subjects wearing an Argus II retinal prosthesis eye position, localization, and retinal prosthesis. Invest Ophthalmol Vis Sci 55(12):8259–8266
Castaldi E, Cicchini GM, Cinelli L, Biagi L, Rizzo S, Morrone MC (2016) Visual BOLD response in late blind subjects with Argus II retinal prosthesis. PLoS Biol 14(10):e1002569
Huber E, Webster JM, Brewer AA, MacLeod DI, Wandell BA, Boynton GM, Fine I (2015) A lack of experience-dependent plasticity after more than a decade of recovered sight. Psychol Sci. https://doi.org/10.1177/0956797614563957
Sabbah N, Sanda N, Authié CN, Mohand-Saïd S, Sahel JA, Habas C, Amedi A, Safran AB (2017) Reorganization of early visual cortex functional connectivity following selective peripheral and central visual loss. Scientific Reports 7:43223
Heimler B, Weisz N, Collignon O (2014) Revisiting the adaptive and maladaptive effects of crossmodal plasticity. Neurosci 283:44–63
Ptito M, Fumal A, de Noordhout AM, Schoenen J, Gjedde A, Kupers R (2008) TMS of the occipital cortex induces tactile sensations in the fingers of blind braille readers. Exp Brain Res 184:193–200
Kupers R, Fumal A, De Noordhout AM, Gjedde A, Schoenen J, Ptito M (2006) Transcranial magnetic stimulation of the visual cortex induces somatotopically organized qualia in blind subjects. Proc Natl Acad Sci 103(35):13256–13260
Busskamp V, Duebel J, Balya D, Fradot M, Viney TJ, Siegert S et al (2010) Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science 329(5990):413–417
Yang Y, Mohand-Said S, Léveillard T, Fontaine V, Simonutti M, Sahel JA (2010) Transplantation of photoreceptor and total neural retina preserves cone function in P23H rhodopsin transgenic rat. PLoS One 5(10):e13469
Davis MF, Velez DXF, Guevarra RP, Yang MC, Habeeb M, Carathedathu MC, Gandhi SP (2015) Inhibitory neuron transplantation into adult visual cortex creates a new critical period that rescues impaired vision. Neuron 86(4):1055–1066
Deidda G, Allegra M, Cerri C, Naskar S, Bony G, Zunino G, Bozzi Y, Caleo M, Cancedda L (2014) Early depolarizing GABA controls critical-period plasticity in the rat visual cortex. Nat Neurosci 18:87
Lunghi C, Emir UE, Morrone MC, Bridge H (2015) Short-term monocular deprivation alters GABA in the adult human visual cortex. Curr Biol 25:1496–1501
Sengpiel F (2014) Plasticity of the visual cortex and treatment of amblyopia. Curr Biol 24(18):R936–R940
Borisoff JF, Elliott SL, Hocaloski S, Birch GE (2010) The development of a sensory substitution system for the sexual rehabilitation of men with chronic spinal cord injury. J Sex Med 7(11):3647–3658
Sadeghi SG, Minor LB, Cullen KE (2012) Neural correlates of sensory substitution in vestibular pathways following complete vestibular loss. J Neurosci 32(42):14685–14695
Vuillerme N, Hlavackova P, Franco C, Diot B, Demongeot J, Payan Y (2011) Can an electro-tactile vestibular substitution system improve balance in patients with unilateral vestibular loss under altered somatosensory conditions from the foot and ankle? In: Engineering in medicine and biology society, EMBC, 2011 annual international conference of the IEEE. IEEE, pp 1323–1326
Kärcher SM, Fenzlaff S, Hartmann D, Nagel SK, König P (2012) Sensory augmentation for the blind. Front Hum Neurosci 6:37
Ward J, Meijer P (2010) Visual experiences in the blind induced by an auditory sensory substitution device. Conscious Cogn 19(1):492–500
Fornazzari L, Fischer CE, Ringer L, Schweizer TA (2012) “Blue is music to my ears”: multimodal synesthesias after a thalamic stroke. Neurocase 18(4):318–322
Ione A, Tyler C (2004) Neuroscience, history and the arts synesthesia: is F-sharp colored violet? J Hist Neurosci 13(1):58–65
Marks LE (1975) On colored-hearing synesthesia: cross-modal translations of sensory dimensions. Psychol Bull 82(3):303
Tyler CW (2005) Varieties of synesthetic experience. In: Robertson LC, Sagiv N (eds) Synesthesia: Perspectives from Cognitive Neuroscience. Oxford University Press, New York
Zamm A, Schlaug G, Eagleman DM, Loui P (2013) Pathways to seeing music: enhanced structural connectivity in colored-music synesthesia. NeuroImage 74:359–366
Chiou R, Stelter M, Rich AN (2013) Beyond colour perception: auditory–visual synaesthesia induces experiences of geometric objects in specific locations. Cortex 49(6):1750–1763
Proulx MJ (2010) Synthetic synaesthesia and sensory substitution. Conscious Cogn 19(1):501–503
Ward J, Wright T (2014) Sensory substitution as an artificially acquired synaesthesia. Neurosci Biobehav Rev 41:26–35
Buchs G, Maidenbaum S, Amedi A (2014) Obstacle identification and avoidance using the ‘EyeCane’: a tactile sensory substitution device for blind individuals. In: International conference on LBHuman haptic sensing and touch enabled computer applications. Springer, Berlin/Heidelberg, pp 96–103
Chebat DR, Schneider FC, Kupers R, Ptito M (2011) Navigation with a sensory substitution device in congenitally blind individuals. Neuroreport 22(7):342–347
Gagnon L, Schneider FC, Siebner HR, Paulson OB, Kupers R, Ptito M (2012) Activation of the hippocampal complex during tactile maze solving in congenitally blind subjects. Neuropsychologia 50(7):1663–1671
Kupers R, Chebat DR, Madsen KH, Paulson OB, Ptito M (2010) Neural correlates of virtual route recognition in congenital blindness. Proc Natl Acad Sci 107(28):12716–12721
Chebat DR, Maidenbaum S, Amedi A (2015) Navigation using sensory substitution in real and virtual mazes. PLoS One 10(6):e0126307
Matteau I, Kupers R, Ricciardi E, Pietrini P, Ptito M (2010) Beyond visual, aural and haptic movement perception: hMT+ is activated by electrotactile motion stimulation of the tongue in sighted and in congenitally blind individuals. Brain Res Bull 82(5):264–270
Striem-Amit E, Dakwar O, Reich L, Amedi A (2011b) The large-scale organization of “visual” streams emerges without visual experience. Cereb Cortex 22(7):1698–1709
Striem-Amit E, Amedi A (2014) Visual cortex extrastriate body-selective area activation in congenitally blind people “seeing” by using sounds. Curr Biol 24(6):687–692
Striem-Amit E, Cohen L, Dehaene S, Amedi A (2012) Reading with sounds: sensory substitution selectively activates the visual word form area in the blind. Neuron 76(3):640–652
Abboud S, Maidenbaum S, Dehaene S, Amedi A (2015) A number-form area in the blind. Nat Commun 6:6026
Bach-y-Rita P (1975) Plastic brain mechanisms in sensory substitution. In: Cerebral localization. Springer, Berlin/Heidelberg, pp 203–216
Bach-y-Rita P, Collins CC, Saunders FA, White B, Scadden L (1969) Vision substitution by tactile image projection. Nature 221(5184):963–964
Nagel SK, Carl C, Kringe T, Märtin R, König P (2005) Beyond sensory substitution—learning the sixth sense. J Neural Eng 2(4):R13
Visell Y (2008) Tactile sensory substitution: models for enaction in HCI. Interacting with Computers 21(1-2):38–53
Bach-y-Rita P, Aiello GL (1996) Nerve length and volume in synaptic vs diffusion neurotransmission: a model. Neuroreport 7(9):1502–1504
Kacznaarek KA, Bach-Y-Rita P (1995) Tactile displays. In: Virtual environments and advanced interface design, vol 55. New York, Oxford, p 349
Renier L, Laloyaux C, Collignon O, Tranduy D, Vanlierde A, Bruyer R, De Volder AG (2005) The Ponzo illusion with auditory substitution of vision in sighted and early-blind subjects. Perception 34(7):857–867
Renier L, Bruyer R, De Volder AG (2006) Vertical-horizontal illusion present for sighted but not early blind humans using auditory substitution of vision. Attention. Percept Psychophys 68(4):535–542
Schinazi VR, Thrash T, Chebat DR (2016) Spatial navigation by congenitally blind individuals. Wiley Interdiscip Rev Cogn Sci 7(1):37–58
Supa M, Cotzin M, Dallenbach KM (1944) " facial vision": the perception of obstacles by the blind. Am J Psychol 57(2):133–183
Cotzin M, Dallenbach KM (1950) “Facial Vision”: the role of pitch and loudness in the perception of obstacles by the blind. Am J Psychol 63:485–515
Cotzin, Dallenbach (1950) “Facial vision”: the role of pitch and loudness in the location of obstacles by the blind. Am J Psychol 63:485
Ashmead DH, Hill EW, Talor CR (1989) Obstacle perception by ongenitally blind children. Atten Percept Psychophys 46(5):425–433
Wilson JP (1967) Psychoacoustics of obstacle detection using ambient or self-generated noise. In: Animal sonar systems: biology and bionics, vol 1. Laboratoire de Physiologie Acoustique, INRA-CNRZ, Jouy-en-Josas, pp 89–114
Bronkhorst AW, Houtgast T (1999) Auditory distance perception in rooms. Nature 397(6719):517–520
Kaye HS (2000) Computer and internet use among people with disabilities. Disability Statistics Report 13
Meijer PB (1992) An experimental system for auditory image representations. IEEE Trans Biomed Eng 39(2):112–121
Hersh MA, Johnson MA (2008) Disability and assistive technology systems. In: Assistive technology for visually impaired and blind people. Springer, London, pp 1–50
Maidenbaum S, Abboud S, Amedi A (2014) Sensory substitution: closing the gap between basic research and widespread practical visual rehabilitation. Neurosci Biobehav Rev 41:3–15
Dunai L, Peris-Fajarnés G, Lluna E, Defez B (2013) Sensory navigation device for blind people. J Navig 66(3):349–362
Hartcher-O'Brien J, Auvray M, Hayward V (2015) Perception of distance-to-obstacle through timedelayed tactile feedback. In: World Haptics Conference (WHC), 2015 I.E. (pp. 7–12). IEEE
Segond H, Weiss D, Sampaio E (2005) Human spatial navigation via a visuo-tactile sensory substitution system. Perception 34(10):1231–1249
Shoval S, Borenstein J, Koren Y (1998) Auditory guidance with the navbelt-a computerized travel aid for the blind. IEEE Trans Syst Man Cybern Part C Appl Rev 28(3):459–467
Stoll C, Palluel-Germain R, Fristot V, Pellerin D, Alleysson D, Graff C (2015) Navigating from a depth image converted into sound. Appl Bionics Biomech 2015:9
Kaspar K, König S, Schwandt J, König P (2014) The experience of new sensorimotor contingencies by sensory augmentation. Conscious Cogn 28:47–63
König SU, Schumann F, Keyser J, Goeke C, Krause C, Wache S, Lytochkin A, Ebert M, Brunsch V, Wahn B, Kaspar K, Nagel SK, Meilinger T, Bülthoff H, Wolbers T, Büchel C, König P (2016) Learning new sensorimotor contingencies: effects of long-term use of sensory augmentation on the brain and conscious perception. PLoS One 11(12):e0166647
Noppeney U, Friston KJ, Ashburner J, Frackowiak R, Price CJ (2005) Early visual deprivation induces structural plasticity in gray and white matter. Curr Biol 15(13):R488–R490
Shimony JS, Burton H, Epstein AA, McLaren DG, Sun SW, Snyder AZ (2006) Diffusion tensor imaging reveals white matter reorganization in early blind humans. Cereb Cortex 16(11):1653–1661
De Volder AG, Bol A, Blin J, Robert A, Arno P, Grandin C, Michel C, Veraart C (1997) Brain energy metabolism in early blind subjects: neural activity in the visual cortex. Brain Res 750(1):235–244
Wanet-Defalque MC, Veraart C, De Volder A, Metz R, Michel C, Dooms G, Goffinet A (1988) High metabolic activity in the visual cortex of early blind human subjects. Brain Res 446(2):369–373
Noppeney U (2007) The effects of visual deprivation on functional and structural organization of the human brain. Neurosci Biobehav Rev 31(8):1169–1180
Sathian K, Zangaladze A (2002) Feeling with the mind's eye: contribution of visual cortex to tactile perception. Behav Brain Res 135(1):127–132
Goodale MA, Milner AD (1992) Separate visual pathways for perception and action. Trends Neurosci 15(1):20–25
Milner AD, Goodale MA (2008) Two visual systems re-viewed. Neuropsychologia 46(3):774–785
Mishkin M, Ungerleider LG (1982) Contribution of striate inputs to the visuospatial functions of parieto-preoccipital cortex in monkeys. Behav Brain Res 6(1):57–77
Ptito M, Matteau I, Zhi Wang A, Paulson OB, Siebner HR, Kupers R (2012) Crossmodal recruitment of the ventral visual stream in congenital blindness. Neural Plast 2012:304045
Amedi A, Stern WM, Camprodon JA, Bermpohl F, Merabet L, Rotman S et al (2007) Shape conveyed by visual-to-auditory sensory substitution activates the lateral occipital complex. Nat Neurosci 10(6):687
Reich L, Szwed M, Cohen L, Amedi A (2011) A ventral visual stream reading center independent of visual experience. Curr Biol 21(5):363–368
Büchel C, Price C, Frackowiak RS, Friston K (1998) Different activation patterns in the visual cortex of late and congenitally blind subjects. Brain J Neurol 121(3):409–419
Ptito M, Matteau I, Gjedde A, Kupers R (2009) Recruitment of the middle temporal area by tactile motion in congenital blindness. Neuroreport 20(6):543–547
Matteau I, Schneider F, Kupers R, Ptito M (2006) Tactile motion discrimination through the tongue in blindness: a fMRI study. Neuroimage 36(Suppl 1):211
Collignon O, Lassonde M, Lepore F, Bastien D, Veraart C (2007) Functional cerebral reorganization for auditory spatial processing and auditory substitution of vision in early blind subjects. Cereb Cortex 17(2):457–465
Bedny M, Konkle T, Pelphrey K, Saxe R, Pascual-Leone A (2010) Sensitive period for a multimodal response in human visual motion area MT/MST. Curr Biol 20(21):1900–1906
Amedi A, Stern W, Striem E, Hertz U, Meijer P, Pascual-Leone A (2008) A what/where visual-toauditory sensory substitution fMRI study: Can blind and sighted hear shapes and locations in the visual cortex. In: 31st European Conference on Visual Perception
Siuda-Krzywicka K, Bola Ł, Paplińska M, Sumera E, Jednoróg K, Marchewka A, Szwed M (2016) Massive cortical reorganization in sighted braille readers. elife 5:e10762
Hertz U, Amedi A (2014) Flexibility and stability in sensory processing revealed using visual-to-auditory sensory substitution. Cereb Cortex 25(8):2049–2064
Hannagan T, Amedi A, Cohen L, Dehaene-Lambertz G, Dehaene S (2015) Origins of the specialization for letters and numbers in ventral occipitotemporal cortex. Trends Cogn Sci 19(7):374–382
Damoiseaux JS, Greicius MD (2009) Greater than the sum of its parts: a review of studies combining structural connectivity and resting-state functional connectivity. Brain Struct Funct 213:525–533
Fox MD, Raichle ME (2007) Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 8:700–711
Bi Y, Wang X, Caramazza A (2016) Object domain and modality in the ventral visual pathway. Trends Cogn Sci 20(4):282–290
Weaver KE, Stevens AA (2007) Attention and sensory interactions within the occipital cortex in the early blind: an fMRI study. J Cogn Neurosci 19(2):315–330
Eger E, Sterzer P, Russ MO, Giraud A-L, Kleinschmidt A (2003) A supramodal number representation in human intraparietal cortex. Neuron 37:719–726
Price CJ (2012) A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading. NeuroImage 62:816
Vigneau M, Beaucousin V, Herve P-Y, Duffau H, Crivello F, Houde O, Mazoyer B, Tzourio-Mazoyer N (2006) Meta-analyzing left hemisphere language areas: phonology, semantics, and sentence processing. NeuroImage 30:1414–1432
Wang X, Peelen MV, Han Z, He C, Caramazza A, Bi Y (2015) How visual is the visual cortex? Comparing connectional and functional fingerprints between congenitally blind and sighted individuals. J Neurosci 35(36):12545–12559
Ptito M, Moesgaard SM, Gjedde A, Kupers R (2005) Cross-modal plasticity revealed by electrotactile stimulation of the tongue in the congenitally blind. Brain 128(3):606–614
Thaler L, Arnott SR, Goodale MA (2011) Neural correlates of natural human echolocation in early and late blind echolocation experts. PLoS One 6:e20162
Théoret H, Merabet L, Pascual-Leone A (2004) Behavioral and neuroplastic changes in the blind: evidence for functionally relevant cross-modal interactions. J Physiol aris 98(1):221–233
Amedi A, Raz N, Pianka P, Malach R, Zohary E (2003) Early 'visual' cortex activation correlates with superior verbal memory performance in the blind. Nat Neurosci 6:758–766
Bedny M, Pascual-Leone A, Dodell-Feder D, Fedorenko E, Saxe R (2011) Language processing in the occipital cortex of congenitally blind adults. Proc Natl Acad Sci 108(11):4429–4434
Burton H, Diamond JB, McDermott KB (2003) Dissociating cortical regions activated by semantic and phonological tasks: a FMRI study in blind and sighted people. J Neurophysiol 90:1965–1982. Epub 2003 Jun 1964
Sadato N, Pascual-Leone A, Grafman J, Ibanez V, Deiber MP, Dold G, Hallett M (1996) Activation of the primary visual cortex by braille reading in blind subjects. Nature 380:526–528
Strnad L, Peelen MV, Bedny M, Caramazza A (2013) Multivoxel pattern analysis reveals auditory motion information in MT+ of both congenitally blind and sighted individuals. PLoS One 8:e63198
Vetter P, Smith FW, Muckli L (2014) Decoding sound and imagery content in early visual cortex. Curr Biol 24:1256–1262
Raz N, Amedi A, Zohary E (2005) V1 activation in congenitally blind humans is associated with episodic retrieval. Cereb Cortex 15(9):1459–1468
Amedi A, Floel A, Knecht S, Zohary E, Cohen LG (2004) Transcranial magnetic stimulation of the occipital pole interferes with verbal processing in blind subjects. Nat Neurosci 7(11):1266–1270
Butt OH, Benson NC, Datta R, Aguirre GK (2013) The fine-scale functional correlation of striate cortex in sighted and blind people. J Neurosci 33:16209
Bock AS, Saenz M, Tungaraza R, Boynton GM, Bridge H, Fine I (2013) Visual callosal topography in the absence of retinal input. NeuroImage 81:325
Bock AS, Fine I (2014) Anatomical and functional plasticity in early blind individuals and the mixture of experts architecture. Front Hum Neurosci 8:971
Burton H, Snyder AZ, Raichle ME (2014) Resting state functional connectivity in early blind humans. Front Syst Neurosci 8:51
Deen B, Saxe R, Bedny M (2015) Occipital cortex of blind individuals is functionally coupled with executive control areas of frontal cortex. J Cogn Neurosci 27(8):1633–1647
Liu Y, Yu C, Liang M, Li J, Tian L, Zhou Y, Qin W, Li K, Jiang T (2007) Whole brain functional connectivity in the early blind. Brain 130:2085–2096
Watkins KE, Cowey A, Alexander I, Filippini N, Kennedy JM, Smith SM, Ragge N, Bridge H (2012) Language networks in anophthalmia: maintained hierarchy of processing in ‘visual’ cortex. Brain 135:1566
Striem-Amit E, Ovadia-Caro S, Caramazza A, Margulies DS, Villringer A, Amedi A (2015) Functional connectivity of visual cortex in the blind follows retinotopic organization principles. Brain 138:1679–1695. awv083
Gougoux F, Zatorre RJ, Lassonde M, Voss P, Lepore F (2005) A functional neuroimaging study of sound localization: visual cortex activity predicts performance in early-blind individuals. PLoS Biol 3:e2
Breitenseher M, Uhl F, Prayer Wimberger D, Deecke L, Trattnig S, Kramer J (1998) Morphological dissociation between visual pathways and cortex: MRI of visually-deprived patients with congenital peripheral blindness. Neuroradiology 40(7):424–427
Pan WJ, Wu G, Li CX, Lin F, Sun J, Lei H (2007) Progressive atrophy in the optic pathway and visual cortex of early blind Chinese adults: a voxel-based morphometry magnetic resonance imaging study. NeuroImage 37(1):212–220
Shu N, Li J, Li K, Yu C, Jiang T (2009) Abnormal diffusion of cerebral white matter in early blindness. Hum Brain Mapp 30(1):220–227
Christensen R, Grey M, Ptito M, Kupers R (2009) Resting state brain metabolism and functional connectivity of the occipital cortex in congenital blindness: a combined rTMS and PET-FDG study. NeuroImage 47:S64
Veraart C, De Volder AG, Wanet-Defalque MC, Bol A, Michel C, Goffinet AM (1990) Glucose utilization in human visual cortex is abnormally elevated in blindness of early onset but decreased in blindness of late onset. Brain Res 510(1):115–121
Kupers R, Ptito M (2014) Compensatory plasticity and cross-modal reorganization following early visual deprivation. Neurosci Biobehav Rev 41:36–52
Coullon GS, Emir UE, Fine I, Watkins KE, Bridge H (2015) Neurochemical changes in the pericalcarine cortex in congenital blindness attributable to bilateral anophthalmia. J Neurophysiol 114(3):1725–1733
Leporé N, Voss P, Lepore F, Chou YY, Fortin M, Gougoux F, Lee AD, Brun C, Lassonde M, Madsen SK, Toga AW, Toga AW, Thompson PM (2010) Brain structure changes visualized in early-and late-onset blind subjects. NeuroImage 49(1):134–140
Maller JJ, Thomson RH, Ng A, Mann C, Eager M, Ackland H et al (2016) Brain morphometry in blind and sighted subjects. J Clin Neurosci 33:89–95
Bonino D, Ricciardi E, Sani L et al (2008) Tactile spatial working memory activates the dorsal extrastriate cortical pathway in congenitally blind individuals. Arch Ital Biol 146:133–146
Striem-Amit E, Hertz U, Amedi A (2011a) Extensive cochleotopic mapping of human auditory cortical fields obtained with phase-encoding FMRI. PLoS One 6(3):e17832
Stronks HC, Mitchell EB, Nau AC, Barnes N (2016) Visual task performance in the blind with the BrainPort V100 vision aid. Expert Rev Med Devices 13(10):919–931
Maidenbaum S, Hannasi S, Abboud S, Arbel R, Shipuznikov A, Levy-Tzedek S et al (2012) The EyeCane-Distance information for the blind. In: Journal of molecular neuroscience, vol 48. Humana Press Inc, Totowa, pp S75–S76
Maidenbaum S, Levy-Tzedek S, Chebat DR, Amedi A (2013) Increasing accessibility to the blind of virtual environments, using a virtual mobility aid based on the “EyeCane”: feasibility study. PLoS One 8(8):e72555
Chebat DR, Harrar V, Kupers R, Maidenbaum M, Amedi A, Ptito M (2017) Sensory SUbstitution and the neural correlates of navigation in blindness. In: Mobility in visually impaired people. Springer. In press
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Chebat, DR., Heimler, B., Hofsetter, S., Amedi, A. (2018). The Implications of Brain Plasticity and Task Selectivity for Visual Rehabilitation of Blind and Visually Impaired Individuals. In: Habas, C. (eds) The Neuroimaging of Brain Diseases. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-319-78926-2_13
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