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Emerging Concepts in Treating Cartilage, Osteochondral Defects, and Osteoarthritis of the Knee and Ankle

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Osteochondral Tissue Engineering

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1059))

Abstract

The management and treatment of cartilage lesions, osteochondral defects, and osteoarthritis remain a challenge in orthopedics. Moreover, these entities have different behaviors in different joints, such as the knee and the ankle, which have inherent differences in function, biology, and biomechanics. There has been a huge development on the conservative treatment (new technologies including orthobiologics) as well as on the surgical approach. Some surgical development upraises from technical improvements including advanced arthroscopic techniques but also from increased knowledge arriving from basic science research and tissue engineering and regenerative medicine approaches. This work addresses the state of the art concerning basic science comparing the knee and ankle as well as current options for treatment. Furthermore, the most promising research developments promising new options for the future are discussed.

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Authors and Affiliations

  1. Orthopedic Department Centro Hospitalar Póvoa de Varzim, Vila do Conde, Portugal

    Hélder Pereira

  2. International Centre of Sports Traumatology of the Ave, Taipas, Portugal

    Hélder Pereira & Pedro L. Ripoll

  3. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, Guimarães, Portugal

    Hélder Pereira, Ibrahim Fatih Cengiz, Carlos Vilela, João Espregueira-Mendes, J. Miguel Oliveira & Rui L. Reis

  4. ICVS/3B’s – PT Government Associate Laboratory, Braga, Guimarães, Portugal

    Hélder Pereira, Ibrahim Fatih Cengiz, Carlos Vilela, João Espregueira-Mendes, J. Miguel Oliveira & Rui L. Reis

  5. Ripoll y De Prado Sports Clinic: Murcia – Madrid FIFA Medical Centre of Excellence, Madrid, Spain

    Hélder Pereira, Pedro L. Ripoll & C. Niek van Dijk

  6. Clínica do Dragão, Espregueira-Mendes Sports Centre – FIFA Medical Centre of Excellence, Porto, Portugal

    João Espregueira-Mendes

  7. Dom Henrique Research Centre, Porto, Portugal

    João Espregueira-Mendes

  8. Orthopedic Department, University of Minho, Braga, Portugal

    João Espregueira-Mendes

  9. The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Guimarães, Portugal

    J. Miguel Oliveira & Rui L. Reis

  10. Department of Orthopaedic Surgery and Academic Center for Evidence-Based Sports Medicine, Academic Medical Center, University of Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands

    C. Niek van Dijk

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  1. Hélder Pereira
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  2. Ibrahim Fatih Cengiz
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  3. Carlos Vilela
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  5. João Espregueira-Mendes
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  6. J. Miguel Oliveira
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  7. Rui L. Reis
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  8. C. Niek van Dijk
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Editors and Affiliations

  1. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

    J. Miguel Oliveira

  2. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

    Sandra Pina

  3. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

    Rui L. Reis

  4. Polymeric Nanomaterials and Biomaterials Department, Institute of Polymer Science and Technology, Spanish Council for Scientific Research (CSIC), Madrid, Spain

    Julio San Roman

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Pereira, H. et al. (2018). Emerging Concepts in Treating Cartilage, Osteochondral Defects, and Osteoarthritis of the Knee and Ankle. In: Oliveira, J., Pina, S., Reis, R., San Roman, J. (eds) Osteochondral Tissue Engineering. Advances in Experimental Medicine and Biology, vol 1059. Springer, Cham. https://doi.org/10.1007/978-3-319-76735-2_2

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