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Transfer Learning for the Fully Automatic Segmentation of Left Ventricle Myocardium in Porcine Cardiac Cine MR Images

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Statistical Atlases and Computational Models of the Heart. ACDC and MMWHS Challenges (STACOM 2017)

Abstract

A fully automatic approach for the segmentation of the left ventricle (LV) myocardium in porcine cardiac cine MRI images is proposed based on deep convolutional neural networks (CNN). We trained a 56-layer residual learning CNN (ResNet-56) from scratch on a set of porcine cine MRI images acquired internally, and another CNN via transfer learning by fine tuning a network previously trained on a public human cine MRI dataset. A leave-one-out validation was performed on an 8-specimen porcine cardiac cine MRI dataset (3,600 slices). Comparisons with manual segmentations show that both CNN models are able to produce precise results (99.94% “good” segmentations), while the CNN trained through transfer learning performs better by achieving Dice similarity coefficient (DSC) of 0.86, Hausdorff distance (HD) of 4.01 mm, and overall average perpendicular distance (APD) of 1.04 mm on average.

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References

  1. Suzuki, Y., Yeung, A.C., Ikeno, F.: The representative porcine model for human cardiovascular disease. Biomed Res. Int. 2011, 1–10 (2010)

    Google Scholar 

  2. Peng, P., Lekadir, K., Gooya, A., Shao, L., Petersen, S.E., Frangi, A.F.: A review of heart chamber segmentation for structural and functional analysis using cardiac magnetic resonance imaging. Magn. Reson. Mater. Phy. Biol. Med. 29(2), 155–195 (2016)

    Article  Google Scholar 

  3. Li, J., Zhang, R., Shi, L., Wang, D.: Automatic whole-heart segmentation in congenital heart disease using deeply-supervised 3D FCN. In: Zuluaga, M.A., Bhatia, K., Kainz, B., Moghari, M.H., Pace, D.F. (eds.) RAMBO/HVSMR -2016. LNCS, vol. 10129, pp. 111–118. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-52280-7_11

    Chapter  Google Scholar 

  4. Tran, P.V.: A fully convolutional neural network for cardiac segmentation in short-axis MRI. arXiv preprint arXiv:1604.00494 (2016)

  5. Poudel, R.P., Lamata, P., Montana, G.: Recurrent fully convolutional neural networks for multi-slice MRI cardiac segmentation. arXiv:1608.03974 (2016)

  6. Zhen, X., Wang, Z., Islam, A., Bhaduri, M., Chan, I., Li, S.: Multi-scale deep networks and regression forests for direct bi-ventricular volume estimation. Med. Image Anal. 30, 120–129 (2016)

    Article  Google Scholar 

  7. Ngo, T.A., Lu, Z., Carneiro, G.: Combining deep learning and level set for the automated segmentation of the left ventricle of the heart from cardiac cine magnetic resonance. Med. Image Anal. 35, 159–171 (2017)

    Article  Google Scholar 

  8. Avendi, M.R., Kheradvar, A., Jafarkhani, H.: A combined deep-learning and deformable-model approach to fully automatic segmentation of the left ventricle in cardiac MRI. Med. Image Anal. 30, 108–119 (2016)

    Article  Google Scholar 

  9. He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: Proceedings the IEEE Conference on Computer Vision and Pattern Recognition, pp. 770–778 (2016)

    Google Scholar 

  10. Lin, X., Cowan, B.R., Young, A.A.: Automated detection of left ventricle in 4D MR images: experience from a large study. In: International Conference on Medical Image Computing and Computer-Assisted Intervention, pp. 728–735 (2006)

    Google Scholar 

  11. Kingma, D., Ba, J.: Adam: a method for stochastic optimization. arXiv preprint arXiv:1412.6980 (2014)

  12. Pan, S.J., Yang, Q.: A survey on transfer learning. IEEE Trans. Knowl. Data Eng. 22(10), 1345–1359 (2010)

    Article  Google Scholar 

  13. Zhou, T., Icke, I., Dogdas, B., Parimal, S., Sampath, S., Forbes, J., Bagchi, A., Chin, C., Chen, A.: Automatic segmentation of left ventricle in cardiac cine MRI images based on deep learning. In: Proceedings of SPIE 10133, Medical Imaging: Image Processing (2017)

    Google Scholar 

  14. Crick, S.J., Sheppard, M.N., Ho, S.Y., Gebstein, L., Anderson, R.H.: Anatomy of the pig heart: comparisons with normal human cardiac structure. J. Anat. 193(1), 105–119 (1998)

    Article  Google Scholar 

  15. Dice, L.R.: Measures of the amount of ecologic association between species. Ecology 26(3), 297–302 (1945)

    Article  Google Scholar 

  16. Huttenlocher, D.P., Klanderman, G.A., Rucklidge, W.J.: Comparing images using the Hausdorff distance. IEEE Trans. Patt. Anal. Mach. Intell. 15(9), 850–863 (1993)

    Google Scholar 

  17. Radau, P., Lu, Y., Connelly, K., Paul, G., Dick, A., Wright, G.: Evaluation framework for algorithms segmenting short axis cardiac MRI. MIDAS J. Card. MR Left Ventricle Segmentation Challenge 49, 134 (2009)

    Google Scholar 

  18. Chen, T., Li, M., Li, Y., Lin, M., Wang, N., Wang, M., Xiao, T., Xu, B., Zhang, C., Zhang, Z.: Mxnet: a flexible and efficient machine learning library for heterogeneous distributed systems. arXiv preprint arXiv:1512.01274 (2015)

  19. Alba, X., Ventura, F., Rosa, M., Lekadir, K., Tobon-Gomez, C., Hoogendoorn, C., Frangi, A.F.: Automatic cardiac LV segmentation in MRI using modified graph cuts with smoothness and interslice constraints. Magn. Reson. Med. 72(6), 1775–1784 (2014)

    Article  Google Scholar 

  20. Bai, W., Shi, W., O’Regan, D.P., Tong, T., Wang, H., Jamil-Copley, S., Peters, N.S., Rueckert, D.: A probabilistic patch-based label fusion model for multi-atlas segmentation with registration refinement: application to cardiac MR images. IEEE Trans. Med. Imaging 32(7), 1302–1315 (2013)

    Article  Google Scholar 

  21. Zhu, Y., Papademetris, X., Sinusas, A.J., Duncan, J.S.: Segmentation of the left ventricle from cardiac MR images using a subject-specific dynamical model. IEEE Trans. Med. Imaging 29(3), 669–687 (2010)

    Article  Google Scholar 

  22. Ronneberger, O., Fischer, P., Brox, T.: U-net: convolutional networks for biomedical image segmentation. In: International Conference on Medical Image Computing and Computer-Assisted Intervention, pp. 234–241 (2015)

    Google Scholar 

  23. Xue, W., Nachum, I.B., Pandey, S., Warrington, J., Leung, S., Li, S.: Direct estimation of regional wall thicknesses via residual recurrent neural network. In: Niethammer, M., Styner, M., Aylward, S., Zhu, H., Oguz, I., Yap, P.-T., Shen, D. (eds.) IPMI 2017. LNCS, vol. 10265, pp. 505–516. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-59050-9_40

    Chapter  Google Scholar 

  24. Parimal, S., Sampath, S., Mazlan, I., Croft, G., Totman, T., Zheng, Y.T.W., Manigbas, E., Klimas, M., Evelhoch, J.L., Kleijn, D.P.V., Chin, C.: Early prediction of chronic infarct size by acute strain: a cardiac MRI study of myocardial infarction in pigs. In: SMRT 26th Annual Meeting of International Society of Magnetic Resonance in Medicine (2017)

    Google Scholar 

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Chen, A. et al. (2018). Transfer Learning for the Fully Automatic Segmentation of Left Ventricle Myocardium in Porcine Cardiac Cine MR Images. In: Pop, M., et al. Statistical Atlases and Computational Models of the Heart. ACDC and MMWHS Challenges. STACOM 2017. Lecture Notes in Computer Science(), vol 10663. Springer, Cham. https://doi.org/10.1007/978-3-319-75541-0_3

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  • DOI: https://doi.org/10.1007/978-3-319-75541-0_3

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