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Larynx: Anatomy, Nonneoplastic, Benign, and Malignant

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Textbook of Head and Neck Pathology

Abstract

This chapter discusses laryngeal anatomy and the range of benign and malignant laryngeal tumors. The most common squamous carcinoma variants in the larynx are covered: spindle cell variant, papillary variant and verrucous carcinoma. The changes in AJCC staging are discussed, as well as the two tiered system of laryngeal precursor lesions. The most common non-squamous laryngeal carcinoma is neuroendocrine carcinoma. The most common true sarcoma is chondrosarcoma, which is usually low-grade.

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References

  1. Reidenbach MM. Aryepiglottic fold: normal topography and clinical implications. Clin Anat. 1998;11:223–35.

    Article  PubMed  CAS  Google Scholar 

  2. Bastian RW, Thomas JP. Do talkativeness and vocal loudness correlate with laryngeal pathology? A study of the vocal overdoer/underdoer continuum. J Voice. 2016;30:557–62.

    Article  PubMed  Google Scholar 

  3. Mattei A, Revis J, Giovanni A. Personality traits inventory in patients with vocal nodules. Eur Arch Otorhinolaryngol. 2017;274:1911–7.

    Article  PubMed  Google Scholar 

  4. Dikkers FG, Nikkels PG. Benign lesions of the vocal folds: histopathology and phonotrauma. Ann Otol Rhinol Laryngol. 1995;104:698–703.

    Article  PubMed  CAS  Google Scholar 

  5. Cipriani NA, Martin DE, Corey JP, Portugal L, Caballero N, Lester R, Anthony B, Taxy JB. The clinicopathologic spectrum of benign mass lesions of the vocal fold due to vocal abuse. Int J Surg Pathol. 2011;19:583–7.

    Article  PubMed  Google Scholar 

  6. Miko TL. Peptic (contact ulcer) granuloma of the larynx. J Clin Pathol. 1989;42:800–4.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Prowse S, Knight L. Congenital cysts of the infant larynx. Int J Pediatr Otorhinolaryngol. 2012;76:708–11.

    Article  PubMed  Google Scholar 

  8. Bando H, Uchida M, Matsumoto S, Ushijima C, Dejima K. Endolaryngeal extension of thyroglossal duct cyst. Auris Nasus Larynx. 2012;39:220–3.

    Article  PubMed  Google Scholar 

  9. Touati MM, Ammar H. Intralaryngeal thyroglossal duct cyst. Pan Afr Med J. 2015 Nov;24(22):294. https://doi.org/10.11604/pamj.2015.22.294.8264.

    Article  Google Scholar 

  10. Aubry K, Kapella M, Ketterer S, Massri K, Bessede JP. A case of laryngeal ductal cyst: antenatal diagnosis and peripartum management. Int J Pediatr Otorhinolaryngol. 2007;71:1639–42.

    Article  PubMed  Google Scholar 

  11. Chang CC, Lee LA, Hsia SH, Hsueh C, Wang CJ. Huge epiglottic cyst: a rare cause of airway obstruction in an adolescent. Paediatr Int Child Health. 2016;36:305–7.

    Article  PubMed  Google Scholar 

  12. Kaur A, Kini U, Alva SK. Cysts of the larynx : a clinicopathologic study of nine cases. Indian J Otolaryngol Head Neck Surg. 1998;50:250–6.

    PubMed  PubMed Central  CAS  Google Scholar 

  13. Saha D, Sinha R, Pai RR, Kumar A, Chakraborti S. Laryngeal cysts in infants and children--a pathologist's perspective (with review of literature). Int J Pediatr Otorhinolaryngol. 2013;77:1112–7.

    Article  PubMed  Google Scholar 

  14. Kim JK, Park KK. Foregut duplication cyst of the hypopharynx: a rare cause of upper airway obstruction. J Pediatr Surg. 2007;42:E5–7.

    Article  PubMed  Google Scholar 

  15. Forte V, Warshawski J, Thorner P, Conley S. Unusual laryngeal cysts in the newborn. Int J Pediatr Otorhinolaryngol. 1996;37:261–7.

    Article  PubMed  CAS  Google Scholar 

  16. Nussenbaum B, McClay JE, Timmons CF. Laryngeal duplication cyst. Arch Otolaryngol Head Neck Surg. 2002;128:1317–20.

    Article  PubMed  Google Scholar 

  17. Brandwein M, Huvos A. Laryngeal oncocytic cystadenomas. Eight cases and a literature review. Arch Otolaryngol Head Neck Surg. 1995;121:1302–5.

    Article  PubMed  CAS  Google Scholar 

  18. Feinstein AJ, Peng KA, Bhuta SM, Abemayor E, Mendelsohn AH. Laryngeal oncocytic cystadenomas masquerading as laryngoceles. Am J Otolaryngol. 2016;37:17–21.

    Article  PubMed  Google Scholar 

  19. Stenner M, Müller KM, Koopmann M, Rudack C. Squamous cell carcinoma of the larynx arising in multifocal pharyngolaryngeal oncocytic papillary cystadenoma: a case report and review of the literature. Medicine (Baltimore). 2014;93(12):e70. https://doi.org/10.1097/MD.0000000000000070.

    Article  Google Scholar 

  20. Stachler RJ, Dworkin-Valenti JP. Allergic laryngitis: unraveling the myths. Curr Opin Otolaryngol Head Neck Surg. 2017;25:242–6.

    Article  PubMed  Google Scholar 

  21. Platt MP, Brook CD, Kuperstock J, Krouse JH. What role does allergy play in chronic ear disease and laryngitis? Curr Allergy Asthma Rep. 2016;16:76.

    Article  PubMed  CAS  Google Scholar 

  22. Krouse JH. Allergy and laryngeal disorders. Curr Opin Otolaryngol Head Neck Surg. 2016;24:221–5.

    Article  PubMed  Google Scholar 

  23. Brook CD, Platt MP, Reese S, Noordzij JP. Utility of allergy testing in patients with chronic laryngopharyngeal symptoms: is it allergic laryngitis? Otolaryngol Head Neck Surg. 2016;154:41–5.

    Article  PubMed  Google Scholar 

  24. Randhawa PS, Nouraei S, Mansuri S, Rubin JS. Allergic laryngitis as a cause of dysphonia: a preliminary report. Logoped Phoniatr Vocol. 2010;35:169–74.

    Article  PubMed  Google Scholar 

  25. Jawale PM, Gulwani HV. Histoplasmosis presenting as laryngeal ulcer in a post-renal transplant male: an unusual case from India. J Mycol Med. 2017;27(4):573–6. doi.org/101016/jmycmed201706003

    Article  PubMed  CAS  Google Scholar 

  26. Bergeron M, Gagné AA, Côté M, Chênevert J, Dubé R, Pelletier R. Primary Larynx Cryptococcus neoformans Infection: a Distinctive Clinical Entity. Open Forum Infect Dis. 2015;2(4):ofv160. https://doi.org/10.1093/ofid/ofv160.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Jeng JY, Tomblinson CM, Ocal IT, Vikram HR, Lott DG. Laryngeal cryptococcosis: Literature review and guidelines for laser ablation of fungal lesions. Laryngoscope. 2016;126:1625–9.

    Article  PubMed  Google Scholar 

  28. Tao T, Zhang YH, Xue SL, Wu DP, Chen F. Fulminant Laryngeal-tracheobronchial-pulmonary Aspergillosis: a Rare and Fatal Complication in Allogeneic Hematopoietic Stem Cell Transplantation Recipients. Intern Med. 2017;56:347–51.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Saha A, Saha K, Chatterjee U. Primary aspergillosis of vocal cord: long-term inhalational steroid use can be the miscreant. Biom J. 2015;38:550–3.

    Google Scholar 

  30. Ohashi T, Mizuta K, Kuze B, Aoki M, Ito Y. Invasive epiglottic aspergillosis: a case report and literature review. Auris Nasus Larynx. 2015;42:501–4.

    Article  PubMed  Google Scholar 

  31. Schwartz JR, Nagle MG, Elkins RC, Mohr JA. Mucormycosis of the trachea: an unusual cause of acute upper airway obstruction. Chest. 1982;81:653–4.

    Article  PubMed  CAS  Google Scholar 

  32. Malinvaud D, Mukundan S, Crevier-Buchman L, Bonfils P, Laccourreye O. Glottic bamboo nodules from systemic lupus erythematosus. Ann Otol Rhinol Laryngol. 2013;122:496–9.

    Article  PubMed  Google Scholar 

  33. Murano E, Hosako-Naito Y, Tayama N, Oka T, Miyaji M, Kumada M, Niimi S. Bamboo node: primary vocal fold lesion as evidence of autoimmune disease. J Voice. 2001;15:441–50.

    Article  PubMed  CAS  Google Scholar 

  34. Woo P, Mendelsohn J, Humphrey D. Rheumatoid nodules of the larynx. Otolaryngol Head Neck Surg. 1995;113:147–50.

    Article  PubMed  CAS  Google Scholar 

  35. Iacovou E, Vlastarakos PV, Nikolopoulos TP. Laryngeal Involvement in Connective Tissue Disorders. Is it Important for Patient Management? Indian J Otolaryngol Head Neck Surg. 2014;66:22–9.

    Article  PubMed  Google Scholar 

  36. Yamashita H, Takahashi Y, Kano T, Mimori A. A case of systemic lupus erythematosus with bamboo joint-like corditis as an antecedent symptom. Rheumatology (Oxford). 2013;52:759–61.

    Article  Google Scholar 

  37. Lee JH, Sung IY, Park JH, Roh JL. Recurrent laryngeal neuropathy in a systemic lupus erythematosus (SLE) patient. Am J Phys Med Rehabil. 2008;87:68–70.

    Article  PubMed  Google Scholar 

  38. Wang CC, Chang MH, Jiang RS, Lai HC, De Virgilio A, Wang CP, Wu SH, Liu SA, Liang KL. Laryngeal electromyography-guided hyaluronic acid vocal fold injection for unilateral vocal fold paralysis: a prospective long-term follow-up outcome report. JAMA Otolaryngol Head Neck Surg. 2015;141:264–71.

    Article  PubMed  Google Scholar 

  39. Wen MH, Cheng PW, Liao LJ, Chou HW, Wang CT. Treatment outcomes of injection laryngoplasty using cross-linked porcine collagen and hyaluronic acid. Otolaryngol Head Neck Surg. 2013;149:900–6.

    Article  PubMed  Google Scholar 

  40. Lakhani R, Fishman JM, Bleach N, Costello D, Birchall M. Alternative injectable materials for vocal fold medialisation in unilateral vocal fold paralysis. Cochrane Database Syst Rev. 2012;10:CD009239. https://doi.org/10.1002/14651858.CD009239.pub2.

    Article  PubMed  Google Scholar 

  41. Cohen MS, Mehta DK, Maguire RC, Simons JP. Injection medialization laryngoplasty in children. Arch Otolaryngol Head Neck Surg. 2011;137:264–8.

    Article  PubMed  Google Scholar 

  42. Gillespie MB, Dozier TS, Day TA, Martin-Harris B, Nguyen SA. Effectiveness of calcium hydroxylapatite paste in vocal rehabilitation. Ann Otol Rhinol Laryngol. 2009;118:546–51.

    Article  PubMed  Google Scholar 

  43. Sulica L, Rosen CA, Postma GN, Simpson B, Amin M, Courey M, Merati A. Current practice in injection augmentation of the vocal folds: indications, treatment principles, techniques, and complications. Laryngoscope. 2010;120:319–25.

    Article  PubMed  Google Scholar 

  44. Rodríguez-Romero R, Vargas-Serrano B, Cortina-Moreno B, Fernández-Gallardo JM, Cervera-Rodilla JL. Calcified amyloidoma of the larynx. AJNR Am J Neuroradiol. 1996;17:1491–3.

    PubMed  PubMed Central  Google Scholar 

  45. Phillips NM, Matthews E, Altmann C, Agnew J, Burns H. Laryngeal amyloidosis: diagnosis, pathophysiology and management. J Laryngol Otol. 2017;131:S41–7.

    Article  PubMed  CAS  Google Scholar 

  46. Hazenberg AJ, Hazenberg BP, Dikkers FG. Long-term follow-up after surgery in localized laryngeal amyloidosis. Eur Arch Otorhinolaryngol. 2016;273:2613–20.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Wang Q, Chen H, Wang S. Laryngo-tracheobronchial amyloidosis: a case report and review of literature. Int J Clin Exp Pathol. 2014;7:7088–93.

    PubMed  PubMed Central  Google Scholar 

  48. Nakamine H, Yamakawa M, Yoshino T, Fukumoto T, Enomoto Y, Matsumura I. Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma: Current Understanding and Differential Diagnosis. J Clin Exp Hematop. 2016;56:109–18.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Duynstee ML, Verwoerd-Verhoef HL, Monnier P, Mooi WJ. Langerhans cell histiocytosis of the larynx. Int J Pediatr Otorhinolaryngol. 2000;56:65–9.

    Article  PubMed  CAS  Google Scholar 

  50. Lhoták J, Dvorăcková I. Histiocytosis X of the larynx. J Laryngol Otol. 1975;1975(89):771–7.

    Article  Google Scholar 

  51. Booth JB, Thomas RS. Histiocytosis X. J Laryngol Otol. 1970;84:1123–32.

    Article  PubMed  CAS  Google Scholar 

  52. Friedmann I, Ferlito A. Primary eosinophilic granuloma of the larynx. J Laryngol Otol. 1981;95:1249–54.

    Article  PubMed  CAS  Google Scholar 

  53. Kim KH, Kim RB, Woo SH. Individual participant data meta-analysis of primary laryngeal lymphoma: Focusing on the clinical characteristics and prognosis. Laryngoscope. 2015;125:2741–8.

    Article  PubMed  Google Scholar 

  54. Liu M, Liu B, Liu B, Cui X, Yang S, Wang Q, Dong L. Mucosa-associated lymphoid tissue lymphoma of the larynx: a case report and literature review. Medicine (Baltimore). 2015 May;94(17):e788. https://doi.org/10.1097/MD.0000000000000788.

    Article  Google Scholar 

  55. Rahman B, Bilal J, Sipra QU, Riaz IB. All that Wheezes Is Not Asthma: a Case of Diffuse Large B-Cell Lymphoma of the Larynx. Case Rep Oncol Med. 2017;2017:7072615. https://doi.org/10.1155/2017/7072615.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Brown NA, Elenitoba-Johnson KS. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: hematolymphoid Tumours. Head Neck Pathol. 2017;11:96–109.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Quimby AE, Caulley L, Rodin D, Purgina B, Eapen L, Shier L, Johnson-Obaseki S. Primary Burkitt lymphoma of the supraglottic larynx: a case report and review of the literature. J Med Case Rep. 2017 Mar 10;11(1):65. https://doi.org/10.1186/s13256-017-1209-3.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Derkay CS. Task force on recurrent respiratory papillomas. A preliminary report. Arch Otolaryngol Head Neck Surg. 1995;121:1386–91.

    Article  PubMed  CAS  Google Scholar 

  59. Silverberg MJ, Thorsen P, Lindeberg H, Grant LA, Shah KV. Condyloma in pregnancy is strongly predictive of juvenile onset recurrent respiratory papillomatosis. Obstet Gynecol. 2003;101:645–52.

    PubMed  Google Scholar 

  60. Silverberg MJ, Thorsen P, Lindeberg H, Ahdieh-Grant L, Shah KV. Clinical course of recurrent respiratory papillomatosis in Danish children. Arch Otolaryngol Head Neck Surg. 2004;130:711–6.

    Article  PubMed  Google Scholar 

  61. Rodier C, Lapointe A, Coutlée F, Mayrand MH, Dal Soglio D, Roger M, Trottier H. Juvenile respiratory papillomatosis: risk factors for severity. J Med Virol. 2013;85:1447–58.

    Article  PubMed  Google Scholar 

  62. Merckx M, Liesbeth WV, Arbyn M, Meys J, Weyers S, Temmerman M, Vanden Broeck D. Transmission of carcinogenic human papillomavirus types from mother to child: a meta-analysis of published studies. Eur J Cancer Prev. 2013;22:277–85.

    Article  PubMed  Google Scholar 

  63. Chatzistamatiou K, Sotiriadis A, Agorastos T. Effect of mode of delivery on vertical human papillomavirus transmission - A meta-analysis. J Obstet Gynaecol. 2016;36:10–4.

    Article  PubMed  CAS  Google Scholar 

  64. DeVoti J, Hatam L, Lucs A, Afzal A, Abramson A, Steinberg B, Bonagura V. Decreased Langerhans cell responses to IL-36γ: altered innate immunity in patients with recurrent respiratory papillomatosis. Mol Med. 2014;20:372–80.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  65. Wang J, Han DM, Ma LJ, Ye JY, Xiao Y, Yang QW. Risk factors of juvenile onset recurrent respiratory papillomatosis in the lower respiratory tract. Chin Med J. 2012;125:3496–9.

    PubMed  Google Scholar 

  66. Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E. Recurrent respiratory papillomatosis: a state-of-the-art review. Respir Med. 2017;126:116–21.

    Article  PubMed  Google Scholar 

  67. Lin HW, Richmon JD, Emerick KS, de Venecia RK, Zeitels SM, Faquin WC, Lin DT. Malignant transformation of a highly aggressive human papillomavirus type 11-associated recurrent respiratory papillomatosis. Am J Otolaryngol. 2010;31:291–6.

    Article  PubMed  CAS  Google Scholar 

  68. Snietura M, Chelmecka-Wiktorczyk L, Pakulo S, Kopec A, Piglowski W, Drabik G, Kosowski B, Wyrobek L, Stanek-Widera A, Balwierz W. Vertically transmitted HPV-dependent squamous cell carcinoma of the external auditory canal : case report of a child. Strahlenther Onkol. 2017;193:156–61.

    Article  PubMed  Google Scholar 

  69. Gelinas JF, Manoukan J, Cote A. Lung involvement in juvenile onset respiratory papillomatosis: a systematic review of the literature. Int J Pediatr Otorhinolaryngol. 2008;72:433–52.

    Article  PubMed  Google Scholar 

  70. Azadarmaki R, Lango MN. Malignant transformation of respiratory papillomatosis in a solid-organ transplant patient: case report and literature review. Ann Otol Rhinol Laryngol. 2013;122:457–60.

    Article  PubMed  Google Scholar 

  71. Huebbers CU, Preuss SF, Kolligs J, Vent J, Stenner M, Wieland U, Silling S, Drebber U, Speel EJ, Klussmann JP. Integration of HPV6 and downregulation of AKR1C3 expression mark malignant transformation in a patient with juvenile-onset laryngeal papillomatosis. PLoS One. 2013;8(2):e57207. https://doi.org/10.1371/journal.pone.0057207.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  72. Gerein V, Rastorguev E, Gerein J, Draf W, Schirren J. Incidence, age at onset, and potential reasons of malignant transformation in recurrent respiratory papillomatosis patients: 20 years’ experience. Otolaryngol Head Neck Surg. 2005;132:392–4.

    Article  PubMed  Google Scholar 

  73. Can NT, Tretiakova MS, Taxy JB. Natural history and malignant transformation in recurrent respiratory papillomatosis: Human Papillomavirus (HPV), dysplasia and an autopsy review. Fetal and Pediatric Pathol. 2015;34:80–90.

    Article  Google Scholar 

  74. Karatayli-Ozgursoy S, Bishop JA, Hillel A, Akst L, Best SR. Risk factors for dysplasia in recurrent respiratory papillomatosis in an adult and pediatric population. Ann Otol Rhinol Laryngol. 2016;125:235–41.

    Article  PubMed  Google Scholar 

  75. Best SR, Mohr M, Zur KB. Systemic bevacizumab for recurrent respiratory papillomatosis: a national survey. Laryngoscope. 2017;127:2225–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  76. Mohr M, Schliemann C, Biermann C, Schmidt LH, Kessler T, Schmidt J, Wiebe K, Müller KM, Hoffmann TK, Groll AH, Werner C, Kessler C, Wiewrodt R, Rudack C, Berdel WE. Rapid response to systemic bevacizumab therapy in recurrent respiratory papillomatosis. Oncol Lett. 2014;8:1912–8.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  77. Best SR, Friedman AD, Landau-Zemer T, Barbu AM, Burns JA, Freeman MW, Halvorsen YD, Hillman RE, Zeitels SM. Safety and dosing of bevacizumab (avastin) for the treatment of recurrent respiratory papillomatosis. Ann Otol Rhinol Laryngol. 2012;121:587–93.

    Article  PubMed  Google Scholar 

  78. Lazar RG, Younis RT, Kluka EA, Joyner RE, Storgion S. Granular cell tumor of the larynx. Report of two pediatric cases. Ear Nose Throat J. 1992;71:440–3.

    PubMed  CAS  Google Scholar 

  79. Montojo J, Echarri R, Santana A, Mico A, Gamboa J, Cobeta I. A multifocal granular cell tumor of the upper airways. Acra Otorrinolaringol Esp. 1999;50:498–501.

    CAS  Google Scholar 

  80. Sproat R, Wong G, Rubin J. Granular cell tumour of the larynx. Head Neck Pathol. 2016;10:538–40.

    Article  PubMed  PubMed Central  Google Scholar 

  81. Santos S, Gutiérrez González IJ, Colmenero I, Domínguez González de Rivera MJ. Granular cell tumor of laryngeal location: description of 2 pediatric cases. Acta Otorrinolaringol Esp. 2014;65:126–8.

    Article  Google Scholar 

  82. Scala WA, Fernandes AM, Duprat Ade C, Costa HO. Granular cell tumor of the larynx in children: a case report. Braz J Otorhinolaryngol. 2008;74:780–5.

    Article  PubMed  Google Scholar 

  83. Aksoy S, Abali H, Kilickap S, Harputluoglu H, Erman M. Metastatic granular cell tumor: a case report and review of the literature. Acta Oncol. 2006;45:91–4.

    Article  PubMed  Google Scholar 

  84. Chiang MJ, Fang TJ, Li HY, Chen IH, Lee KF. Malignant granular cell tumor in larynx mimicking laryngeal carcinoma. Am J Otolaryngol. 2004;25:270–3.

    Article  PubMed  Google Scholar 

  85. Brandwein M, Le Benger J, Strauchen J, Biller H. Atypical granular cell tumor of the larynx. Head Neck Surg. 1990;12:154–9.

    Article  CAS  Google Scholar 

  86. McGuire LS, Yakoub D, Möller MG, Rosenberg A, Livingstone A. Malignant granular cell tumor of the back: a case report and review of the literature. Case Rep Med. 2014;2014:794648. https://doi.org/10.1155/2014/794648.

    Article  PubMed  PubMed Central  Google Scholar 

  87. Meling TR, Fridrich K, Evensen JF, Nedregaard B. Malignant granular cell tumor of the skull base. Skull Base. 2008;18:59–66.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  88. Morita S, Hiramatsu M, Sugishita M, Gyawali B, Shibata T, Shimokata T, Urakawa H, Mitsuma A, Moritani S, Kubota T, Ichihara S, Ando Y. Pazopanib monotherapy in a patient with a malignant granular cell tumor originating from the right orbit: a case report. Oncol Lett Aug. 2015;10:972–4.

    Article  CAS  Google Scholar 

  89. Brandwein M, Levi G, Som P, Urken ML. Paraganglioma of the inferior laryngeal paraganglia. A case report. Arch Otolaryngol Head Neck Surg. 1992;118:994–6.

    Article  PubMed  CAS  Google Scholar 

  90. Zhou X, Jiang S, Li H. A case of laryngeal paraganglioma and literature review. Int J Clin Exp Med. 2015;8:16934–6.

    PubMed  PubMed Central  Google Scholar 

  91. Berta E, Camuzard O, Poissonnet G. A strange form of dysphonia… Laryngeal paraganglioma. Eur Ann Otorhinolaryngol Head Neck Dis. 2015;132:297–300.

    Article  PubMed  Google Scholar 

  92. Naik SM, Shenoy AM, Chavan P, Patil A, Gupta S. Laryngeal paraganglioma: a rare clinical entity managed by supraselective embolization and lateral pharygotomy. Indian J Otolaryngol Head Neck Surg. 2013;65:95–104.

    Article  PubMed  Google Scholar 

  93. Uçar Ş, Zorlu P, Yıldırım I, Metin Ö. Hamartoma of the larynx: an unusual cause of stridor. Balkan Med J. 2014;31:349–51.

    Article  PubMed  PubMed Central  Google Scholar 

  94. Webb S, Richmond S, Wright C, Adair S. Laryngeal hamartoma causing polyhydramnios and lethal pulmonary hypoplasia. Aust N Z J Obstet Gynaecol. 2010;50:297–8.

    Article  PubMed  CAS  Google Scholar 

  95. García Rica E, Maza Solano JM, Herrero Salado T, Sánchez Gómez S. Chondroid hamartoma of the larynx: an exceptional case. Acta Otorrinolaringol Esp. 2016;67:117–9.

    Article  PubMed  Google Scholar 

  96. Leoncini G, Maio V, Mirabile L, Baggi R, Franchi A. Glandular hamartoma of the larynx: report of a case. Auris Nasus Larynx. 2008;35:149–51.

    Article  PubMed  Google Scholar 

  97. Yigitbasi OG, Guler G, Ozturk F, Guney E. Glandular hamartoma of the larynx. Int J Pediatr Otorhinolaryngol. 2002;65:163–6.

    Article  PubMed  Google Scholar 

  98. Mäkitie AA, Lehtonen H, Bäck L, Aaltonen LM, Leivo I. Hamartoma of the larynx: an unusual cause of dyspnea. Ann Otol Rhinol Laryngol. 2003;112:841–3.

    Article  PubMed  Google Scholar 

  99. Işik Gönül I, Asal K, Ceylan A, Akyol G. Hamartoma of the larynx: an unusual cause of upper airway obstruction. Eur Arch Otorhinolaryngol. 2004;261:435–8.

    PubMed  Google Scholar 

  100. Rinaldo A, Mannarà GM, Fisher C, Ferlito A. Hamartoma of the larynx: a critical review of the literature. Ann Otol Rhinol Laryngol. 1998;107:264–7.

    Article  PubMed  CAS  Google Scholar 

  101. Cannon CR, Johns ME, Fechner RE. Immature teratoma of the larynx. Otolaryngol Head Neck Surg. 1987;96:366–8.

    Article  PubMed  CAS  Google Scholar 

  102. Carta F, Sionis S, Gerosa C, Puxeddu R. Endoscopic management of adult-type rhabdomyoma of the glottis: case report and review of the literature. Braz J Otorhinolaryngol. 2016;82:244–7.

    Article  PubMed  Google Scholar 

  103. Pinho MM, de Carvalho E, Castro J, Ramos RG. Adult rhabdomyoma of the larynx. Int Arch Otorhinolaryngol. 2013;17:415–8.

    Article  PubMed  PubMed Central  Google Scholar 

  104. Orlandi A, Fratoni S, Hermann I, Spagnoli LG. Symptomatic laryngeal nodular chondrometaplasia: a clinicopathological study. J Clin Pathol. 2003;56:976–7.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  105. Natt RS, Helliwell T, McCormick M. Tracheopathia chondro-osteoplastica—an unusual cause of stridor. J Laryngol Otol. 2009;123:1039–41.

    Article  PubMed  CAS  Google Scholar 

  106. Härmä RA, Suurkari S. Tracheopathia chondro-osteoplastica. A clinical study of thirty cases. Acta Otolaryngol. 1977;84:118–23.

    Article  PubMed  Google Scholar 

  107. Jones HA, Manjaly JG, Sandison A, Almeyda JS, Sandhu GS. Acute airway obstruction secondary to vocalfold heterotopic ossification. Head Neck Pathol. 2015;9:96–9.

    Article  PubMed  Google Scholar 

  108. Hellquist HB, Hellqvist H, Vejlens L, Lindholm CE. Epithelioid leiomyoma of the larynx. Histopathology. 1994;24:155–9.

    Article  PubMed  CAS  Google Scholar 

  109. Kleinsasser O, Glanz H. Myogenic tumours of the larynx. Arch Otorhinolaryngol. 1979;225:107–19.

    Article  PubMed  CAS  Google Scholar 

  110. Hirakawa K, Harada Y, Tatsukawa T, Nagasawa A, Fujii M. A case of vascular leiomyoma of the larynx. J Laryngol Otol. 1994;108:593–5.

    Article  PubMed  CAS  Google Scholar 

  111. McKiernan DC, Watters WR. Smooth muscle tumours of the larynx. J Laryngol Otol. 1995;109:77–9.

    PubMed  CAS  Google Scholar 

  112. Xu Y, Zhou S, Wang S. Vascular leiomyoma of the larynx: a rare entity. Three case reports and literature review. ORL J Otorhinolaryngol Relat Spec. 2008;70:264–47.

    Article  PubMed  Google Scholar 

  113. Jun F, Li L, Ning L, Yan L, Siquan T, Shixi L. Giant laryngeal angioleiomyomas: a case report with review of literature. Am J Otolaryngol. 2009;30:2192–20.

    Article  Google Scholar 

  114. Matsumoto T, Nishiya M, Ichikawa G, Fujii H. Leiomyoma with atypical cells (atypical leiomyoma) in the larynx. Histopathology. 1999;34:532–6.

    Article  PubMed  CAS  Google Scholar 

  115. Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin. 2017;67:7–30.

    Article  PubMed  Google Scholar 

  116. Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF. An update on larynx cancer. CA Cancer J Clin. 2017;67:31–50.

    Article  PubMed  Google Scholar 

  117. Stell PM, McGill T. Asbestos and laryngeal carcinoma. Lancet. 1973; 2:416–417. 12. Paget-Bailly S, Cyr D, Luce D. Occupational exposures and cancer of the larynx systematic review and meta-analysis. J Occup Environ Med 2012;54:71–84.

    Google Scholar 

  118. Mourad M, Jetmore T, Jategaonkar AA, Moubayed S, Moshier E, Urken ML. Epidemiological trends of head and neck Cancer in the United States: a SEER population study. J Oral Maxillofac Surg. 2017. pii:0278–2391(17) 30537–2.

    Google Scholar 

  119. Riga M, Chelis L, Danielides V, Vogiatzaki T, Pantazis TL, Pantazis D. Systematic review on T3 laryngeal squamous cell carcinoma; still far from a consensus on the optimal organ preserving treatment. Eur J Surg Oncol. 2017;43:20–31.

    Article  PubMed  CAS  Google Scholar 

  120. Hoffman HT, Porter K, Karnell LH, Cooper JS, Weber RS, Langer CJ, Ang KK, Gay G, Stewart A, Robinson RA. Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival. Laryngoscope. 2006;116:1–13.

    Article  PubMed  Google Scholar 

  121. Lassen P, Primdahl H, Johansen J, Kristensen CA, Andersen E, Andersen LJ, Evensen JF, Eriksen JG, Overgaard J, Danish Head and Neck Cancer Group (DAHANCA). Impact of HPV-associated p16-expression on radiotherapy outcome in advanced oropharynx and non-oropharynx cancer. Radiother Oncol. 2014;113(3):310–6.

    Article  PubMed  Google Scholar 

  122. Wittekindt C, Wuerdemann N, Gattenlöhner S, Brobeil A, Wierzbicka M, Wagner S, Klußmann JP. The role of high-risk human papillomavirus infections in laryngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol. 2017;274:3837–42.

    Article  PubMed  Google Scholar 

  123. Xu Y, Liu S, Yi H, Wang J, Dong P, Li X, Yin S. Human papillomavirus infection in 674 Chinese patients with laryngeal squamous cell carcinoma. PLoS One. 2014;9(12):e115914. https://doi.org/10.1371/journal.pone.0115914.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  124. Thompson LD. Laryngeal dysplasia, squamous cell carcinoma, and variants. Surg Pathol Clin. 2017;10:15–33.

    Article  PubMed  Google Scholar 

  125. Gale N, Zidar N, Poljak M, Cardesa A. Current views and perspectives on classification of squamous intraepithelial lesions of the head and neck. Head Neck Pathol. 2014;8:16–23.

    Article  PubMed  PubMed Central  Google Scholar 

  126. Gale N, Poljak M, Zidar N. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: What is New in the 2017 WHO Blue Book for Tumours of the Hypopharynx, Larynx, Trachea and Parapharyngeal Space. Head Neck Pathol. 2017;11:23–32.

    Article  PubMed  PubMed Central  Google Scholar 

  127. Weller MD, Nankivell PC, McConkey C, et al. The risk and interval to malignancy of patients with laryngeal dysplasia; a systematic review of case series and meta-analysis. Clin Otolaryngol. 2010;35:364–72.

    Article  PubMed  CAS  Google Scholar 

  128. Gerry D, Fritsch VA, Lentsch EJ. Spindle cell carcinoma of the upper aerodigestive tract: an analysis of 341 cases with comparison to conventional squamous cell carcinoma. Ann Otol Rhinol Laryngol. 2014;123:576–83.

    Article  PubMed  Google Scholar 

  129. Dubal PM, Marchiano E, Kam D, Dutta R, Kalyoussef E, Baredes S, Eloy JA. Laryngeal spindle cell carcinoma: A population-based analysis of incidence and survival. Laryngoscope. 2015;125:2709–14.

    Article  PubMed  Google Scholar 

  130. Bice TC, Tran V, Merkley MA, Newlands SD, van der Sloot PG, Wu S, Miller MC. Disease-specific survival with spindle cell carcinoma of the head and neck. Otolaryngol Head Neck Surg. 2015;53:973–80.

    Article  Google Scholar 

  131. Marioni G, Altavilla G, Marino F, Marchese-Ragona R, Lelli-Mami G, Staffieri A. Squamous cell carcinoma of the larynx with osteosarcoma-like stromal metaplasia. Acta Otolaryngol. 2004;124:870–3.

    Article  PubMed  Google Scholar 

  132. Mosalleum E, Afrogheh A, Stofberg S, Bezuidenhout AF, Schneider J, Hille J. A review of primary osteosarcoma of the larynx and case report. Head Neck Pathol. 2015;9:158–64.

    Article  PubMed  Google Scholar 

  133. Mehrad M, Carpenter DH, Chernock RD, Wang H, Ma XJ, Luo Y, Luo J, Lewis JS Jr, El-Mofty SK. Papillary squamous cell carcinoma of the head and neck: clinicopathologic and molecular features with special reference to human papillomavirus. Am J Surg Pathol. 2013;37:1349–56.

    Article  PubMed  PubMed Central  Google Scholar 

  134. Jo VY, Mills SE, Stoler MH, Stelow EB. Papillary squamous cell carcinoma of the head and neck: frequent association with human papillomavirus infection and invasive carcinoma. Am J Surg Pathol. 2009;33:1720–4.

    Article  PubMed  Google Scholar 

  135. Dutta R, Husain Q, Kam D, Dubal PM, Baredes S, Eloy JA. Laryngeal papillary squamous cell carcinoma: a population-based analysis of incidence and survival. Otolaryngol Head Neck Surg. 2015;153:54–9.

    Article  PubMed  Google Scholar 

  136. Dubal PM, Svider PF, Kam D, Dutta R, Baredes S, Eloy JA. Laryngeal verrucous carcinoma: a population-based analysis. Otolaryngol Head Neck Surg. 2015;153:799–805.

    Article  PubMed  Google Scholar 

  137. Huang SH, Lockwood G, Irish J, Ringash J, Cummings B, Waldron J, Kim J, Dawson LA, Bayley A, Hope A, O'Sullivan B. Truths and myths about radiotherapy for verrucous carcinoma of larynx. Int J Radiat Oncol Biol Phys. 2009;73:1110–5.

    Article  PubMed  Google Scholar 

  138. Santoro A, Pannone G, Contaldo M, Sanguedolce F, Esposito V, Serpico R, Lo Muzio L, Papagerakis S, Bufo P. A troubling diagnosis of verrucous squamous cell carcinoma (“the bad kind” of keratosis) and the need of clinical and pathological correlations: a review of the literature with a case report. J Skin Cancer. 2011;2011:370605. https://doi.org/10.1155/2011/370605.

    Article  PubMed  CAS  Google Scholar 

  139. Teymoortash A, Silver CE, Rinaldo A, Cardesa A, Folz BJ, Ferlito A. Verrucous carcinoma: a retrospective diagnosis in three historic patients. Eur Arch Otorhinolaryngol. 2014;271:631–3.

    Article  PubMed  Google Scholar 

  140. Cardesa A, Zidar N, Alos L, Nadal A, Gale N, Klöppel G. The Kaiser's cancer revisited: was Virchow totally wrong? Virchows Arch. 2011;458:649–57.

    Article  PubMed  Google Scholar 

  141. Lewis JS Jr. Not your usual cancer case: variants of laryngeal squamous cell carcinoma. Head Neck Pathol. 2011;5:23–30.

    Article  PubMed  Google Scholar 

  142. Orvidas LJ, Olsen KD, Lewis JE, Suman VJ. Verrucous carcinoma of the larynx: a review of 53 patients. Head Neck. 1998;20:197–203.

    Article  PubMed  CAS  Google Scholar 

  143. Ghosh R, Dutta R, Dubal PM, Park RC, Baredes S, Eloy JA. Laryngeal neuroendocrine carcinoma: a population-based analysis of incidence and survival. Otolaryngol Head Neck Surg. 2015;153:966–72.

    Article  PubMed  Google Scholar 

  144. van der Laan TP, Plaat BE, van der Laan BF, Halmos GB. Clinical recommendations on the treatment of neuroendocrine carcinoma of the larynx: a meta-analysis of 436 reported cases. Head Neck. 2015;37:707–15.

    Article  PubMed  Google Scholar 

  145. Perez-Ordonez B, Bishop JA, Gnepp DR, Hunt JL, Thompson LDR: Neuroendocrine tumors. In WHO classifications of head and neck tumours. El-Naggar, AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, IARC Lyon 2017, pp 95–98.

    Google Scholar 

  146. La Rosa S, Sessa F, Uccella S. Mixed neuroendocrine-nonneuroendocrine neoplasms (MiNENs): unifying the concept of a heterogeneous group of neoplasms. Endocr Pathol. 2016;27:284–311.

    Article  PubMed  CAS  Google Scholar 

  147. Thompson ED, Stelow EB, Mills SE, Westra WH, Bishop JA. Large cell neuroendocrine carcinoma of the head and neck: a clinicopathologic series of 10 cases with an emphasis on HPV status. Am J Surg Pathol. 2016;40:471–8.

    Article  PubMed  PubMed Central  Google Scholar 

  148. Alos L, Hakim S, Larque AB, de la Oliva J, Rodriguez-Carunchio L, Caballero M, Nadal A, Marti C, Guimera N, Fernandez-Figueras MT, Quint W, Ordi J. p16 overexpression in high-grade neuroendocrine carcinomas of the head and neck: potential diagnostic pitfall with HPV-related carcinomas. Virchows Arch. 2016;469:277–84.

    Article  PubMed  CAS  Google Scholar 

  149. Dubal PM, Svider PF, Kanumuri VV, Patel AA, Baredes S, Eloy JA. Laryngeal chondrosarcoma: a population-based analysis. Laryngoscope. 2014;124:1877–81.

    Article  PubMed  Google Scholar 

  150. Chin OY, Dubal PM, Sheikh AB, Unsal AA, Park RC, Baredes S, Eloy JA. Laryngeal chondrosarcoma: a systematic review of 592 cases. Laryngoscope. 2017;2017(127):430–9.

    Article  Google Scholar 

  151. Choi J, Dharmarajan H, Victores A, Wenaas A, Ongkasuwan J. Chondrosarcoma of the epiglottis: a case report and literature review. J Voice 2017, pii: S0892–1997(17)30244–8. https://doi.org/10.1016/j.jvoice.2017.07.014.

  152. Hu R, Xu W, Liu H, Chen X. Laryngeal chondrosarcoma of the arytenoid cartilage presenting as bilateral vocal fold immobility: a case report and literature review. J Voice. 2014; 28(1):129.e13–129.e17.

    Article  PubMed  Google Scholar 

  153. Horta M, Fernandes L, Borges A. Chondrosarcoma of the hyoid bone: an atypical site of a sarcoma of the head and the neck. BMJ Case Rep. 2015;2015:pii:bcr2015212291. https://doi.org/10.1136/bcr-2015-212291.

    Article  Google Scholar 

  154. Ciolofan MS, Ioniţă E, Ioniţă I, Mogoantă CA, Anghelina F, Enescu AŞ, Ciobîrcă DM, Osman A, Foarfă MC, Mateescu GO. Chondrosarcoma of the hyoid bone: a case report. Romanian J Morphol Embryol. 2015;56:811–6.

    Google Scholar 

  155. Maki D, Mori T, Teshima M, Kobayashi K, Matsumoto F, Sakai A, Okami K, Yoshimoto S. Chondrosarcoma of the hyoid bone - Report of a case and a literature review of the suitable treatment strategy. Auris Nasus Larynx. 2017;44:629–34.

    Article  PubMed  Google Scholar 

  156. Lewis JE, Olsen KD, Inwards CY. Cartilaginous tumors of the larynx: clinicopathologic review of 47 cases. Ann Otol Rhinol Laryngol. 1997;106:94–100.

    Article  PubMed  CAS  Google Scholar 

  157. Gökdoğan O, Koybasioglu A, Laryngeal Chondroma IF. An unusual complication endotracheal entubation. J Craniofac Surg. 2016;27:1007–9.

    Article  PubMed  Google Scholar 

  158. Brandwein M, Moore S, Som P, Biller H. Laryngeal chondrosarcomas: a clinicopathologic study of 11 cases, including two “dedifferentiated” chondrosarcomas. Laryngoscope. 1992;102:858–67.

    Article  PubMed  CAS  Google Scholar 

  159. Magliocca KR, Edgar MA, Corey A, Villari CR. Dedifferentiated chondrosarcoma of the larynx: radiological, gross, microscopic and clinical features. Ann Diagn Pathol. 2017;30:42–6.

    Article  PubMed  Google Scholar 

  160. Thompson LD, Gannon FH. Chondrosarcoma of the larynx: a clinicopathologic study of 111 cases with a review of the literature. Am J Surg Pathol. 2002;26:836–51.

    Article  PubMed  Google Scholar 

  161. Alexander J, Wakely PE Jr. Primary laryngeal clear cell chondrosarcoma: report of a case and literature review. Head Neck Pathol. 2014;8:307–10.

    Article  PubMed  PubMed Central  Google Scholar 

  162. Eble JN, Hull MT, Bojrab D. Laryngeal blastoma. A light and electron microscopic study of a novel entity analogous to pulmonary blastoma. Am J Clin Pathol. 1985;84:378–85.

    Article  PubMed  CAS  Google Scholar 

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Brandwein-Weber, M.S. (2018). Larynx: Anatomy, Nonneoplastic, Benign, and Malignant. In: Textbook of Head and Neck Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-76106-0_5

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