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Fractional Photothermolysis

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Lasers in Dermatology and Medicine

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Abbreviations

FP:

Fractional photothermolysis

FR:

Fractional resurfacing

MEND:

Microscopic epidermal-necrotic-debris

MTZ:

Microthermal treatment zone

OPD:

Optical penetration depth

References

  1. Hruza GJ, Dover JS. Laser skin resurfacing. Arch Dermatol. 1996;132(4):451–5.

    CAS  PubMed  Google Scholar 

  2. Waldorf HA, Kauvar AN, Geronemus RG. Skin resurfacing of fine to deep rhytides using a char-free carbon dioxide laser in 47 patients. Dermatol Surg. 1995;21(11):940–6.

    CAS  PubMed  Google Scholar 

  3. Williams EF III, Dahiya R. Review of nonablative laser resurfacing modalities. Facial Plast Surg Clin North Am. 2004;12(3):305–10. v.

    PubMed  Google Scholar 

  4. Bernstein LJ, Kauvar AN, Grossman MC, Geronemus RG. The short- and long-term side effects of carbon dioxide laser resurfacing. Dermatol Surg. 1997;23(7):519–25.

    CAS  PubMed  Google Scholar 

  5. Helm TN, Shatkin S Jr. Alabaster skin after CO laser resurfacing: evidence for suppressed melanogenesis rather than just melanocyte destruction. Cutis. 2006;77(1):15–7.

    PubMed  Google Scholar 

  6. Laws RA, Finley EM, McCollough ML, Grabski WJ. Alabaster skin after carbon dioxide laser resurfacing with histologic correlation. Dermatol Surg. 1998;24(6):633–6.

    CAS  PubMed  Google Scholar 

  7. Hohenleutner S, Koellner K, Lorenz S, Landthaler M, Hohenleutner U. Results of nonablative wrinkle reduction with a 1,450-nm diode laser: difficulties in the assessment of “subtle changes”. Lasers Surg Med. 2005;37(1):14–8.

    PubMed  Google Scholar 

  8. Manstein D, Herron GS, Sink RK, Tanner H, Anderson RR. Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers Surg Med. 2004;34(5):426–38.

    PubMed  Google Scholar 

  9. Laubach HJ, Manstein D. Fractional photothermolysis. Hautarzt. 2007;58(3):216–8. 220–223.

    PubMed  Google Scholar 

  10. Anderson RR, Parrish JA. Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. Science. 1983;220(4596):524–7.

    CAS  PubMed  Google Scholar 

  11. Xia Jiang HG, Zhou C, Chai X, Deng H. The role of transforming growth factor β1 in fractional laser resurfacing with a carbon dioxide laser. Lasers Med Sci. 2014;29:681–7.

    PubMed  Google Scholar 

  12. Wind BS, Meesters AA, Kroon MW, Beek JF, van der Veen JP, van der Wal AC, Bos JD, Wolkerstorfer A. Formation of fibrosis after nonablative and ablative fractional laser therapy. Dermatol Surg. 2012;38(3):437–42.

    CAS  PubMed  Google Scholar 

  13. Grossman AR, Majidian AM, Grossman PH. Thermal injuries as aresult of CO2 laser resurfacing. Plast Reconstr Surg. 1998;102(4):1247–52.

    CAS  PubMed  Google Scholar 

  14. Hantash BM, Bedi VP, Chan KF, Zachary CB. Ex vivo histological characterization of a novel ablative fractional resurfacing device. Lasers Surg Med. 2007;39(2):87–95.

    PubMed  Google Scholar 

  15. Alexiades-Armenakas MR, Dover JS, Arndt KA. Fractional laser skin resurfacing. J Drugs Dermatol. 2012;11(11):1274–87.

    PubMed  Google Scholar 

  16. Walsh JT Jr, Deutsch TF. Pulsed CO2 laser tissue ablation: measurement of the ablation rate. Lasers Surg Med. 1988;8(3):264–75.

    PubMed  Google Scholar 

  17. Hale GM, Querry MR. Optical constants of water in the 200-nm to 200-microm wavelength region. Appl Opt. 1973;12(3):555–63.

    CAS  PubMed  Google Scholar 

  18. Warner DW, Morgan NE, Eby TA, Myers MC, Taylor DA. Water measurement in biological tissue. In: Romig AD, Chambers WF, editors. Microbeam analysis. 21st ed. San Francisco: San Francisco Press; 1987. p. 238–40.

    Google Scholar 

  19. Walsh JT Jr, Cummings JP. Effect of the dynamic optical properties of water on midinfrared laser ablation. Lasers Surg Med. 1994;15(3):295–305.

    PubMed  Google Scholar 

  20. Manstein D, Zurakowski D, Thongsima S, Laubach H, Chan HH. The effects of multiple passes on the epidermal thermal damage pattern in nonablative fractional resurfacing. Lasers Surg Med. 2009;41(2):149–53.

    PubMed  Google Scholar 

  21. Laubach H, Chan HH, Rius F, Anderson RR, Manstein D. Effects of skin temperature on lesion size in fractional photothermolysis. Lasers Surg Med. 2007;39(1):14–8.

    PubMed  Google Scholar 

  22. Kositratna G, Manstein D. Skin freezing during ablative fractional resurfacing: in-vitro effects on thermal lesion size. Lasers Surg Med. 2009;(Suppl 21).

    Google Scholar 

  23. Brightman L, Goldman MP, Taub AF. Sublative rejuvenation: experience with a new fractional radiofrequency system for skin rejuvenation and repair. J Drugs Dermatol. 2009;8(11 Suppl):s9–s13.

    PubMed  Google Scholar 

  24. Hantash BM, Ubeid AA, Chang H, Kafi R, Renton B. Bipolar fractional radiofrequency treatment induces neoelastogenesis and neocollagenesis. Lasers Surg Med. 2009;41(1):1–9.

    PubMed  Google Scholar 

  25. Laubach HJ, Makin IR, Barthe PG, Slayton MH, Manstein D. Intense focused ultrasound: evaluation of a new treatment modality for precise microcoagulation within the skin. Dermatol Surg. 2008;34(5):727–34.

    CAS  PubMed  Google Scholar 

  26. Gliklich RE, White WM, Slayton MH, Barthe PG, Makin IR. Clinical pilot study of intense ultrasound therapy to deep dermal facial skin and subcutaneous tissues. Arch Facial Plast Surg. 2007;9(2):88–95.

    PubMed  Google Scholar 

  27. Bedi VP, Chan KF, Sink RK, et al. The effects of pulse energy variations on the dimensions of microscopic thermal treatment zones in nonablative fractional resurfacing. Lasers Surg Med. 2007;39(2):145–55.

    PubMed  Google Scholar 

  28. Thongsima S, Zurakowski D, Manstein D. Histological comparison of two different fractional photothermolysis devices operating at 1,550 nm. Lasers Surg Med. 2010;42(1):32–7.

    PubMed  Google Scholar 

  29. Laubach HJ, Tannous Z, Anderson RR, Manstein D. Skin responses to fractional photothermolysis. Lasers Surg Med. 2006;38(2):142–9.

    PubMed  Google Scholar 

  30. Hantash BM, Bedi VP, Sudireddy V, Struck SK, Herron GS, Chan KF. Laser-induced transepidermal elimination of dermal content by fractional photothermolysis. J Biomed Opt. 2006;11(4):041115.

    PubMed  Google Scholar 

  31. Alster TS, Tanzi EL, Lazarus M. The use of fractional laser photo-thermolysis for the treatment of atrophic scars. Dermatol Surg. 2007;33(3):295–9.

    CAS  PubMed  Google Scholar 

  32. Kono T, Chan HH, Groff WF, et al. Prospective direct comparison study of fractional resurfacing using different fluences and densities for skin rejuvenation in Asians. Lasers Surg Med. 2007;39(4):311–4.

    PubMed  Google Scholar 

  33. Fisher GH, Kim KH, Bernstein LJ, Geronemus RG. Concurrent use of a handheld forced cold air device minimizes patient discomfort during fractional photothermolysis. Dermatol Surg. 2005;31(9 Pt 2):1242–3. discussion 1244

    CAS  PubMed  Google Scholar 

  34. Chan HH, Manstein D, Yu CS, Shek S, Kono T, Wei WI. The prevalence and risk factors of post-inflammatory hyperpigmentation after fractional resurfacing in Asians. Lasers Surg Med. 2007;39(5):381–5.

    PubMed  Google Scholar 

  35. Lin JY, Chan HH. Pigmentary disorders in Asian skin: treatment with laser and intense pulsed light sources. Skin Therapy Lett. 2006;11(8):8–11.

    CAS  PubMed  Google Scholar 

  36. Bak H, Kim BJ, Lee WJ, et al. Treatment of striae distensae with fractional photothermolysis. Dermatol Surg. 2009;35(8):1215–20.

    CAS  PubMed  Google Scholar 

  37. Tierney EP, Kouba DJ, Hanke CW. Review of fractional photothermolysis: treatment indications and efficacy. Dermatol Surg. 2009;35(10):1445–61.

    CAS  PubMed  Google Scholar 

  38. Cohen SR, Henssler C, Johnston J. Fractional photothermolysis for skin rejuvenation. Plast Reconstr Surg. 2009;124(1):281–90.

    CAS  PubMed  Google Scholar 

  39. Haedersdal M, Moreau KE, Beyer DM, Nymann P, Alsbjorn B. Fractional nonablative 1540 nm laser resurfacing for thermal burn scars: a randomized controlled trial. Lasers Surg Med. 2009;41(3):189–95.

    PubMed  Google Scholar 

  40. Laubach HJ, Anderson RR, Luger T, Manstein D. Fractional photo-thermolysis for involuted infantile hemangioma. Arch Dermatol. 2009;145(7):748–50.

    PubMed  Google Scholar 

  41. Friedmann DP, Tzu JE, Kauvar AN, Goldman MP. Treatment of facial photodamage and rhytides using a novel 1,565 nm non-ablative fractional erbium-doped fiber laser. Lasers Surg Med. 2016;48:174–80.

    PubMed  Google Scholar 

  42. Hwang YJ, Lee YN, Lee YW, Choe YB, Ahn KJ. Treatment of acne scars and wrinkles in asian patients using carbon-dioxide fractionl laser resurfacing: its effects on skin biophysical profiles. Ann Dermatol. 2013;25(4):445–53.

    PubMed  PubMed Central  Google Scholar 

  43. Karsai S, Raulin C. Fractional photothermolysis: a new option for treating melasma? Hautarzt. 2008;59(2):92–100.

    CAS  PubMed  Google Scholar 

  44. Izikson L, Anderson RR. Resolution of blue minocycline pigmentation of the face after fractional photothermolysis. Lasers Surg Med. 2008;40(6):399–401.

    PubMed  Google Scholar 

  45. Karsai S, Hammes S, Rutten A, Raulin C. Fractional photothermolysis for the treatment of granuloma annulare: a case report. Lasers Surg Med. 2008;40(5):319–22.

    PubMed  Google Scholar 

  46. Katz TM, Goldberg LH, Friedman PM. Nonablative fractional photothermolysis for the treatment of striae rubra. Dermatol Surg. 2009;35(9):1430–3.

    CAS  PubMed  Google Scholar 

  47. Kouba DJ, Fincher EF, Moy RL. Nevus of Ota successfully treated by fractional photothermolysis using a fractionated 1440-nm Nd:YAG laser. Arch Dermatol. 2008;144(2):156–8.

    PubMed  Google Scholar 

  48. Yoo KH, Kim MN, Kim BJ, Kim CW. Treatment of alopecia areata with fractional photothermolysis laser. Int J Dermatol. 2010;49(7):845–7.

    PubMed  Google Scholar 

  49. Behroozan DS, Goldberg LH, Glaich AS, Dai T, Friedman PM. Fractional photothermolysis for treatment of poikiloderma of civatte. Dermatol Surg. 2006;32(2):298–301.

    CAS  PubMed  Google Scholar 

  50. Khatri KA, Ross V, Grevelink JM, Magro CM, Anderson RR. Comparison of erbium:YAG and carbon dioxide lasers in resurfacing of facial rhytides. Arch Dermatol. 1999;135(4):391–7.

    CAS  PubMed  Google Scholar 

  51. Walsh JT Jr, Flotte TJ, Anderson RR, Deutsch TF. Pulsed CO laser tissue ablation: effect of tissue type and pulse duration on thermal damage. Lasers Surg Med. 1988;8(2):108–18.

    PubMed  Google Scholar 

  52. Fitzpatrick RE, Ruiz-Esparza J, Goldman MP. The depth of thermal necrosis using the CO laser: a comparison of the superpulsed mode and conventional mode. J Dermatol Surg Oncol. 1991;17(4):340–4.

    CAS  PubMed  Google Scholar 

  53. Fitzpatrick RE, Goldman MP, Satur NM, Tope WD. Pulsed carbon dioxide laser resurfacing of photo-aged facial skin. Arch Dermatol. 1996;132(4):395–402.

    CAS  PubMed  Google Scholar 

  54. Wanner M, Farinelli W, Manstein D. Ablative fractional resurfacing evaluation of different exposure parameters in a pig model. Lasers Surg Med. 2008;20(Suppl):28.

    Google Scholar 

  55. Hantash BM, Bedi VP, Kapadia B, et al. In vivo histological evaluation of a novel ablative fractional resurfacing device. Lasers Surg Med. 2007;39(2):96–107.

    PubMed  Google Scholar 

  56. Hunzeker CM, Weiss ET, Geronemus RG. Fractionated CO2 laser resurfacing: our experience with more than 2000 treatments. Aesthet Surg J. 2009;29(4):317–22.

    PubMed  Google Scholar 

  57. Chapas AM, Brightman L, Sukal S, et al. Successful treatment of acneiform scarring with CO2 ablative fractional resurfacing. Lasers Surg Med. 2008;40(6):381–6.

    PubMed  Google Scholar 

  58. Waibel J, Beer K. Ablative fractional laser resurfacing for the treatment of a third-degree burn. J Drugs Dermatol. 2009;8(3):294–7.

    PubMed  Google Scholar 

  59. Rahman Z, MacFalls H, Jiang K, et al. Fractional deep dermal ablation induces tissue tightening. Lasers Surg Med. 2009;41(2):78–86.

    PubMed  Google Scholar 

  60. Dierickx CC, Khatri KA, Tannous ZS, et al. Micro-fractional ablative skin resurfacing with two novel erbium laser systems. Lasers Surg Med. 2008;40(2):113–23.

    PubMed  Google Scholar 

  61. Avram MM, Tope WD, Yu T, Szachowicz E, Nelson JS. Hypertrophic scarring of the neck following ablative fractional carbon dioxide laser resurfacing. Lasers Surg Med. 2009;41(3):185–8.

    PubMed  PubMed Central  Google Scholar 

  62. Haedersdal M, Sakamoto FH, Farinelli WA, Doukas AG, Tam J, Anderson RR. Fractional CO(2) laser-assisted drug delivery. Lasers Surg Med. 2010;42(2):113–22.

    PubMed  Google Scholar 

  63. Erlendsson AM, Anderson RR, Manstein D, Waibel JS. Developing technology: ablative fractional lasers enhance topical drug delivery. Dermatol Surg. 2014;(Suppl 12):S142–6.

    Google Scholar 

  64. James Leyden TJS, Herndon JH Jr. Multicenter clinical trial of a home-use nonablative fractional laser device for wrinkle reduction. J Am Acad Dermatol. 2012;67(5):975–84.

    PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Dieter Manstein

  2. Dermatologische Abteilung Universitäre Krankenhäuser von Gen, Genf, Schweiz, Switzerland

    Hans-Joachim Laubac

  3. Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA

    Sofia Iglesia, Alaleh Dormishian, Ali Rajabi-Estarabadi & Keyvan Nouri

Authors
  1. Dieter Manstein
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  2. Hans-Joachim Laubac
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  3. Sofia Iglesia
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  4. Alaleh Dormishian
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  5. Ali Rajabi-Estarabadi
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  6. Keyvan Nouri
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Corresponding author

Correspondence to Dieter Manstein .

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Editors and Affiliations

  1. Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA

    Keyvan Nouri

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Manstein, D., Laubac, HJ., Iglesia, S., Dormishian, A., Rajabi-Estarabadi, A., Nouri, K. (2018). Fractional Photothermolysis. In: Nouri, K. (eds) Lasers in Dermatology and Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-76118-3_10

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  • DOI: https://doi.org/10.1007/978-3-319-76118-3_10

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