Advertisement

Statistics of Curve Fitting

  • Lee D. Hansen
  • Mark K. Transtrum
  • Colette F. Quinn
Chapter
Part of the SpringerBriefs in Molecular Science book series (BRIEFSMOLECULAR)

Abstract

In many cases, the goal of ITC measurements is to infer quantitative values for reaction parameters such as equilibrium constants, enthalpy changes, and rate constants. To do this, a mathematical model of the reaction(s) going on in the calorimeter is first constructed. Then the predictions of the model are compared against the experimental observations. Because the model includes several unknown parameters, it is necessary to vary the parameters until the model predictions are “as close as possible” to the observed data.

Copyright information

© The Author(s) 2018

Authors and Affiliations

  • Lee D. Hansen
    • 1
  • Mark K. Transtrum
    • 2
  • Colette F. Quinn
    • 3
  1. 1.Department of Chemistry and BiochemistryBrigham Young UniversityProvoUSA
  2. 2.Department of Physics and AstronomyBrigham Young UniversityProvoUSA
  3. 3.TA InstrumentsLindonUSA

Personalised recommendations