Clinical Features
Abstract
Clinical features in neuropsychiatric systemic lupus erythematosus (NPSLE) include a variety of manifestations, which are too complicated to understand. In 1999, the American college of rheumatology (ACR) proposed nomenclature and case definitions of NPSLE as nosology for clinical descriptions and research. Clinically, NPSLE is classified into 2 different categories; one is diffuse psychiatric/neuropsychological syndromes and the other is neurologic syndromes. This discrimination is not always advantageous for clinical practice including a diagnosis and therapeutic intervention. Moreover, the severities of each manifestation differ among NPSLE. For example, acute confusional state is very severe form with poor prognosis, whereas headache, mood disorders, anxiety disorders and cognitive dysfunction are sometimes mild, and are also common in individuals without SLE. Also, we need to remember that NPSLE can be developed even in the absence of systemic disease activities. Finally, some neuropsychiatric manifestations have not been adequately defined in the ACR nomenclature.
Keywords
NPSLE ACR nomenclature Diffuse psychiatric/neuropsychological Syndromes Acute confusional state Neurologic syndromesSupplementary material
Reference
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