Histopathology and Drug Abuse

  • Reinhard B. Dettmeyer
Chapter

Abstract

One-off or regular use of drugs in the narrower sense, i.e., heroin, cocaine, amphetamines, ecstasy, or the inhalation of hairspray, can lead to numerous histopathological findings: pulmonary granulomatosis known as “junkie pneumopathy” or the detection of pulmonary microhemorrhages following i.v. drug use. Less pronounced heroin-related kidney diseases are seen following mostly long-term drug use, whereas chronic hepatitis is a frequent side effect of i.v. drug use. In the case of a particular genetic disposition, malignant hyperthermia and rhabdomyolysis may prove fatal following ecstasy use; again, in such cases, histopathological and immunohistochemical investigations are able to determine the cause of death, ideally in combination with the results of chemical-toxicological analysis. “Cocaine cardiomyopathy” is also known, but with regular drug use, morphological abnormalities of the myocardium or endocarditis in the form of heart valve inflammation may be observed. Less attention is paid to acute, allergic-immunological reactions to drugs that have been consumed or more discrete changes to liver tissue, such as drug-induced hepatic peliosis.

References

  1. Addington WW, Cugell DW, Bazley ES, Westerhoff TR, Shapiro B, Smith RT (1972) The pulmonary edema of heroin toxicity – an example of the stiff lung syndrome. Chest 62:199–205Google Scholar
  2. Angelos MG, Sheets CA, Zych PR (1986) Needle emboli to lung following intravenous drug abuse. J Emerg Med 4:391–396PubMedGoogle Scholar
  3. Aretz TH (1987) Myocarditis – the Dallas criteria. Hum Pathol 18:619–624PubMedGoogle Scholar
  4. Arruda JAL, Kurtzman NA, Pillay VKG (1975) Prevalence of renal disease in asymptomatic heroin addicts. Arch Intern Med 135:535–537PubMedGoogle Scholar
  5. Bakir A, Dunea G (1996) Drugs of abuse and renal disease. Curr Opin Nephrol Hypertens 5:122–126PubMedGoogle Scholar
  6. Bakir AA, Bazilinski NG, Rhee LH, Ainis H, Dunes G (1989) Focal segmental glomerulosclerosis. A common entity in nephrotic black adults. Arch Intern Med 149:1802–1804PubMedGoogle Scholar
  7. Bartok I, Remenar E, Toth J (1976) Demonstration of hepatitis B surface antigen by orcein staining in paraffin sections of cirrhotic liver. Virchows Arch A Pathol Anat Histol 369:239–248PubMedGoogle Scholar
  8. Berger P, Walls AF, Marthan R, Tunon-de-Lara JM (1998) Immunoglobulin E-induced passive sensibilization of human airways. Am J Respir Crit Care Med 157:610–616PubMedGoogle Scholar
  9. Blanck RR, Ream N, Conrad M (1979) Hepatitis B antigen and antibody in heroin users. Am J Gastroenterol 71:164–167PubMedGoogle Scholar
  10. Blanco Garcia S, Martinez Ubieto J, Sanchez Tirado JA, Laglera Trebol S, Gomez Munoz C, Garcia Laborda C, Urieta Solanas A (1999) Rhabdomyolysis and compartment syndrome associated with drug abuse. Rev Esp Anestesiol Reanim 46:46–47PubMedGoogle Scholar
  11. Bogomeletz WV (1976) Orcein staining of hepatitis B antigen in conventional paraffin sections of liver biopsies. Acta Hepatogastroenterol 23:412–414Google Scholar
  12. Borchard F, Gussmann V (1979) Detection of HBsAg containing cells in liver biopsies by different stains and classification of positively reacting ground-glass hepatocytes. Virchows Arch A Pathol Anat Histol 384:245–261PubMedGoogle Scholar
  13. Brander PE, Tukiainen P (1983) Acute eosinophilic pneumonia in a heroin smoker. Eur Respir J 6:750–752Google Scholar
  14. Brayn C (2000) Gangrene bug killed 35 heroin users. Br Med J 320:1690Google Scholar
  15. Brinkmann B, Kollmeier J, Müller KM (1991) Fremdkörper-Endangiitis bei Fixerpneumopathie. Atemwegs Lungenkr 17:282–283Google Scholar
  16. Brown SM, Stimmel B, Taub RN, Kochwa S, Rosenfeld RE (1974) Immunologic dysfunction in heroin addicts. Arch Intern Med 134:1001–1006PubMedGoogle Scholar
  17. Brown DN, Rosenholtz MJ, Marshall JB (1994) Ischemic colitis related to cocaine abuse. Am J Gastroenterol 89:1558–1561PubMedGoogle Scholar
  18. Busch HW, Riechman S, HEyen P, Heidenreich S, Kaufman CC, Rahn KH, Zidek W (1994) Albuminuria in HIV-infected patients. AIDS Res Hum Retroviruses 10:717–719PubMedGoogle Scholar
  19. Büttner A, Rohrmoser K, Mall G, Penning R, Weis S (2006) Widespread axonal damage in the brain of drug abusers as evidenced by accumulation of beta-amyloid precursor protein (beta-APP): an immunohistochemical investigation. Addiction 101:1339–1346PubMedGoogle Scholar
  20. Campkin NJ, Davies UM (1993) Treatment of “ecstasy” overdose with dantrolene. Anaesthesia 48:82–83PubMedGoogle Scholar
  21. Carbone L, D’Agati V, Cheng JT, Appel GB (1989) Course and prognosis of human immunodeficiency virus-associated nephropathy. Am J Med 67:389–395Google Scholar
  22. Carlson RW, Schaeffer RC, Michaels SG, Weil MH (1979) Pulmonary edema fluid. Spectrum of features in 37 patients. Circulation 60:1161–1169PubMedGoogle Scholar
  23. Casanova S, Mazzucco G, Barbiano del Belgiojoso G, Motta M, Boldorini R, Genderini A, Monga G (1995) Pattern of glomerular involvement in human immunodeficiency virus-infected patients: an Italian study. Am J Kidney Dis 26:446–453PubMedGoogle Scholar
  24. Cejtin HE, Young SA, Ungaretti J, Anciaux D, Imam S, Teopengco E, Sander CM (1999) Effects of cocaine on the placenta. Pediatr Dev Pathol 2:143–147PubMedGoogle Scholar
  25. Cerretani D, Riezzo I, Fiaschi AI, Centini F, Giorgi G, D’Errico S, Fiore C, Karch SB, Neri M, Pomara C, Turillazzi E, Fineschi V (2008) Cardiac oxidative stress determination and myocardial morphology after a single ecstasy (MDMA) administration in a rat model. Int J Legal Med 122:461–469PubMedGoogle Scholar
  26. Chander P, Soni A, Suri A, Bhagwat T, Yoo J, Treser G (1987) Renal ultrastructural markers in AIDS-associated nephropathy. Am J Pathol 126:513–526PubMedPubMedCentralGoogle Scholar
  27. Cohen AH, Nast CC (1988) HIV-associated nephropathy – a unique combined glomerular, tubular, and interstitial lesion. Mod Pathol 1:87–97PubMedGoogle Scholar
  28. Collignon PJ, Sorrell TC (1983) Disseminated candidiasis: evidence of a distinctive syndrome in heroin abusers. Br Med J 287:861–862Google Scholar
  29. Conway N (1969) Endocarditis in heroin addicts. Br Heart J 31:543–545PubMedPubMedCentralGoogle Scholar
  30. Cordner S (2016) A rare report of fatal torture. Forensic Sci Med Pathol 12:204–205PubMedGoogle Scholar
  31. Cregler LL, Mark H (1985) Relation of acute myocardial infarction to cocaine abuse. Am J Cardiol 56:794PubMedGoogle Scholar
  32. Crouch E, Churg A (1983) Progressive massive fibrosis of the lung secondary to intravenous injection of talc. A pathologic and mineralogic analysis. Am J Clin Pathol 80:520–526PubMedGoogle Scholar
  33. Cunningham EE, Brentjens JR, Zielezny MA, Andres GA, Venuto RC (1980) Heroin nephropathy – a clinicopathologic and epidemiologic study. Am J Med 68:47–53PubMedGoogle Scholar
  34. Cunningham EE, Zielezny MA, Venuto RC (1983) Heroin-associated nephropathy – a nationwide problem. JAMA 250:2935–2936PubMedGoogle Scholar
  35. Cunningham EE, Venuto RC, Zielezny MA (1984) Adulterants in heroin/cocaine: implications concerning heroin-associated nephropathy. Drug Alcohol Depend 14:19–22PubMedGoogle Scholar
  36. D’Agati V, Suh J, Carbone L, Cheng JT, Appel G (1989) Pathology of HIV-associated nephropathy: a detailed morphologic and comparative study. Kidney Int 35:1358–1370PubMedGoogle Scholar
  37. Dancer SJ, McNair D, Finn P, Kolsto AB (2002) Bacillus cereus cellulitis from contaminated heroin. J Med Microbiol 51:278–281PubMedGoogle Scholar
  38. Dar KJ, McBrien ME (1996) MDMA induced hyperthermia: report of a fatality and review of current therapy. Intensive Care Med 22:995–996PubMedGoogle Scholar
  39. Daras M, Tuchman AJ, Koppel BS, Samkoff LM, Weitzner I, Marc J (1994) Neurovascular complications of cocaine. Acta Neurol Scand 90:124–129PubMedGoogle Scholar
  40. de Gans J, Stam J, van Wijngaarden GK (1985) Rhabdomyolysis and concomitant neurological lesions after intravenous heroin abuse. J Neurol Neurosurg Psychiatry 48:1057–1059PubMedPubMedCentralGoogle Scholar
  41. Deighan CJ, Wong KM, McLaughlin KJ, Harden P (2000) Rhabdomyolysis and acute renal failure resulting from alcohol and drug abuse. J Med 93:29–33Google Scholar
  42. Delcker A, Dux R, Diener HC (1992) Acute plexus lesions in heroin dependence. Nervenarzt 63:240–243PubMedGoogle Scholar
  43. Dettmeyer R, Wessling B, Madea B (1998) Heroin-associated nephropathy – a post mortem study. Forensic Sci Int 95:109–116PubMedGoogle Scholar
  44. Dettmeyer R, Schmidt P, Musshoff F, Dreisvogt C, Madea B (2000) Pulmonary edema in fatal heroin overdose: immunohistological investigations with IgE, collagen IV and laminin – no increase of defects of alveolar-capillary membranes. Forensic Sci Int 110:87–96PubMedGoogle Scholar
  45. Dettmeyer R, Stojanovski G, Madea B (2001) Pathogenesis of heroin-associated glomerulonephritis. Correlation between the inflammatory activity and renal deposits of immunoglobulin and complement? Forensic Sci Int 113:227–231Google Scholar
  46. Dettmeyer RM, Schlamann MB, Madea B (2004) Cocaine-associated abscesses with lethal sepsis after splenic infarction in a 17-year-old woman. Forensic Sci Int 140:21–23PubMedGoogle Scholar
  47. Dettmeyer R, Preuß J, Wollersen H, Madea B (2005) Heroin-associated nephropathy. Expert Opin Drug Saf 4:19–28PubMedGoogle Scholar
  48. Dettmeyer R, Friedrich K, Schmidt P, Madea B (2009a) Heroin-associated myocardial damages – conventional and immunohistochemical investigations. Forensic Sci Int 187:42–46Google Scholar
  49. Dettmeyer R, Verhoff MA, Brückel B, Walter D (2009b) Widespread pulmonary granulomatosis following long time intravenous drug abuse – a case report. Forensic Sci Int 197:e27–e30Google Scholar
  50. Doutrelepont JM, Adler M, Willems M, Durez P, Yap SH (1993) Hepatitis C infection and membranoproliferative glomerulonephritis. Lancet 341:317PubMedGoogle Scholar
  51. Dressler FA, Roberts WC (1989) Infective endocarditis in opiate addicts: analysis of 80 cases studied at necropsy. Am J Cardiol 63:1240–1257PubMedGoogle Scholar
  52. Dries V, Odenthal M, Schirmacher P, Dienes HP (2001) Liver biopsy in chronic hepatitis C. Histopathology, molecular diagnostic analysis, and implications for therapeutic management. Pathologe 22:362–368PubMedGoogle Scholar
  53. Dubrow A, Mittman N, Ghali V, Flamenbaum W (1985) The changing spectrum of heroin-associated nephropathy. Am J Kidney Dis 5:36–41PubMedGoogle Scholar
  54. Edgecombe A, Milroy C (2012) Sudden death from superior mesenteric artery thrombosis in a cocaine user. Forensic Sci Med Pathol 8:48–51PubMedGoogle Scholar
  55. Edston E, van Hage-Hamsten M (1997) Anaphylactoid shock – a common cause of death in heroin addicts. Allergy 52:950–954PubMedGoogle Scholar
  56. Eknoyan G, Györkey F, Dichoso C, Martinez-Maldonado M, Suki WN, Györkey P (1972) Renal morphological and immunological changes associated with acute viral hepatitis. Kidney Int 1:413–419PubMedGoogle Scholar
  57. Eknoyan G, Györkey F, Dichoso C, Hyde SE, Györkey P, Suki WN, Martinez-Maldonada M (1973) Renal involvement in drug abuse. Arch Intern Med 132:801–806PubMedGoogle Scholar
  58. Ellis FR, Halsall PJ, Christian AS (1990) Clinical presentation of suspected malignant hyperthermia during anaesthesia in 402 probands. Anaesthesia 45:838–841PubMedGoogle Scholar
  59. Erbersdobler A, Wullbrand A, Kneissler U, Helmchen U (1995) Heroin-assoziierte membranoproliferative Glomerulonephritis Typ I: Eine neue Entität? Verh Dtsch Ges Pathol 79:459Google Scholar
  60. Ferries JAJ, Rice J (1979) Drug-induced myocarditis: a report of two cases. Forensic Sci Int 13:261–265Google Scholar
  61. Fineschi V, Wetli CV, Di Paolo M, Baroldi G (1997) Myocardial necrosis and cocaine – a quantitative morphologic study in 26 cocaine-associated deaths. Int J Legal Med 110:193–198PubMedGoogle Scholar
  62. Fineschi V, Centini F, Mazzeo E, Turillazzi E (1999) Adam (MDMA) and Eve (MDEA) misuse: an immunohistochemical study on three fatal cases. Forensic Sci Int 104:65–74PubMedGoogle Scholar
  63. Fineschi V, Baroldi G, Centini F, Cerretani D, Fiaschi AI, Micheli L, Parolini M, Turillazi E, Giorgi G (2001a) Markers of cardiac oxidative stress and altered morphology after intraperitoneal cocaine injection in a rat model. Int J Legal Med 114:323–330PubMedGoogle Scholar
  64. Fineschi V, Cecchi R, Centini F, Paglicci Reattelli L, Turillazzi E (2001b) Immunohistochemical quantification of pulmonary mast-cells and post-mortem blood dosages of tryptase and eosinophil cationic protein in 48 heroin-related deaths. Forensic Sci Int 120:189–194PubMedGoogle Scholar
  65. Forrester JM, Steele AW, Waldron JA, Parsons PE (1989) Crack lung: an acute pulmonary syndrome with a spectrum of clinical and histopathologic findings. Am Rev Respir Dis 142:462–467Google Scholar
  66. Freeman BC, Kreps EM, Ronsheim NJ, Lejano RF, Sommers SC (1974) Poststaphylococcal glomerulonephritis in heroin addicts. N Y State J Med 74(12):2241–2243PubMedGoogle Scholar
  67. Friedman EA, Rao TKS (1995) Disappearance of uremia due to heroin-associated nephropathy. Am J Kidney Dis 25:689–693PubMedGoogle Scholar
  68. Friedman EA, Sreepada Rao TK (1983) Why does uremia in heroin abusers occur predominantly among blacks? JAMA 250:2965–2966PubMedGoogle Scholar
  69. Friedman EA, Rao TKS, Nicastri AD (1974) Heroin-associated nephropathy. Nephron 13:421–426PubMedGoogle Scholar
  70. Garbino J, Henry JA, Mentha G, Romand JA (2001) Ecstasy ingestion and fulminant hepatic failure: liver transplantation to be considered as a last therapeutic option. Vet Hum Toxicol 43:99–102PubMedGoogle Scholar
  71. Genderini A, Bertani T, Bertoli S, Scorza D, Barbiano di Belgiojoso G (1990) HIV-associated nephropathy: a new entity. A study of 12 cases. Nephrol Dial Transplant 1:84–87Google Scholar
  72. Gill JR, Hayes JA, De Souza IS, Marker E, Stajic M (2002) Ecstasy (MDMA) deaths in New York City: a case series and review of the literature. J Forensic Sci 47:121–126PubMedGoogle Scholar
  73. Gillet DG, Fort GT (1978) Drug-induced lung disease. In: Thurlbeck WM, Abell MR (eds) The lung: structure, function and disease. Williams and Wilkins, Baltimore, pp 21–42Google Scholar
  74. Gitmann MD, Singhal PC (2004) Cocaine-induced renal disease. Expert Opin Drug Saf 3:441–448Google Scholar
  75. Gomez A, Stockert JC, Mosquera RM, del Castillo P, Tena G, Sancho M (1989) Chronic intoxication by heroin: histopathological effects on seminiferous tubules. Forensic Sci Int 43:97–101PubMedGoogle Scholar
  76. Gonzalo A, Barcena R, Mampaso F, Zea A, Ortuno J (1993) Membranoproliferative glomerulonephritis and hepatitis C virus infection. Nephron 63:475–476PubMedGoogle Scholar
  77. Gourgoutis G, Das G (1994) Gastrointestinal manifestations of cocaine addiction. Int J Clin Pharmacol Ther 32:136–141PubMedGoogle Scholar
  78. Grass G, Ahrens B, Schleenbecker U, Dobrzykowski L, Wagner M, Krüger C, Wölfel R (2016) Technical note: simple, scalable, and sensitive protocol for retrieving Bacillus anthracis (and other live bacteria) from heroin. Forensic Sci Int 259:32–35PubMedGoogle Scholar
  79. Grellner W, Madea B, Sticht G (1996) Pulmonary histopathology and survival period in morphine-involved deaths. J Forensic Sci 41:433–437PubMedGoogle Scholar
  80. Grishman E, Churg J, Porush JG (1976) Glomerular morphology in nephrotic heroin addicts. Lab Investig 35:415–424PubMedGoogle Scholar
  81. Gross EM (1973) Talc embolism: sudden death following intravenous injection of phenyltoloxamine. Forensic Sci Int 2:475–480Google Scholar
  82. Groth HD, McKay R, Crable JV, Cochran TH (1972) Intravenous injection of talc in a narcotic addict. Arch Pathol 94:171–178PubMedGoogle Scholar
  83. Grunow R, Verbeek L, Jacob D, Holzmann T, Birkenfeld G, Wiens D, von Eichel-Streiber L, Grass G, Reischl U (2012) Injection anthrax – a new outbreak in heroin users. Dtsch Ärztebl Int 109:843–848PubMedPubMedCentralGoogle Scholar
  84. Hamilton RJ, Perrone J, Hoffman R et al (2000) A descriptive study of an epidemic of poisoning caused by heroin adulterated with scopolamine. J Toxicol Clin Toxicol 38:597–608PubMedGoogle Scholar
  85. Haskell LP, Glicklich D, Senitzer D (1988) HLA associations in heroin-associated nephropathy. Am J Kidney Dis 12:45–50PubMedGoogle Scholar
  86. Hejna P, Janík M, Dobiáš M (2014) Tricuspid valve endocarditis complicated by septic pulmonary embolism in an intravenous drug user. Forensic Sci Med Pathol 10:126–129PubMedGoogle Scholar
  87. Heng MC, Haberfeld G (1987) Thrombotic phenomenon associated with intravenous cocaine. J Am Acad Dermatol 16:462–468PubMedGoogle Scholar
  88. Henning RJ, Cuevas J (2006) Cocaine activates calcium/calmodulin kinase II and causes cardiomyocyte hypertrophy. J Cardiovasc Pharmacol 48:802–813PubMedGoogle Scholar
  89. Henry JA, Jeffreys KJ, Dawling S (1992) Toxicity and deaths from 3,4-methylenedioxymeth-amphetamine (“ecstasy”). Lancet 340:384–387PubMedGoogle Scholar
  90. Hill GS (1986) Drug-associated glomerulopathies. Toxicol Pathol 14:37–44PubMedGoogle Scholar
  91. Hollander LMA, Young GP, Briglia E, Wetle CV, Gawad Y (1998) Effect of recent cocaine use on the specificity of cardiac markers for diagnosis of acute myocardial infarction. Am Heart J 135:245–252PubMedGoogle Scholar
  92. Holmass G, Gilhus NE, Gjerde IO, Lund-Tonnessen S, Langorgen J (1998) Wound botulism in heroin addiction. Tiddsskr Nor Laegeforen 118:4357–4359Google Scholar
  93. Hopkins GB (1972) Pulmonary angiothrombotic granulomas in drug offenders. JAMA 221:909–911PubMedGoogle Scholar
  94. Horikoshi S, Okada T, Shirato I, Inokuchi S, Ohmuro H, Tomino Y, Koide H (1993) Diffuse proliferative glomerulonephritis with hepatitis C Virus-like particles in paramesangial dense deposits in a patient with chronic hepatitis C Virus hepatitis. Nephron 64:462–464PubMedGoogle Scholar
  95. Inglesby TV, O’Toole T, Henderson DA et al (2002) Anthrax as a biological weapon. Updated recommendations for management. JAMA 287:2236–2252PubMedGoogle Scholar
  96. Ishigami A, Tokunaga I, Gotohda T, Kubo S (2003) Immunohistochemical study of myoglobin and oxidative injury-related markers in the kidney of methamphetamine abusers. Legal Med 5:42–48PubMedGoogle Scholar
  97. Ishikawa T, Zhu BL, Miyaishi S, Ishizu H, Maeda H (2007) Increase in clusterin-containing follicles in the adenohypophysis of drug abusers. Int J Legal Med 121:395–402PubMedGoogle Scholar
  98. Islam MN, Jesmine K, Molh AKS, Hasnan J (2009) Histopathological studies of cardiac lesions after long term administration of methamphetamine in high dosage – part II. Legal Med 11:S147–S150PubMedGoogle Scholar
  99. Johnson RJ, Couser WG (1990) Hepatitis B infection and renal disease: clinical, immunopathogenic and therapeutic considerations. Editorial review. Kidney Int 37:663–676PubMedGoogle Scholar
  100. Johnson RJ, Gretch DR, Yamabe H, Hart J, Bacchi CE, Hartwell P, Couser WG, Corey L, Wener MH, Alpers CE, Willson R (1993) Membranoproliferative glomerulonephritis associated with hepatitis C virus infection. N Engl J Med 328:465–470PubMedGoogle Scholar
  101. Kapasi AA, Gibbons N, Mattana J, Singhal PC (2000) Morphine stimulates mesangial cell TNF-alpha and nitrite production. Inflammation 24:463–476PubMedGoogle Scholar
  102. Karch SB (2002) Pathology of drug abuse, 3rd edn. CRC Press, Boca Raton, pp 91–106Google Scholar
  103. Karch SB (2005) Cocaine cardiovascular toxicity. South Med J 98:794–799PubMedGoogle Scholar
  104. Karch SB (2009) Karch’s pathology of drug abuse, 4th edn. CRC Press, Boca Raton, pp 523–533Google Scholar
  105. Karch SB (2011) The unique histology of methamphetamine cardiomyopathy: a case report. Forensic Sci Int 212:e1–e4PubMedGoogle Scholar
  106. Karch SB, Green GS et al (1995) Myocardial hypertrophy and coronary artery disease in male cocaine users. J Forensic Sci 40:591–595PubMedGoogle Scholar
  107. Karch SB, Busardó FP, Vaiano F, Portelli F, Zaami S, Bertol E (2016) Levamisole adulterated cocaine and pulmonary vasculitis: presentation of two lethal cases and brief literature review. Forensic Sci Int 265:96–102PubMedGoogle Scholar
  108. Kathrein H, Kirchmair W, Konig P, von Dittrich P (1983) Rhabdomyolysis with acute kidney failure after heroin poisoning. Dtsch Med Wochenschr 108:464–467PubMedGoogle Scholar
  109. Katz S, Aberman A et al (1972) Heroin pulmonary edema. Evidence for increased pulmonary capillary permeability. Am Rev Respir Dis 106:472–474PubMedGoogle Scholar
  110. Kiloyne MM, Gocke DJ, Meltzer JI, Daly JJ, Thomson GE, Hsu KC (1972) Nephrotic syndrome in heroin addicts. Lancet 1:17–20Google Scholar
  111. Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, Kiernan TW, Wollman J (1981) Formulation and application of numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1:431–435PubMedGoogle Scholar
  112. Kock KF, Simonsen KW (1994) Renal myoglobin in drug addicts: occurrence and significance in a postmortem study. Forensic Sci Int 65:113–119PubMedGoogle Scholar
  113. Kopfler D, Paronetto F (1965) Immunofluorescent localization of immunoglobulins, complement and fibrinogen in human diseases. II. Acute, subacute and chronic glomerulonephritis. J Clin Invest 44:1665–1671Google Scholar
  114. Kramer RK, Turner RC (1993) Renal infarction associated with cocaine use and latent protein C deficiency. South Med J 86:1436–1438PubMedGoogle Scholar
  115. Kringsholm B, Christoffersen P (1987a) Lung and heart pathology in fatal drug addiction. A consecutive autopsy study. Forensic Sci Int 34:39–51PubMedGoogle Scholar
  116. Kringsholm B, Christoffersen P (1987b) The nature and the occurrence of birefringent material in different organs in fatal drug addiction. Forensic Sci Int 34:53–62PubMedGoogle Scholar
  117. Kubat B (2013) Drugs, muscle pallor, and pyositis. Forensic Sci Med Pathol 9:564–567PubMedGoogle Scholar
  118. Lang J, Dettmeyer R, Henn V, Birngruber CG, Veit F (2016) Fatal ecstasy-induced malignant hyperthermia with rhabdomyolysis. A case report. Rom J Legal Med 24:212–215Google Scholar
  119. Lapachinske SF, Okai GC, dos Santos A, Valle de Bairros A, Yonamine M (2015) Analysis of cocaine and its adulterants in drugs for international trafficking seized by the Brazilian Federal Police. Forensic Sci Int 247:48–53PubMedGoogle Scholar
  120. Lapkus M, Prahlow JA (2015) Infective endocarditis in an intravenous drug abuser. Forensic Sci Med Pathol 11:609–613PubMedGoogle Scholar
  121. Larner AJ (1993) Dantrolene and “ecstasy” overdose. Anaesthesia 48:179–180PubMedGoogle Scholar
  122. Lazareth H, Peytavin G, Poliovka L, Dupin N (2012) The hairy-print for levamisole-induced vasculitis. Br Med J Case Rep.  https://doi.org/10.1136/bcr-2012-006602
  123. Levine SB, Grimes ET (1973) Pulmonary edema and heroin overdose in Vietnam. Arch Pathol 95:330–332PubMedGoogle Scholar
  124. Lewis TD, Henry DA (1985) Needle embolus: a unique complication of intravenous drug abuse. Ann Emerg Med 14:906–908PubMedGoogle Scholar
  125. Li W, Zhang L, Liang Y, Tong F, Zhou Y (2017) Sudden death due to malignant hyperthermia with a mutation of RYR1: autopsy, morphology and genetic analysis. Forensic Sci Med Pathol 13:444–449PubMedGoogle Scholar
  126. Llach F, Descoeudres C, Massry SG (1979) Heroin-associated nephropathy: clinical and histological studies in 19 patients. Clin Nephrol 11:7–12PubMedGoogle Scholar
  127. Lockemann U, Pueschel K (1993) Siderophages in the lung of drug addicts. Forensic Sci Int 59:169–175PubMedGoogle Scholar
  128. Louria DB, Henslet T, Rose J (1967) The major medical complications of heroin addiction. Ann Intern Med 67:1–22PubMedGoogle Scholar
  129. Mah MW, Shafran SD (1990) Polymicrobial endocarditis with eight pathogens in an intravenous drug abuser. Scand J Infect Dis 22:735–737PubMedGoogle Scholar
  130. Mahfoud B, Heinemann A, Gehl A, Püschel K (2002) Nekrotisierende Myositis durch Clostridium perfringens nach intravenöser Heroinapplikation. Rechtsmedizin 12:109–111Google Scholar
  131. Matalon R, Katz L, Gallo G, Waldo E, Cabaluna C, Eisinger RP (1974) Glomerular sclerosis in adults with nephrotic syndrome. Ann Intern Med 80:488–495PubMedGoogle Scholar
  132. Matsubara O, Tamura A, Ohdama S, Mark EJ (1995) Alveolar basement membrane breaks down in diffuse alveolar damage: an immunohistochemical study. Pathol Int 45:473–482PubMedGoogle Scholar
  133. May D, Helderman H, Eigenbrodt EH, Silva FG (1986) Chronic sclerosing glomerulopathy (heroin-associated nephropathy) in intravenous T’s and blues abusers. Am J Kidney Dis 8:404–409PubMedGoogle Scholar
  134. McAllister CJ, Horn R, Havron S, Abramson JH (1979) Granulomatous interstitial nephritis: a complication of heroin abuse. South Med J 72:162–165PubMedGoogle Scholar
  135. McGinn JT, McGinn TG, Hoffman RS (1970) Nephrotic syndrome in heroin (HER) and cocaine (COC) addicts. Clin Res 18:699Google Scholar
  136. McGinn JT, McGinn TG, Cherubin CE, Hoffman RS (1974) Nephrotic syndrome in drug addicts. N Y State J Med 74(1):92–95PubMedGoogle Scholar
  137. Meador KH, Sharon Z, Lewis EJ (1979) Renal amyloidosis and subcutaneous drug abuse. Ann Intern Med 91:565–567PubMedGoogle Scholar
  138. Menchel S, Cohen D, Gross E, Frangione B, Gallo G (1983) AA protein-related renal amyloidosis in drug addicts. Am J Pathol 112:195–199PubMedPubMedCentralGoogle Scholar
  139. Michaud K, Grabherr S, Shiferaw K, Doenz F, Augsburger M, Mangin P (2014) Acute coronary syndrome after levamisole-adulterated cocaine abuse. J Forensic Legal Med 21:48–52Google Scholar
  140. Monteil-Ganiere C, Gaulier JM, Chopineaux D, Barrios L, Pineau A, Dailly E, Clément R (2014) Fatal anoxia due to rachacha consumption: two cases reported. Forensic Sci Int 245:e1–e5PubMedGoogle Scholar
  141. Montoliu J, Miró JM, Campistol JM, Trilla A, Mensa J, Torras A, Revert L (1987) Henoch-Schönlein purpura complicating staphylococcal endocarditis in a heroin addict. Am J Nephrol 7:137–139PubMedGoogle Scholar
  142. Morris DC (1991) Cocaine heart disease. Hosp Pract 26:81–90Google Scholar
  143. Mu J, Li M, Guo Y, Lv B, Qiu M, Dong H (2017) Methamphetamine-induced toxic leukoencephalopathy: clinical, radiological and autopsy findings. Forensic Sci Med Pathol 13:362–366.  https://doi.org/10.1007/s12024-017-9893-2 CrossRefPubMedGoogle Scholar
  144. Müller KM (2004) Fixerpneumopathie. Pneumologie 58:552PubMedGoogle Scholar
  145. Nalbandian H, Sheth N, Dietrich R et al (1985) Intestinal ischemia caused by cocaine ingestion: report of two cases. Surgery 97:374–376PubMedGoogle Scholar
  146. National Anthrax Outbreak Control Team (2011) An outbreak of anthrax among drug users in Scotland, December 2009 to December 2010. Health Protection Scotland, Glasgow, pp 1–117Google Scholar
  147. Ness RB, Grisso JA, Hirschinger N, Markovic N, Shaw LM, Day NL, Kline J (1999) Cocaine and tobacco use and the risk of spontaneous abortion. N Engl J Med 340:333–339PubMedGoogle Scholar
  148. Neugarten J, Baldwin DS (1984) Glomerulonephritis in bacterial endocarditis. Am J Med 77:297–304PubMedGoogle Scholar
  149. Neugarten J, Gallo G, Buxbaum J, Katz LA, Rubinstein J, Baldwin DS (1986) Amyloidosis in subcutaneous heroin abusers (“skin poppers’ amyloidosis”). Am J Med 81:635–640PubMedGoogle Scholar
  150. Norheim Andersen S, Skullerud K (1999) Hypoxic/ischaemic brain damage, especially pallidal lesions, in heroin addicts. Forensic Sci Int 102:51–59Google Scholar
  151. Novielli KD, Chambers CV (1991) Splenic infarction after cocaine use. Ann Intern Med 114:251–252PubMedGoogle Scholar
  152. Nzerue CM, Hewan-Lowe K, Riley LJ (2000) Cocaine and the kidney: a synthesis of pathophysiologic and clinical prospectives. Am J Kidney Dis 35:783–795PubMedGoogle Scholar
  153. Oehler U, Sinicina I, Helpap B (2002) Ausgedehnte bilaterale Unterschenkelmuskelnekrosen nach nasaler Heroinapplikation. Pathologe 23:318–320PubMedGoogle Scholar
  154. Pääkkö P, Sutinen S, Anttila S, Autio-Harmainen H, Sormunen R (1988) Bronchiolo-alveolitis with pulmonary basal lamina injury in a rheumatoid patient during gold treatment. Pathol Res Pract 183:46–53PubMedGoogle Scholar
  155. Palmiere C, Burkhardt S, Staub C, Hallenbarter M, Pizzolato G, Dettmeyer R, La Harpe R (2004) Thoracic aortic dissection associated with cocaine abuse. Forensic Sci Int 141:137–142PubMedGoogle Scholar
  156. Pan CO, Singhal PC (1994) Coordinate and independent effects of cocaine, alcohol, and morphine on accumulation of IgG aggregates in the rat glomeruli. Proc Soc Exp Biol Med 205:29–34PubMedGoogle Scholar
  157. Pare JP, Cote G, Fraser RS (1984) Long-term follow-up of drug abusers with intravenous talcosis. Am Rev Respir Dis 139:233–241Google Scholar
  158. Passarino G, Ciccone G et al (2005) Histopathological findings in 851 autopsies of drug addicts, with toxicologic and virologic correlations. Am J Forensic Med Pathol 26:106–116PubMedGoogle Scholar
  159. Passaro DJ, Werner SB, McGee J, McKenzie WR, Vugia DJ (1998) Wound botulism associated with black tar heroin among injecting drug users. JAMA 279:859–863PubMedGoogle Scholar
  160. Patel J, Manjappan N, Bhat R, Mehrotra P, Bhaskaran M, Singhal PC (2003) Role of oxidative stress and heme oxygenase activity in morphine-induced glomerular epithelial cell growth. Am J Physiol Renal Physiol 285:F861–F869PubMedGoogle Scholar
  161. Pawlik E, Mahler H, Hartung B, Plässer G, Daldrup T (2015) Drug-related death: adulterants from cocaine preparations in lung tissue and blood. Forensic Sci Int 249:294–303PubMedGoogle Scholar
  162. Perazella MA (2005) Drug-induced nephropathy: an update. Expert Opin Drug Saf 4:689–706PubMedGoogle Scholar
  163. Pernegger TV, Klag MJ, Whelton PK (2001) Recreational drug use: a neglected risk factor for end-stage renal disease. Am J Kidney Dis 38:49–56Google Scholar
  164. Perskvist N, Söderberg C, van Hage M, Edston E (2007) Pathogenetic role of cardiac mast cell activation/degranulation, TNF-alpha, and cell death in acute drug related fatalities. Vasc Health Risk Manag 3:1053–1062PubMedPubMedCentralGoogle Scholar
  165. Phillips MS, Khanna VK, De Leon S, Frodis W, Britt BA, MacLennan DH (1994) The substitution of Arg for Gly2433 in the human skeletal muscle ryanodine receptor is associated with malignant hyperthermia. Hum Mol Genet 3:2181–2186PubMedGoogle Scholar
  166. Pogue VA, Nurse HM (1989) Cocaine-associated acute myoglobinuric renal failure. Am J Med 86:183–186PubMedGoogle Scholar
  167. Pollanen MS (2016) Fatal rhabdomyolysis after torture by reverse hanging. Forensic Sci Med Pathol 12:170–173PubMedGoogle Scholar
  168. Prendergast BD, George CF (1993) Drug-induced rhabdomyolysis-mechanisms and management. Postgrad Med J 69:333–336PubMedPubMedCentralGoogle Scholar
  169. Püschel K (1986) Fremdkörpergranulome nach i.v. Drogenapplikation. Beitr Path 102:400–401Google Scholar
  170. Püschel K (1988) Pulmonales Mikroemboliesyndrom durch Injektion einer Tablettensuspension. In: Bauer G (ed) Gerichtsmedizin. Festschrift für Wilhelm Holczabek. Franz Deuticke, Wien, pp 163–166Google Scholar
  171. Püschel K, Schoof W (1987) Zur Morphogenese hämatogen entstandener Fremdkörpergranulome im Lungenparenchym. Beitr Gerichtl Med 45:121–128Google Scholar
  172. Quan L, Ishikawa T, Michiue T, Li DR, Zhao D, Oritani S, Zhu BL, Maeda H (2005) Ubiquitin-immunoreactive structures in the midbrain of methamphetamine abusers. Legal Med 7:144–150PubMedGoogle Scholar
  173. Rabl W, Markwalder C (1996) Fatal posture- and heroin-related intestinal infarction and leg muscle necrosis after snorting heroin. A case report. Am J Forensic Med Pathol 17:163–166PubMedGoogle Scholar
  174. Raijs J, Harm T, Ormstad K (1984) Postmortem findings of pulmonary lesions of older datum in intravenous drug addicts. A forensic-pathologic study. Virchows Arch A Pathol Anat Histopathol 402:405–414Google Scholar
  175. Rajs J, Falconer B (1979) Cardiac lesions in intravenous drug addicts. Forensic Sci Int 13:193–209PubMedGoogle Scholar
  176. Ramirez G, Stinson JB, Zawada ET, Moatamed F (1983) Acute interstitial nephritis associated with chronic active hepatitis. South Med J 76:391–394PubMedGoogle Scholar
  177. Reijula K, Sutinen S (1985) Detection of antigens in lung biopsies by immunoperoxidase staining in extrinsic allergic bronchiolo-alveolitis (EABA). Acta Histochem 76:121–125PubMedGoogle Scholar
  178. Rice EK, Isbel NM, Becker GJ, Atkins RC, McMahon LP (2000) Heroin overdose and myoglobinuric acute renal failure. Clin Nephrol 54:449–454PubMedGoogle Scholar
  179. Richter RW, Challenor YB, Pearson J, Kagen L, Hamilton LL, Ramsey W (1971) Acute myoglobinuria associated with heroin addiction. JAMA 216:1172–1176PubMedGoogle Scholar
  180. Riße M, Weiler G (1984) Heroinsucht als seltene Ursache einer symmetrischen Pallidumnekrose. Z Rechtsmed 93:227–235PubMedGoogle Scholar
  181. Rollina C, Roccatello D, Giachino O, Basolo B, Piccoli G (1991) Hepatitis C virus infection and membranous glomerulonephritis. Nephron 59:319–320Google Scholar
  182. Romas E, Power DA, Machet D, Powell H, D’Apice AJF (1994) Membranous glomerulonephritis associated with hepatitis C virus infection in an adolescent. Pathology 26:399–402PubMedGoogle Scholar
  183. Rostoker G, Pawlotsky A, Bastie A, Weil B, Dhumeaux D (1996) Type I membranoproliferative glomerulonephritis and HCV infection. Nephrol Dial Transplant 11:22–24PubMedGoogle Scholar
  184. Sagar S, Sorbi D, Arbeit LD, Singhal PC (1994) Morphine modulates 72-kDa matrix metalloproteinase. Am J Phys 267:F654–F659Google Scholar
  185. Saleem TM, Singh M, Murtaza M, Singh A, Kasubhai M, Gnanasekaran I, Freudenberger RS, Cappell MS, Hutt DA (2001) Renal infarction: a rare complication of cocaine abuse. Am J Emerg Med 19:528–529PubMedGoogle Scholar
  186. Salomon MI, Poon TP, Goldblatt M, Tchertkoff V (1972) Renal lesions in heroin addicts. A study based on kidney biopsies. Nephron 9:356–363PubMedGoogle Scholar
  187. Sameiro Faria M, Sampaio S, Faria V, Carvalho E (2003) Nephropathy associated with heroin abuse in Caucasian patients. Nephrol Dial Transplant 18:2308–2313PubMedGoogle Scholar
  188. Scandting J, Spital A (1988) Amphetamine-associated myoglobinuric renal failure. South Med J 75:237–240Google Scholar
  189. Schalinski S, Tsokos M (2008) Fatal pyomyositis: a report of 8 autopsy cases. Am J Forensic Med Pathol 29:131–135PubMedGoogle Scholar
  190. Schmidt P, Schröder H, Maderspach K et al (1994) Immunohistochemical localization of kappa opioid receptors in the human frontal cortex. Brain Res 654:223–233PubMedGoogle Scholar
  191. Schmidt P, Wevers A, Maderspach K et al (1996) Cerebrocortical delta-opioid receptor mRNA expression in morphine addicts. Soc Neurosci Abstr 22:823Google Scholar
  192. Schmidt P, Padosch SA, Dettmeyer R, Madea B (2004) Rechtsmedizinische Aspekte des Drogentodes. Med Welt 55:199–205Google Scholar
  193. Scholer J, Derosena R, Appel GB, Jao W, Boyd MT, Pirani CL (1979) Amyloidosis in chronic heroin addicts with the nephrotic syndrome. Ann Intern Med 91:26–29Google Scholar
  194. Schorle H (2002) Anthrax. Die keimende Gefahr. Pathologe 23:167–169PubMedGoogle Scholar
  195. Screaton GR, Singer M, Cairns HS, Thrasher A, Sarner M, Cohen SL (1992) Hyperpyrexia and rhabdomyolysis after MDMA (“ecstasy”) abuse. Lancet 339:677–678PubMedGoogle Scholar
  196. Segal A, Dowling JP, Ireton HJ, Rhodes H, Thomas GW, Kerr PG, Spagnolo DV (1998) Granulomatous glomerulonephritis in intravenous drug users: a report of three cases in oxycodone addict. Hum Pathol 29:1246–1249PubMedGoogle Scholar
  197. Servais D, Schiwy-Bochat KH (1998) Beurteilung der Entzündungs-Intensität einer Hepatitis C-Virus Infektion mit Hilfe eines histologischen “Leberzellschaden-Index”. Rechtsmedizin 8:229–231Google Scholar
  198. Shah SV, Madhavan T, Saeed S, Levin NW, Quinn EL (1977) Focal glomerulonephritis and interstitial nephritis in methicillin-treated, heroin-related infective endocarditis. South Med J 70:1132–1134PubMedGoogle Scholar
  199. Singhal PC, Gibbons N, Abramovici M (1992) Long term effects of morphine on mesangial cell proliferation and matrix synthesis. Kidney Int 41:1560–1570PubMedGoogle Scholar
  200. Singhal PC, Sharma P, Gibbons N, Franki N, Kapasi A, Wagner JD (1997) Effect of morphine on renomedullary interstitial cell proliferation and matrix accumulation. Nephron 77:225–234PubMedGoogle Scholar
  201. Singhal PC, Sharma P, Sanwal V, Prasad A, Kapasi A, Ranjan R, Franki N, Reddy K, Gibbons N (1998) Morphine modulates proliferation of kidney fibroblasts. Kidney Int 53:350–357PubMedGoogle Scholar
  202. Smith WR, Glauser FL, Dearden LC, Wells ID, Novey HS, McRae DM, Reid JS, Sand BA, Newcomb KA (1978) Deposits of immunoglobulin and complement in the pulmonary tissue of patients with “Heroin Lung”. Chest 73:471–475PubMedGoogle Scholar
  203. Soni A, Agarval A, Chander P, Yoo J, Singhal D, Salomon N, Robinson B, Treser G (1989) Evidence for an HIV-related nephropathy: a clinico-pathological study. Clin Nephrol 31:12–17PubMedGoogle Scholar
  204. Sreepada Rao TK (1993) A decade of human immunodeficiency virus-associated nephropathy (HIVAN). Transplant Proc 25:2439–2440Google Scholar
  205. Sreepada Rao TK, Friedman EA (1989) AIDS (HIV)-associated nephropathy. Does it exist? Am J Nephrol 9:441–453Google Scholar
  206. Sreepada Rao TK, Nicastri AD, Friedman EA (1974) Natural history of heroin-associated nephropathy. N Engl J Med 290:19–23Google Scholar
  207. Sreepada Rao TK, Filippone EJ, Nicastri AD, Landesman SH, Frank E, Chen CK, Friedman EA (1984) Associated focal and segmental glomerulosclerosis in the acquired immunodeficiency syndrome. N Engl J Med 310:669–673Google Scholar
  208. Sreepada Rao TK, Friedman EA, Nicastri AD (1987) The types of renal disease in the acquired immunodeficiency syndrome. N Engl J Med 316:1062–1068Google Scholar
  209. Stone DS, Appel RG (1994) Human immunodeficiency virus-associated nephropathy: current concepts. Am J Med Sci 307:212–217PubMedGoogle Scholar
  210. Tazelaar HD, Karch SB, Stevens BG, Billingham ME (1987) Cocaine and the heart. Hum Pathol 18:195–199PubMedGoogle Scholar
  211. Tehan B (1993) Ecstasy and dantrolene. Br Med J 306:146Google Scholar
  212. Tella SR, Schindler CW, Goldberg SR (1992) Cardiovascular effects of cocaine in conscious rats: relative significance of central sympathetic stimulation and peripheral neuronal monoamine uptake and release mechanism. J Pharmacol Exp Ther 262:602–610PubMedGoogle Scholar
  213. Thomashefski JF Jr, Hirsch CS (1980) The pulmonary vascular lesions of intravenous drug abuse. Hum Pathol 11:133–145Google Scholar
  214. Thorne LB, Collins KA (1998) Speedballing with needle embolization: case study and review of the literature. J Forensic Sci 43:1074–1076PubMedGoogle Scholar
  215. Toth AR, Varga T (2009) Myocardium and striated muscle damage caused by licit or illicit drugs. Legal Med 11:S484–S487PubMedGoogle Scholar
  216. Trauer H, Günzel A, Dreßler J (2015) Methamphatin-assoziierte Todesfälle bei gerichtlichen Sektionen im Bereich Leipzig/Chemnitz. Rechtsmedizin 25:350–351Google Scholar
  217. Tsokos M, Erbersdobler A (2005) Pathology of peliosis. Forensic Sci Int 149:25–33PubMedGoogle Scholar
  218. Vaghjimal A (1996) Splenic infarction related to cocaine use. Postgrad Med J 72:768PubMedPubMedCentralGoogle Scholar
  219. Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H (2014) Molecular pathology of brain matrix metalloproteases, claudin5, and aquaporins in forensic autopsy cases with special regard to methamphetamine intoxication. Int J Legal Med 128:469–474PubMedGoogle Scholar
  220. Wehner F, Mittmeyer HJ, Wehner HD, Schieffer MC (1998) Insulin – or morphine-injection? Immunohistochemical contribution to the elucidation of a case. Forensic Sci Int 95:241–246PubMedGoogle Scholar
  221. Wehner F, Wehner HD, Schieffer MC, Subke J (2000) Immunohistochemical detection of methadone in the human brain. Forensic Sci Int 112:11–16PubMedGoogle Scholar
  222. Wehner F, Mittmeyer HJ, Wehner HD (2002) Immunhistochemischer Morphinnachweis an der subkutanen Injektionsstelle. Rechtsmedizin 1:10–12Google Scholar
  223. Welte TB, Bohnert M, Pollak S (2004) Prevalence of rhabdomyolysis in drug deaths. Forensic Sci Int 139:21–25PubMedGoogle Scholar
  224. Zamora-Quizada JC, Dinerman H, Stadecker MJ et al (1988) Skin infarction after free-basing cocaine (crack). Ann Intern Med 108:564–566Google Scholar
  225. Zeltner TB, Nussbaumer U, Rudin O, Zimmermann A (1982) Unusual pulmonary vascular lesions after intravenous injections of microcrystalline cellulose. Virchows Arch Pathol Anat 395:207–216PubMedGoogle Scholar
  226. Zielezny MA, Cunningham EE, Veuto RC (1980) The impact of heroin abuse on a regional end-stage renal disease program. Am J Public Health 70:829–831PubMedPubMedCentralGoogle Scholar
  227. Zientara M, Moore S (1970) Fatal talc embolism in a drug addict. Hum Pathol 1:324–327PubMedGoogle Scholar

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Reinhard B. Dettmeyer
    • 1
  1. 1.University Hospital Giessen Institute of Forensic MedicineGiessenGermany

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