Abstract
Small-intestinal dysfunction is a common finding in patients with long-standing diabetes. The most frequent clinical symptoms are abdominal bloating, nausea, diarrheal syndrome, constipation, and abdominal pain. Considering the diversity of clinical scenarios in intestinal dysfunction, detection of the cause of gastrointestinal symptoms is crucial for decreasing morbidity and mortality in diabetic patients. Differential diagnostic procedures demand the taking into consideration of dysmotility, small intestinal infection, celiac disease, inflammatory bowel disease, amyloidosis, intestinal lymphangiectasia, intestinal lymphoma, lactose intolerance, small bowel obstruction, tropical sprue, Whipple’s disease, tumors of the small intestine, angioneurotic edema, exocrine pancreatic insufficiency and bile salt diarrhea. Prior to starting investigations it is necessary to exclude iatrogenic cause of the symptoms, focusing on the drug history. A multidisciplinary approach is necessary for diagnosis and treatment of diabetic patients with symptoms of small-intestine enteropathy.
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References
Maisey A. A practical approach to gastrointestinal complications of diabetes. Diabetes Ther. 2016;7:379–86.
Krentz AJ, Bailey CJ. Oral antidiabetic agents: current role in type 2 diabetes mellitus. Drugs. 2005;65(3):385–411.
Quan C, Talley NJ, Cross S, Jones M, Hammer J, Giles N, et al. Development and validation of the Diabetes Bowel Symptom Questionnaire. Aliment Pharmacol Ther. 2003;17(9):1179–87.
Huizinga JD, Zarate N, Farrugia G. Physiology, injury and recovery of interstitial cells of Cajal: basic and clinical science. Gastroenterology. 2009;137(5):1548–56.
Huizinga JD, Chen JH, Zhu YF, Pawelka A, McGinn RJ, Barkadjian BL, et al. The origin of segmentation motor activity in the intestine. Nat Commun. 2014;5:3326.
Munot K, Kotler DP. Small intestinal infections. Curr Gastroenterol Rep. 2016;18(6):31.
Fasano A, Catassi C. Celiac disease. N Engl J Med. 2012;367:2419–26.
Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PHR, et al. The Oslo definitions for celiac disease and related terms. Gut. 2013;62:43–52.
Mustalahti K, Catassi C, Reunanen A, Fabiani E, Heier M, McMillan S, et al. The prevalence of celiac disease in Europe: results of a centralized, international mass screening project. Ann Med. 2010;42:587–95.
Akirov A, Pinhas-Hamiel O. Co-occurrence of type 1 diabetes mellitus and celiac disease. World J Diabetes. 2015;6:707–14.
Ludvigsson JF, Ludvigsson J, Ekbom A, Montgomery SM. Celiac disease and risk of subsequent type-1 diabetes: a general population cohort study of children and adolescents. Diabetes Care. 2006;29:2483–8.
Elfstrom P, Sundstrom J, Ludvigsson JF. Systematic review with meta-analysis: associations between celiac disease and type 1 diabetes. Aliment Pharmacol Ther. 2014;40:1123–32.
Brusca I. Overview of biomarkers for diagnosis and monitoring of celiac disease. Adv Clin Chem. 2015;68:1–55.
Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (“celiac sprue”). Gastroenterology. 1992;102:330–54.
Bai JC, Fried M, Corazza GR, et al. World Gastroenterology Organisation global guidelines on celiac disease. J Clin Gastroenterol. 2013;47:121–6.
Rubio-Tapia A, Hill ID, Kelly CP, et al. ACG clinical guidelines: diagnosis and management of celiac disease. Am J Gastroenterol. 2013;108:656–76. Quiz 677.
Catassi C, Fasano A. Celiac disease diagnosis: simple rules are better than complicated algorithms. Am J Med. 2010;123:691–3.
Ludvigsson JF, Bai JC, Biagi F, Card TR, Ciacci C, Ciclitira PJ, et al. Diagnosis and management od adult celiac disease: guidelines from the British Society of Gastroenterology. Gut. 2014;63:1210–28.
Husby S, Koletzko S, Karponay-Szabo IR, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of celiac disease. J Pediatr Gastroenterol. 2012;54:136–60.
Parzanese I, Qehajaj D, Patrinicola F, Aralica M, Chiriva-UInternati M, Stifter S, et al. From pathophysiology to treatment. World J Gastrointest Pathophysiol. 2017;15(8):27–38.
Pennazio M, Spada C, Eliakim R, Keuchel M, May A, Mulder CJ, et al. Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) clinical guideline. Endoscopy. 2015;47:352–76.
Bakker SF, Tushuizen ME, von Blomberg BM, Bontkes HJ, Mulder CJ, Simsek S. Screening for celiac disease in adult patients with type 1 diabetes mellitus: myths, facts and controversy. Diabetol Metab Syndr. 2016;8:51.
Smith LA, Gaya DR. Utility of faecal calprotectin analysis in adult inflammatory bowel disease. World J Gastroenterol. 2012;18(46):6782–9.
Panes J, Bouhnik Y, Reinisch W, et al. Imaging techniques for assessment of inflammatory bowel disease: joint ECCO and ESGAR evidence-based consensus guidelines. J Crohns Colitis. 2013;7(7):556–85.
Nylund K, Maconi G, Hollerweger A, et al. EFSUMB recommendations and guidelines for gastrointestinal ultrasound. Ultraschall Med. 2017;38:e1–15.
Sipe JD, Benson MD, Buxbaum JN, Ikeda S, Merlini G, Saraiva MJ, et al. Amyloid fibril protein nomenclature: 2010 recommendations from the nomenclature committee of the International Society of Amyloidosis. Amyloid. 2010;17(3–4):101–4.
Vignes S, Bellanger J. Primary intestinal lymphangiectasia (Waldmann’s disease). Orphanet J Rare Dis. 2008;22:3–5.
Ghimire P, Wu GY, Zhu L. Primary gastrointestinal lymphoma. World J Gastroenterol. 2011;17(6):697–707.
Misselwitz B, Pohl D, Frühauf H, Fried M, Vavricka S, Fox M. Lactose malabsorption and intolerance: pathogenesis, diagnosis and treatment. United European Gastroenterol J. 2013;1(3):151–9.
Brown IS, Bettington A, Bettington M, Rosty C. Tropical sprue: revisiting an underrecognized disease. Am J Surg Pathol. 2014;38(5):666–72.
Kala Z, Valek V, Kysela P, Svoboda T. A shift in the diagnostics of the small intestine tumors. Eur J Radiol. 2007;62(2):160–5.
Schneider T, Moos V, Loddenkemper C, Marth T, Fenollar F, Raoult D. Whipple’s disease: new aspects of pathogenesis and treatment. Lancet Infect Dis. 2008;8(3):179–90.
Rezaie A, Buresi M, Lembo A, Lin H, McCallum R, Rao S, et al. Hydrogen and methane-based breath testing in gastrointestinal disorders: the North American consensus. Am J Gastroenterol. 2017;112:775–84.
Domínguez-Munõz JE, Harddt PD, Lerch MM, Lo MJ. Potential for screening for pancreatic exocrine insufficiency using the fecal elastase-1 test. Dig Dis Sci. 2017;62:1119–30.
Murray IA, Murray LK, Woolson KL, Sherfi H, Dixon I, Palmer J, Sulkin T. Incidence and predictive factors for positive 75SeHCAT test: improving the diagnosis of bile acid diarrhoea. Scand J Gastroenterol. 2017;52(6–7):698–703.
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Ladić, A., Čuković-Čavka, S. (2018). Diagnostic Approach. In: Duvnjak, M., Smirčić-Duvnjak, L. (eds) Gastrointestinal Complications of Diabetes . Clinical Gastroenterology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-75856-5_10
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