Biology and Epidemiology of Human Papillomavirus-Related Head and Neck Cancer

  • Alexander Y. Deneka
  • Jeffrey C. Liu
  • Camille C. R. RaginEmail author
Part of the Current Cancer Research book series (CUCR)


Human papillomavirus (HPV) infection is now established as a major causative agent for development of the head and neck cancers. HPV-initiated tumors of the oropharynx have better survival rates than HPV-negative cancers, and this appears likely to be associated with differences in the biology underlying these two diseases. We will discuss the role of HPV-encoded proteins in host infection and carcinogenesis; will review the emerging biology of intratypic variants of HPV, with numerous variants possessing different potential for malignancy; and will suggest areas for the further study. Finally, we will highlight global trends in HPV-associated oropharyngeal head and neck cancer incidence and prevalence rates, with recent data showing a dramatic increase of infection worldwide and differing infection rates in developed and developing nations.


Human papillomavirus Oropharyngeal cancers Variants Incidence Mortality 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Alexander Y. Deneka
    • 1
    • 2
  • Jeffrey C. Liu
    • 3
  • Camille C. R. Ragin
    • 3
    • 4
    Email author
  1. 1.Molecular Therapeutics ProgramFox Chase Cancer CenterPhiladelphiaUSA
  2. 2.Kazan Federal UniversityKazanRussia
  3. 3.Department of OtolaryngologyLewis Katz School of Medicine at Temple UniversityPhiladelphiaUSA
  4. 4.Cancer Prevention and Control ProgramFox Chase Cancer CenterPhiladelphiaUSA

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