Abstract
Prenatal diagnosis of congenital heart disease has been shown to have a positive impact on postnatal morbidity and mortality for some, but not all cardiac lesions. Overall, prenatal diagnosis has a positive impact on lesions with duct-dependent systemic or pulmonary circulation and where there is failure of mixing in transposition of the great arteries. The impact on other lesions such as septal defects, tetralogy of Fallot or total anomalous pulmonary venous drainage does not show improvement of outcome based on current evidence.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Beaton AZ, Pike JI, Stallings C, Donofrio MT. Predictors of repair and outcome in prenatally diagnosed atrioventricular septal defects. JASE. 2013;26:208–16.
Divanović A, Hor K, Cnota J, Hirsch R, Kinsel-Ziter M, Michelfelder E. Prediction and perinatal management of severely restrictive atrial septum in fetuses with critical left heart obstruction: clinical experience using pulmonary venous Doppler analysis. J Thorac Cardiovasc Surg. 2011;141(4):988–94.
Hunter LE, Simpson JM. Atrioventricular block during fetal life. J Saudi Heart Assoc. 2015;27(3):164–78.
Hunter LE, Chubb H, Miller O, Sharland G, Simpson JM. Fetal aortic valve stenosis: a critique of case selection criteria for fetal intervention. Prenat Diagn. 2015;35(12):1176–81.
Jaeggi ET, Carvalho JS, De Groot E, Api O, Clur SB, Rammeloo L, McCrindle BW, Ryan G, Manlhiot C, Blom NA. Comparison of transplacental treatment of fetal supraventricular tachyarrhythmias with digoxin, flecainide, and sotalol results of a nonrandomized multicenter study. Circulation. 2011;124:1747–54.
Jouannic JM, Gavard L, Fermont L, Le Bidois J, Parat S, Vouhe PR, Dumez Y, Sidi D, Bonnet D. Sensitivity and specificity of prenatal features of physiological shunts to predict neonatal clinical status in transposition of the great arteries. Circulation. 2004;110:1743–6.
Lloyd DF, van Amerom JF, Pushparajah K, Simpson JM, Zidere V, Miller O, et al. An exploration of the potential utility of fetal cardiovascular MRI as an adjunct to fetal echocardiography. Pren Diagn. 2016;36(10):916–25.
Matsui H, Mellander M, Roughton M, Jicinska H, Gardiner HM. Morphological and physiological predictors of fetal aortic coarctation. Circulation. 2008;118(18):1793–801.
Miranda JO, Hunter LE, Tibby S, Sharland G, Miller O, Simpson JM. Myocardial deformation in fetuses with coarctation of the aorta: a case controlled study. Ultrasound Obstet Gynecol. 2016. https://doi.org/10.1002/uog.15939.
Moon-Grady AJ, Morris SA, Belfort M, Chmait R, Dangel J, Devlieger R, Emery S, Frommelt M, Galindo A, Gelehrter S, Gembruch U, Grinenco S, Habli M, Herberg U, Jaeggi E, Kilby M, Kontopoulos E, Marantz P, Miller O, Otaño L, Pedra C, Pedra S, Pruetz J, Quintero R, Ryan G, Sharland G, Simpson J, Vlastos E, Tworetzky W, Wilkins-Haug L, Oepkes D, International Fetal Cardiac Intervention Registry. International fetal cardiac intervention registry: a worldwide collaborative description and preliminary outcomes. J Am Coll Cardiol. 2015;66(4):388–99.
Morlandoa M, Bhidea A, Familiaria A, Khalila A, Morales-Rosellóa J, Papageorghioua AT, Carvalho JS. The association between prenatal atrioventricular septal defects and chromosomal abnormalities. Eur J Obstet Gynecol Reprod Biol. 2017;208:31–5.
Peyvandi S, De Santiago V, Chakkarapani E, Chau V, Campbell A, Poskitt KJ, Duan X, Barkovich AJ, Miller S, McQuillen P. Association of prenatal diagnosis of critical congenital heart disease with postnatal brain development and the risk of brain injury. JAMA Pediatr. 2016;170(4):e154450.
Saul D, Degenhardt K, Iyoob SD, Surrey LF, Johnson AM, Johnson MP, Rychik J, Victoria T. Hypoplastic left heart syndrome and the nutmeg lung pattern in utero: a cause and effect relationship or prognostic indicator? Pediatr Radiol. 2016;46(4):483–9.
Schidlow DN, Tworetzky W, Wilkins-Haug LE. Percutaneous fetal cardiac interventions for structural heart disease. Am J Perinatol. 2014;31(07):629–36.
Seale AN, Carvalho JS, Gardiner HM, Mellander M, Roughton M, Simpson J, Tometzki A, Uzun O, Webber SA, Daubeney PE, British Congenital Cardiac Association. Total anomalous pulmonary venous connection: impact of prenatal diagnosis. Ultrasound Obstet Gynecol. 2012;40:310–8.
Slodki M, Respondek-Liberska M, Pruetz JD, Donofrio MT. Fetal cardiology: changing the definition of critical heart disease in the newborn. J Perinatol. 2016;36(8):575–80.
Thakur V, Munk N, Mertens L, Nield L. Does prenatal diagnosis of hypoplastic left heart syndrome make a difference?—a systematic review. Prenat Diagn. 2016;36:854–63.
Tworetzky W, McElhinney D, Reddy V, Brook M, Hanley F, Silverman N. Improved surgical outcome after fetal diagnosis of hypoplastic left heart syndrome. Circulation. 2001;103(9):1269–73.
Vigneswaran TV, Zidere V, Miller OI, Simpson JM, Sharland GK. Usefulness of the prenatal echocardiogram in fetuses with isolated transposition of the great arteries to predict the need for balloon atrial septostomy. Am J Cardiol. 2017;119(9):1463–7.
Zeng S, Zhou J, Peng Q, Deng W, Zhang M, Zhao Y, et al. Sustained maternal hyperoxygenation improves aortic arch dimensions in fetuses with coarctation. Sci Rep. 2016;6:39304.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Electronic Supplementary Material
Four chamber view of the fetal heart at 19Â weeks gestation, demonstrating hypoplastic left heart syndrome (HLHS). The right ventricle is well developed and the tricuspid valve is seen to open normally. Sweeping to the well-developed arterial duct and hypoplastic aortic arch (MP4 2073 kb)
Four chamber view of the heart demonstrating ventricular disproportion secondary to coarctation of the aorta (MP4 6803 kb)
Transposition of the great arteries. The four chamber view and great arteries are balanced. The pulmonary artery arises posteriorly from the left ventricle and the aorta anteriorly from the right ventricle (MP4 742 kb)
Four chamber view of pulmonary atresia intact ventricular septum. The right ventricle is poorly functioning with evidence of endocardial fibroelastosis (EFE) (AVI 29431 kb)
Tetralogy of Fallot. The aorta overrides the ventricular septum and the pulmonary artery and arterial duct are significantly smaller than the left sided aortic arch (MP4 3758 kb)
Four chamber view of the fetal heart. Complete atrioventricular septal defect (AVSD) with a balanced ventricular view (MP4 1834 kb)
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Hunter, L.E. (2018). Impact of Prenatal Diagnosis of Congenital Heart Disease on Outcome. In: Simpson, J., Zidere, V., Miller, O.I. (eds) Fetal Cardiology. Springer, Cham. https://doi.org/10.1007/978-3-319-77461-9_16
Download citation
DOI: https://doi.org/10.1007/978-3-319-77461-9_16
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-77460-2
Online ISBN: 978-3-319-77461-9
eBook Packages: MedicineMedicine (R0)