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Liver Function

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Book cover Gastrointestinal Complications of Diabetes

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Abstract

The liver is designed to maintain the body’s chemical and metabolic homeostasis. It plays a major role in protein, carbohydrate, lipid, bile acid, and iron metabolism, and the body’s immune defense. About 90% of the body’s nutrients pass through the liver from the intestines. The liver is also responsible for the synthesis of many plasma proteins with different functions, and acts as a filter to remove harmful substances from the blood. Finally, it performs important endocrine functions. Knowledge of the relationship between structure and function of the liver under normal conditions is essential for understanding derangements observed in clinical diseases affecting the liver.

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References

  1. Ger R. Surgical anatomy of the liver. Surg Clin North Am. 1989;69:179–92.

    Article  CAS  PubMed  Google Scholar 

  2. Bismuth H. Surgical anatomy and anatomical surgery of the liver. World J Surg. 1982;6:3–9.

    Article  CAS  PubMed  Google Scholar 

  3. Skandalakis JE, Skandalakis LJ, Skandalakis PN, Mirilas P. Hepatic surgical anatomy. Surg Clin North Am. 2004;84:413–35.

    Article  PubMed  Google Scholar 

  4. Jamieson GG. The anatomy of general surgical operations. 2nd ed. Edinburgh/New York: Churchill Livingstone/Elsevier; 2006. p. 8–23.

    Google Scholar 

  5. Kogure K, Ishizaki M, Nemoto M, Kuwano H, Yorifuji H, Ishikawa H, et al. Close relation between the inferior vena cava ligament and the caudate lobe in the human liver. J Hepato-Biliary-Pancreat Surg. 2007;14:297–301.

    Article  Google Scholar 

  6. Ludwig J, Ritman EL, LaRusso NF, Sheedy PF, Zump G. Anatomy of the human biliary system studied by quantitative computer aided three-dimensional imaging techniques. Hepatology. 1998;27:893–9.

    Article  CAS  PubMed  Google Scholar 

  7. Blumgart LH, Belghiti J. Surgery of the liver, biliary tract, and pancreas. 3rd ed. Philadelphia: Saunders Elsevier; 2007. p. 3–30.

    Book  Google Scholar 

  8. Sherlock S. Assessment of liver function. In: Sherlock S, editor. Disease of liver and biliary system. 10th ed. London: Blackwell Science Ltd; 1997. p. 17–32.

    Google Scholar 

  9. Wijekoon EP, Skinner C, Brosnan ME, Brosnan JT. Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes. Can J Physiol Pharmacol. 2004;82:506–14.

    Article  CAS  PubMed  Google Scholar 

  10. Malandro MS, Kilberg MS. Molecular biology of amino acid transporters. Annu Rev Biochem. 1996;65:305–36.

    Article  CAS  PubMed  Google Scholar 

  11. Kadowaki M, Kanazawa T. Amino acids as regulators of proteolysis. J Nutr. 2003;133(6 Suppl 1):20525–65.

    Google Scholar 

  12. Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, et al. Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders. J Physiol. 2006;574:41–53.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Stinkens R, Goossens G, Jocken J, Blaak E. Targeting fatty acid metabolism to improve glucose metabolism. Obes Rev. 2015;16:715–57.

    Article  CAS  PubMed  Google Scholar 

  14. Abboud S, Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem. 2000;275:19906–12.

    Article  CAS  PubMed  Google Scholar 

  15. Aisen P, Leibman A, Zweier J. Stoichiometric and site characteristics of the binding of iron to human transferrin. J Biol Chem. 1978;253:1930–7.

    PubMed  CAS  Google Scholar 

  16. Weiss G. Iron metabolism in the anemia of chronic disease. Biochim Biophys Acta. 2009;1790:682–93.

    Article  CAS  PubMed  Google Scholar 

  17. Dawson PA, Lan T, Rao A. Bile acid transporters. J Lipid Res. 2009;50:2340–57.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Thomas C, Pellicciari R, Pruzanski M, Auwerx J, Schoonjans K. Targeting bile acid signalling for metabolic diseases. Nat Rev Drug Discov. 2008;7:678–93.

    Article  CAS  PubMed  Google Scholar 

  19. Kamisako T, Kobayashi Y, Takeuchi K, Ishihara T, Higuchi K, Tanaka Y, Gabazza EC, Adachi Y. Recent advances in bilirubin metabolism research: the molecular mechanism of hepatocyte bilirubin transport and its clinical relevance. J Gastroenterol. 2000;35:659–64.

    Article  CAS  PubMed  Google Scholar 

  20. Chiang YIL. Bile acid metabolism and signaling. Compr Physiol. 2013;3:1191–212.

    PubMed  PubMed Central  Google Scholar 

  21. Maddrey W. Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. Gastroenterology. 2000;118:984–5.

    Article  Google Scholar 

  22. Notas G, Kisseleva T, Brenner D. NK and NKT cells in liver injury and fibrosis. Clin Immunol. 2009;130:16–26.

    Article  CAS  PubMed  Google Scholar 

  23. Racanelli V, Rehermann B. The liver as an immunological organ. Hepatology. 2006;43:S54–62.

    Article  CAS  PubMed  Google Scholar 

  24. Zakhari S. Overview: How is alcohol metabolized by the body? Alcohol Res Health. 2006;30:709–19.

    Google Scholar 

  25. Lieber CS. Metabolism of alcohol. Clin Liver Dis. 2005;9:1–35.

    Article  PubMed  Google Scholar 

  26. Navarro VJ, Senior JR. Drug-related hepatotoxicity. N Engl J Med. 2006;354:731–9.

    Article  CAS  PubMed  Google Scholar 

  27. Zieve L. Pathogenesis of hepatic encephalopathy. Metab Brain Dis. 1987;2:147–65.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Lucija Virović-Jukić .

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Virović-Jukić, L., Živković, M. (2018). Liver Function. In: Duvnjak, M., Smirčić-Duvnjak, L. (eds) Gastrointestinal Complications of Diabetes . Clinical Gastroenterology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-75856-5_20

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  • DOI: https://doi.org/10.1007/978-3-319-75856-5_20

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  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-75855-8

  • Online ISBN: 978-3-319-75856-5

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