Skip to main content

Abstract

The management of enteropathy in diabetes represents a challenge today and often requires a multidisciplinary approach. Current therapies are mostly symptomatic, suboptimal, and in some cases ineffective (Ördög et al., Minerva gastroenterologica e dietologica 55:315–43, 2009; Maisey, Diabetes Ther 7:379–86, 2016). Diarrhea is a less common gastrointestinal abnormality than constipation in patients with diabetes, but it is clinically more relevant and troubling (Sellin and Chang, Nat Clin Pract Gastroenterol Hepatol 5:162–71, 2008). The management of patients with diabetic diarrhea should focus on general supportive measures, symptomatic treatment, and treatment of underlying cause. Constipation is one of the most common gastrointestinal complication in patients with diabetes. There is no specific therapy for diabetes-related constipation, and the majority of patients are treated in the same way as patients with idiopathic chronic constipation (Sellin and Chang, Nat Clin Pract Gastroenterol Hepatol 5:162–71, 2008). Better glycemic control may be of some benefit, but the overall management is challenging (Attaluri et al., Aliment Pharmacol Ther 33:822–8, 2011). Fecal incontinence is a common gastrointestinal complication of patients with diabetes, but infrequently reported. The management of fecal incontinence in diabetes includes supportive care, medical therapy, behavioral measures, and more invasive surgical options.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 89.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 119.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Ördög T, Hayashi Y, Gibbons SJ. Cellular pathogenesis of diabetic gastroenteropathy. Minerva Gastroenterol Dietol. 2009;55(3):315–43.

    PubMed  PubMed Central  Google Scholar 

  2. Sellin JH, Chang EB. Therapy insight: gastrointestinal complications of diabetes pathophysiology and management. Nat Clin Pract Gastroenterol Hepatol. 2008;5(3):162–71.

    Article  PubMed  Google Scholar 

  3. Yarandi SS, Srinivasan S. Diabetic gastrointestinal motility disorders and the role of enteric nervous system: current status and future directions. Neurogastroenterol Motil. 2014;26(5):611–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Azpiroz F, Malagelada C. Diabetic neuropathy in the gut: pathogenesis and diagnosis. Diabetologia. 2016;59(3):404–8.

    Article  CAS  PubMed  Google Scholar 

  5. Rayner CK, Samsom M, Jones KL, Horowitz M. Relationships of upper gastrointestinal motor and sensory function with glycemic control. Diabetes Care. 2001;24(2):371–81.

    Article  CAS  PubMed  Google Scholar 

  6. Maisey A. A practical approach to gastrointestinal complications of diabetes. Diabetes Therapy. 2016;7(3):379–86. https://doi.org/10.1007/s13300-016-0182-y.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Bytzer P, Talley NJ, Leemon M, Young LJ, Jones MP, Horowitz M. Prevalence of gastrointestinal symptoms associated with diabetes Mellitus. A population-based survey of 15000 adults. Arch Intern Med. 2001;161(16):1989–96.

    Article  CAS  PubMed  Google Scholar 

  8. Bharucha AE. Fecal incontinence. Gastroenterology. 2003;124(6):1672–85.

    Article  PubMed  Google Scholar 

  9. Krishnan B, Babu S, Walker J, Walker AB, Pappachan JM. Gastrointestinal complications of diabetes mellitus. World J Diabetes. 2013;4(3):51–63.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Lysy J, Israeli E, Goldin E. The prevalence of chronic diarrhea among diabetic patients. Am J Gastroenterol. 1999;94(8):2165–70.

    Article  CAS  PubMed  Google Scholar 

  11. Consoli A, Formoso G. Potential side effects to GLP-1 agonists: understanding their safety and tolerability. Expert Opin Drug Saf. 2015;14(2):207–18.

    Article  CAS  PubMed  Google Scholar 

  12. Fenofibrate 267mg capsules—summary of product characteristics. http://www.medicine.org.uk/emc/medicine/22425/SPC. Accessed July 2017

  13. Bytzer P, Talley NJ, Jones MP, Horowitz M. Oral hypoglycaemic drugs and gastrointestinal symptoms in diabetes mellitus. Aliment Pharmacol Ther. 2001;15(1):137–42.

    Article  CAS  PubMed  Google Scholar 

  14. Badiga MS, Jain NK, Casanova C, Pitchumoni CS. Diarrhea in diabetics: the role of sorbitol. J Am Coll Nutr. 1990;9(6):578–82.

    Article  CAS  PubMed  Google Scholar 

  15. Shakil A, Church RJ, Rao SS. Gastrointestinal complications of diabetes. Am Fam Physician. 2008;77(12):1697–702.

    PubMed  Google Scholar 

  16. Fedorak R, Field M. Antidiarrheal therapy. Prospects for new agents. Dig Dis Sci. 1987;32:195–205.

    Article  CAS  PubMed  Google Scholar 

  17. Bretzke G. Therapy of diarrhea in diabetic enteropathy with clonidine. Z Gesamte Inn Med. 1987;42:680–2.

    PubMed  CAS  Google Scholar 

  18. Morali G, Braverman D, Lissi J, Goldstein R, Jacobsohn W. Effect of clonidine on gallbladder contraction and small bowel transit time in insulin-treated diabetics. Am J Gastroenterol. 1991;86:995–9.

    PubMed  CAS  Google Scholar 

  19. Bharucha A, Fletcher J, Camilleri M, Edge J, Carlson P, Zinsmeister A. Effects of clonidine in women with fecal incontinence. Clin Gastroenterol Hepatol. 2014;12(5):843–51.e842; quiz e44.

    Google Scholar 

  20. Sacerdote A. Topical clonidine for diabetic diarrhea. Ann Intern Med. 1986;105:139.

    Article  CAS  PubMed  Google Scholar 

  21. Roof L. Treatment of diabetic diarrhea with clonidine. Am J Med. 1987;83:603–4.

    Article  CAS  PubMed  Google Scholar 

  22. Migliore A, Barone C, Manna R, Greco A. Diabetic diarrhea and clonidine. Ann Intern Med. 1988;109:170–1.

    Article  CAS  PubMed  Google Scholar 

  23. Fragkos KC, Zárate-Lopez N, Frangos CC. What about clonidine for diarrhoea? A systematic review and meta-analysis of its effect in humans. Ther Adv Gastroenterol. 2016;9(3):282–301.

    Article  CAS  Google Scholar 

  24. Soudah HC, Hasler WL, Owyang C. Effect of octreotide on intestinal motility and bacterial overgrowth in scleroderma. N Engl J Med. 1991;325(21):1461–7.

    Article  CAS  PubMed  Google Scholar 

  25. Dudl RJ, Anderson DS, Forsythe AB, Ziegler MG, O’Dorisio TM. Treatment of diabetic diarrhea and orthostatic hypotension with somatostatin analogue SMS 201-995. Am J Med. 1987;83(3):584–8.

    Google Scholar 

  26. Mourad FH, Gorard D, Thillainayagam AV, Colin-Jones D, Farthing MJ. Effective treatment of diabetic diarrhoea with somatostatin analogue, octreotide. Gut. 1992;33(11):1578–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Walker JJ, Kaplan DS. Efficacy of the somatostatin analog octreotide in the treatment of two patients with refractory diabetic diarrhea. Am J Gastroenterol. 1993;88(5):765–7.

    PubMed  CAS  Google Scholar 

  28. Corbould A, Campbell J. Efficacy of octreotide but not long-acting somatostatin analogue for severe refractory diabetic diarrhea. Diabet Med. 2009;26(8):828–9.

    Article  CAS  PubMed  Google Scholar 

  29. Pimentel M. Review of rifaximin as treatment for SIBO and IBS. Expert Opin Investig Drugs. 2009;18:349–58.

    Article  CAS  PubMed  Google Scholar 

  30. Gerard L, Garey KW, DuPont HL. Rifaximin: a nonabsorbable rifamycin antibiotic for use in nonsystemic gastrointestinal infections. Expert Rev Anti-Infect Ther. 2005;3:201–11.

    Article  CAS  PubMed  Google Scholar 

  31. Jiang ZD, DuPont HL. Rifaximin: in vitro and in vivo antibacterial activity—a review. Chemotherapy. 2005;51(Suppl 1):67–72.

    Article  CAS  PubMed  Google Scholar 

  32. Maleki D, Camilleri M, Burton DD, et al. Pilot study of pathophysiology of constipation among community diabetics. Dig Dis Sci. 1998;43(11):2373–8.

    Article  CAS  PubMed  Google Scholar 

  33. Attaluri A, Donahoe R, Valestin J, Brown K, Rao SS. Randomised clinical trial: dried plums (prunes) vs. psyllium for constipation. Aliment Pharmacol Ther. 2011;33(7):822–8.

    Article  CAS  PubMed  Google Scholar 

  34. Lembo A, Camilleri M. Chronic constipation. N Engl J Med. 2003;349:1360–8.

    Article  CAS  PubMed  Google Scholar 

  35. Bharucha AE, Pemberton JH, Locke GR. American Gastroenterological Association technical review on constipation. Gastroenterology. 2013;144(1):218–38. https://doi.org/10.1053/j.gastro.2012.10.028.

    Article  PubMed  Google Scholar 

  36. Müller-Lissner SA, Kamm MA, Scarpignato C, Wald A. Myths and misconceptions about chronic constipation. Am J Gastroenterol. 2005;100:232–42.

    Article  PubMed  Google Scholar 

  37. Wald A. Is chronic use of stimulant laxatives harmful to the colon? J Clin Gastroenterol. 2003;36(5):386–9.

    Article  PubMed  Google Scholar 

  38. Lee-Robichaud H, Thomas K, Morgan J, Nelson RL. Lactulose versus polyethylene glycol for chronic constipation. Cochrane Database Syst Rev. 2010;7:CD007570.

    Google Scholar 

  39. Emmanuel A, Mattace-Raso F, Neri MC, Petersen KU, Rey E, Rogers J. Constipation in older people: a consensus statement. Int J Clin Pract 2017;71(1).

    Google Scholar 

  40. Mendoza J, Legido J, Rubio S, Gisbert JP. Systematic review: the adverse effects of sodium phosphate enema. Aliment Pharmacol Ther. 2007;26(1):9–20.

    Article  CAS  PubMed  Google Scholar 

  41. Enck P. Biofeedback training in disordered defecation: a critical review. Dig Dis Sci. 1993;38:1953–60.

    Article  CAS  PubMed  Google Scholar 

  42. Bassotti G, Chistolini F, Sietchiping-Nzepa F, de Roberto G, Morelli A, Chiarioni G. Biofeedback for pelvic floor dysfunction in constipation. BMJ. Br Med J. 2004;328(7436):393–6.

    Article  CAS  Google Scholar 

  43. Lembo AJ, Schneier HA, Shiff SJ, et al. Two randomized trials of linaclotide for chronic constipation. N Engl J Med. 2011;365(6):527–36.

    Article  CAS  PubMed  Google Scholar 

  44. Johanson JF, Ueno R. Lubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: a double-blind, placebo-controlled, dose-ranging study to evaluate efficacy and safety. Aliment Pharmacol Ther. 2007;25(11):1351–61.

    Article  CAS  PubMed  Google Scholar 

  45. Lang L. The Food and Drug Administration approves lubiprostone for irritable bowel syndrome with constipation. Gastroenterology. 2008;135(1):7.

    PubMed  Google Scholar 

  46. Schey R, Rao SSC. Lubiprostone for the treatment of adults with constipation and irritable bowel syndrome. Dig Dis Sci. 2011;56:1619–25.

    Article  CAS  PubMed  Google Scholar 

  47. Camilleri M, Kerstens R, Rykx A, Vandeplassche L. A placebo-controlled trial of prucalopride for severe chronic constipation. N Engl J Med. 2008;358:2344–54.

    Article  CAS  PubMed  Google Scholar 

  48. Quigley EM, Vandeplassche L, Kerstens R, Ausma J. Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation—a 12-week, randomized, double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2009;29:315–28.

    Article  CAS  PubMed  Google Scholar 

  49. Tack J, van Outryve M, Beyens G, Kerstens R, Vandeplassche L. Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives. Gut. 2009;58:357–65.

    Article  CAS  PubMed  Google Scholar 

  50. Müller-Lissner S, Rykx A, Kerstens R, Vandeplassche L. A double-blind, placebo-controlled study of prucalopride in elderly patients with chronic constipation. Neurogastroenterol Motil. 2010;22:991–8.

    Article  CAS  PubMed  Google Scholar 

  51. Ford A, Suares N. Effect of laxatives and pharmacological therapies in chronic idiopathic constipation: systematic review and meta-analysis. Gut. 2011;60:209–18.

    Article  PubMed  Google Scholar 

  52. Suares NC, Ford AC. Systematic review: the effects of fibre in the management of chronic idiopathic constipation. Aliment Pharmacol Ther. 2011;33:895–901.

    Article  CAS  PubMed  Google Scholar 

  53. Di Palma JA, Cleveland MV, McGowan J, Herrera JL. A randomized, multicenter comparison of polyethylene glycol laxative and tegaserod in treatment of patients with chronic constipation. Am J Gastroenterol. 2007;102:1964–71.

    Article  CAS  PubMed  Google Scholar 

  54. Wexner SD, Daniel N, Jagelman DG. Colectomy for constipation: physiologic investigation is the key to success. Dis Colon Rectum. 1991;34:851–6.

    Article  CAS  PubMed  Google Scholar 

  55. Nyam DC, Pemberton JH, Ilstrup DM, Rath DM. Long-term results of surgery for chronic constipation. Dis Colon Rectum. 1997;40:273–9.

    Article  CAS  PubMed  Google Scholar 

  56. Kamm MA, Dudding TC, Melenhorst J, et al. Sacral nerve stimulation for intractable constipation. Gut. 2010;59:333–40.

    Article  PubMed  Google Scholar 

  57. Maeda Y, Lundby L, Buntzen S, Laurberg S. Sacral nerve stimulation for constipation: suboptimal outcome and adverse events. Dis Colon Rectum. 2010;53:995–9.

    Article  PubMed  Google Scholar 

  58. Maria G, Cadeddu F, Brandara F, Marniga G, Brisinda G. Experience with type A botulinum toxin for treatment of outlet-type constipation. Am J Gastroenterol. 2006;101:2570–5.

    Article  PubMed  Google Scholar 

  59. Faried M, El Nakeeb A, Youssef M, Oman N, El Monem HA. Comparative study between surgical and non-surgical treatment of anismus in patients with symptoms of obstructed defecation: a prospective randomized study. J Gastrointest Surg. 2010;14:1235–43.

    Article  PubMed  Google Scholar 

  60. Titu LV, Riyad K, Carter H, Dixon AR. Stapled transanal rectal resection for obstructed defecation: a cautionary tale. Dis Colon Rectum. 2009;52:1716–22.

    Article  PubMed  Google Scholar 

  61. Dodi G, Pietroletti R, Milito G, Binda G, Pescatori M. Bleeding, incontinence, pain and constipation after STARR transanal double stapling rectotomy for obstructed defecation. Tech Coloproctol. 2003;7:148–53.

    Article  CAS  PubMed  Google Scholar 

  62. Corman ML, Carriero A, Hager T, et al. Consensus conference on the stapled transanal rectal resection (STARR) for disordered defaecation. Color Dis. 2006;8:98–101.

    Article  CAS  Google Scholar 

  63. Sangwan YP, Coller JA. Fecal incontinence. Surg Clin North Am. 1994;74(6):1377–98.

    Article  CAS  PubMed  Google Scholar 

  64. Rothbarth J, Bemelman WA, Meijerink WJ, et al. What is the impact of fecal incontinence on quality of life? Dis Colon Rectum. 2001;44(1):67–71.

    Article  CAS  PubMed  Google Scholar 

  65. Lee D, Arora G. Medical management of fecal incontinence in challenging populations: a review. Clin Colon Rectal Surg. 2014;27(3):91–8.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Bliss DZ, Jung HJ, Savik K, et al. Supplementation with dietary fiber improves fecal incontinence. Nurs Res. 2001;50(4):203–13.

    Article  CAS  PubMed  Google Scholar 

  67. Lauti M, Scott D, Thompson-Fawcett MW. Fibre supplementation in addition to loperamide for faecal incontinence in adults: a randomized trial. Color Dis. 2008;10(6):553–62.

    Article  CAS  Google Scholar 

  68. Sze EH, Hobbs G. Efficacy of methylcellulose and loperamide in managing fecal incontinence. Acta Obstet Gynecol Scand. 2009;88(7):766–71.

    Article  CAS  PubMed  Google Scholar 

  69. Wald A, Bharucha AE, Cosman BC, Whitehead WE. ACG clinical guideline: management of benign anorectal disorders. Am J Gastroenterol. 2014;109(8):1141–57.

    Article  PubMed  Google Scholar 

  70. Ouslander JG, Simmons S, Schnelle J, Uman G, Fingold S. Effects of prompted voiding on fecal continence among nursing home residents. J Am Geriatr Soc. 1996;44(4):424–8.

    Article  CAS  PubMed  Google Scholar 

  71. Schnelle JF, Leung FW, Rao SS, et al. A controlled trial of an intervention to improve urinary and fecal incontinence and constipation. J Am Geriatr Soc. 2010;58(8):1504–11.

    Article  PubMed  PubMed Central  Google Scholar 

  72. Schnelle JF, Alessi CA, Simmons SF, Al-Samarrai NR, Beck JC, Ouslander JG. Translating clinical research into practice: a randomized controlled trial of exercise and incontinence care with nursing home residents. J Am Geriatr Soc. 2002;50(9):1476–83.

    Article  PubMed  Google Scholar 

  73. Cheetham M, Brazzelli M, Norton C, Glazener CM. Drug treatment for faecal incontinence in adults. Cochrane Database Syst Rev. 2003;3:CD002116.

    Google Scholar 

  74. Ehrenpreis ED, Chang D, Eichenwald E. Pharmacotherapy for fecal incontinence: a review. Dis Colon Rectum. 2007;50(5):641–9.

    Article  PubMed  Google Scholar 

  75. Schiller LR, Santa Ana CA, Morawski SG, Fordtran JS. Mechanism of the antidiarrheal effect of loperamide. Gastroenterology. 1984;86(6):1475–80.

    PubMed  CAS  Google Scholar 

  76. Regnard C, Twycross R, Mihalyo M, Wilcock A. Loperamide. J Pain Symptom Manag. 2011;42(2):319–23.

    Article  Google Scholar 

  77. Palmer KR, Corbett CL, Holdsworth CD. Double-blind cross-over study comparing loperamide, codeine and diphenoxylate in the treatment of chronic diarrhea. Gastroenterology. 1980;79(6):1272–5.

    PubMed  CAS  Google Scholar 

  78. Wald A, Tunuguntla AK. Anorectal sensorimotor dysfunction in fecal incontinence and diabetes mellitus. Modification with biofeedback therapy. N Engl J Med. 1984;310(20):1282–7.

    Article  CAS  PubMed  Google Scholar 

  79. Maeda Y, Laurberg S, Norton C. Perianal injectable bulking agents as treatment for faecal incontinence in adults. Cochrane Database Syst Rev. 2013;2:CD007959.

    Google Scholar 

  80. Tjandra JJ, Chan MK, Yeh CH, Murray-Green C. Sacral nerve stimulation is more effective than optimal medical therapy for severe fecal incontinence: a randomized, controlled study. Dis Colon Rectum. 2008;51:494–502.

    Article  PubMed  Google Scholar 

  81. Gourcerol G, Gallas S, Michot F, Denis P, Leroi AM. Sacral nerve stimulation in fecal incontinence: are there factors associated with success? Dis Colon Rectum. 2007;50:3–12.

    Article  PubMed  Google Scholar 

  82. Hetzer FH, Bieler A, Hahnloser D, Löhlein F, Clavien PA, Dematines N. Outcome and cost analysis of sacral nerve stimulation for faecal incontinence. Br J Surg. 2006;93:1411–7.

    Article  CAS  PubMed  Google Scholar 

  83. Leroi AM, Parc Y, Lehur PA, et al. Efficacy of sacral nerve stimulation for fecal incontinence: results of a multicenter double-blind crossover study. Ann Surg. 2005;242:662–9.

    Article  PubMed  PubMed Central  Google Scholar 

  84. Rosen HR, Urbarz C, Holzer B, Novi G, Schiessel R. Sacral nerve stimulation as a treatment for fecal incontinence. Gastroenterology. 2001;121:536–41.

    Article  CAS  PubMed  Google Scholar 

  85. Matzel KE, Stadelmaier U, Hohenfellner M, Gall FP. Electrical stimulation of sacral spinal nerves for treatment of faecal incontinence. Lancet. 1995;46:1124–7.

    Article  Google Scholar 

  86. Jarrett ME, Matzel KE, Christiansen J, et al. Sacral nerve stimulation for faecal incontinence in patients with previous partial spinal injury including disc prolapse. Br J Surg. 2005;92:734–9.

    Article  CAS  PubMed  Google Scholar 

  87. Uludağ O, Koch SM, van Gemert WG, Dejong CH, Baeten CG. Sacral neuromodulation in patients with fecal incontinence: a single-center study. Dis Colon Rectum. 2004;47:1350–7.

    Article  PubMed  Google Scholar 

  88. Matzel KE, Kamm MA, Stösser M, et al. Sacral spinal nerve stimulation for faecal incontinence: multicentre study. Lancet. 2004;363:1270–6.

    Article  PubMed  Google Scholar 

  89. Malouf AJ, Norton CS, Engel AF, Nicholls RJ, Kamm MA. Long-term results of overlapping anterior anal-sphincter repair for obstetric trauma. Lancet. 2000;355:260–5.

    Article  CAS  PubMed  Google Scholar 

  90. Madoff RD, Rosen HR, Baeten CG, et al. Safety and efficacy of dynamic muscle plasty for anal incontinence: lessons from a prospective, multicenter trial. Gastroenterology. 1999;116:549–56.

    Article  CAS  PubMed  Google Scholar 

  91. Rongen MJ, Uludag O, El Naggar K, Gerdes BP, Konsten J, Baeten CG. Long-term follow-up of dynamic graciloplasty for fecal incontinence. Dis Colon Rectum. 2003;46:716–21.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Marinko Marušić .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Marušić, M., Perić, R.T., Karaula, N.T. (2018). Treatment. In: Duvnjak, M., Smirčić-Duvnjak, L. (eds) Gastrointestinal Complications of Diabetes . Clinical Gastroenterology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-75856-5_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-75856-5_15

  • Published:

  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-75855-8

  • Online ISBN: 978-3-319-75856-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics