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Hepatobiliary System

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Nuclear Medicine Companion

Abstract

Hepatobiliary scintigraphy is used to assess hepatobiliary function, patency of cystic duct, intrahepatic and extrahepatic bile ducts, and gallbladder function.

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References

  1. Tulchinsky M, Ciak BW, Delbeke D, Hilson A, Holes-Lewis KA et al (2010) Society of Nuclear Medicine. SNM practice guideline for hepatobiliary scintigraphy 4.0. J Nucl Med Technol 38:210–218

    Article  PubMed  Google Scholar 

  2. Ziessman HA, Tulchinsky M, Lavely WC, Gaughan JP, Allen TW et al (2010) Sincalide-stimulated cholescintigraphy: a multicenter investigation to determine optimal infusion methodology and gallbladder ejection fraction normal values. J Nucl Med 51:277–281

    Article  PubMed  Google Scholar 

  3. Poddar U, Bhattacharya A, Thapa BR, Mittal BR, Singh K (2004) Ursodeoxycholic acid-augmented hepatobiliary scintigraphy in the evaluation of neonatal jaundice. J Nucl Med 45:1488–1492

    PubMed  CAS  Google Scholar 

  4. Harvey E, Loberg M, Ryan J, Sikorski S, Faith W et al (1979) Hepatic clearance mechanism of Tc-99m-HIDA and its effect on quantitation of hepatobiliary function: concise communication. J Nucl Med 20:310–313

    PubMed  CAS  Google Scholar 

  5. Society of Nuclear Medicine Procedure Guideline for Hepatic and Splenic Imaging 3.0 version 3.0, approved July 20, 2003

    Google Scholar 

  6. Boulahdour H, Cherqui D, Charlotte F, Rahmouni A, Dhumeaux D et al (1993) The hot spot hepatobiliary scan in focal nodular hyperplasia. J Nucl Med 34:2105

    PubMed  CAS  Google Scholar 

  7. Lubbers PR, Ros PR, Goodman ZD, Ishak KG (1987) Accumulation of technetium-99m sulfur colloid by hepatocellular adenoma: scintigraphic-pathologic correlation. AJR Am J Roentgenol 148:1105–1108

    Article  CAS  PubMed  Google Scholar 

  8. Groshar D, Slobodin G, Zuckerman E (2002) Quantitation of liver and spleen uptake of (99m)Tc-phytate colloid using SPECT: detection of liver cirrhosis. J Nucl Med 43:312–317

    PubMed  CAS  Google Scholar 

  9. Matesan MM, Bowen SR, Chapman TR, Miyaoka RS, Velez JW et al (2017) Assessment of functional liver reserve: old and new in 99mTc-sulfur colloid scintigraphy. Nucl Med Commun 38:577–586

    Article  PubMed  Google Scholar 

  10. Bowen SR, Chapman TR, Borgman J, Miyaoka RS, Kinahan PE et al (2016) Measuring total liver function on sulfur colloid SPECT/CT for improved risk stratification and outcome prediction of hepatocellular carcinoma patients. EJNMMI Res 6:57

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Roy SG, Karunanithi S, Agarwal KK, Bal C, Kumar R (2015) Importance of SPECT/CT in detecting multiple hemangiomas on 99mTc-labeled RBC blood pool scintigraphy. Clin Nucl Med 40:345–346

    Article  PubMed  Google Scholar 

  12. Krause T, Hauenstein K, Studier-Fischer B, Schuemichen C, Moser E (1993) Improved evaluation of technetium-99m-red blood cell SPECT in hemangioma of the liver. J Nucl Med 34:375–380

    PubMed  CAS  Google Scholar 

  13. Ziessman HA, Silverman PM, Patterson J, Harkness B, Fahey FH et al (1991) Improved detection of small cavernous hemangiomas of the liver with high-resolution three-headed SPECT. J Nucl Med 32:2086–2091

    PubMed  CAS  Google Scholar 

  14. Society of Nuclear Medicine Procedure Guideline for Hepatic and Splenic Imaging 3.0 version 3.0, approved 2003

    Google Scholar 

  15. Pare P, Shaffer EA, Rosenthall L (1978) Nonvisualization of the gallbladder by 99mTc-HIDA cholescintigraphy as evidence of cholecystitis. Can Med Assoc J 118:384–386

    PubMed  PubMed Central  CAS  Google Scholar 

  16. Kim CK, Tse KK, Juweid M, Mozley PD, Woda A et al (1993) Cholescintigraphy in the diagnosis of acute cholecystitis: morphine augmentation is superior to delayed imaging. J Nucl Med 34:1866–1870

    PubMed  CAS  Google Scholar 

  17. Meekin GK, Ziessman HA, Klappenbach RS (1987) Prognostic value and pathophysiologic significance of the rim sign in cholescintigraphy. J Nucl Med 28:1679–1682

    PubMed  CAS  Google Scholar 

  18. Tulchinsky M (2013) SPECT/CT unequivocally depicts dilated cystic duct sign on hepatobiliary scintigraphy in acute cholecystitis. Clin Nucl Med 38:149–152

    Article  PubMed  Google Scholar 

  19. Pounds TR, Hattner RS (1994) Normal cholescintigram in In-111 WBC positive acute acalculous cholecystitis. The converse photopenic 'rim' sign. Clin Nucl Med 19:483–485

    Article  CAS  PubMed  Google Scholar 

  20. Raymond F, Lepanto L, Rosenthall L (1988) Fried GM (1988) Tc-99m-IDA gallbladder kinetics and response to CCK in chronic cholecystitis. Eur J Nucl Med 14:378–381

    PubMed  CAS  Google Scholar 

  21. Ziessman HA (2014) Hepatobiliary scintigraphy in 2014. J Nucl Med 55:967–975

    Article  CAS  PubMed  Google Scholar 

  22. Gracie WA, Ransohoff DF (1982) The natural history of silent gallstones: the innocent gallstone is not a myth. N Engl J Med 307:798–800

    Article  CAS  PubMed  Google Scholar 

  23. Topper TE, Ryerson TW, Nora PF (1980) Quantitative gallbladder imaging following cholecystokinin. J Nucl Med 21:694–696

    PubMed  CAS  Google Scholar 

  24. Chamarthy M, Freeman LM (2010) Hepatobiliary scan findings in chronic cholecystitis. Clin Nucl Med 35:244–251

    Article  PubMed  Google Scholar 

  25. Kim CK, Palestro CJ, Solomon RW, Molinari DS, Lee SO et al (1990) Delayed biliary-to-bowel transit in cholescintigraphy after cholecystokinin treatment. Radiology 176:553–556

    Article  CAS  PubMed  Google Scholar 

  26. Weissmann HS, Badia J, Sugarman LA, Sugarman LA, Badia J et al (1981) Spectrum of 99mTc-IDA cholescintigraphic patterns in acute cholecystitis. Radiology 138:167–175

    Article  CAS  PubMed  Google Scholar 

  27. Williams W, Krishnamurthy GT, Brar HSS, Bobba VR (1984) Scintigraphic variations of normal biliary physiology. J Nucl Med 25:160–165

    PubMed  CAS  Google Scholar 

  28. Steinberg WM (1988) Sphincter of Oddi dysfunction: a clinical controversy. Gastroenterology 95:1409–1415

    Article  CAS  PubMed  Google Scholar 

  29. Bar-Meir S, Halpern Z, Bardan E, Gilat T (1984) Frequency of papillary dysfunction among cholecystectomized patients. Hepatology 4:328–330

    Article  CAS  PubMed  Google Scholar 

  30. Sostre S, Kalloo AN, Spiegler EJ, Camargo EE, Wagner HN Jr (1992) A noninvasive test of sphincter of Oddi dysfunction in postcholecystectomy patients: the scintigraphic score. J Nucl Med 33:1216–1222

    PubMed  CAS  Google Scholar 

  31. McEvoy CF, Suchy FJ (1996) Biliary tract disease in children. Pediatr Clin N Am 43:75–98

    Article  CAS  Google Scholar 

  32. Kasai M, Suzuki H, Ohashi E, Ohi R, Chiba T et al (1978) Technique and results of operative management of biliary atresia. World J Surg 2:571–579

    Article  CAS  PubMed  Google Scholar 

  33. Sevilla A, Howman-Giles R, Saleh H, Trpezanovski J, Concannon R et al (2007) Hepatobiliary scintigraphy with SPECT in infancy. Clin Nucl Med 32:16–23

    Article  PubMed  Google Scholar 

  34. Kianifar HR, Tehranian S, Shojaei P, Adinehpoor Z, Sadeghi R et al (2013) Accuracy of hepatobiliary scintigraphy for differentiation of neonatal hepatitis from biliary atresia: systematic review and meta-analysis of the literature. Pediatr Radiol 43:905–919

    Article  PubMed  Google Scholar 

  35. Majd M, Reba RC, Altman RP (1981) Effect of phenobarbital on 99mTc-IDA scintigraphy in the evaluation of neonatal jaundice. Semin Nucl Med 11:194–204

    Article  CAS  PubMed  Google Scholar 

  36. Ramachandran A, Gupta SM, Johns WD (2001) Various presentations of postcholecystectomy bile leak diagnosed by scintigraphy. Clin Nucl Med 26:495–498

    Article  CAS  PubMed  Google Scholar 

  37. Tan KG, Bartholomeusz FD, Chatterton BE (2004) Detection and follow up of biliary leak on Tc-99m DIDA SPECT-CT scans. Clin Nucl Med 29:642–643

    Article  PubMed  Google Scholar 

  38. Bonanno N, Baldari S, Cerrito A, Zimbaro G, Restifo G et al (1991) Diagnosis of hepatic hemangiomas with 99mTc-labeled red blood cell scanning: value of SPECT. J Nucl Biol Med 35:135–140

    PubMed  CAS  Google Scholar 

  39. Birnbaum BA, Weinreb JC, Megibow AJ, Sanger JJ, Lubat E et al (1990) Definitive diagnosis of hepatic hemangiomas: MR imaging versus Tc-99m-labeled red blood cell SPECT. Radiology 176:95–101

    Article  CAS  PubMed  Google Scholar 

  40. Schillaci O, Danieli R, Manni C, Capoccetti F, Simonetti G (2004) Technetium-99m-labelled red blood cell imaging in the diagnosis of hepatic haemangiomas: the role of SPECT/CT with a hybrid camera. Eur J Nucl Med Mol Imaging 31:1011–1015

    Article  PubMed  Google Scholar 

  41. Ginsberg F, Slavin JD Jr, Spencer RP (1986) Hepatic angiosarcoma: mimicking of angioma on three-phase technetium-99m red blood cell scintigraphy. J Nucl Med 27:1861–1863

    PubMed  CAS  Google Scholar 

  42. Larcos G, Farlow DC, Grunewald SM, Antico VF (1989) Atypical appearance of a hepatic hemangioma with technetium-99m-red blood cell scintigraphy. J Nucl Med 30:1885–1888

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Nuclear Medicine, Kuwait University, Safat, Kuwait

    Abdelhamid H. Elgazzar & Ismet Sarikaya

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  1. Abdelhamid H. Elgazzar
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  2. Ismet Sarikaya
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Elgazzar, A.H., Sarikaya, I. (2018). Hepatobiliary System. In: Nuclear Medicine Companion. Springer, Cham. https://doi.org/10.1007/978-3-319-76156-5_7

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  • DOI: https://doi.org/10.1007/978-3-319-76156-5_7

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