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Neuropsychiatric Systemic Lupus Erythematosus

Abstract

Extensive studies revealed more than 70 strong candidate regions for susceptibility genes to systemic lupus erythematosus (SLE), and efforts to identify the causative variants in each candidate region are under way. The list of candidate genes points to the crucial pathways that play a role in the development of SLE, such as HLA and immune system signaling, upregulated type I interferon and nucleic acids response, and defective clearance of dying cells. Among these pathways, type I interferon pathway may be particularly relevant to neuropsychiatric SLE (NPSLE), because Aicardi-Goutières syndrome (AGS), a group of single gene diseases with enhanced type I IFN response and exhibits severe central nervous system symptoms, has some similarities with SLE. In fact, variants in some of the genes responsible for AGS are also reported in familial and sporadic patients with SLE. On the other hand, the efforts to identify NPSLE associated genes using case-case association analysis have not been very successful thus far. In the future, large-scale case-case association analysis, not limited to the genes associated with overall SLE, may be necessary in order to identify variants associated with clinical subphenotypes including neuropsychiatric manifestations.

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Authors and Affiliations

  1. Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    Naoyuki Tsuchiya

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  1. Naoyuki Tsuchiya
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Correspondence to Naoyuki Tsuchiya .

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Editors and Affiliations

  1. Department of Rheumatology, Nobubara Hospital, Tatsuno, Hyogo, Japan

    Shunsei Hirohata

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Tsuchiya, N. (2018). Genetics. In: Hirohata, S. (eds) Neuropsychiatric Systemic Lupus Erythematosus. Springer, Cham. https://doi.org/10.1007/978-3-319-76496-2_2

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