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Textbook of Head and Neck Pathology pp 187–245Cite as

Oropharynx, Hypopharynx, and Parapharyngeal Space: Anatomy, Histology, Benign and Malignant Neoplasia

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Abstract

The range of benign and malignant entities encountered in the oropharynx is much smaller, relative to the oral cavity and there are no “precursor” lesions in the oropharynx. The biology, morphology, treatment, and staging of oropharyngeal squamous carcinomas are vastly different than squamous carcinomas just centimeters anterior, in the oral cavity. High-risk Human Papillomavirus (HR-HPV) -mediated oropharyngeal cancers can be recognized by the following possible features: nonkeratinizing, “inside-out” maturation, and multinucleated and/pr pleomorphic tumor cells. Metastatic HR-HPV mediated oropharyngeal cancers are frequently cystic. Immunohistochemistry for p16 is now standard of care for staging oropharyngeal carcinomas according to new 8th American Joint Cancer Committee standards.

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References

  1. Perry ME. The specialised structure of crypt epithelium in the human palatine tonsil and its functional significance. J Anat. 1994;185:111–27.

    PubMed  PubMed Central  Google Scholar 

  2. Gloghini A, Colombatti A, Bressan G, Carbone A. Basement membrane components in lymphoid follicles: immunohistochemical demonstration and relationship to the follicular dendritic cell network. Hum Pathol. 1989;20:1001–7.

    Article  PubMed  CAS  Google Scholar 

  3. Jović M, Avramović V, Vlahović P, Savić V, Veličkov A, Petrović V. Ultrastructure of the human palatine tonsil and its functional significance. Romanian J Morphol Embryol. 2015;56:371–7.

    Google Scholar 

  4. Doorbar J. Latent papillomavirus infections and their regulation. Curr Opin Virol. 2013;3:416–21.

    Article  PubMed  CAS  Google Scholar 

  5. Doorbar J, Quint W, Banks L, Bravo IG, Stoler M, Broker TR, Stanley MA. The biology and life-cycle of human papillomaviruses. Vaccine. 2012;30:F55–70.

    Article  PubMed  CAS  Google Scholar 

  6. Israr M, Biryukov J, Ryndock EJ, Alam S, Meyers C. Comparison of human papillomavirus type 16 replication in tonsil and foreskin epithelia. Virology. 2016;499:82–90.

    Article  PubMed  CAS  Google Scholar 

  7. Chow W, Rotenberg BW. Discontinuing routine histopathological analysis after adult tonsillectomy for benign indication. Laryngoscope. 2015;125:1595–9.

    Article  PubMed  Google Scholar 

  8. Rokkjaer MS, Klug TE. Malignancy in routine tonsillectomy specimens: a systematic literature review. Eur Arch Otorhinolaryngol. 2014;271:2851–61.

    Article  PubMed  Google Scholar 

  9. Haughey BH, Sinha P, Kallogjeri D, Goldberg RL, Lewis JS Jr, Piccirillo J, Jackson RS, Moore EJ, Brandwein-Gensler M, Magnuson JS, Carroll WR, Jones TM, Wilkie MD, Lau A, Upile NS, Sheard J, Lancaster J, Tandon S, Robinson M, Husband D, Ganly I, Shah JP, Brizel DM, O’Sullivan B, Ridge JA, Lydiatt W. Pathology-based staging for HPV-positive squamous carcinoma of the oropharynx. Oral Oncol. 2016;62:11–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  10. Carranza Leon BG, Turcu A, Bahn R, Dean DS. Lingual thyroid: 35-year experience at a tertiary care referral center. Endocr Pract. 2016;22:343–9.

    Article  PubMed  Google Scholar 

  11. Neinas FW, Gorman CA, Devine KD, Woolner LB. Lingual thyroid. Clinical characteristics of 15 cases. Ann Intern Med. 1973;79:205–10.

    Article  PubMed  CAS  Google Scholar 

  12. Meng Z, Lou S, Tan J, Jia Q, Zheng R, Liu G, Zhu M, He Q, Li D. Scintigraphic detection of dual ectopic thyroid tissue: experience of a chinese tertiary hospital. PLoS One. 2014. https://doi.org/10.1371/journal.pone.0095686.

  13. Jain A, Pathak S. Rare developmental abnormalities of thyroid gland, especially multiple ectopia: a review and our experience. Indian J Nucl Med. 2010;25:143–6.

    PubMed  PubMed Central  Google Scholar 

  14. Castro PH, Volpato LE, Tramujas J, Borges AH. Ectopic thyroid at the base of the tongue of a young patient. Case Rep Dent. 2016;2016:9174970. Epub 2016

    PubMed  PubMed Central  Google Scholar 

  15. Sturniolo G, Vermiglio F, Moleti M. Thyroid cancer in lingual thyroid and thyroglossal duct cyst. Endocrinol Diabetes Nutr. 2017;64:40–3.

    Article  PubMed  Google Scholar 

  16. Mardekian S, Karp JK. Lymphangioma of the palatine tonsil. Arch Pathol Lab Med. 2013;137:1837–42.

    Article  PubMed  Google Scholar 

  17. Cengiz BP, Acar M, Giritli E. A pedunculated lymphangiomatous polyp of the palatine tonsil: a case report. Braz J Otorhinolaryngol. 2013;79:402.

    Article  PubMed  Google Scholar 

  18. Iliadou E, Papapetropoulos N, Karamatzanis E, Saravakos P, Saravakos K. Primary lymphangioma of the palatine tonsil in a 9-year-old boy: a case presentation and literature review. Case Rep Otolaryngol. 2016;2016:1505202. Epub 2016

    PubMed  PubMed Central  Google Scholar 

  19. Khatib Y, Gite V, Patel R, Shoeb M, Oraon A. Lymphangiomatous polyp of palatine tonsil in a child presenting with dysphagia and dysarthria. J Clin Diagn Res. 2015;9(5):ED01-2. https://doi.org/10.7860/JCDR/2015/11296.5877. Epub 2015

    Article  PubMed  Google Scholar 

  20. Chen HH, Lovell MA, Chan KH. Bilateral lymphangiomatous polyps of the palatine tonsils. Int J Pediatr Otorhinolaryngol. 2010;74:87–8.

    Article  PubMed  Google Scholar 

  21. Devi RS, Rajsekhar B, Srinivas GV, Moon NJ. Unusual length of pedicle: pedunculated squamous papilloma of uvula causing unusual dysphagia of long duration in a child of 10 years. Case Rep Dent. 2014;2014:313506. https://doi.org/10.1155/2014/313506.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Zhao M, Yu J, Li C. Lymphoid papillary hyperplasia of the palatine tonsil: a Chinese case report. Int J Clin Exp Pathol. 2013;6:1957–60.

    PubMed  PubMed Central  Google Scholar 

  23. Dias EP, Alfaro SE, De Piro SC. Lymphoid papillary hyperplasia: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95:77–9.

    Article  PubMed  Google Scholar 

  24. Peitz U, Vieth M, Evert M, Arand J, Roessner A, Malfertheiner P. The prevalence of gastric heterotopia of the proximal esophagus is underestimated, but preneoplasia is rare – correlation with Barrett’s esophagus. BMC Gastroenterol. 2017;17:87.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Di Nardo G, Cremon C, Bertelli L, Oliva S, De Giorgio R, Pagano N. Esophageal inlet patch: an under-recognized cause of symptoms in children. J Pediatr. 2016;176:99–104.

    Article  PubMed  Google Scholar 

  26. Rodríguez-Martínez A, Salazar-Quero JC, Tutau-Gómez C, Espín-Jaime B, Rubio-Murillo M, Pizarro-Martín A. Heterotopic gastric mucosa of the proximal oesophagus (inlet patch): endoscopic prevalence, histological and clinical characteristics in paediatric patients. Eur J Gastroenterol Hepatol. 2014;26:1139–45.

    Article  PubMed  Google Scholar 

  27. Sahin G, Adas G, Koc B, Akcakaya A, Dogan Y, Goksel S, Yalcin O. Is cervical inlet patch important clinical problem? Int J Biomed Sci. 2014;10:129–35.

    PubMed  PubMed Central  Google Scholar 

  28. Govani SM, Metko V, Rubenstein JH. Prevalence and risk factors for heterotopic gastric mucosa of the upper esophagus among men undergoing routine screening colonoscopy. Dis Esophagus. 2015;28:442–7.

    Article  PubMed  CAS  Google Scholar 

  29. Bingöl F, Balta H, Bingöl BÖ, Mazlumoğlu RM, Kılıç K. Lymphoepithelial cyst in the palatine tonsil. Case Rep Otolaryngol. 2016;2016:6296840. Epub 2016 Sep 18

    PubMed  PubMed Central  Google Scholar 

  30. Castro JG, Ferreira GM, Mendonça EF, Castro LA. A rare occurrence of lymphoepithelial cyst in the palatine tonsil: a case report and discussion of the etiopathogenesis. Int J Clin Exp Pathol. 2015;8:4264–8.

    PubMed  PubMed Central  Google Scholar 

  31. White JR, Weiss S, Anderson D, Mason SE, Schexnaildre MA, Nuss DW, Walvekar RR. Transoral resection of a retropharyngeal myxoma: a case report. Skull Base Rep. 2011;1:139–44.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Sinha SN, Yadav YC. Myxoma of the pharynx. Arch Otolaryngol. 1970;91:82–3.

    Article  PubMed  CAS  Google Scholar 

  33. Ayache S, Chatelain D, Tramier B, Strunski V. Oropharyngeal and hypopharyngeal myxoma: case report and literature review. J Laryngol Otol. 2007;121(5):e5.

    Article  PubMed  CAS  Google Scholar 

  34. Stratakis CA, Salpea P, Raygada M. Carney Complex. 2003 Feb 5 [Updated 2015 Jan 29]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2017. Available from: https://www.ncbi.nlm.nih.gov/books/NBK1286/

  35. Pereira GW, Pereira VD, Pereira Junior JA, da Silva RM. Cartilaginous choristoma of the tongue with an immunohistochemical study. BMJ Case Rep. 2012;2012. pii: bcr2012006752. https://doi.org/10.1136/bcr-2012-006752.

    Google Scholar 

  36. Kannar V, Prabhakar K, Shalini S. Cartilaginous choristoma of tonsil: a hidden clinical entity. J Oral Maxillofac Pathol. 2013;17:292–3.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Rossi-Schneider TR, Salum FG, Cherubini K, Yurgel LS, Figueredo MA. Cartilaginous choristoma of the tongue. Gerodontology. 2009;26:78–80.

    Article  PubMed  CAS  Google Scholar 

  38. Norris O, Mehra P. Chondroma (cartilaginous choristoma) of the tongue: report of a case. J Oral Maxillofac Surg. 2012;70:643–6.

    Article  PubMed  Google Scholar 

  39. Iglesias-Moreno MC, López-Salcedo MA, Gómez-Serrano M, Gimeno-Hernández J, Poch-Broto J. Parapharyngeal space tumors: fifty-one cases managed in a single tertiary care center. Acta Otolaryngol. 2016;136:298–303.

    Article  PubMed  CAS  Google Scholar 

  40. Locketz GD, Horowitz G, Abu-Ghanem S, Wasserzug O, Abergel A, Yehuda M, Fliss DM. Histopathologic classification of parapharyngeal space tumors: a case series and review of the literature. Eur Arch Otorhinolaryngol. 2016;273:727–34.

    Article  PubMed  Google Scholar 

  41. Caldarelli C, Bucolo S, Spisni R, Destito D. Primary parapharyngeal tumours: a review of 21 cases. Oral Maxillofac Surg. 2014;18:283–92.

    Article  PubMed  Google Scholar 

  42. Shi X, Tao L, Li X, Wu H, Huang W, Chen X, Li C, Shen Y, Chen Q, Tang D, Wei C, Wang D, Zhou L. Surgical management of primary parapharyngeal space tumors: a 10-year review. Acta Otolaryngol. 2017;137(6):656–61.

    Article  PubMed  Google Scholar 

  43. Grilli G, Suarez V, Muñoz MG, Costales M, Llorente JL. Parapharyngeal space primary tumours. Acta Otorrinolaringol Esp. 2017;68:138–44.

    Article  Google Scholar 

  44. Li G, Xin X, Wang X, Ren C. Dysphagia caused by giant schwannoma of the supraglottic oropharynx: a case report and review of the literature. Ann Med Surg (Lond). 2017;20:84–6.

    Article  Google Scholar 

  45. Zheng Z, Jordan AC, Hackett AM, Chai RL. Pediatric desmoid fibromatosis of the parapharyngeal space: a case report and review of literature. Am J Otolaryngol. 2016;37:372–5.

    Article  PubMed  Google Scholar 

  46. Garcia-Perla A, Belmonte-Caro R, Infante-Cossio P, Muñoz-Ramos M, Esteban-Ortega F. Upper airway distress due to an oropharyngeal infantile myofibroma. J Craniomaxillofac Surg. 2012;40:e112–4.

    Article  PubMed  Google Scholar 

  47. Lin HW, Jung D, Lee LN, Sadow PM, Rocco JW. Solitary myofibroma of the oropharynx causing airway obstruction in an adult. Ear Nose Throat J. 2014;2014(93):410–7.

    Google Scholar 

  48. Smith MH, Reith JD, Cohen DM, Islam NM, Sibille KT, Bhattacharyya I. An update on myofibromas and myofibromatosis affecting the oral regions with report of 24 new cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124:62–75.

    Article  PubMed  Google Scholar 

  49. Panja S, Champaka G, Shenoy AM. Infantile myofibroma of the pharynx presenting with severe upper airway obstruction in a child. Indian J Cancer. 2010;47:78–9.

    Article  PubMed  CAS  Google Scholar 

  50. Venkatesh V, Kumar BP, Kumar KA, Mohan AP. Myofibroma-a rare entity with unique clinical presentation. J Maxillofac Oral Surg. 2015;14:64–8.

    Article  PubMed  CAS  Google Scholar 

  51. Lopes RN, Alves Fde A, Rocha AC, Suassuna TM, Kowalski LP, de Castro JF, Perez DE. Head and neck solitary infantile myofibroma: Clinicopathological and immunohistochemical features of a case series. Acta Histochem. 2015;117:431–6.

    Article  PubMed  CAS  Google Scholar 

  52. Lu DY, Chang S, Cook H, Alizadeh Y, Karam AK, Moatamed NA, Dry SM. Genital rhabdomyoma of the urethra in an infant girl. Hum Pathol. 2012;43:597–600.

    Article  PubMed  Google Scholar 

  53. Pichi B, Manciocco V, Marchesi P, Pellini R, Ruscito P, Vidiri A, Covello R, Spriano G. Rhabdomyoma of the parapharyngeal space presenting with dysphagia. Dysphagia. 2008;23:202–4.

    Article  PubMed  Google Scholar 

  54. Saini AT, Hernandez-Prera JC, Teng MS. Pyriform sinus soft-tissue mass recurring in esophagus after excision. JAMA Otolaryngol Head Neck Surg. 2015;141:573–4.

    Article  PubMed  Google Scholar 

  55. Helmberger RC, Stringer SP, Mancuso AA. Rhabdomyoma of the pharyngeal musculature extending into the prestyloid parapharyngeal space. AJNR Am J Neuroradiol. 1996;17:1115–8.

    PubMed  CAS  PubMed Central  Google Scholar 

  56. Papaspyrou G, Werner JA, Roessler M, Devaney KO, Rinaldo A, Ferlito A. Adult rhabdomyoma in the parapharyngeal space: report of 2 cases and review of the literature. Am J Otolaryngol. 2011;32:240–6.

    Article  PubMed  Google Scholar 

  57. Wang CP, Kwan PC, Ho CY. Lipoma of the palatine tonsil. J Formos Med Assoc. 2007;106:673–5.

    Article  PubMed  Google Scholar 

  58. Navaneetham A, Rao A, Gandhi A, Jeevan CA. Lipoma involving the masticator space. Ann Maxillofac Surg. 2011;1(1):93–4. https://doi.org/10.4103/2231-0746.83147.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Iwai K, Tomoda K, Nakai T, Kimura HA. Hypopharyngeal lipoma resulting in obstructive sleep apnea. Intern Med. 2015;54(21):2789–90. https://doi.org/10.2169/internalmedicine.54.4287. Epub 2015

    Article  PubMed  Google Scholar 

  60. Acquaviva G, Varakliotis T, Badia S, Casorati F, Eibenstein A, Bellocchi G. Lipoma of piriform sinus: a case report and review of the literature. Case Rep Otolaryngol. 2016;2016:2521583. Epub 2016

    PubMed  PubMed Central  Google Scholar 

  61. Zhu H, Sun J, Wei S, Wang D, Brandwein M. Well-differentiated laryngeal/hypopharyngeal liposarcoma in the MDM2 era report of three cases and literature review. Head Neck Pathol. 2017;11(2):146–51. https://doi.org/10.1007/s12105-016-0747-0. Epub 2016 Aug 4

    Article  PubMed  Google Scholar 

  62. Wenig BM, Heffner DK. Liposarcomas of the larynx and hypopharynx: a clinicopathologic study of eight new cases and a review of literature. Laryngoscope. 1995;105:747–56.

    Article  PubMed  CAS  Google Scholar 

  63. Gardner JM, Dandekar M, Thomas D, Goldblum JR, Weiss SW, Billings SD, Lucas DR, McHugh JB, Patel RM. Cutaneous and subcutaneous pleomorphic liposarcoma: a clinicopathologic study of 29 cases with evaluation of MDM2 gene amplification in 26. Am J Surg Pathol. 2012;36(7):1047–51. https://doi.org/10.1097/PAS.0b013e3182517b96.

    Article  PubMed  Google Scholar 

  64. Davis EC, Ballo MT, Luna MA, Patel SR, Roberts DB, Nong X, Sturgis EM. Liposarcoma of the head and neck: the University of Texas M. D. Anderson Cancer Center experience. Head Neck. 2009;31(1):28–36. https://doi.org/10.1002/hed.20923.

    Article  PubMed  Google Scholar 

  65. Golledge J, Fisher C, Rhys-Evans PH. Head and neck liposarcoma. Cancer. 1995;76(6):1051–8. Review. PubMed PMID: 8625207

    Article  PubMed  CAS  Google Scholar 

  66. Cheah A, Billings S, Goldblum J, Hornick J, Uddin N, Rubin B. Spindle cell/pleomorphic lipomas of the face: an under-recognized diagnosis. Histopathology. 2015;66:430–7.

    Article  PubMed  Google Scholar 

  67. Sachdeva MP, Goldblum JR, Rubin BP, Billings SD. Low-fat and fat-free pleomorphic lipomas: a diagnostic challenge. Am J Dermatopathol. 2009;31:423–6.

    Article  PubMed  Google Scholar 

  68. Frisch M, Hjalgrim H, Jaeger AB, Biggar RJ. Changing patterns of tonsillar squamous cell carcinoma in the United States. Cancer Causes Control. 2000;11:489–95.

    Article  PubMed  CAS  Google Scholar 

  69. Dahlstrom KR, Adler-Storthz K, et al. HPV type 16 infection and squamous cell carcinoma of the head and neck in never-smokers: a matched pair analysis. Clin Cancer Res. 2003;9:2620–6.

    PubMed  Google Scholar 

  70. D'Souza G, Kreimer AR, Viscidi R, et al. Case-control study of HPV and oropharyngeal cancer. N Engl J Med. 2007;356:1944–56.

    Article  PubMed  CAS  Google Scholar 

  71. El-Mofty SK, Lu DW. Prevalence of HPV type 16 DNA in squamous cell carcinoma of the palatine tonsil, and not the oral cavity, in young patients: a distinct clinicopathologic and molecular disease entity. Am J Surg Pathol. 2003;11:1463–70.

    Article  Google Scholar 

  72. El-Mofty SK, Patil S. HPV-related oropharyngeal nonkeratinizing squamous cell carcinoma: characterization of a distinct phenotype. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:339–45.

    Article  PubMed  Google Scholar 

  73. Furniss CS, McClean MD, Smith JF, et al. HPV 16 and head and neck squamous cell carcinoma. Int J Cancer. 2007;120:2386–92.

    Article  PubMed  CAS  Google Scholar 

  74. Gillison ML, Koch WM, Capone RB, et al. Evidence for a causal association between HPV and a subset of head and neck cancers. J Natl Cancer Inst. 2000;92:709–20.

    Article  PubMed  CAS  Google Scholar 

  75. Hansson BG, Rosenquist K, Antonsson A, et al. Strong association between infection with HPV and oral and oropharyngeal squamous cell carcinoma: a population-based case-control study in southern Sweden. Acta Otolaryngol. 2005;125:1337–44.

    Article  PubMed  Google Scholar 

  76. Kreimer AR, Clifford GM, Snijders PJ, et al. HPV16 semiquantitative viral load and serologic biomarkers in oral and oropharyngeal squamous cell carcinomas. Int J Cancer. 2005;115:329–32.

    Article  PubMed  CAS  Google Scholar 

  77. Mork J, Lie AK, Glattre E, et al. HPV infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med. 2001;344:1125–31.

    Article  PubMed  CAS  Google Scholar 

  78. Nemes JA, Deli L, Nemes Z, Marton IJ. Expression of p16(INK4A), p53, and Rb proteins are independent from the presence of HPV genes in oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102:344–52.

    Article  PubMed  Google Scholar 

  79. Ringstrom E, Peters E, Hasegawa M, et al. HPV type 16 and squamous cell carcinoma of the head and neck. Clin Cancer Res. 2002;10:3187–92.

    Google Scholar 

  80. Schlecht NF, Burk RD, Adrien L, et al. Gene expression profiles in HPV-infected head and neck cancer. J Pathol. 2007;213:283–93.

    Article  PubMed  CAS  Google Scholar 

  81. Schwartz SR, Yueh B, McDougall JK, et al. HPV infection and survival in oral squamous cell cancer: a population-based study. Otolaryngol Head Neck Surg. 2001;125:1–9.

    Article  PubMed  CAS  Google Scholar 

  82. Weinberger PM, Yu Z, Haffty BG, et al. Molecular classification identifies a subset of HPV-associated oropharyngeal cancers with favorable prognosis. J Clin Oncol. 2006;24:736–47.

    Article  PubMed  CAS  Google Scholar 

  83. Lydiatt WM, Patel SG, O'Sullivan B, Brandwein MS, Ridge JA, Migliacci JC, Loomis AM, Shah JP. Head and neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clin. 2017;67:122–37.

    Article  PubMed  Google Scholar 

  84. Black CC, Ogomo C. Does pTis exist in HPV-driven tonsillar carcinomas? An ultrastructural review and examination of two cases. Ultrastruct Pathol. 2017;41:55–61.

    Article  PubMed  Google Scholar 

  85. Lassen P, Eriksen JG, Hamilton-Dutoit S, Tramm T, Alsner J, Overgaard J, Danish Head and Neck Cancer Group (DAHANCA). HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer. Radiother Oncol. 2010;94:30–5.

    Article  PubMed  CAS  Google Scholar 

  86. Schlecht NF, Brandwein-Gensler M, Nuovo GJ, Li M, Smith RV, Burk RD, Prystowsky MB. A comparison of clinically utilized human papillomavirus detection methods in head and neck cancer. Mod Pathol. 2011;24:1295–305.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  87. Isayeva T, Xu J, Dai Q, Whitley AC, Bonner J, Nabell L, Spencer S, Carroll W, Jones G, Ragin C, Brandwein-Gensler M. African Americans with oropharyngeal carcinoma have significantly poorer outcomes despite similar rates of human papillomavirus-mediated carcinogenesis. Hum Pathol. 2014;45:310–9.

    Article  PubMed  CAS  Google Scholar 

  88. Hong A, Jones D, Chatfield M, Lee CS, Zhang M, Clark J, Elliott M, Harnett G, Milross C, Rose B. HPV status of oropharyngeal cancer by combination HPV DNA/p16 testing: biological relevance of discordant results. Ann Surg Oncol. 2013. https://doi.org/10.1245/s10434-012-2778-4.

  89. Liu SZ, Zandberg DP, Schumaker LM, Papadimitriou JC, Cullen KJ. Correlation of p16 expression and HPV type with survival in oropharyngeal squamous cell cancer. Oral Oncol. 2015;51:862–9.

    Article  PubMed  CAS  Google Scholar 

  90. Liu JC, Parajuli S, Blackman E, Gibbs D, Ellis A, Hull A, Beck JR, Giri V, Iherjirka P, Khurana JS, Ragin CR. High prevalence of discordant human papillomavirus and p16 oropharyngeal squamous cell carcinomas in an African American cohort. Head Neck. 2016;38(Suppl 1):E867–72.

    Article  PubMed  Google Scholar 

  91. Koncar RF, Feldman R, Bahassi EM, Hashemi Sadraei N. Comparative molecular profiling of HPV-induced squamous cell carcinomas. Cancer Med. 2017;6:1673–85.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  92. Faraji F, Zaidi M, Fakhry C, Gaykalova DA. Molecular mechanisms of human papillomavirus-related carcinogenesis in head and neck cancer. Microbes Infect. 2017. https://doi.org/10.1016/j.micinf.2017.06.001.

  93. Seiwert TY, Zuo Z, Keck MK, Khattri A, Pedamallu CS, Stricker T, Brown C, Pugh TJ, Stojanov P, Cho J, Lawrence MS, Getz G, Brägelmann J, DeBoer R, Weichselbaum RR, Langerman A, Portugal L, Blair E, Stenson K, Lingen MW, Cohen EE, Vokes EE, White KP, Hammerman PS. Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas. Clin Cancer. 2015. https://doi.org/10.1158/1078-0432.CCR-13-3310.

  94. Cancer Genome AtlasN. Comprehensive genominc characterization of head nd neck squamous carcinomas. Nature. 2015;517:576–82.

    Article  CAS  Google Scholar 

  95. Keck MK, Zuo Z, Khattri A, Stricker TP, Brown CD, Imanguli M, Rieke D, Endhardt K, Fang P, Brägelmann J, DeBoer R, El-Dinali M, Aktolga S, Lei Z, Tan P, Rozen SG, Salgia R, Weichselbaum RR, Lingen MW, Story MD, Ang KK, Cohen EE, White KP, Vokes EE, Seiwert TY. Integrative analysis of head and neck cancer identifies two biologically distinct HPV and three non-HPV subtypes. Clin Cancer Res. 2015;21:870–81.

    Article  PubMed  CAS  Google Scholar 

  96. Morris LG, Chandramohan R, West L, Zehir A, Chakravarty D, Pfister DG, Wong RJ, Lee NY, Sherman EJ, Baxi SS, Ganly I, Singh B, Shah JP, Shaha AR, Boyle JO, Patel SG, Roman BR, Barker CA, McBride SM, Chan TA, Dogan S, Hyman DM, Berger MF, Solit DB, Riaz N, Ho AL. The molecular landscape of recurrent and metastatic head and neck cancers: insights from a precision oncology sequencing platform. JAMA Oncol. 2016. https://doi.org/10.1001/jamaoncol.2016.1790.

  97. Sepiashvili L, Bruce JP, Huang SH, O'Sullivan B, Liu FF, Kislinger T. Novel insights into head and neck cancer using next-generation “omic” technologies. Cancer Res. 2015;75:480–6.

    Article  PubMed  CAS  Google Scholar 

  98. Nulton TJ, Olex AL, Dozmorov M, Morgan IM, Windle B. Analysis of the cancer genome atlas sequencing data reveals novel properties of the human papillomavirus 16 genome in head and neck squamous cell carcinoma. Oncotarget. 2017;8:17684–99.

    Article  PubMed  PubMed Central  Google Scholar 

  99. Walline HM, Goudsmit CM, McHugh JB, Tang AL, Owen JH, Teh BT, McKean E, Glover TW, Graham MP, Prince ME, Chepeha DB, Chinn SB, Ferris RL, Gollin SM, Hoffmann TK, Bier H, Brakenhoff R, Bradford CR, Carey TE. University of Michigan Head and Neck Specialized Program of Research Excellence (SPORE) Program. Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines. Head Neck. 2017;39:840–52.

    Article  PubMed  PubMed Central  Google Scholar 

  100. Gao G, Johnson SH, Vasmatzis G, Pauley CE, Tombers NM, Kasperbauer JL, Smith DI. Common fragile sites (CFS) and extremely large CFS genes are targets for human papillomavirus integrations and chromosome rearrangements in oropharyngeal squamous cell carcinoma. Genes Chromosomes Cancer. 2017;56:59–74.

    Article  PubMed  CAS  Google Scholar 

  101. Walline HM, Komarck CM, McHugh JB, Bellile EL, Brenner JC, Prince ME, McKean EL, Chepeha DB, Wolf GT, Worden FP, Bradford CR, Carey TE. Genomic integration of high-risk HPV alters gene expression in oropharyngeal squamous cell carcinoma. Mol Cancer Res. 2016;14:941–52.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  102. Kelly JR, Husain ZA, Burtness B. Treatment de-intensification strategies for head and neck cancer. Eur J Cancer. 2016;68:125–33.

    Article  PubMed  PubMed Central  Google Scholar 

  103. Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006;354(6):567e78.

    Article  Google Scholar 

  104. Marur S, Lee J-W, Cmelak A, Zhao W, Westra WH, Chung CH, et al. ECOG 1308: a phase II trial of induction chemotherapy followed by cetuximab with low dose versus standard dose IMRT in patients with HPV-associated resectable squamous cell carcinoma of the oropharynx (OP). In: ASCO Annual Meeting Proceedings, vol. 2012; 2012. p. 5566.

    Google Scholar 

  105. Cmelak A, Li S, Marur S, Zhao W, Westra WH, Chung CH, et al. Symptom reduction from IMRT dose deintensification: results from ECOG 1308 using the Vanderbilt Head and Neck Symptom Survey version 2 (VHNSS V2). In: ASCO Annual Meeting Proceedings, vol. 2015; 2015. p. 6021.

    Google Scholar 

  106. Lewis JS Jr, Khan RA, Masand RP, Chernock RD, Zhang Q, Al-Naief NS, Muller S, McHugh JB, Prasad ML, Brandwein-Gensler M, Perez-Ordonez B, El-Mofty SK. Recognition of nonkeratinizing morphology in oropharyngeal squamous cell carcinoma - a prospective cohort and interobserver variability study. Histopathology. 2012;60:427–36.

    Article  PubMed  Google Scholar 

  107. Gondim DD, Haynes W, Wang X, Chernock RD, El-Mofty SK, Lewis JS Jr. Histologic typing in oropharyngeal squamous cell carcinoma: a 4-year prospective practice study with p16 and high-risk HPV mRNA testing correlation. Am J Surg Pathol. 2016;40:1117–24.

    Article  PubMed  Google Scholar 

  108. Carpenter DH, El-Mofty SK, Lewis JS Jr. Undifferentiated carcinoma of the oropharynx: a human papillomavirus-associated tumor with a favorable prognosis. Mod Pathol. 2011;24:1306–12.

    Article  PubMed  CAS  Google Scholar 

  109. Lewis JS Jr, Scantlebury JB, Luo J, Thorstad WL. Tumor cell anaplasia and multinucleation are predictors of disease recurrence in oropharyngeal squamous cell carcinoma, including among just the human papillomavirus-related cancers. Am J Surg Pathol. 2012;36:1036–46.

    Article  PubMed  PubMed Central  Google Scholar 

  110. Lewis JS Jr, Ali S, Luo J, Thorstad WL, Madabhushi A. A quantitative histomorphometric classifier (QuHbIC) identifies aggressive versus indolent p16-positive oropharyngeal squamous cell carcinoma. Am J Surg Pathol. 2014;38:128–37.

    Article  PubMed  PubMed Central  Google Scholar 

  111. Bishop JA, Westra WH. Ciliated HPV-related carcinoma: a well-differentiated form of head and neck carcinoma that can be mistaken for a benign cyst. Am J Surg Pathol. 2015;39:1591–5.

    Article  PubMed  PubMed Central  Google Scholar 

  112. Radkay-Gonzalez L, Faquin W, McHugh JB, Lewis JS Jr, Tuluc M, Seethala RR. Ciliated adenosquamous carcinoma: expanding the phenotypic diversity of human papillomavirus-associated tumors. Head Neck Pathol. 2016;10:167–75.

    Article  PubMed  Google Scholar 

  113. Chen L, Al-Kzayer LF, Liu Y, Liu T. B-cell lymphomas involving Waldeyer’s ring characterized by distinctive clinical and histopathological features: a comparison of pediatric to adult patients. Oncotarget. 2017;8:11544–54.

    PubMed  PubMed Central  Google Scholar 

  114. Guimarães AC, de Carvalho GM, Bento LR, Correa C, Gusmão RJ. Clinical manifestations in children with tonsillar lymphoma: a systematic review. Crit Rev Oncol Hematol. 2014;90:146–51.

    Article  PubMed  Google Scholar 

  115. Tan LH. Lymphomas involving Waldeyer’s ring: placement, paradigms, peculiarities, pitfalls, patterns and postulates. Ann Acad Med Singap. 2004;33:15–26.

    PubMed  CAS  Google Scholar 

  116. Laskar S, Mohindra P, Gupta S, Shet T, Muckaden MA. Non-Hodgkin lymphoma of the Waldeyer’s ring: clinicopathologic and therapeutic issues. Leuk Lymphoma. 2008;49:2263–71.

    Article  PubMed  Google Scholar 

  117. Jing XM, Yu JR, Luo YK, Zhang SC, Liu JF, Li L, Wu P, Zhang ZH. Clinical characteristics and prognosis of primary Waldeyer’s ring and lymph node diffuse large B-cell lymphoma in the rituximab era. Leuk Res. 2017;60:89–93.

    Article  PubMed  Google Scholar 

  118. Lee SJ, Suh CW, Lee SI, Kim WS, Lee WS, Kim HJ, Choi CW, Kim JS, Shin HJ, Consortium for Improving Survival of Lymphoma. Clinical characteristics, pathological distribution, and prognostic factors in non-Hodgkin lymphoma of Waldeyer’s ring: nationwide Korean study. Korean J Intern Med. 2014;29:352–60.

    Article  PubMed  PubMed Central  Google Scholar 

  119. Oh SY, Kim WS, Kim JS, Kim SJ, Lee S, Lee DH, Won JH, Hwang IG, Kim MK, Lee SI, Chae YS, Yang DH, Kang HJ, Choi CW, Park J, Kim HJ, Kwon JH, Lee HS, Lee GW, Eom HS, Kwak JY, Lee WS, Suh C, Kim HJ. Multiple mucosa-associated lymphoid tissue organs involving marginal zone B cell lymphoma: organ-specific relationships and the prognostic factors. Consortium for improving survival of lymphoma study. Int J Hematol. 2010;92:510–7.

    Article  PubMed  Google Scholar 

  120. Brownson RJ, Jaques WE, LaMonte SE, Zollinger WK. Hypernephroma metastatic to the palatine tonsils. Ann Otol Rhinol Laryngol. 1979;88:235–40.

    Article  PubMed  CAS  Google Scholar 

  121. D’Antonio C, Lombardini A, Onesti CE, Falcone R, Romiti A, Lombardi M, Lauro S, Marchetti P. A rare case of palatin tonsillar metastasis from small cell lung cancer. Transl Lung Cancer Res. 2016;5:709–11.

    Article  PubMed  PubMed Central  Google Scholar 

  122. Unsal M, Kutlar G, Sullu Y, Yurtlu S. Tonsillar metastasis of small cell lung carcinoma. Clin Respir J. 2016;10:681–3.

    Article  PubMed  Google Scholar 

  123. Tajima S, Koda K. Palatine tonsillar metastasis of a small pulmonary adenocarcinoma showing an invasive micropapillary carcinoma pattern and Pagetoid spread at the tonsil: a case suggesting retrograde lymphatic metastasis from bulky lymph node metastases of the neck. Int J Clin Exp Pathol. 2015;8:13601–5.

    PubMed  PubMed Central  Google Scholar 

  124. Niu FY, Zhou Q, Yang JJ, Zhong WZ, Chen ZH, Deng W, He YY, Chen HJ, Zeng Z, Ke EE, Zhao N, Zhang N, Sun HW, Zhang QY, Xie Z, Zhang XC, Wu YL. Distribution and prognosis of uncommon metastases from non-small cell lung cancer. BMC Cancer. 2016. https://doi.org/10.1186/s12885-016-2169-5.

  125. Sera T, Kashiwagi S, Takashima T, Asano Y, Goto W, Iimori N, Noda S, Onoda N, Ohsawa M, Hirakawa K, Ohira M. Multiple metastatic malignant phyllodes tumor of the breast with tonsillar metastasis: a case report. BMC Res Notes. 2017. https://doi.org/10.1186/s13104-017-2375-5.

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    Margaret S. Brandwein-Weber

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Brandwein-Weber, M.S. (2018). Oropharynx, Hypopharynx, and Parapharyngeal Space: Anatomy, Histology, Benign and Malignant Neoplasia. In: Textbook of Head and Neck Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-76106-0_4

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