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Biology and Epidemiology of Human Papillomavirus-Related Head and Neck Cancer

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Molecular Determinants of Head and Neck Cancer

Part of the book series: Current Cancer Research ((CUCR))

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Abstract

Human papillomavirus (HPV) infection is now established as a major causative agent for development of the head and neck cancers. HPV-initiated tumors of the oropharynx have better survival rates than HPV-negative cancers, and this appears likely to be associated with differences in the biology underlying these two diseases. We will discuss the role of HPV-encoded proteins in host infection and carcinogenesis; will review the emerging biology of intratypic variants of HPV, with numerous variants possessing different potential for malignancy; and will suggest areas for the further study. Finally, we will highlight global trends in HPV-associated oropharyngeal head and neck cancer incidence and prevalence rates, with recent data showing a dramatic increase of infection worldwide and differing infection rates in developed and developing nations.

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Authors and Affiliations

  1. Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, USA

    Alexander Y. Deneka

  2. Kazan Federal University, Kazan, Russia

    Alexander Y. Deneka

  3. Department of Otolaryngology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA

    Jeffrey C. Liu & Camille C. R. Ragin

  4. Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA, USA

    Camille C. R. Ragin

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Correspondence to Camille C. R. Ragin .

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  1. Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

    Barbara Burtness

  2. Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

    Erica A. Golemis

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Deneka, A.Y., Liu, J.C., Ragin, C.C. (2018). Biology and Epidemiology of Human Papillomavirus-Related Head and Neck Cancer. In: Burtness, B., Golemis, E. (eds) Molecular Determinants of Head and Neck Cancer. Current Cancer Research. Humana Press, Cham. https://doi.org/10.1007/978-3-319-78762-6_20

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