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Different Tumor Microenvironments Lead to Different Metabolic Phenotypes

  • Chapter
The Heterogeneity of Cancer Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1063))

Abstract

The beginning of the twenty-first century offered new advances in cancer research, including the expansion of the knowledge about the tumor microenvironment (TME). Because TMEs provide the niches in which cancer cells, fibroblast, lymphocyte, and immune cells reside, they play a key role in cancer cell development, differentiation, survival, and proliferation. Throughout cancer progression, the TME constantly evolves, causing cancer cells to adapt to the new conditions. The heterogeneity of cancer, evidenced by diverse proliferation rates, cellular structure, metabolism, and gene expression, presents challenges for cancer treatments despite the advances in research. This chapter discusses how different tumor microenvironments lead to specific metabolic adaptations which drive cancer progression.

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Abbreviations

α-KG:

α-ketoglutarate

ACC:

Acetyl-CoA carboxylase

AMPK:

AMP-activated protein kinase

ATP:

Adenosine triphosphate

CAF:

Cancer-associated fibroblasts

Cav-1:

Caveolin-1

ETC:

Electron transport chain

FABP4:

Fatty acid-binding protein 4

FASN:

Fatty acid synthase

HBx:

Hepatitis B virus X protein

HCC:

Hepatocellular carcinoma

hMSCs:

Human mesenchymal stem cells

KRAS:

Kirsten rat sarcoma viral oncogene homolog

NADPH:

Nicotinamide adenine dinucleotide phosphate

SCD1:

Stearoyl-CoA desaturase 1

TME:

Tumor microenvironment

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Author information

Authors and Affiliations

  1. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Marjorie Justine Antonio

  2. Department of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Anne Le

Authors
  1. Marjorie Justine Antonio
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  2. Anne Le
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Corresponding author

Correspondence to Anne Le .

Editor information

Editors and Affiliations

  1. Johns Hopkins Medicine, Baltimore, MD, USA

    Anne Le MD, HDR

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© 2018 Springer International Publishing AG, part of Springer Nature

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Antonio, M.J., Le, A. (2018). Different Tumor Microenvironments Lead to Different Metabolic Phenotypes. In: Le, A. (eds) The Heterogeneity of Cancer Metabolism. Advances in Experimental Medicine and Biology, vol 1063. Springer, Cham. https://doi.org/10.1007/978-3-319-77736-8_9

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