Abstract
Particulating or mincing articular cartilage allows the chondrocytes to escape their lacunae and migrate. The freed chondrocytes are able to multiply and form new extracellular matrix. Over time, the new chondrocyte/matrix construct matures into hyaline-like cartilage. This technique has both autograft (noncommercial) and allograft (DeNovo® NT, Zimmer, Warsaw, IN) applications. Positive animal outcomes have been followed by encouraging clinical outcomes for chondral and osteochondral applications with repair tissue being a mixture of hyaline cartilage and fibrocartilage. The position for these techniques in the cartilage restoration/repair algorithm is under investigation, but it appears to be similar to current cell therapy techniques.
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Albrecht FH. Closure of joint cartilage defects using cartilage fragments and fibrin glue. Fortschr Med. 1983;101(37):1650–2.
Lu Y, Dhanaraj S, Wang Z, Bradley DM, Bowman SM, Cole BJ, et al. Minced cartilage without cell culture serves as an effective intraoperative cell source for cartilage repair. J Orthop Res. 2006;24(6):1261–70.
Frisbie DD, Lu Y, Kawcak CE, DiCarlo EF, Binette F, McIlwraith CW. In vivo evaluation of autologous cartilage fragment-loaded scaffolds implanted into equine articular defects and compared with autologous chondrocyte implantation. Am J Sports Med 2009;37 Suppl 1:71S–80S.
Cole BJ, Farr J, Winalski CS, Hosea T, Richmond J, Mandelbaum B, et al. Outcomes after a single-stage procedure for cell-based cartilage repair: a prospective clinical safety trial with 2-year follow-up. Am J Sports Med. 2011;39:1170–9.
Christensen BB. Autologous tissue transplantations for osteochondral repair. Dan Med J. 2016;63(4)
Christensen BB, Foldager CB, Jensen J, Lind M. Autologous dual-tissue transplantation for osteochondral repair: early clinical and radiological results. Cartilage. 2015;6(3):166–73.
Farr J, Yao Q. Chondral defect repair with particulated juvenile cartilage allograft. Cartilage. 2011;2(3):346–53.
Cheung HS, Cottrell WH, Stephenson K, Nimni ME. In vitro collagen biosynthesis in healing and normal rabbit articular cartilage. J Bone Joint Surg Am. 1978;60(8):1076–81.
Namba RS, Meuli M, Sullivan KM, Le AX, Adzick NS. Spontaneous repair of superficial defects in articular cartilage in a fetal lamb model. J Bone Joint Surg Am. 1998;80(1):4–10.
Yanke AB, Tilton AK, Wetters NG, Merkow DB, Cole BJ. DeNovo NT particulated juvenile cartilage implant. Sports Med Arthrosc. 2015;23(3):125–9.
Adkisson HD 4th, Martin JA, Amendola RL, Milliman C, Mauch KA, Katwal AB, et al. The potential of human allogeneic juvenile chondrocytes for restoration of articular cartilage. Am J Sports Med. 2010;38(7):1324–33.
Farr J, Tabet SK, Margerrison E, Cole BJ. Clinical, radiographic, and histological outcomes after cartilage repair with particulated juvenile articular cartilage: a 2-year prospective study. Am J Sports Med. 2014;42(6):1417–25.
Christensen BB, Olesen ML, Lind M, Foldager CB. Autologous cartilage chip transplantation improves repair tissue composition compared with marrow stimulation. Am J Sports Med. 2017;45(7):1490–6.
Salzmann GM, Calek AK, Preiss S. Second-generation autologous minced cartilage repair technique. Arthrosc Tech. 2017;6(1):e127–e31.
Gomoll AH, Madry H, Knutsen G, van Dijk N, Seil R, Brittberg M, et al. The subchondral bone in articular cartilage repair: current problems in the surgical management. Knee Surg Sports Traumatol Arthrosc. 2010;18(4):434–47.
Bonasia DE, Marmotti A, Mattia S, Cosentino A, Spolaore S, Governale G, et al. The degree of chondral fragmentation affects extracellular matrix production in cartilage autograft implantation: an in vitro study. Arthroscopy. 2015;31(12):2335–41.
Buckwalter JA, Bowman GN, Albright JP, Wolf BR, Bollier M. Clinical outcomes of patellar chondral lesions treated with juvenile particulated cartilage allografts. Iowa Orthop J. 2014;34:44–9.
Tompkins M, Hamann JC, Diduch DR, Bonner KF, Hart JM, Gwathmey FW, et al. Preliminary results of a novel single-stage cartilage restoration technique: particulated juvenile articular cartilage allograft for chondral defects of the patella. Arthroscopy. 2013;29(10):1661–70.
Coetzee JC, Giza E, Schon LC, Berlet GC, Neufeld S, Stone RM, et al. Treatment of osteochondral lesions of the talus with particulated juvenile cartilage. Foot Ankle Int. 2013;34(9):1205–11.
Grawe B, Burge A, Nguyen J, Strickland S, Warren R, Rodeo S, et al. Cartilage regeneration in full-thickness patellar chondral defects treated with particulated juvenile articular allograft cartilage: an MRI analysis. Cartilage. 2017:1947603517710308.
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Christensen, B.B., Lind, M., Foldager, C.B. (2018). Particulated Cartilage Auto- and Allograft. In: Farr, J., Gomoll, A. (eds) Cartilage Restoration. Springer, Cham. https://doi.org/10.1007/978-3-319-77152-6_23
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DOI: https://doi.org/10.1007/978-3-319-77152-6_23
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