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Textbook of Head and Neck Pathology pp 15–80Cite as

Oral Cavity: Nonneoplastic and Benign Neoplasia

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Abstract

The universal challenge of writing about diagnostic surgical pathology is the flawed process of distilling experiential learning at the microscope into words on a page. Experiencing pathology and reading about pathology, are two very different processes that will forever be entwined. One cannot become a pathologist and maintain competency without be grounded in both. This massive chapter covers the wide array of autoimmune, infectious, idiopathic, and benign processes, and benign tumors that can affect the oral cavity; its very diversity defies summary into key points. My goal is to strike the right balance of tersely presented information, diagnostic descriptors, pitfalls, and histological examples, to companion you, as you experience oral pathology.

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References

  1. Kurago ZB. Etiology and pathogenesis of oral lichen planus: an overview. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122:72–80.

    Article  PubMed  Google Scholar 

  2. Edwards PC, Kelsch R. Oral lichen planus: clinical presentation and management. J Can Dent Assoc. 2002;68:494–9.

    PubMed  Google Scholar 

  3. Patil A, Prasad S, Ashok L, Sujatha GP. Oral bullous lichen planus: case report and review of management. Contemp Clin Dent. 2012;3:344–8.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Garouhi F, Davari P, Fazel N. Cutaneous and mucosal lichen planus: a comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis. Sci World J. 2014;2014:22. 742826 https://doi.org/10.1155/2014/742826.

  5. Gupta S, Ghosh S, Gupta S. Interventions for the management of oral lichen planus: a review of the conventional and novel therapies. Oral Dis. 2017. https://doi.org/10.1111/odi.12634.

  6. Santoro FA, Stoopler ET, Werth VP. Pemphigus. Dent Clin N Am. 2013;57:597–610.

    Article  PubMed  Google Scholar 

  7. Ruocco E, Wolf R, Ruocco V, Brunetti G, Romano F, Lo Schiavo A. Pemphigus: associations and management guidelines: facts and controversies. Clin Dermatol. 2013;31:382–90.

    Article  PubMed  Google Scholar 

  8. Atzmony L, Hodak E, Leshem YA, Rosenbaum O, Gdalevich M, Anhalt GJ, Mimouni D. The role of adjuvant therapy in pemphigus: a systematic review and meta-analysis. J Am Acad Dermatol. 2015;73:264–71.

    Article  PubMed  Google Scholar 

  9. Yasukochi A, Teye K, Ishii N, Hashimoto T. Clinical and immunological studies of 332 Japanese patients tentatively diagnosed as anti-BP180-type mucous membrane pemphigoid: a novel BP180 C-terminal domain enzyme-linked immunosorbent assay. Acta Derm Venereol. 2016;96:762–7.

    PubMed  CAS  Google Scholar 

  10. Amber KT, Bloom R, Hertl M. A systematic review with pooled analysis of clinical presentation and immunodiagnostic testing in mucous membrane pemphigoid: association of anti-laminin-332 IgG with oropharyngeal involvement and the usefulness of ELISA. J Eur Acad Dermatol Venereol. 2016;30:72–7.

    Article  PubMed  CAS  Google Scholar 

  11. Balasubramaniam R, Kuperstein AS, Stoopler ET. Update on oral herpes virus infections. Dent Clin N Am. 2014;58:265–80.

    Article  PubMed  Google Scholar 

  12. Jiang YC, Feng H, Lin YC, Guo XR. New strategies against drug resistance to herpes simplex virus. Int J Oral Sci. 2016;8:1–6.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. Yadav S, Malik S, Mittal HC, Singh G, Kamra H. Bimaxillary oral focal mucinosis. J Craniofac Surg. 2016;27:e665–7.

    Article  PubMed  Google Scholar 

  14. Joshi CP, Dani NH, Mahale SA, Patel NR. A case of oral focal mucinosis of gingiva: lesion in disguise. J Indian Soc Periodontol. 2015;19:586–8.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Rambhia KD, Khopkar US. Verrucous oral focal mucinosis. Indian J Dermatol Venereol Leprol. 2016;82:330–2.

    Article  PubMed  Google Scholar 

  16. Kauzman A, Pavone M, Blanas N, Bradley G. Pigmented lesions of the oral cavity: review, differential diagnosis, and case presentations. J Can Dent Assoc. 2004;70:682–3.

    PubMed  Google Scholar 

  17. Marakoğlu K, Gürsoy UK, Toker HC, Demirer S, Sezer RE, Marakoğlu I. Smoking status and smoke-related gingival melanin pigmentation in army recruitments. Mil Med. 2007;172:110–3.

    Article  PubMed  Google Scholar 

  18. Sarswathi TR, Kumar SN, Kavitha KM. Oral melanin pigmentation in smoked and smokeless tobacco users in India. Clinico-pathological study. Indian J Dent Res. 2003;14:101–6.

    PubMed  CAS  Google Scholar 

  19. Gondak RO, da Silva-Jorge R, Jorge J, Lopes MA, Vargas PA. Oral pigmented lesions: clinicopathologic features and review of the literature. Med Oral Patol Oral Cir Bucal. 2012;17:e919–24.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Ferreira L, Jham B, Assi R, Readinger A, Kessler HP. Oral melanocytic nevi: a clinicopathologic study of 100 cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;120:358–67.

    Article  PubMed  Google Scholar 

  21. Marangon Júnior H, Souza PE, Soares RV, de Andrade BA, de Almeida OP, Horta MC. Oral congenital melanocytic nevus: a rare case report and review of the literature. Head Neck Pathol. 2015;9:481–7.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Magliocca KR, Fitzpatrick SG. Autoimmune disease manifestations in the oral cavity. Surg Pathol Clin. 2017;10:57–88.

    Article  PubMed  Google Scholar 

  23. Nandini DB, Bhavana SB, Deepak BS, Ashwini R. Paediatric geographic tongue: a case report, review and recent updates. J Clin Diagn Res. 2016;31. https://doi.org/10.7860/JCDR/2016/16452.7191.

  24. Dafar A, Bankvall M, Garsjö V, Jontell M, Çevik-Aras H. Salivary levels of interleukin-8 and growth factors are modulated in patients with geographic tongue. Oral Dis. 2017. https://doi.org/10.1111/odi.12654.

  25. Seiden G, Curland S. The tongue as an excitable medium. New J Phys. 2015;31:1–8.

    Google Scholar 

  26. Goregen M, Miloglu O, Buyukkurt MC, Caglayan F, Aktas AE. Median rhomboid glossitis: a clinical and microbiological study. Eur J Dent. 2011;5:367–72.

    PubMed  PubMed Central  Google Scholar 

  27. Ghabanchi J, Tadbir A, Darafshi R, Sadegholvad M. The prevalence of median rhomboid glossitis in diabetic patients: a case-control study. Iran Red Crescent Med J. 2011;13:503–6.

    PubMed  PubMed Central  CAS  Google Scholar 

  28. Williams D, Lewis M. Pathogenesis and treatment of oral candidosis. J Oral Microbiol. 2011;3. https://doi.org/10.3402/jom.v3i0.5771.

  29. Singh A, Verma R, Murari A, Agrawal A. Oral candidiasis: an overview. J Oral Maxillofac Pathol. 2014;18:S81–5.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Junqueira JC, Fuchs BB, Muhammed M, Coleman JJ, Suleiman JMAH, Vilela SFG, Costa ACB, Rasteiro VMC, Jorge AOC, Mylonakis E. Oral Candida albicans isolates from HIV-positive individuals have similar in vitro biofilm-forming ability and pathogenicity as invasive Candida isolates. BMC Microbiol. 2011;11:247–56.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  31. Dongari-Bagtzoglou A, Dwivedi P, Ioannidou E, Shaqman M, Hull D, Burleson J. Oral Candida infection and colonization in solid organ transplant recipients. Oral Microbiol Immunol. 2009;24:249–54.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  32. Choudhary S, McLeod M, Torchia D, Romanelli P. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Clin Aesthet Dermatol. 2012;5:18–22.

    Google Scholar 

  33. Ferre EMN, Rose RS, Rosenzweig SD, Burbelo PD, Romito KR, Niemela JE, Rosen LB, Break TJ, Gu W, Hunsberger S, Browne SK, Hsu AP, Rampertaap S, Swamydas M, Collar AL, Kong HH, Chyi-Chia RL, Chascsa D, Simcox T, Pham A, Bondici A, Natarajan M, Monsale J, Kleiner DE, Quezado M, Alevizos I, Moutsopoulos NM, Yockey L, Frein C, Soldatos A, Calvo KR, Adjemian J, Similuk MN, Lang DM, Stone KD, Uzel G, Kopp JB, Bishop RJ, Holland SM, Olivier KN, Fleisher TA, Heller T, Winer KK, Lionakis MS. Redefined clinical features and diagnostic criteria in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. JCI Insight. 2016;1(13):e88782. Published online 2016 Aug 18. https://doi.org/10.1172/jci.insight.88782.

    Article  PubMed  PubMed Central  Google Scholar 

  34. O’Donnell LE, Robertson D, Nile CJ, Cross LJ, Riggio M, Sherriff A, Bradshaw D, Lambert M, Malcolm J, Buijs MJ, Zaura E, Crielaard W, Brandt BW, Ramage G. The oral microbiome of denture wearers is influenced by levels of natural dentition. PLoS One. 2015;10(9):e0137717. https://doi.org/10.1371/journal.pone.0137717.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  35. Chandra J, Mukherjee PK. Candida biofilms: development, architecture, and resistance. Microbiol Spectr. 2015;3. https://doi.org/10.1128/microbiolspec.MB-0020-2015.

  36. Taff HT, Mitchell KF, Edward JA, Andes DR. Mechanisms of Candida biofilm drug resistance. Future Microbiol. 2013;8. https://doi.org/10.2217/fmb.13.101.

  37. Castro LA, Castro JGLE, Cruz ADL, Barbosa BHDS, Spindula-Filho JV, Costa MB. Focal epithelial hyperplasia (Heck’s disease) in a 57-year-old Brazilian patient: a case report and literature review. J Clin Med Res. 2016;8:346–50.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Ozden B, Gunduz K, Gunhan O, Ozden FO. A case report of focal epithelial hyperplasia (Heck’s disease) with PCR detection of human papillomavirus. J Maxillofac Oral Surg. 2011;10:357–60.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Mansouri Z, Bakhtiari S, Noormohamadi R. Extensive focal epithelial hyperplasia: a case report. Iran J Pathol. 2015;10:300–5.

    PubMed  PubMed Central  Google Scholar 

  40. Galanakis A, Palaia G, Tenore G, Del Vecchio A, Romeo U. Focal epithelial hyperplasia in a human immuno-deficiency virus patient treated with laser surgery. World J Clin Cases. 2014;2:293–6.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Steinhoff M, Metze D, Stockfleth E, Luger TA. Successful topical treatment of focal epithelial hyperplasia (Heck’s disease) with interferon-beta. Brit J Dermatol. 2001;144:1067–9.

    Article  CAS  Google Scholar 

  42. Pfister H, Hettich I, Runne U, Gissmann L, Chilf GN. Characterization of human papillomavirus type 13 from focal epithelial hyperplasia Heck lesions. J Virol. 1983;47:363–6.

    PubMed  PubMed Central  CAS  Google Scholar 

  43. Bascones-Martinez A, Cok S, Bascones-Ilundain C, Arias-Herrera S, Gomez-Font R, Bascones-Ilundain J. Multifocal epithelial hyperplasia: a potentially precancerous disease? Oncol Lett. 2012;3:255–8.

    Article  PubMed  CAS  Google Scholar 

  44. Gupta RR, Puri UP, Mahajan BB, Sahni SS, Garg G. Intraoral giant condyloma accuminatum. Indian J Dermatol Venerol Leprol. 2001;67:264–5.

    CAS  Google Scholar 

  45. Ozdamar SS, Ozdamar O, Kucukodaci Z. Giant intraoral condyloma accuminatum lesion coexisting with genital condyloma. Pak J Med Sci. 2014;30:1143–6.

    PubMed  PubMed Central  Google Scholar 

  46. McNamara K, Allen C, Kalmar J. Multiple papillary lesions of the gingival. J Am Dent Assoc. 2013;144:279–82.

    Article  PubMed  Google Scholar 

  47. Percinoto AC, Danelon M, Crivelini MM, Cunha RF, Percinoto C. Condyloma acuminata in the tongue and palate of a sexually abused child: a case report. BMC Res Notes. 2014;7:467–74.

    Article  PubMed  PubMed Central  Google Scholar 

  48. King MD, Reznik DA, O’Daniels CM, Larsen NM, Osterholt D, Blumberg HM. Human papillomavirus-associated oral warts among human immunodeficiency virus-seropositive patients in the era of highly active antiretroviral therapy: an emerging infection. Clin Infect Dis. 2002;34:641–8.

    Article  PubMed  Google Scholar 

  49. Curi DS, Leite-Ribeiro PM, Torregrossa VR, Vieira VC, Sarmento VA. Efficacy of imidazolquinoline on treatment of condyloma acuminatum of the buccal mucosa. Spec Care Dentist. 2017;37:51–4.

    Article  PubMed  Google Scholar 

  50. Braz-Silva PH, Rezende NPM, Ortega KL, Santos RTM, Magalhães MHCG. Detection of the Epstein–Barr Virus (EBV) by in-situ hybridization as definitive diagnosis of hairy leukoplakia. Head Neck Pathol. 2008;2:19–24.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Zakrzewska JM, Aly Z, Speight PM. Oral hairy leukoplakia in a HIV-negative asthmatic patient on systemic steroids. J Oral Pathol Med. 1995;24:282–4.

    Article  PubMed  CAS  Google Scholar 

  52. Piperi E, Omlie J, Koutlas IG, Pambuccian S. Oral hairy leukoplakia in HIV-negative patients: report of 10 cases. Int J Surg Pathol. 2010;18:177–83.

    Article  PubMed  Google Scholar 

  53. Chambers AE, Conn B, Pemberton M, Robinson M, Banks R, Sloan P. Twenty-first-century oral hairy leukoplakia--a non-HIV-associated entity. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119:326–32.

    Article  PubMed  Google Scholar 

  54. Fornatora ML, Reich RF, Gray RG, Freedman PD. Intraoral molluscum contagiosum: a report of a case and a review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92:318–20.

    Article  PubMed  CAS  Google Scholar 

  55. de Carvalho CH, de Andrade AL, de Oliveira DH, de Araújo Lima ED, da Silveira EJ, de Medeiros AM. Intraoral molluscum contagiosum in a young immunocompetent patient. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114:e57–60.

    Article  PubMed  Google Scholar 

  56. Sharma D, McKendry A, Nageshwaran S, Cartledge J. A case of oral ulceration and disseminated histoplasmosis in HIV infection. Int J STD AIDS. 2012;23:522–3.

    Article  PubMed  CAS  Google Scholar 

  57. Mohammed S, Sinha M, Chavan P, Premalata C, Shivaprakash M, Chakrabarti A, Jayshree RS. Oral histoplasmosis masquerading as oral cancer in HIV-infected patient: a case report. Med Mycol Case Rep. 2012;18:85–7.

    Article  Google Scholar 

  58. Vidyanath S, Shameena P, Sudha S, Nair RG. Disseminated histoplasmosis with oral and cutaneous manifestations. J Oral Maxillofac Pathol. 2013;17:139–42.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  59. de Paulo LF, Rosa RR, Durighetto Júnior AF. Primary localized histoplasmosis: oral manifestations in immunocompetent patients. Int J Infect Dis. 2013;17:e139–40.

    Article  PubMed  Google Scholar 

  60. Klein IP, Martins MA, Martins MD, Carrard VC. Diagnosis of HIV infection on the basis of histoplasmosis-related oral ulceration. Spec Care Dentist. 2016;36:99–103.

    Article  PubMed  Google Scholar 

  61. Folk GA, Nelson BL. Oral histoplasmosis. Head Neck Pathol. 2017. https://doi.org/10.1007/s12105-017-0797-y.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Marla V, Shrestha A, Goel K, Shrestha S. The histopathological spectrum of pyogenic granuloma: a case series. Case Rep Dent. 2016;2016:1323798. https://doi.org/10.1155/2016/1323798.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Gomes SR, Shakir QJ, Thaker PV, Tavadia JK. Pyogenic granuloma of the gingiva: a misnomer? – a case report and review of literature. J Indian Soc Periodontol. 2013;17:514–9.

    Article  PubMed  PubMed Central  Google Scholar 

  64. Sachdeva SK. Extragingival pyogenic granuloma: an unusual clinical presentation. J Dent (Shiraz). 2015;16:282–5.

    Google Scholar 

  65. Anitua E, Pinas L. Pyogenic granuloma in relation to dental implants: clinical and histopathological findings. J Clin Exp Dent. 2015;7:e447–50.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Kang YH, Byun JH, Choi MJ, Lee JS, Jang JH, Kim YI, Park BW. Co-development of pyogenic granuloma and capillary hemangioma on the alveolar ridge associated with a dental implant: a case report. J Med Case Rep. 2014;8:192. https://doi.org/10.1186/1752-1947-8-192.

    Article  PubMed  PubMed Central  Google Scholar 

  67. Thada SR, Pai KM, Agarwal P. A huge oral pyogenic granuloma with extensive alveolar bone loss and ‘sun-ray’ appearance mimicking a malignant tumour. BMJ Case Rep. 2014. https://doi.org/10.1136/bcr-2013-20236.

  68. George SMC, Gossain SR, Morrison IK, Coburn PR. Recurrent pyogenic granuloma with satellitosis. BMJ Case Rep. 2012. https://doi.org/10.1136/bcr.11.2011.5162.

  69. Erbasar GNH, Senguven B, Gultekin SE, Cetiner S. Management of a recurrent pyogenic granuloma of the hard palate with diode laser: a case report. J Lasers Med Sci. 2016;7:56–61.

    Article  Google Scholar 

  70. Shadman N, Ebrahimi SF, Jafari S, Eslami M. Peripheral giant cell granuloma: a review of 123 cases. Dent Res J. 2009;6:47–50.

    Google Scholar 

  71. Ogbureke EI, Vigneswaran N, Seals M, Frey G, Johnson CD, Ogbureke KUE. A peripheral giant cell granuloma with extensive osseous metaplasia or a hybrid peripheral giant cell granuloma-peripheral ossifying fibroma: a case report. J Med Case Rep. 2015. https://doi.org/10.1186/1752-1947-9-14.

  72. Gupta M, Gupta M, Singh S, Kaur R. Central giant cell granuloma of the maxilla. BMJ Case Rep. 2013. https://doi.org/10.1136/bcr-2013-009102.

  73. Ishinaga H, Otsu K, Mouri G, Takeuchi K. Aggressive giant cell reparative granuloma of the nasal cavity. Case Rep Otolaryngol. 2013. https://doi.org/10.1155/2013/690194.

  74. Jadu FM, Pharoah MJ, Lee L, Baker GI, Allidina A. Central giant cell granuloma of the mandibular condyle: a case report and review of the literature. Dentomaxillofac Radiol. 2011;40:60–4.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  75. Yadav S, Singh A, Kumar P, Tyagi S. Recurrent case of central giant cell granuloma with multiple soft tissue involvement. Natl J Maxillofac Surg. 2014;5:60–6.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Shen WR, Chang JY, Wu YC, Cheng SJ, Chen HM, Wang YP. Oral traumatic ulcerative granuloma with stromal eosinophilia: a clinicopathological study of 34 cases. J Formos Med Assoc. 2015;114:881–5.

    Article  PubMed  Google Scholar 

  77. Sharma B, Koshy G, Kapoor S. Traumatic ulcerative granuloma with stromal eosinophila: a case report and review of pathogenesis. J Clin Diagn Res. 2016;10:ZD07–9.

    PubMed  PubMed Central  Google Scholar 

  78. Sarangarajan R, Vaishnavi Vedam VK, Sivadas G, Sarangarajan A, Meera S. Traumatic ulcerative granuloma with stromal eosinophilia – mystery of pathogenesis revisited. J Pharm Bioallied Sci. 2015;7:S420–3.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  79. Brasileiro BF, Alves DB, Andrade BA, Vargas PA, León JE, Almeida OP. Traumatic ulcerative granuloma with stromal eosinophilia of the palate showing an angiocentric/angiodestructive growth pattern. Contemp Clin Dent. 2012;3:S109–11.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  80. Gagari E, Stathopoulos P, Katsambas A, Avgerinou G. Traumatic ulcerative granuloma with stromal eosinophilia: a lesion with alarming histopathologic presentation and benign clinical course. Am J Dermatopathol. 2011;33:192–4.

    Article  PubMed  Google Scholar 

  81. Hirshberg A, Amariglio N, Akrish S, Yahalom R, Rosenbaum H, Okon E, Kaplan I. Traumatic ulcerative granuloma with stromal eosinophilia: a reactive lesion of the oral mucosa. Am J Clin Pathol. 2006;126:522–9.

    Article  PubMed  CAS  Google Scholar 

  82. Alves MGO, Kitakawa D, Carvalho YR, Cabral LAG, Almeida JD. Necrotizing sialometaplasia as a cause of a non-ulcerated nodule in the hard palate: a case report. J Med Case Rep. 2011. https://doi.org/10.1186/1752-1947-5-406.

  83. Gatti A, Broccardo E, Poglio G, Benech A. Necrotizing sialometaplasia of the hard palate in a patient treated with topical nonsteroidal anti-inflammatory drug. Case Rep Dent. 2016. https://doi.org/10.1155/2016/9545861.

  84. Samir A, Joshi SA, Rajshekhar Halli R, Vaishali Koranne V, Sarita Singh S. Necrotizing sialometaplasia: a diagnostic dilemma! J Oral Maxillofac Pathol. 2014;18:420–2.

    Article  Google Scholar 

  85. Krishna S, S Ramnarayan BK. Necrotizing sialometaplasia of palate: a case report. Imaging Sci Dent. 2011;41:35–8.

    Article  PubMed  PubMed Central  Google Scholar 

  86. Yagi T, Ueda H, Amitani H, Asakawa A, Miyawaki S, Inui A. The role of ghrelin, salivary secretions, and dental care in eating disorders. Forum Nutr. 2012;4:967–89.

    CAS  Google Scholar 

  87. Khan FY, Jan SM, Mushtaq M. Multicentric peripheral ossifying fibroma: a case report and review of the literature. J Indian Soc Periodontol. 2013;17:648–52.

    Article  PubMed  PubMed Central  Google Scholar 

  88. Sousa SF, Caldeira PC, Grossmann SMC, de Aguiar MCF, Mesquita RA. Desmoplastic fibroblastoma (Collagenous fibroma): a case identified in the buccal mucosa. Head Neck Pathol. 2011;5:175–9.

    Article  PubMed  PubMed Central  Google Scholar 

  89. Bhagalia S, Jain M, Pardhe N, Sireesha SK. Collagenous fibroma (desmoplastic fibroblastoma) of the oral cavity. J Oral Maxillofac Pathol. 2012;16:277–9.

    Article  PubMed  PubMed Central  Google Scholar 

  90. Darling MR, Kutalowski M, MacPherson DG, Jackson-Boeters L, Wysocki GP. Oral elastofibromatous lesions: a review and case series. Head Neck Pathol. 2011;5:254–8.

    Article  PubMed  PubMed Central  Google Scholar 

  91. Narayen V, Ahmed SA, Suri C, Tanveer S. Myofibroma of the gingiva: a rare case report and literature review. Case Rep Dent. 2015. https://doi.org/10.1155/2015/243894.

  92. Lee YM, Son SM, Kim KW, Lee OJ. Solitary myofibroma of the adult mandible: a case report and review of literature. Korean J Pathol. 2014;48:307–10.

    Article  PubMed  PubMed Central  Google Scholar 

  93. Satomi T, Kohno M, Enomoto A, Abukawa H, Fujikawa K, Koizumi T, Chikazu D, Matsubayashi J, Nagao T. Solitary myofibroma of the mandible: an immunohistochemical and ultrastructural study with a review of the literature. Med Mol Morphol. 2014;47:176–83.

    Article  PubMed  CAS  Google Scholar 

  94. Aiki M, Yoshimura H, Ohba S, Kimura S, Imamura Y, Sano K. Rapid growing myofibroma of the gingiva: report of a case and review of the literature. J Oral Maxillofac Surg. 2014;72:99–105.

    Article  PubMed  Google Scholar 

  95. Haspel AC, Coviello VF, Stevens M, Robinson PG. Myofibroma of the mandible in an infant: case report, review of the literature, and discussion. J Oral Maxillofac Surg. 2012;70:1599–604.

    Article  PubMed  Google Scholar 

  96. Foss RD, Ellis GL. Myofibromas and myofibromatosis of the oral region: a clinicopathologic analysis of 79 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89:57–65.

    Article  PubMed  CAS  Google Scholar 

  97. Loukas M, Hulsberg P, Tubbs RS, Kapos T, Wartmann CT, Shaffer K, Moxham BJ. The tori of the mouth and ear: a review. Clin Anat. 2013;26:953–60.

    Article  PubMed  Google Scholar 

  98. García-García AS, Martínez-González JM, Gómez-Font R, Soto-Rivadeneira A, Oviedo-Roldán L. Current status of the torus palatinus and torus mandibularis. Med Oral Patol Oral Cir Bucal. 2010;15:e353–60.

    Article  PubMed  Google Scholar 

  99. Gonsalves WC, Chi AC, Neville BW. Common oral lesions: Part II. Masses and neoplasia. Am Fam Physician. 2007;75:509–12.

    PubMed  Google Scholar 

  100. Mahajan D, Khurana N, Setia N. Sialadenoma papilliferum in a young patient: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:e51–4.

    Article  PubMed  Google Scholar 

  101. Gomes AP, Sobral AP, Loducca SV, de Araújo VC. Sialadenoma papilliferum: immunohistochemical study. Int J Oral Maxillofac Surg. 2004;33:621–4.

    Article  PubMed  CAS  Google Scholar 

  102. Brannon RB, Sciubba JJ, Giulani M. Ductal papillomas of salivary gland origin: a report of 19 cases and a review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92:68–77.

    Article  PubMed  CAS  Google Scholar 

  103. Argyres MI, Golitz LE. Sialadenoma papilliferum of the palate: case report and literature review. J Cutan Pathol. 1999;26:259–62.

    Article  PubMed  CAS  Google Scholar 

  104. Markopoulos A, Kayavis I, Papanayotou P. Sialadenoma papilliferum of the oral cavity: report of a case and literature review. J Oral Maxillofac Surg. 1997;55:1181–4.

    Article  PubMed  CAS  Google Scholar 

  105. Liu W, Gnepp DR, de Vries E, Bibawy H, Solomon M, Gloster ES. Mucoepidermoid carcinoma arising in a background of sialadenoma papilliferum: a case report. Head Neck Pathol. 2009;3:59–62.

    Article  PubMed  PubMed Central  Google Scholar 

  106. Solomon MP, Rosen Y, Alfonso A. Intraoral papillary squamous cell tumor of the soft palate with features of sialadenoma papilliferum-? malignant sialadenoma papilliferum. Cancer. 1978;42:1859–69.

    Article  PubMed  CAS  Google Scholar 

  107. Shimoda M, Kameyama K, Morinaga S, Tanaka Y, Hashiguchi K, Shimada M, Okada Y. Malignant transformation of sialadenoma papilliferum of the palate: a case report. Virchows Arch. 2004;445:641–6.

    Article  PubMed  Google Scholar 

  108. Ponniah I. A rare case of sialadenoma papilliferum with epithelial dysplasia and carcinoma in situ. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104:e27–9.

    Article  PubMed  CAS  Google Scholar 

  109. Lack EE, Worsham GF, Callihan MD, Crawford BE, Klappenbach S, Rowden G, Chun B. Granular cell tumor: a clinicopathologic study of 110 patients. J Surg Oncol. 1980;13:301–16.

    Article  PubMed  CAS  Google Scholar 

  110. Van de Loo S, Thunnissen E, Postmus P, Van der Waal I. Granular cell tumor of the oral cavity; a case series including a case of metachronous occurrence in the tongue and the lung. Med Oral Patol Oral Cir Bucal. 2015;20:e30–3.

    PubMed  Google Scholar 

  111. Barbieri M, Musizzano Y, Boggio M, Carcuscua C. Granular cell tumour of the tongue in a 14-year-old boy: case report. Acta Otorhinolaryngol Ital. 2011;31:186–9.

    PubMed  PubMed Central  CAS  Google Scholar 

  112. Cole E, Rahman N, Webb R. Case series: two cases of an atypical presentation of oral granular cell tumour. Case Rep Med. 2012. https://doi.org/10.1155/2012/159803.

  113. Vera-Sirera B, Zabala P, Aviño-Mira C, Vera-Sempere FJ. Multiple granular cell tumors with metachronous occurrence in tongue and vulva. Clinicopathological and immunohistochemical study. J Oral Maxillofac Pathol. 2014;18:437–41.

    Article  PubMed  PubMed Central  Google Scholar 

  114. Tobouti PL, Pigatti FM, Martins-Mussi MC, Sedassari BT. Orsini-Machado de Sousa SC: extra-tongue oral granular cell tumor: Histological and immunohistochemical aspect. Med Oral Patol Oral Cir Bucal. 2017;22:e31–5.

    PubMed  Google Scholar 

  115. Li X, Parke RB, Rushton JR, Sienko AS, Zhai QJ. An unusually large granular cell tumor of the pharynx: a case report and literature review. Int J Clin Exp Pathol. 2009;2:300–2.

    PubMed  Google Scholar 

  116. Solomon LW, Velez I. S-100 negative granular cell tumor of the oral cavity. Head Neck Pathol. 2016;10:367–73.

    Article  PubMed  Google Scholar 

  117. Ferreira JCB, Oton-Leite AF, Guidi R, Mendonça EF. Granular cell tumor mimicking a squamous cell carcinoma of the tongue: a case report. BMC Res Notes. 2017. https://doi.org/10.1186/s13104-016-2325-7.

  118. Said-Al-Naief N, Brandwein M, Lawson W, Gordon R, Lumerman H. Synchronous lingual granular cell tumor and squamous cell carcinoma: a case report and review of literature. Arch Otolaryngol Head Neck Surg. 1997;123:543–7.

    Article  PubMed  CAS  Google Scholar 

  119. Tucker MC, Rusnock EJ, Azumi N, Hoy GR, Lack EE. Gingival granular cell tumors of the newborn. An ultrastructural and immunohistochemical study. Arch Pathol Lab Med. 1990;114:895–8.

    PubMed  CAS  Google Scholar 

  120. Lack EE, Perez-Atayde AR, McGill TJ, Vawter GF. Gingival granular cell tumor of the newborn (congenital “epulis”): ultrastructural observations relating to histogenesis. Hum Pathol. 1982;13:686–9.

    Article  PubMed  CAS  Google Scholar 

  121. Bang KO, Bodhade AS, Dive AM. Congenital granular cell epulis of a newborn. Dent Res J (Isfahan). 2012;9(Suppl 1):S136–8.

    Google Scholar 

  122. Aparna HG, Jayanth BS, Shashidara R, Jaishankar P. Congenital epulis in a newborn: a case report, immunoprofiling and review of literature. Ethiop J Health Sci. 2014;24:359–62.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  123. Kumar R, Jaiswal S, Singhal A, Garg R. Congenital granular cell lesion: a rare tumor of new born. J Oral Maxillofac Pathol. 2013;17:440–2.

    Article  PubMed  PubMed Central  Google Scholar 

  124. Kailash Narasimhan K, Arneja JS, Rabah R. Treatment of congenital epulis (granular cell tumour) with excision and gingivoperiosteoplasty. Can J Plast Surg. 2007;15:215–8.

    Article  PubMed  PubMed Central  Google Scholar 

  125. Yuwanati M, Mhaske S, Mhaske A. Congenital granular cell tumor – a rare entity. J Neonatal Surg. 2015;4(2):17. PMCID: PMC4447470

    PubMed  PubMed Central  Google Scholar 

  126. McGuire LS, Yakoub D, Möller MG, Rosenberg A, Livingstone A. Malignant granular cell tumor of the back: a case report and review of the literature. Case Rep Med. 2014. https://doi.org/10.1155/2014/794648.

  127. Meling TR, Fridrich K, Evensen JF, Nedregaard B. Malignant granular cell tumor of the skull base. Skull Base. 2008;18:59–66.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  128. Morita S, Hiramatsu M, Sugishita M, Gyawali B, Shibata T, Shimokata T, Urakawa H, Mitsuma A, Moritani S, Kubota T, Ichihara S, Ando Y. Pazopanib monotherapy in a patient with a malignant granular cell tumor originating from the right orbit: a case report. Oncol Lett. 2015;10:972–4.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  129. Brandwein M, Le Benger J, Strauchen J, Biller H. Atypical granular cell tumor of the larynx. Head Neck Surg. 1990;12:154–9.

    Article  CAS  Google Scholar 

  130. Trey LA, Schmid S, Huber GF. Multifocal adult rhabdomyoma of the head and neck manifestation in 7 locations and review of the literature. Case Rep Otolaryngol. 2013. https://doi.org/10.1155/2013/758416.

  131. Souza AA, Araújo VC, Santos FP, Martinez EF, Filho JFM, Araujo NS, Soares AB. Intraoral adult rhabdomyoma: a case report. Case Rep Dent. 2013. https://doi.org/10.1155/2013/741548.

  132. Helliwell TR, Sissons MC, Stoney PJ, Ashworth MT. Immunochemistry and electron microscopy of head and neck rhabdomyoma. J Clin Pathol. 1988;41:1058–63.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  133. Maglio R, Francesco S, Paolo M, Stefano V, Francesco D, Giovanni R. Voluminous extracardiac adult rhabdomyoma of the neck: a case presentation. Case Rep Surg. 2012. https://doi.org/10.1155/2012/984789.

  134. Pinho MM, Castro JC, Ramos RG. Adult rhabdomyoma of the larynx. Int Arch Otorhinolaryngol. 2013;17:415–8.

    Article  PubMed  PubMed Central  Google Scholar 

  135. Limbach AL, Goyal A. Adult rhabdomyoma: a challenging diagnosis on cytology. Cytojournal. 2012. https://doi.org/10.4103/1742-6413.100124.

  136. Wang CP, Chang YH, Chang YT. Fetal rhabdomyoma of the right tonsil with polyp-like appearance. Case Rep Otolaryngol. 2015. https://doi.org/10.1155/2015/713278.

  137. Hettmer S, Teot LA, Kozakewich H, Werger AM, Davies KJ, Fletcher CDM, Grier HE, Rodriguez-Galindo C, Wagers AJ. Myogenic tumors in nevoid basal cell carcinoma syndrome. J Pediatr Hematol Oncol. 2015;37:147–9.

    Article  PubMed  PubMed Central  Google Scholar 

  138. Hettmer S, Teot LA, van Hummelen P, MacConaill L, Bronson RT, Dall’Osso C, Mao J, McMahon AP, Gruber PJ, Grier HE, Rodriguez-Galindo C, Fletcher CD, Wagers AJ. Mutations in Hedgehog pathway genes in fetal rhabdomyomas. J Pathol. 2013. https://doi.org/10.1002/path.4229.

  139. Cosso R, Nuzzo V, Zuccoli A, Brandi ML, Falchetti A. Giant cell tumor in a case of Paget’s disease of bone: an aggressive benign tumor exhibiting a quick response to an innovative therapeutic agent. Clin Cases Miner Bone Metab. 2010;7:145–52.

    PubMed  PubMed Central  Google Scholar 

  140. Kofoed K, Sand C, Forslund O, Madsen K. Prevalence of human papillomavirus in anal and oral sites among patients with genital warts. Acta Derm Venereol. 2014;94:207–11.

    Article  PubMed  Google Scholar 

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    Margaret S. Brandwein-Weber

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Brandwein-Weber, M.S. (2018). Oral Cavity: Nonneoplastic and Benign Neoplasia. In: Textbook of Head and Neck Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-76106-0_2

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