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The Extracellular Matrix, Growth Factors and Morphogens in Biomaterial Design and Tissue Engineering

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Extracellular Matrix for Tissue Engineering and Biomaterials

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Cells , morphogens, growth factors , and custom scaffolds are the critical ingredients for successful tissue regeneration in which morphogens and growth factors function sequentially. Extensive studies, in vitro and in vivo, have been made to explore the mechanisms and the roles played by these molecules. As a consequence, precise, localized control over the signaling of these factors and appropriate strategy selection, depending on the tissue or organ to be repaired or regenerated, is known to permit specific management of regenerative processes. The first part of the chapter examines natural ECMs which are a set of molecules secreted by cells that provide structural and biochemical support to the surrounding cells . ECMs also perform many other functions, such as actively regulating cell function through the control of biochemical gradients, cell density, spatial organization , and ligand attachment, thus influencing various types of cell processes. Subsequently, growth factors and morphogens are examined in greater depth to clarify to what degree progress has been made into improving methodologies and functionality and, perhaps, to hint at what remains to be done for the future of tissue engineering .

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Authors and Affiliations

  1. Department of Medicine, University of Verona, 37134, Verona, Italy

    Caterina Bason

  2. Department of Pharmacy, University G. d’Annunzio Chieti-Pescara, Pescara, Italy

    Marialucia Gallorini

  3. Research Laboratory “Stem Cells” U.O.C. Immunohematology, Transfusion Center and Laboratory of Hematology, Hospital Santo Spirito, Pescara, Italy

    Anna C. Berardi

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  1. Caterina Bason
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  2. Marialucia Gallorini
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  3. Anna C. Berardi
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Correspondence to Anna C. Berardi .

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  1. Department of Hematology, Transfusional Medicine and Biotechnology, Spirito Santo Hospital, Pescara, Italy

    Anna C. Berardi

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Bason, C., Gallorini, M., Berardi, A.C. (2018). The Extracellular Matrix, Growth Factors and Morphogens in Biomaterial Design and Tissue Engineering. In: Berardi, A. (eds) Extracellular Matrix for Tissue Engineering and Biomaterials. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-77023-9_1

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