Skip to main content

Developing Remedies for Oral Mucosal Diseases

  • Chapter
  • First Online:
Translational Oral Health Research

Abstract

Collaboration for several years between the faculties of pharmaceutical sciences and odontology at the University of Iceland has led to the development of several drug formulations that have been tested in clinical trials for treating diseases in the oral cavity that are relatively common. While numerous worthwhile treatment advances have been made, there is still a need for commercial collaboration to bring several successful drug developments onto the market, so that patients may gain access to these new products.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Shojaei AH. Buccal mucosa as a route for systemic drug delivery: a review. J Pharm Pharm Sci. 1998;1(1):15–30.

    PubMed  Google Scholar 

  2. Popovic N. Development of films for local administration on the oral mucosa. Master’s thesis, Faculty of Pharmaceutical Science, University of Iceland, 2017.

    Google Scholar 

  3. Ólafsdóttir I. Development of polymer films for administration of drug on oral mucosa. Master’s thesis, Faculty of Pharmaceutical Science, University of Iceland, 2016.

    Google Scholar 

  4. Toi CS, Mogodisi R, Cleaton-Jones PE. Mutans streptococci and lactobacilli on healthy and carious teeth in the same mouth of children with and without dental caries. Microb Ecol Health Dis. 2000;12(1):35–41.

    Google Scholar 

  5. Holbrook WP, Kristmundsdottir T, Loftsson T. Aqueous hydrocortisone mouthwash solution: clinical evaluation. Acta Odontol Scand. 1998;56(3):157–60.

    Article  Google Scholar 

  6. Hayrinen-Immonen R, Sorsa T, Nordstrom D, Malmstrom M, Konttinen YT. Collagenase and stromelysin in recurrent aphthous ulcers (RAU). Int J Oral Maxillofac Surg. 1993;22(1):46–9.

    Article  Google Scholar 

  7. Golub LM, Ramamurthy NS, McNamara TF, Greenwald RA, Rifkin BR. Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs. Crit Rev Oral Biol Med. 1991;2(3):297–321.

    Article  Google Scholar 

  8. Skulason S, Holbrook WP, Kristmundsdottir T. Clinical assessment of the effect of a matrix metalloproteinase inhibitor on aphthous ulcers. Acta Odontol Scand. 2009;67(1):25–9.

    Article  Google Scholar 

  9. Yarom N, Zelig K, Epstein JB, Gorsky M. The efficacy of minocycline mouth rinses on the symptoms associated with recurrent aphthous stomatitis: a randomized, double-blind, crossover study assessing different doses of oral rinse. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123(6):675–9.

    Article  Google Scholar 

  10. Power DF, Greg F. Tetracycline stabilizing formulations. Patent: World Intellectual Property Organization, 2010.

    Google Scholar 

  11. Libinson GS, Ushakova TA. Doxycycline. Stability in solutions. Pharm Chem J. 1976;10(8):1076–8.

    Article  Google Scholar 

  12. Akazawa Y, Nozawa S, Yagyu M, Yasad S. Aqueous doxycycline compositions. US Patent 3,846,548, 1974.

    Google Scholar 

  13. Wu H, et al . Veterinary doxycycline hydrochloride injection and preparation method thereof. European Patent Office 101972226, 2011.

    Google Scholar 

  14. Beutel RE, et al. Aqueous doxycycline compositions. US Patent 3,674,859 A, 1972.

    Google Scholar 

  15. He Z-x, Wang Z-h, Zhang H-h, Pan X, Su W-r, Liang D, et al. Doxycycline and hydroxypropyl-β-cyclodextrin complex in poloxamer thermal sensitive hydrogel for ophthalmic delivery. Acta Pharm Sin B. 2011;1(4):254–60.

    Article  Google Scholar 

  16. Su W, Li Z, Lin M, Li Y, He Z, Wu C, et al. The effect of doxycycline temperature-sensitive hydrogel on inhibiting the corneal neovascularization induced by BFGF in rats. Graefes Arch Clin Exp Ophthalmol. 2011;249(3):421–7.

    Article  Google Scholar 

  17. Kogava AC, Zoppi A, Quevedo MA, Nunes Salgado HR, Longhi MR. Complexation between doxycycline hyclate and B-cyclodextrin. Experimental and theoretical studies. Congreso; eighth international congress of pharmaceutical sciences, 2011.

    Google Scholar 

  18. Jutglar Sellarés M, Ramon Pou G, Foradada Sellabona M, Caballero Gobern F. Stable pharmaceutical compositions of tetracyclines in solution, method for obtaining them and their uses. European Patent Office EP1902706, 2008.

    Google Scholar 

  19. Patlolla VGR. In situ forming hydrogels for drug delivery to the oral mucosa. Master’s thesis, Faculty of Pharmaceutical Science, University of Iceland, 2014.

    Google Scholar 

  20. Thorgeirsdottir TO, Kjoniksen AL, Knudsen KD, Kristmundsdottir T, Nystrom B. Viscoelastic and structural properties of pharmaceutical hydrogels containing monocaprin. Eur J Pharm Biopharm. 2005;59(2):333–42.

    Article  Google Scholar 

  21. Thorgeirsdottir TO, Kristmundsdottir T, Thormar H, Axelsdottir I, Holbrook WP. Antimicrobial activity of monocaprin: a monoglyceride with potential use as a denture disinfectant. Acta Odontol Scand. 2006;64(1):21–6.

    Google Scholar 

  22. Thorgeirsdottir TO, Hilmarsson H, Thormar H, Kristmundsdottir T. Development of a virucidal cream containing the monoglyceride monocaprin. Pharmazie. 2005;60(12):897–9.

    Google Scholar 

  23. Thorgeirsdottir TO, Thormar H, Kristmundsdottir T. Effects of polysorbates on antiviral and antibacterial activity of monoglyceride in pharmaceutical formulations. Pharmazie. 2003;58(4):286–7.

    Google Scholar 

  24. Thorgeirsdottir TO, Thormar H, Kristmundsdottir T. Viscoelastic properties of a virucidal cream containing the monoglyceride monocaprin: effects of formulation variables: a technical note. AAPS PharmSciTech. 2006;7(2):E44.

    Article  Google Scholar 

  25. Skulason S, Holbrook WP, Thormar H, Gunnarsson GB, Kristmundsdottir T. A study of the clinical activity of a gel combining monocaprin and doxycycline: a novel treatment for herpes labialis. J Oral Pathol Med. 2012;41(1):61–7.

    Article  Google Scholar 

  26. Helgadóttir H. Hydrogel containing monocaprion in the treatment of Candida associated denture stomatitis: clinical research. Master’s thesis, Faculty of Pharmaceutical Science, University of Iceland, 2013.

    Google Scholar 

  27. Merz S. Monocaprin in denture adhesive for the treatment and prevention of Candida-associated denture stomatitis. Master’s thesis, Faculty of Pharmaceutical Science, University of Iceland, 2012.

    Google Scholar 

  28. Jónsdóttir SÁ. The effect of denture adhesive containing monocaprin on Candida associated denture stomatitis—a clinical trial. Master’s thesis, Faculty of Pharmaceutical Science, University of Iceland, 2013.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to W. Peter Holbrook .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Holbrook, W.P., Patlolla, V.G., Kristmundsdóttir, T. (2018). Developing Remedies for Oral Mucosal Diseases. In: Meurman, J. (eds) Translational Oral Health Research. Springer, Cham. https://doi.org/10.1007/978-3-319-78205-8_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-78205-8_12

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-78204-1

  • Online ISBN: 978-3-319-78205-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics