Introduction to Titration Calorimetry

  • Lee D. Hansen
  • Mark K. Transtrum
  • Colette F. Quinn
Part of the SpringerBriefs in Molecular Science book series (BRIEFSMOLECULAR)


Titration calorimetry is a relatively rapid way of obtaining thermodynamic data on reactions in solution. Enthalpy changes for solution of solids, for sorption of solutes on suspensions of sorbents, for reactions of gases with solutes, and for mixing of liquids and solutions can all be done in calorimeters equipped to handle gases, liquids, and solids, e.g., see Russell et al. (2006). However, this brief is largely limited to consideration of methods involving titration of a solution of one reactant into a solution of a second reactant. Titration calorimetry has three applications, analytical determinations of concentrations of reactants in solution, determination of enthalpy changes for reactions in solution, and under certain conditions, simultaneous determination of equilibrium constants and enthalpy changes for reactions in solution. This last application provides a full complement of thermodynamics for reactions in solution, i.e., the Gibbs energy change (ΔrG = −RTlnK), the enthalpy change (ΔrH), and the entropy change (ΔrS = (ΔrH − ΔrG)/T); R is the gas constant, and T is the Kelvin temperature.


  1. Demarse NA, Quinn CF, Eggett DL, Russell DJ, Hansen LD (2011) Calibration of nanowatt isothermal titration calorimeters with overflow reaction vessels. Anal Biochem 417:247–255CrossRefGoogle Scholar
  2. Hansen LD, Jensen TE, Mayne S, Eatough DJ, Izatt RM, Christensen JJ (1975) Heat-loss corrections for small, isoperibol calorimeter reaction vessels. J Chem Thermodyn 7:919–926CrossRefGoogle Scholar
  3. Hansen LD, Fellingham GW, Russell DJ (2011b) Simultaneous determination of equilibrium constants and enthalpy changes by titration calorimetry: methods, instruments, and uncertainties. Anal Biochem 409:220–229CrossRefGoogle Scholar
  4. Russell DJ, Thomas D, Hansen LD (2006) Batch calorimetry with solids, liquids and gases in less than 1 mL total volume. Thermochim Acta 446:161–167CrossRefGoogle Scholar

Copyright information

© The Author(s) 2018

Authors and Affiliations

  • Lee D. Hansen
    • 1
  • Mark K. Transtrum
    • 2
  • Colette F. Quinn
    • 3
  1. 1.Department of Chemistry and BiochemistryBrigham Young UniversityProvoUSA
  2. 2.Department of Physics and AstronomyBrigham Young UniversityProvoUSA
  3. 3.TA InstrumentsLindonUSA

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