The Sympathetic Nervous System in Hypertension

  • Gino Seravalle
  • Giuseppe Mancia
  • Guido Grassi
Part of the Contemporary Endocrinology book series (COE)


It has been clearly shown that adrenergic tone has a primary role in blood pressure control due to the regulatory effects on cardiac output and systemic vascular resistance. Several mechanisms, both at central and peripheral levels, participate in this control exerted by the sympathetic nervous system. This chapter will review the main mechanisms involved starting from the new evidences from genetic studies. The effects of the sympathetic nervous system on the hypertensive state will be also evaluated in the different conditions starting from prehypertension to the resistant hypertensive state and the main secondary forms of hypertension.


Sympathetic nervous system Arterial hypertension Prehypertension Dipping profile White-coat effect Secondary hypertension Resistant hypertension 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Gino Seravalle
    • 1
  • Giuseppe Mancia
    • 2
  • Guido Grassi
    • 3
    • 4
  1. 1.Cardiologia, Ospedale San Luca, IRCCS Istituto Auxologico ItalianoMilanItaly
  2. 2.Università Milano BicoccaMonzaItaly
  3. 3.Clinica Medica, Università Milano-Bicocca, Monza, and IRCCS MultimedicaSesto San Giovanni/MilanItaly
  4. 4.Clinica Medica, Ospedale S. Gerardo dei TintoriMonzaItaly

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