Abstract
Nanoparticles, nanostructures of variety of shapes, sizes and morphology are prominently being use for medical and disease diagnostics, element and impurity detection and monitoring of cells and tissues and in living beings. Recently, drug-delivery system based on nano-particle coating of drugs getting much attention and interest for the cure of cancer and heart diseases. The purpose is to increase the human health and safety from diseases by using novel nano-structures and devices. Number of drug-delivery systems like Oral, intranasal, parental and nano-networking etc. are discussed in detail. Detail view of synthesis techniques for different sizes, shapes and morphology of nano-architectures is described. These varieties of nano-structures and devices are specifically designed for delivering the drug in better and easy way to malfunctioning area in the human and living beings.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Baranello MP, Bauer L, Benoit DS (2014) Poly(styrene-alt-maleic anhydride)-based diblock copolymer micelles exhibit versatile hydrophobic drug loading, drug-dependent release, and internalization by multidrug resistant ovarian cancer cells. Biomacromolecules 15(7):2629–2641
Boulaiz H, Alvarez PJ, Ramirez A, Marchal JA, Prados J, RodrÃguez-Serrano F, Perán M, Melguizo C, Aranega A (2011) Nanomedicine: Application areas and development prospects. Int J Mol Sci 12(5):3303–3321
Boysen E of Hawk’s Perch Technical Writing, LLC and UnderstandingNano.com. Copyright ©20072016 Hawk’s Perch Technical Writing, LLC-All Rights Reserved
Bradbury J (2003) Nanoshell destruction of inoperable tumours. Lancet Oncol 4:711
Britten MB, Abolmaali ND, Assmus B, Lehmann R, Honold J, Schmitt J, Vogl TJ, Martin H, Schachinger V, Dimmeler S, Zeiher AM (2003) Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction (TOPCARE-AMI) mechanistic insights from serial contrast-enhanced magnetic resonance imaging. Circulation 108:2212–2218
Brunetti FG, Herrero MA, Muñoz JM, Giordani S, DÃaz-Ortiz A, Filippone S, Ruaro G, Meneghetti M, Prato M, Vázquez E (2007) Reversible microwave-assisted cycloaddition of aziridines to carbon nanotubes. J Am Chem Soc 129:14580–14581
Carlmark A, Hawker C, Hult A, Malkoch M (2009) New methodologies in the construction of dendritic materials. Chem Soc Rev 38:352–362
Cho H, Kwon GS (2014) Thermosensitive poly-(d,l-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly-(d,l-lactide-co-glycolide) hydrogels for multi-drug delivery. J Drug Target 22:669–677
Cho H, Lai TC, Kwon GS (2013) Poly(ethylene glycol)-block-poly(ε-caprolactone) micelles for combination drug delivery: Evaluation of paclitaxel, cyclopamine and gossypol in intraperitoneal xenograft models of ovarian cancer. J Contr Release 166(1):1–9
Cho H, Lai TC, Tomoda K, Kwon GS (2014) Polymeric micelles for multi-drug delivery in cancer. AAPS Pharm Sci Tech 16:10–20
Darbre T, Reymond J (2006) Peptide dendrimers as artificial enzymes, receptors, and drug-delivery agents. Acc Chem Res 39(12):925–934
Deb KD, Griffith M, Muinck ED, Rafat M (2012) Nanotechnology in stem cells research: advances and applications. Front Biosci (Landmark Ed) 17:1747–1760
Dikmen G, Genç L, Güney G (2011) Advantage and disadvantage in drug delivery system. J Mater Sci Eng 5(4):468–472
Dufes C, Uchegbu IF, Schatzlein AG (2005) Dendrimers in gene delivery. Adv Drug Delivery Rev 57:2177–2202
Edina CW, Andrew ZW (2014) Nanoparticles and their applications in cell and molecular biology. Integr Biol (Camb) 6(1):9–26
Emeje MO, Obidike IC, Akpabio EI, Ofoefule SI (2012) Nanotechnology in drug delivery. In: Sezer AD (ed) InTech, Rijeka, Croatia, pp 70–106
Eskiler G G, Gökhan D, Lütfi G (2013) Nano-based drug delivery system, Intech. (2013):90–146. http://iapc-obp.com/assets/files/106072_08_NBDD_03.pdf
Estanqueiro M, Amaral MH, Conceiçao J, Lobo JMS (2015) Nanotechnological carriers for cancer chemotherapy: the state of the art. Colloids Surf B 126:631–648
Fukushima S, Varela-Carver A, Coppen S R, Yamahara K, Felkin L E, Lee J, Barton P J, Terracciano C M, Yacoub M H, Suzuki K (2007) Direct intramyocardial but not intracoronary injection of bone marrow cells induces ventricular arrhythmias in a rat chronic ischemic heart failure model. Circulation 115(17):2254–2261
Gaucher G, Satturwar P, Jones MC, Furtos A, Leroux JC (2010) Polymeric micelles for oral drug delivery. Eur J Pharm Biopharm 76:147–158
Güney G, Genç L, Dikmen G (2011) J Mater Sci Eng 5(5):577–582
Gupta A, Arora A, Menakshi A, Sehgal A, Sehgal R (2012) nanotechnology and its applications in drug delivery: a review. Int J Med. Mol Med 3(1):1–9
Haley B, Frenkel E (2008) Nanoparticles for drug delivery in cancer treatment. Urol Oncol Semın Ori 26:57–64
Han Y, He Z, Schulz A, Bronich TK, Jordan R, Luxenhofer R, Kabanov AV (2012) Long-circulating PEG-PE micelles co-loaded with paclitaxel and elacridar (GG918) overcome multidrug resistance. Mol Pharm 9:2302–2313
Herrero MA, Toma FM, Al-Jamal KT, Kostarelos K, Bianco A, Ros TD, Bano F, Casalis L, Scoles G, Prato M (2009) Synthesis and characterization of a carbon nanotube−dendron series for efficient siRNA delivery. J Am Chem Soc 131(28):9843–9848
Hornyak GL, Tibbals HF, Dutta J, Moore JJ (2008) Introduction of nano science and nanotechnology. Chapter no: 9, Carob-based nanomaterials, December 22. CRC Press, Boca Raton
http://www.understandingnano.com/cancer-therapy-platinum-gold-nanoparticles.html
http://www.understandingnano.com/nanotechnology-drug-delivery.html
Jaafar-Maalej C, Diab R, Andrieu V, Elaissari A, Fessi H (2010) Ethanol injection method for hydrophilic and lipophilic drug-loaded liposome preparation. J Liposome Res 20(3):228–243
Katayose S, Kataoka K (1998) Remarkable increase in nuclease resistance of plasmid DNA through supramolecular assembly with poly (ethylene glycol)—poly (L-lysine) block copolymer. J Pharm Sci 87:160–163
Kesharwani P, Jain K, Jain NK (2014) Dendrimer as nanocarrier for drug delivery. Prog Polym Sci 39(2):268–307
Kozlov M, Melik-Nubarov N, Batrakova E, Kabanov A (2011) Relationship between pluronic block copolymer structure, critical micellization concentration and partitioning coefficients of low molecular mass solutes. Macromolecules 33:3305–3313
Krishnamurthy S, Ng VW, Gao S, Tan MH, Yang YY (2014) Phenformin-loaded polymeric micelles for targeting both cancer cells and cancer stem cells in vitro and in vivo. Biomaterials 35(33):9177–9186
Kumar R, Kulkarni A, Nagesha DK, Sridhar S (2012) In vitro evaluation of theranostic polymeric micelles for imaging and drug delivery in cancer. Theranostics 2(7):714–722
Kutty RV, Feng SS (2013) Cetuximab conjugated vitamin E TPGS micelles for targeted delivery of docetaxel for treatment of triple negative breast cancers. Biomaterials 34(38):10160–10171
Laouini A, Jaafar-Maalej C, Limayem-Blouza I, Sfar S, Charcosset C, Fessi H (2012) Preparation, Characterization and Applications of Liposomes: State of the Art. J Colloids Sci Biotechnol 1:147–168
Lee H, Soo PL, Liu J, Butler M, Allen C (2007) Polymeric micelles for formulation of anti-cancer drugs. In: Amiji MM (ed) CRC Press, New York, pp 318–355
Lencioni R, Bartolozzi C (1996) Ethanol injection for the treatment of hepatic tumours. Eur Radiol 6(5):682–696
Lopes S C A, Giuberti C S, Rocha T G R, Ferreira D S, Leite E A, Oliveira M C (2013). Liposomes as carrier of anticancer drugs, L. Rangel (Ed.), Intech.
Mader K, Mehnert W (2004). Solid lipid nanoparticles – concepts, procedures and physicochemical aspects, C. Nastruzzi (Ed.), CRC Press, Boca Rotan: 1–22.
Makino K, Shibata A (2006). Surface properties of liposomes depending on their composition. In: Liu AL (ed) Elsevier, New York, pp 49–53
Malik A, Chaudhary S, Garg G, Tomar A (2012) Dendrimers: a tool for drug delivery. Adv Biol Res 6(4):165–169
Molina EJ, Palma J, Gupta D, Torres D, Gaughan JP, Houser S, Macha S, Thorac J (2008) Improvement in hemodynamic performance, exercise capacity, inflammatory profile, and left ventricular reverse remodeling after intracoronary delivery of mesenchymal stem cells in an experimental model of pressure overload hypertrophy. Cardiovasc Surg 135:292–299
Molina EJ, Palma J, Gupta D, Gaughan JP, Houser S, Macha M (2009) Right ventricular effects of intracoronary delivery of mesenchymal stem cells (MSC) in an animal model of pressure overload heart failure. Biomed Pharmacother 63:767–772
Mussi SV, Torchilin VP (2013) Recent trends in the use of lipidic nanoparticles as pharmaceutical carriers for cancer therapy and diagnostics. J Mater Chem B 1:5201–5209
Na HS, Lim YK, Jeong YI, Lee HS, Lim YJ, Kang MS, Cho CS, Lee HC (2010) Combination antitumor effects of micelle-loaded anticancer drugs in a CT-26 murine colorectal carcinoma model. Int J Pharm 383(1–2):192–200
Nakamura K, Ryuichi E, Takeda M (1976) Surface properties of styrene – ethylene oxide block copolymers. J Polym Sci 14(7):1287–1295
Nasibullah M, Hassan F, Ahmad N, Khan AR, Rahman M (2013) Dendrimers as novel polymeric material: a review on its synthesis, characterization and their applications. Adv Sci Focus 1(3):197–204
Neal DP, Hirsch LR, Halas NJ, Payne JD, West JL (2004) Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles. Cancer Lett 209(2):171–176
Patil J, Gurav P, Kulkarni R, Jadhav S, Mandave S, Shete S, Chipade V (2013) Applications of solid lipid nanoparticle in novel drug delivery system. Brit. Biomed Bull 1(2):103–118
Ramandeep Singh MK (2016) Kale and Atul Bodkhe, Liposomes: from concept to commercialization. Euorpian J Biomed Pharm sci 3(7):189–206
Ramasamy T, Kim J, Choi HG, Yong CS, Kim JOJ (2014) Novel dual drug-loaded block monomer complex micelles for enhancing the efficacy of chemotherapy treatments. Nanotechnology 10(7):1304–1312
Sajomsang W, Gonil P, Saesoo S, Ruktanonchai UR, Srinuanchai W, Puttipipatkhachorn S (2014) Synthesis and anticervical cancer activity of novel pH responsive micelles for oral curcumin delivery. Int J Pharm 477(1–2):261–272
Sanganalmath SK, Bolli R (2013) Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions. Circ Res 113:810–834
Sarisozen C, Vural I, Levchenko T, Hincal AA, Torchilin VP (2012) Long-circulating PEG-PE micelles co-loaded with paclitaxel and elacridar (GG918) overcome multidrug resistance. Drug Deliv 19(8):363–370
Satchi-Fainaro R, Duncan R, BarnesB C M (2006) Polymer therapeutics for cancer: current status and future challenges. In: Satchi-Fainaro R, Duncan R (eds) Springer, New York, pp 1–65
Schwarz MA, Raith K, Neubert RHH (1998) Characterization of micelles by capillary electrophoresis. Electrophoresis 19:2145–2150
Shen Y, Pei A, Sun A, Xu J, Song Y, Huang G, Sun X, Zhang S, Qin Q, Zhu H, Yang S, Yang X, Zou Y, Qian J, Ge J (2013) Comparison of magnetic intensities for mesenchymal stem cell targeting therapy on ischemic myocardial repair: high magnetic intensity improves cell retention but has no additional functional benefit. Biomaterials 34:9905–9916
Shi S, Shi K, Tan L, Qu Y, Shen G, Chu B, Zhang S, Su X, Li X, Wei Y, Qian Z (2014) The use of cationic MPEG-PCL-g-PEI micelles for co-delivery of Msurvivin T34A gene and doxorubicin. Biomaterials 35(15):4536–4547
Singh SK, Sharma VK (2013) Dendrimers: A class of polymer in the nanotechnology for drug delivery. In: AK Mishra (ed), Scrivener Publishing, Beverly
Sosnik A, Raskin MM (2015) Polymeric micelles in mucosal drug delivery: Challenges towards clinical translation. Biotechnol Adv 33(6):1380–1392
Sun CY, Ma YC, Cao ZY, Li DD, Fan F, Wang JX, Tao W, Yang XZ (2014) Effect of Hydrophobicity of Core on the Anticancer Efficiency of Micelles as Drug Delivery Carriers. ACS Appl Mater Interfaces 6(24):22709–22718
Tiwari G, Tiwari R, Sriwastawa B, Bhati L, Pandey S, Pandey P, Saurabh KB (2012) Drug delivery systems: an updated review. Int J Pharm Investig 2(1):2–11
Tripathy S, Das MK (2013) Dendrimers and their applications as novel drug delivery carriers. J Appl Pharmaceut Sci 3(9):142–149
Vemuri S, Rhodes CT (1995) Preparation and characterization of liposomes as therapeutic delivery systems: a review. Pharm Acta Helv 70(2):95–111
Venkataraman S, Hedrick SL, Ong ZY, Yang C, Pui Lai Rachel Ee, Hammond PT, Yang YY (2011) The effects of polymeric nanostructure shape on drug delivery. Adv Drug Deliv Rev 63(14-15):1228–1246
Wang H, Zhao Y, Wu Y, Hu YL, Nan K, Nie G (2011) Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles. Biomaterials 32:8281–8290
Weissig V, Whiteman KR, Torchilin VP (1998) Accumulation of protein-loaded long-circulating micelles and liposomes in subcutaneous lewis lung carcinoma in mice. Pharm Res 15:1552–1556
Welch PM, Welch CF (2009) Tecto-dendrimers: a study of covalently bound nanospheres. Macromolecules 42:7571–7578
Wilczewska AZ, Niemirowicz K, Markiewicz KH, Car H (2012) Nanoparticles as drug delivary systems. Pharmacol Rep 64:1020–1037
Xie X, Sun A, Zhu W, Huang Z, Hu X, Jia J, Zou Y, Ge J (2012) Transplantation of mesenchymal stem cells preconditioned with hydrogen sulfide enhances repair of myocardial infarction in rats. Tohoku J Exp Med 226:29–36
Yhee J Y, Son S, Son S, Joo MK, Kwon IC (2013). The EPR effect in cancer therapy. In: Bae YH, Mrsny RJ, Park K (eds) Springer, New York, pp 621–632
Yokoyama M (2010) Polymeric micelles as a new drug carrier system and their required considerations for clinical trials. Expert Opin Drug Deliv 7:145–158
Zhang X, Liu B, Yang Z, Li H, Luo X, Luo H, Gao D, Jiang Q, Liu J, Jiang Z (2014a) Micelles of enzymatically synthesized PEG-poly(amine-co-ester) block copolymers as pH-responsive nanocarriers for docetaxel delivery. Colloids Surf B 115:349–358
Zhang X, Zeng X, Liang X, Yang Y, Li X, Chen H, Huang L, Mei L, Feng S S (2014b) The chemotherapeutic potential of PEG-b-PLGA copolymer micelles that combine chloroquine as autophagy inhibitor and docetaxel as an anti-cancer drug. Biomaterials 35(33):9144–9154
Zharov V, Galitovsky V, Viegas M (2003) Photothermal detection of local thermal effects during selective nanophotothermolysis. Appl Phys Lett 83(24):4897–4899
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Sabah, A., Hornyak, G.L. (2018). Nano Drugs. In: Javad, S., Butt, A. (eds) Nanobotany. Springer, Cham. https://doi.org/10.1007/978-3-319-77119-9_5
Download citation
DOI: https://doi.org/10.1007/978-3-319-77119-9_5
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-77118-2
Online ISBN: 978-3-319-77119-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)