Abstract
Morbid obesity is a chronic, progressive, relentless and multifactorial disease leading to catastrophic repercussions for the patient. Although surgery is currently the only effective alternative in its treatment, the “ideal” bariatric operation is yet to be found. After performing many of the available open and laparoscopic options in bariatric surgery, and aware of several issues with the Roux-en-Y gastric bypass which we were performing at the time, we decided to evaluate the Mini-gastric bypass (MGB) which had recently been reported. The laparoscopic One-Anastomosis Gastric Bypass (OAGB) was thus created in the year 2002, as a modification of the MGB with differentiated conceptual principles and technical features. Since then, we have periodically reported our outcomes both in scientific meetings and publications. This chapter updates our experience with a prospectively collected database of now 3000 patients during a 15 year period.
Demographics included age: 43 y.(12–74), BMI: 46 (31–86) and EBW: 65 kg (28–220). There were 4 (0.13%) conversions. Length of stay for uncomplicated patients (99%) was 24 h. (15–120) and 9 days (4–32) for those with major complications. These prompted further operations in 23 (0.9%) and were solved conservatively in 12 (0.4%). Long-term complications occurred in 83 (2.8%). There were three deaths (0.1%) due to PTE, nosocomial pneumonia and DIC. Postoperative %EWL was 84%, 81%, 77%, 70% and 70% at 1,3,5,10 and 15 years, respectively. Overall total or partial resolution of co-morbidities was achieved in 97% and 92% at 2 and 15 years, respectively. Quality of life (GIQoLI) was satisfactory in all parameters assessed postoperatively.
OAGB provides reduced difficulty and very low morbidity-mortality. Long term %EWL and co-morbidity resolution are similar to the best results obtained with more aggressive and complex operations. OAGB has established itself as one of the safest and more effective alternatives in bariatric surgery.
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- BMI:
-
Body mass index
- BP:
-
Biliopancreatic
- BR:
-
Bile reflux
- BS:
-
Bariatric surgery
- EAC:
-
European accreditation council
- EG:
-
Esophago-gastric
- EW:
-
Excess weight
- EWL:
-
Excess weight loss
- FU:
-
Follow-up
- GERD:
-
Gastroesophageal reflux disease
- GI:
-
Gastrointestinal
- HP:
-
Helicobacter pylori
- IFSO:
-
International Federation for the Surgery of Obesity and Metabolic Disorders
- IWQoL:
-
Impact of weight on quality of life
- LAGB:
-
Laparoscopic adjustable gastric banding
- LOS:
-
Lenght of stay
- LSG:
-
Laparoscopic sleeve gastrectomy
- LSML:
-
Left subcostal mini-laparotomy
- MGB:
-
Mini-gastric bypass
- MO:
-
Morbid obesity
- MU:
-
Marginal ulcers
- NPO:
-
Nil per os
- OAGB:
-
One anastomosis gastric bypass
- PPI’s:
-
Proton pump inhibitors
- QoL:
-
Quality of life
- RYGB:
-
Roux-Y gastric bypass
- SB:
-
Small bowel
- SBO:
-
Small bowel obstruction
- TPN:
-
Total parenteral nutrition
- WL:
-
Weight loss
- WR:
-
Weight regain
References
Malik VS, Willett WC, Hu FB. Global obesity: trends, risk factors and policy implications. Nat Rev Endocrinol. 2013;9:13–27.
Guh DP, Zhang W, Bansback N, et al. The incidence of comorbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health. 2009;9:88. https://doi.org/10.1186/1471-2458-9-88.
Flegal KM, Kit BK, Orpana H, Graubard BI. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA. 2013;309:71–82.
Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292:1724–37.
Sjostrom L, Lindroos AK, Peltonen M, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351:2683–93.
Sjostrom L, Narbro K, Sjostrom D, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357:741–52.
Thaler JP, Cummings DE. Minireview: hormonal and metabolic mechanisms of diabetes remission after gastrointestinal surgery. Endocrinology. 2009;150(6):2518–25.
Jennings NA, Small PK. Procedure selection in bariatric surgery. In: Agrawal S, editor. Obesity, bariatric and metabolic surgery: a practical guide. Switzerland: Springer International Publishing; 2016. p. 85–9. https://doi.org/10.1007/978-3-319-04343-2_9.
Rutledge R. The mini-gastric bypass: experience with the first 1274 cases. Obes Surg. 2001;11(3):276–80.
Carbajo M, Garcia-Caballero M, Toledano M, et al. One-anastomosis gastric bypass by laparoscopy: results of the first 209 patients. Obes Surg. 2005;15(3):398–404.
Carbajo MA, Luque-de-León E, Jimenez JM, et al. Laparoscopic one-anastomosis gastric bypass: Technique, results and long-term follow-up in 1200 patients. Obes Surg. 2017;27(5):1153–67.
Luque-de-León E, Carbajo M. Laparoscopic one-anastomosis gastric bypass (LOAGB): 12 year experience with 2600 patients. Obes Surg. 2015;25(S1):S199.
Carbajo MA, Luque-de-León E. Laparoscopic one-anastomosis gastric bypass (OAGB): Outcomes with 3000 patients during 15 years (Conference). 17th Mediterranean & Middle Eastern Endoscopic Surgery Association (MMESA) Congress. Isfahan (Iran) - October 25th–27th, 2017.
Kolotkin RL, Head S, Hamilton M, Tse CKJ. Assessing impact of weight on quality of life. Obes Res. 1995;3:49–56.
Carbajo MA, Vázquez-Pelcastre R, Aparicio-Ponce R, Luque-de-León E, et al. 12-year old adolescent with super morbid obesity treated with laparoscopic one anastomosis gastric bypass (LOAGB/BAGUA): A case report after 5-year follow-up. Nutr Hosp. 2015;31(5):2327–32.
Carbajo MA, Castro MJ, Kleinfinger S, et al. Effects of a balanced energy and high protein formula diet (Vegestart complet®) vs. low-calorie regular diet in morbid obese patients prior to bariatric surgery (laparoscopic single anastomosis gastric bypass): a prospective, double-blind randomized study. Nutr Hosp. 2010;25(6):939–48.
Gastrointestinal surgery for severe obesity. National Institutes of Health consensus development conference draft statement. Obes Surg. 1991;1:257–66.
Buchwald H. Consensus conference statement: bariatric surgery for morbid obesity: health implications for patients, health professionals, and third-party payers. J Am Coll Surg. 2005;200:593–604.
Mahawar KK, Jennings N, Brown J, et al. “Mini” gastric bypass: systematic review of a controversial procedure. Obes Surg. 2013;23:1890–8.
Rutledge R, Walsh W. Continued excellent results with the mini-gastric bypass: six-year study in 2,410 patients. Obes Surg. 2005;15:1304–8.
Wang W, Wei PL, Lee YC, et al. Short-term results of laparoscopic mini-gastric bypass. Obes Surg. 2005;15(5):648–54.
Lee WJ, Ser KH, Lee YC, et al. Laparoscopic Roux-en-Y vs. mini-gastric bypass for the treatment of morbid obesity: a 10-year experience. Obes Surg. 2012;22:1827–34.
Lee WJ, Yu PJ, Wang W, et al. Laparoscopic Roux-en-Y versus mini-gastric bypass for the treatment of morbid obesity: a prospective randomized controlled clinical trial. Ann Surg. 2005;242:20–8.
Georgiadou D, Sergentanis TN, Nixon A, et al. Efficacy and safety of laparoscopic mini-gastric bypass. A systematic review. Surg Obes Relat Dis. 2014;10:984–91.
Jones KB. The left subcostal incision revisited. Obes Surg. 1998;8:29–34.
Carbajo MA, Martin del Olmo JC, Toledano M. Left subcostal minilaparotomy in silastic ring vertical gastroplasty and transected Roux-en-Y gastric bypass. Obes Surg. 2002;2:124–5.
Lee WJ, Lin YH. Single-anastomosis gastric bypass (SAGB): appraisal of clinical evidence. Obes Surg. 2014;24:1749–56.
Fernandez AZ Jr, DeMaria EJ, Tichansky DS, et al. Experience with over 3000 open and laparoscopic bariatric procedures: multivariate analysis of factors related to leak and resultant mortality. Surg Endosc. 2004;18:193–7.
Aurora AR, Khaitan L, Saber AA. Sleeve gastrectomy and the risk of leak: a systematic analysis of 4,888 patients. Surg Endosc. 2012;26(6):1509–15.
Padwal R, Klarenbach S, Wiebe N, et al. Bariatric surgery: a systematic review and network meta-analysis of randomized trials. Obes Rev. 2011;12:602–21.
Moszkowicz D, Arienzo R, Khettab I, et al. Sleeve gastrectomy severe complications: is it always a reasonable surgical option? Obes Surg. 2013;3:676–86.
Ben Yaacov A, Sadot E, Ben David M, et al. Laparoscopic total gastrectomy with Roux-y esophagojejunostomy for chronic gastric fistula after laparoscopic sleeve gastrectomy. Obes Surg. 2014;24(3):425–9.
Griffen WO, Young VL, Stevenson CC. A prospective comparison of gastric and jejunoileal bypass procedures for morbid obesity. Ann Surg. 1977;186:500–9.
Johnson WH, Fernandez AZ, Farrell TM, et al. Surgical revision of loop (“mini”) gastric bypass procedure: multicenter review of complications and conversions to Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2007;3(1):37–41.
Chevallier JM, Arman GA, Guenzi M, et al. One thousand single anastomosis (omega loop) gastric bypasses to treat morbid obesity in a 7-year period: outcomes show few complications and good efficacy. Obes Surg. 2015;25:951–8.
Musella M, Sousa A, Greco F, et al. The laparoscopic mini-gastric bypass: The Italian experience: outcomes from 974 consecutive cases in a multi-center review. Surg Endosc. 2014;28:156–63.
Kular KS, Manchanda N, Rutledge R. A 6-year experience with 1,054 mini-gastric bypasses-First study from Indian subcontinent. Obes Surg. 2014;24:1430–5.
Noun R, Skaff J, Riachi E, et al. One thousand consecutive mini-gastric bypass: short and long-term outcome. Obes Surg. 2012;22:697–703.
Husain S, Ahmed AR, Johnson J, et al. Small-bowel obstruction after laparoscopic Roux-en-Y gastric bypass: etiology, diagnosis and management. Arch Surg. 2007;142(10):988–93.
Higa K, Ho T, Tercero F, et al. Laparoscopic Roux- en-Y gastric bypass: 10-year follow-up. Surg Obes Relat Dis. 2011;7:516–25.
Paroz A, Calmes JM, Giusti V, Suter M. Internal hernia after laparoscopic Roux-en-Y gastric bypass for morbid obesity: a continuous challenge in bariatric surgery. Obes Surg. 2006;16:1482–7.
Al-Mansour MR, Mundy R, Canoy JM, et al. Internal hernia after laparoscopic antecolic Roux-en-Y gastric bypass. Obes Surg. 2015;25(11):2106–11.
Jones KB. Biliopancreatic limb obstruction in gastric bypass at or proximal to the jejunojejunostomy: a potentially deadly, catastrophic event. Obes Surg. 1996;6:485–93.
Almulaifi AM, Ser KH, Lee WJ. Acute gastric remnant dilatation, a rare early complication of laparoscopic mini-gastric bypass. Asian J Endosc Surg. 2014;7(2):185–7.
Woodward GA, Morton JM. Stomal stenosis after gastric bypass. In: Deitel M, Gagner M, Dixon JB, Himpens J, editors. Handbook of obesity surgery. Toronto: FD-Communications; 2010. p. 102–7.
Sataloff DM, Lieber CP, Seinige UL. Strictures following gastric stapling for morbid obesity: results of endoscopic dilatation. Am Surg. 1990;56(3):167–74.
Coblijn UK, Goucham AB, Lagarde SM, et al. Development of ulcer disease after Roux-en-Y gastric bypass, incidence, risk factors and patient presentation: a systematic review. Obes Surg. 2014;24(2):299–309.
Mason EE, Ito C. Gastric bypass in obesity. Surg Clin North Am. 1967;47:1345–52.
Fuchs KH, Maroske J, Fein M, et al. Variability in the composition of physiologic duodenogastric reflux. J Gastrointest Surg. 1999;3(4):389–95.
Atak I, Ozdil K, Yücel M, et al. The effect of laparoscopic cholecystectomy on the development of alkaline reflux gastritis and intestinal metaplasia. Hepato-Gastroenterology. 2012;59(113):59–61.
Parrilla P, Lujan JA, Robles R, et al. Duodenogastric reflux quantification in peptic ulcer surgery: comparison between different surgical techniques. Surgery. 1993;113(1):43–7.
Schindlbeck NE, Heinrich C, Stellaard F, et al. Healthy controls have as much bile reflux as gastric ulcer patients. Gut. 1987;28(12):1577–83.
Chevallier JM, Trelles N, Arienzo R, et al. Endoscopic findings after laparoscopic omega loop gastric bypass. Obes Surg. 2011;21:956.
Tolone S, Cristiano S, Savarino E, et al. Effects of omega-loop bypass on esophagogastric junction function. Surg Obes Relat Dis. 2016;12:62–9.
Rosenthal RJ. International sleeve gastrectomy expert panel consensus statement best practice guidelines based on experience of >12,000 cases. Surg Obes Relat Dis. 2012;8(1):8–19.
DuPree CE, Blair K, Steele SR, Martin MJ. Laparoscopic sleeve gastrectomy in patients with preexisting gastroesophageal reflux disease a national analysis. JAMA Surg. 2014;149(4):328–34.
Weiner RA, Theodoridou S, Weiner S. Failure of laparoscopic sleeve gastrectomy—further procedure? Obes Facts. 2011;4(suppl 1):42–6.
Lee WJ, Lee YC, Ser KH, et al. Revisional surgery for laparoscopic minigastric bypass. Surg Obes Relat Dis. 2011;7(4):486–92.
Facchiano E, Leuratti L, Veltri M, et al. Laparoscopic conversion of one anastomosis gastric bypass to Roux-en-Y gastric bypass for chronic bile reflux. Obes Surg. 2016;26(3):701–3. https://doi.org/10.1007/s11695-015-2017-8.
Cerón-Rodríguez F, Márquez-González SM, Ampudia-Chávez JD, et al. Bypass gástrico López Mateos. Descripción de la técnica. Cir End. 2014;15:6–9.
Luque-de-León E, Carbajo MA. Conversion of one-anastomosis gastric bypass (OAGB) is rarely needed if standard operative techniques are performed. Obes Surg. 2016;26:1588–91.
Viste A, Bjørnestad E, Opheim P, et al. Risk of carcinoma following gastric operations for benign disease. A historical cohort study of 3470 patients. Lancet. 1986;2(8505):502–5.
Schafer LW, Larson DE, Melton LJ III, et al. The risk of gastric carcinoma after surgical treatment for benign ulcer disease. A population-based study in Olmsted County, Minnesota. N Engl J Med. 1983;309(20):1210–3.
Sitarz R, Maciejewski R, Polkowski WP, Offerhaus GJA. Gastroenterostoma after Billroth antrectomy as a premalignant condition. World J Gastroenterol. 2012;18(25):3201–6.
Seoane A, Bessa X, Alameda F, et al. Role of Helicobacter pylori in stomach cancer after partial gastrectomy for benign ulcer disease. Rev Esp Enferm Dig. 2005;97(11):778–85.
McQuaid KR, Laine L, Fennerty MB, et al. Systematic review: the role of bile acids in the pathogenesis of gastro-oesophageal reflux disease and related neoplasia. Aliment Pharmacol Ther. 2011;34(2):146–65.
Taha AS, Angerson WJ, Morran CG. Reflux and Barrett’s oesophagitis after gastric surgery—long-term follow-up and implications for the roles of gastric acid and bile in oesophagitis. Aliment Pharmacol Ther. 2003;17(4):547–52.
Champion G, Richter JE, Vaezi MF, et al. Duodenogastroesophageal reflux: relationship to pH and importance in Barrett’s esophagus. Gastroenterology. 1994;107(3):747–54.
Wu CC, Lee WJ, Ser KH, et al. Gastric cancer after mini-gastric bypass surgery: a case report. Asian J Endosc Surg. 2013;6:303–6.
Lagergren J, Lindam A, Mason RM. Gastric stump cancer after distal gastrectomy for benign gastric ulcer in a population-based study. Int J Cancer. 2012;131(6):E1048–52.
Babor R, Booth M. Adenocarcinoma in the gastric pouch 26 years after loop gastric bypass. Obes Surg. 2006;16:935–8.
Scozzari G, Trapani R, Toppino M, Morino M. Esophagogastric cancer after bariatric surgery: systematic review of the literature. Surg Obes Relat Dis. 2013;9(1):133–42.
Himpens J, Dobbeleir J, Peeters G. Long-term results of laparoscopic sleeve gastrectomy for obesity. Ann Surg. 2010;252:319–24.
Del Genio G, Tolone S, Limongelli P, et al. Sleeve gastrectomy and development of “de novo” gastroesophageal reflux. Obes Surg. 2014;24:71–7.
Chang JT, Katzka DA. Gastroesophageal reflux disease, Barrett’s esophagus, and esophageal adenocarcinoma. Arch Intern Med. 2004;164:1482–8.
Lee WJ, Wang W, Lee YC, et al. Laparoscopic mini-gastric bypass: experience with tailored bypass limb according to body weight. Obes Surg. 2008;18:294–9.
Piazza L, Ferrara F, Leanza S, et al. Laparoscopic mini-gastric bypass: short-term single-institute experience. Updat Surg. 2011;63:239–42.
García-Caballero M, Reyes-Ortiz A, Garcia M, et al. Changes of body composition in patients with BMI 23-50 after tailored one anastomosis gastric bypass (BAGUA): influence of diabetes and metabolic syndrome. Obes Surg. 2014;24:2040–7.
Dang H, Arias E, Szomstein S, Rosenthal R. Laparoscopic conversion of distal mini-gastric bypass to proximal Roux-en-Y gastric bypass for malnutrition: case report and review of the literature. Surg Obes Relat Dis. 2009;5:383–6.
Ali M, Motamedi K, Barzim M, et al. Severe fatal protein malnutrition and liver failure in a morbidily obese patient after mini-gastric bypass: case report. Int J Surg. 2017;33:71–4.
Reinhold RB. Critical analysis of long term weight loss following gastric bypass. Surg Gynecol Obstet. 1982;155:385–94.
Dykstra MA, Switzer NJ, Sherman V, et al. Roux-en-Y gastric bypass: how and why it fails? Surg Curr Res. 2014;4:1–4.
Bessler M, Daud A, Kim T, DiGiorgi M. Prospective randomized trial of banded versus non banded gastric bypass for the superobese: early results. Surg Obes Relat Dis. 2007;3(4):480.
Rawlins ML, Teel D II, Hedgcorth K, Maguire JP. Revision of Roux- en-Y gastric bypass to distal bypass for failed weight loss. Surg Obes Relat Dis. 2011;7:45–9.
Kular KS, Manchanda N, Rutledge R. Analysis of the five-year outcomes of sleeve gastrectomy and mini gastric bypass: A report from the Indian sub-continent. Obes Surg. 2014;24:1724–8.
Jammu GS, Sharma R. A 7-year clinical audit of 1,107 cases comparing sleeve gastrectomy, Roux-en-Y gastric bypass, and mini-gastric bypass, to determine an effective and safe bariatric and metabolic procedure. Obes Surg. 2016;26(5):926–32. https://doi.org/10.1007/s11695-015-1869-2.
Disse E, Pasquer A, Espalieu P, et al. Greater weight loss with the omega loop bypass compared to Roux-en-Y gastric bypass: a comparative study. Obes Surg. 2014;24(6):841.
Karra E, Yousseif A, Batterham RL. Mechanisms facilitating weight loss and resolution of type 2 diabetes following bariatric surgery. Trends Endocrin Met. 2010;21:337–44.
Carbajo MA, Jimenez JM, Castro MJ, et al. Outcomes in weight loss, fasting blood glucose and glycosylated hemoglobin in a sample of 415 obese patients, included in the database of the European Accreditation Council for Excellence Centers for Bariatric Surgery with laparoscopic one-anastomosis gastric bypass. Nutr Hosp. 2014;30(5):1032–8.
Carbajo MA, Fong-Hirales A, Luque-de-León E, et al. Weight loss and improvement of lipid profiles in morbidly obese patients after laparoscopic one-anastomosis gastric bypass: 2-year follow-up. Surg Endosc. 2017;31:416–21. https://doi.org/10.1007/s00464-016-4990-y.
Quan Y, Huang A, Ye M, et al. Efficacy of laparoscopic mini gastric bypass for obesity and type 2 diabetes mellitus: a systematic review and meta-analysis. Gastroent Res Prac. 2015;2015:13. https://doi.org/10.1155/2015/152852.
Rutledge R, Kular KS, Marchanda N, et al. A comparison of the outcomes of revision of the Roux-en-Y (RNY) and mini-gastric bypass (MGB); hard vs. easy. Eur J Endosc Laparosc Surg. 2014;1:1–6.
Wang W, Huang MT, Wei PL, et al. Laparoscopic mini-gastric bypass for failed vertical banded gastroplasty. Obes Surg. 2004;14:777–82.
Rutledge R. Revision of failed gastric banding to mini-gastric bypass. Obes Surg. 2006;16:521–3.
Noun R, Zeidan S, Riachi E, et al. Mini-gastric bypass for revision of failed primary restrictive procedures: a valuable option. Obes Surg. 2007;17:684–8.
Moszkowicz D, Rau C, Guenzi M, et al. Laparoscopic omega-loop gastric bypass for the conversion of failed sleeve gastrectomy: early experience. J Vis Surg. 2013;150:373–8.
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Luque-de-León, E., Carbajo, M.A. (2018). Results of the One-Anastomosis Gastric Bypass (OAGB): Safety, Nutritional Considerations and Effects on Weight, Co-Morbidities, Diabetes and Quality of Life. In: Deitel, M. (eds) Essentials of Mini ‒ One Anastomosis Gastric Bypass. Springer, Cham. https://doi.org/10.1007/978-3-319-76177-0_25
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