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Neuroprotective Agents Target Molecular Mechanisms of Programmed Cell Death After Traumatic Brain Injury

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Acute Neuronal Injury

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Abstract

The review is to update the current state of knowledge in post-TBI pathophysiological mechanisms, including programmed cell death mechanisms and mechanism-based preclinical pharmacological intervention used in animal models. Their effects on cell death, inflammatory events, and prolonged motor and cognitive deficits will be summarized, and their potential success for clinical application will be evaluated. Many of the above-mentioned mechanisms may be important targets for limiting the consequences of TBI.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 81530062), and Dr. Cheng-liang Luo did the mainly work of this chapter.

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Authors and Affiliations

  1. Department of Forensic Medicine, Soochow University, Suzhou, China

    Lu-Yang Tao

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  1. Lu-Yang Tao
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Correspondence to Lu-Yang Tao .

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  1. Department of Neurology, VA Greater Los Angeles Healthcare System, North Hills, California, USA

    Denson G. Fujikawa

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Tao, LY. (2018). Neuroprotective Agents Target Molecular Mechanisms of Programmed Cell Death After Traumatic Brain Injury. In: Fujikawa, D. (eds) Acute Neuronal Injury. Springer, Cham. https://doi.org/10.1007/978-3-319-77495-4_5

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