Abstract
Cyclodextrins are naturally occurring cyclic oligosaccharides, which are non-toxic and biodegradable. The main feature of cyclodextrins is the ability to encapsulate lipophilic compounds, and thus many applications have been developped in various disciplines. Although many cyclodextrin derivatives have become available in the market, their price is in the range of fine chemicals, and thus they are still often synthesised in laboratories. The actual number of cyclodextrin derivatives exceeds 11,000, but new cyclodextrin derivatives are still needed for more advanced applications. Therefore, many newcomers or beginners in cyclodextrin chemistry struggle with a reliable choice of a synthetic route.
This chapter reviews the synthesis cyclodextrin derivatives that are able to be subsequently modified. Indeed, the modification of a cyclodextrin already substituted with a suitable functional group is much easier than the optimisation of the substitution for every new cyclodextrin derivative desired. This chapter describes the synthesis of different types of cyclodextrine derivatives: persubstituted, randomly substituted, persubstituted at selected positions, selectively substituted and monosubstituted.
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Acknowledgements
This work was supported by project LO1201 of the Ministry of Education, Youth and Sports in the framework of the targeted support of the “National Programme for Sustainability I”; and by the project 16-02316Y of the Czech Science Foundation (GA CR).
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Řezanka, M. (2018). Synthesis of Cyclodextrin Derivatives. In: Fourmentin, S., Crini, G., Lichtfouse, E. (eds) Cyclodextrin Fundamentals, Reactivity and Analysis. Environmental Chemistry for a Sustainable World, vol 16. Springer, Cham. https://doi.org/10.1007/978-3-319-76159-6_2
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