Abstract
Cell is generally considered a classical system. The molecular structures inside it appear with ultra-level complexities. General physics concepts help construct popular biophysics techniques to understand the energy states and physiological functions of various cellular structures. Besides using statistical mechanics, classical mechanics, and other general physics rules, it is also found recently that quantum mechanics may be utilized to understand some of the crucial cellular aspects.
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References
Chance, B., Nishimura, M. 1960. The mechanism of chlorophyll-cytochrome interaction: the temperature insensitivity of light-induced cytochrome oxidation in Chromatium. Proc. US Nat. Acad. Sci., 46, 19–24.
Vredenberg, W.J., Duysens, L.N.M. 1964. Light-induced oxidation of cytochromes photosynthetic bacteria between 20 and-170°. Biochim. Biophys. Acta, 79, 456–463.
Devault, D., Parkes, J.H., Chance, B. 1967. Electron Tunnelling in Cytochromes. Nature 215, 642–644.
Ashrafuzzaman, Md., Tuszynski, J., Membrane Biophysics, Springer (Heidelberg), 2012, ISSN 1618-7210, ISBN 978-3-642-16104-9 ISBN 978-3-642-16105-6 (eBook), https://doi.org/10.1007/978-3-642-16105-6.
Ashrafuzzaman M, Tseng CY, Tuszynski JA. Regulation of channel function due to physical energetic coupling with a lipid bilayer. Biochem Biophys Res Commun. 2014 Mar 7;445(2):463–8.
Md. Ashrafuzzaman. Phenomenology and energetics of diffusion across cell phase states. Saudi J. Biol. Sci. (2015a), 22, 666–673.
Md. Ashrafuzzaman. Diffusion across cell phase states. Biomedical Sciences Today (2015b), 1:e4.
P. Ball. Physics of life: The dawn of quantum biology. Nature 474, 272–274 (2011)
G. Panitchayangkoon, D. Hayes, K. A. Fransted, J. R. Caram, E. Harel, J. Wen, R. E. Blankenship, and G. S. Engel. Long-lived quantum coherence in photosynthetic complexes at physiological temperature. PNAS. 2010:107 (29), 12766–12770
Alisher M. Kariev, Vasiliy S. Znamenskiy, and Michael E. Green. Quantum Mechanical calculations of charge effects on gating the KcsA channel. Biochim Biophys Acta. 2007 May; 1768(5): 1218–1229.
Doyle DA, Cabral JM, Pfuetzner RA, Kuo A, Gulbis JM, Cohen SL, Chait BT, MacKinnon R. The structure of the potassium channel: molecular basis of K + conduction and selectivity. Science. 1998;280:69–77.
MacKinnon R, Cohen SL, Kuo A, Lee A, Chait BT. Structural conservation in prokaryotic and eukaryotic potassium channels. Science. 1998;280:106–109.
Jiang Y, Lee A, Chen J, Cadene M, Chait BT, MacKinnon R. The open pore conformation of potassium channels. Nature. 2001;417:523–526.
Alisher M. Kariev, Philipa Njau, and Michael E. Green. The Open Gate of the KV1.2 Channel: Quantum Calculations Show the Key Role of Hydration. Biophys J. 2014 February 4; 106(3): 548–555.
Varma S., Rogers D.M., Rempe S.B. Perspectives on: ion selectivity: design principles for K + selectivity in membrane transport. J. Gen. Physiol. 2011;137:479–488.
Dudev T., Lim C. Determinants of K + vs Na + selectivity in potassium channels. J. Am. Chem. Soc. 2009;131:8092–8101. [PubMed]
Dudev T., Lim C. Factors governing the Na(+) vs K(+) selectivity in sodium ion channels. J. Am. Chem. Soc. 2010;132:2321–2332. [PubMed]
Dudev T., Lim C. Why voltage-gated Ca2 + and bacterial Na + channels with the same EEEE motif in their selectivity filters confer opposite metal selectivity. Phys. Chem. Chem. Phys. 2012;14:12451–12456. [PubMed]
Varma S., Rempe S.B. Multibody effects in ion binding and selectivity. Biophys. J. 2010;99:3394–3401.
Bucher D., Rothlisberger U., Carloni P. QM/MM Car-Parrinello molecular dynamics study of selectivity in a potassium channel. ACS. 2004 Abstract PHYS-309.
Bucher D., Rothlisberger U. Molecular simulations of ion channels: a quantum chemist’s perspective. J. Gen. Physiol. 2010;135:549–554. [PubMed]
Maupin C.M., Wong K.F., Voth G.A. A multistate empirical valence bond description of protonatable amino acids. J. Phys. Chem. A. 2006;110:631–639.
Michael A. Crawford, C. Leigh Broadhurst, Martin Guest, Atulya Nagar, Yiqun Wang, Kebreab Ghebremeskel, Walter F. Schmidt. A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), Volume 88, Issue 1, January 2013, Pages 5–13
R.H. Steele, A. Szent-Gyorgyi. On excitation of biological substances. Proc. Natl. Acad. Sci., 43 (1957), pp. 478–491
J. Avery, Z. Bay, A. Szent-Gyorgi. On energy transfer in biological systems. Proc. Natl. Acad. Sci., 47 (1961), pp. 1742–1744
D. Bendall, Interprotein Electron Transfer, in: D.S. Bendall, (Ed.), Protein Electron Transfer, Bios Scientific Publishers, Oxford, UK, 1996, pp. 43–68
J.J. Hopfield. Electron transfer between biological molecules by thermally activated tunneling. Proc. Natl. Acad. Sci. USA, 71 (1974), pp. 3640–3644
L. Hackermüller, S. Uttenthaler, K. Hornberger, E. Reiger, B. Brezger, A. Zeilinger, M. Arndt, M. Wave. Nature of biomolecules and fluorofullerenes. Phys. Rev. Lett., 91 (2003), p. 090408
S. Hameroff, R. Penrose. Quantum computation in brain microtubules the Penrose-Hameroff Orch OR model of consciousness. Philos. Trans. R. Soc. London A, 356 (1998), pp. 1869–1896
S. Hameroff. The conscious pilot-dendritic synchrony moves through the brain to mediate consciousness. J. Biol. Phys., 36 (1) (2010), pp. 71–93
A.E. Allen, M.A. Cameron, T.M. Brown, A.A. Vugler, R.J. Lucas. Visual responses in mice lacking critical components of all known retinal phototransduction cascades. PLoS One, 5 (11) (2010), p. e15063
K. Gawrisch, N.V. Eldho, L.L. Holte. The structure of DHA in phospholipid membranes. Lipids, 38 (4) (2003), pp. 445–452
Horrocks LA, Yeo YK. Health benefits of docosahexaenoic acid (DHA). Pharmacol Res. 1999 Sep;40(3):211–25.
Gregory S. Engel, Tessa R. Calhoun, Elizabeth L. Read, Tae-Kyu Ahn, Tomáš Mančal, Yuan-Chung Cheng, Robert E. Blankenship, Graham R. Fleming. Evidence for wavelike energy transfer through quantum coherence in photosynthetic systems. Nature 446, 782–786 (2007).
Gregory D. Scholes. Quantum-Coherent Electronic Energy Transfer: Did Nature Think of It First? J. Phys. Chem. Lett., 2010, 1 (1), pp 2–8
Collini, E.; Curutchet, C.; Mirkovic, T.; Scholes, G. D. Electronic Energy Transfer in Photosynthetic Antenna Systems. In Energy Transfer Dynamics in Biomaterial Systems; Burghardt, I., May, V., Micha, D. A., Bittner, E. R., Eds.; Springer Verlag: Heidelberg/Berlin, Germany, 2009; Vol. 93.
Hofmann, E.; Wrench, P. M.; Sharpies, F. P.; Hiller, R. G.; Welte, W.; Diederichs, K. Structural Basis of Light Harvesting by Carotenoids: Peridinin-Chlorophyll-Protein from Amphidinium Carterae. Science 1996, 272, 1788–1791.
Wilk, K. E.; Harrop, S. J.; Jankova, L.; Edler, D.; Keenan, G.; Sharpes, F.; Hiller, R. G.; Curmi, P. M. G. Evolution of a Light-Harvesting Protein by Addition of New Subunits and Rearrangement of Conserved Elements: Crystal Structure of a Cryptophyte Phycoerythrin at 1.63-Å Resolution. Proc. Natl. Acad. Sci. U.S.A. 1999, 96, 8901–8906.
Liu, Z. F.; Yan, H. C.;Wang, K. B.; Kuang, T. Y.; Zhang, J. P.; Gui, L. L.; An, X. M.; Chang, W. R. Crystal Structure of Spinach Major Light-Harvesting Complex at 2.72 Å Resolution. Nature 2004, 428, 287–292.
Ganapathy, S.; Oostergetel, G. T.; Wawrzyniak, P. K.; Reus, M.; Chew,A.G.M.;Buda, F.; Boekema, E. J.;Bryant, D. A.;Holzwarth, A. R.; de Groot, H. J. M. Alternating Syn-Anti Bacteriochlorophylls Form Concentric HelicalNanotubes in Chlorosomes. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 8525–8530.
McDermott, G.; Prince, S. M.; Freer, A. A.; Hawthornthwaite-Lawless, A. M.; Papiz,M. Z.; Cogdell,R. J.; Isaacs, N. W. Crystal Structure of an Integral Membrane Light-Harvesting Complex from Photosynthetic Bacteria. Nature 1995, 374, 517–521.
Barros, T.; K€uhlbrandt, W. Crystallisation, Structure and Function of Plant Light-Harvesting Complex II. Biochim. Biophys. Acta 2009, 1787, 753–772.
van der Weij-De Wit, C. D.; Doust, A. B.; van Stokkum, I. H. M.; Dekker, J. P.; Wilk, K. E.; Curmi, P. M. G.; Scholes, G. D.; van Grondelle, R. How. Energy Funnels from the Phycoerythrin Antenna Complex to Photosystem I and Photosystem II in Cryptophyte Rhodomonas CS24 Cells. J. Phys. Chem. B 2006, 110, 25066–25073.
Collini, E.; Wong, C. Y.; Wilk, K. E.; Curmi, P. M. G.; Brumer, P.; Scholes, G. D. Coherently Wired Light-Harvesting in Photosynthetic Marine Algae at Ambient Temperature. Nature 2010, 463, 644–647
Richard Hildner, Daan Brinks, Niek F. van Hulst. Femtosecond coherence and quantum control of single molecules at room temperature. Nature Physics 7, 172–177 (2011)
Mohan Sarovar, Akihito Ishizaki, Graham R. Fleming, K. Birgitta Whaley. Quantum entanglement in photosynthetic light-harvesting complexes. Nature Physics 6, 462–467 (2010)
Alivisatos, P. The use of nanocrystals in biological detection. Nature Biotechnol. 22, 47–52 (2004).
Maze, J. R. et al. Nanoscale magnetic sensing with an individual electronic spin in diamond. Nature 455, 644–648 (2008).
Balasubramanian, G. et al. Nanoscale imaging magnetometry with diamond spins under ambient conditions. Nature 455, 648–651 (2008).
Chernobrod, B. M. & Berman, G. P. Spin microscope based on optically detected magnetic resonance. J. Appl. Phys. 97, 014903 (2005).
Taylor, J. M. et al. High-sensitivity diamond magnetometer with nanoscale resolution. Nature Phys. 4, 810–816 (2008).
Degen, C. L. Scanning magnetic field microscope with a diamond single-spin sensor. Appl. Phys. Lett. 92, 243111 (2008).
Cole, J. H. & Hollenberg, L. C. L. Scanning quantum decoherence microscopy. Nanotechology 20, 495401 (2009).
Hall, L. T., Cole, J. H., Hill, C. D. & Hollenberg, L. C. L. Sensing of fluctuating nanoscale magnetic fields using nitrogen-vacancy centers in diamond. Phys. Rev. Lett. 103, 220802 (2009).
L. P. McGuinness, Y. Yan, A. Stacey, D. A. Simpson, L. T. Hall, D. Maclaurin, S. Prawer, P. Mulvaney, J. Wrachtrup, F. Caruso, R. E. Scholten, L. C. L. Hollenberg. Quantum measurement and orientation tracking of fluorescent nanodiamonds inside living cells. Nature Nanotechnology 6, 358–363 (2011)
C. Bradac, T. Gaebel, N. Naidoo1, M. J. Sellars, J. Twamley, L. J. Brown, A. S. Barnard, T. Plakhotnik, A. V. Zvyagin & J. R. Rabeau. Observation and control of blinking nitrogen-vacancy centres in discrete nanodiamonds. Nature Nanotech. 5, 345–349 (2010).
Dudev T., Lim C. Competition among Ca2 +, Mg2 +, and Na + for model ion channel selectivity filters: determinants of ion selectivity. J. Phys. Chem. B. 2012a;116:10703–10714.
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Ashrafuzzaman, M. (2018). Quantum Mechanics of the Cell: An Emerging Field. In: Nanoscale Biophysics of the Cell. Springer, Cham. https://doi.org/10.1007/978-3-319-77465-7_9
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DOI: https://doi.org/10.1007/978-3-319-77465-7_9
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