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Challenges of Endocrine Disruption and Cardiac Development

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Development and Environment

Abstract

The endocrine system plays a crucial role in the survival of animals. It regulates many signaling processes that control the cardiovascular, immune, reproductive, and central nervous systems. In addition to its role in maintaining the functions of major organ systems, signaling by the endocrine system is critical for normal development. For example, estrogen signaling has been shown to regulate cellular physiology by influencing its proliferation rate. With the diverse array of pathways that the endocrine system regulates, disruption by exogenous agents can impair vital functions, not just at the cellular and organismal levels but also at the population level. The integrated role of various biological systems and the interaction between organs can make it difficult to assess the effects of endocrine-disrupting compounds (EDCs). Adding to the challenges of studying the effects of EDCs is the complex series of signaling events that occur in a precise spatiotemporal manner during embryogenesis. However, using model organisms with a well-characterized developmental pattern such as zebrafish can facilitate the study of EDCs on physiological endpoints with apical relevance, such as cardiovascular development. Consequently, this review will focus on the developmental challenge of EDC exposure on cardiac development in aquatic organisms.

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    Graciel Diamante & Daniel Schlenk

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Diamante, G., Schlenk, D. (2018). Challenges of Endocrine Disruption and Cardiac Development. In: Burggren, W., Dubansky, B. (eds) Development and Environment. Springer, Cham. https://doi.org/10.1007/978-3-319-75935-7_13

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