Abstract
The insula can be affected by both low- and high-grade gliomas. Due to its location and its functional integration role, resection of the insula tumors has traditionally been viewed as hazardous (Jones, Ward and Critchley, J Neurol Neurosurg Psychiatry 81:611–8, 2010). In particular, their tendency to spread along the intricate network of afferent and efferent connections between the insula itself and the surrounding cortical areas constitutes a major difficulty in reaching a gross total resection (Skrap, et al. Neurosurgery 70:1081–93, 2011). Neuropsychological evaluation is mandatory and should encompass, due to the multimodal nature of this areas, a wide range of tasks. Here we present our approach and experience with neuropsychological assessment during, prior, and after surgery. In particular, we describe a real-time neuropsychological testing administered during resection of insular gliomas in two exemplificative cases with lesions involving the left and the right hemisphere.
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References
Chen LM. Imaging of pain. Int Anesthesiol Clin. 2007;45:39–57.
Craig AD. How do you feel? Interoception: the sense of the physiological condition of the body. Nat Rev Neurosci. 2002;3:655–66.
Kurth F, Zilles K, Fox PT, Laird AR, Eickhoff SB. A link between the systems: functional differentiation and integration within the human insula revealed by meta-analysis. Brain Struct Funct. 2010;214:519–34.
Mesulam MM, Mufson EJ. Insula of the old world monkey. III: Efferent cortical output and comments on function. J Comp Neurol. 1982;212:38–52.
Mufson EJ, Mesulam MM. Insula of the old world monkey. II: Afferent cortical input and comments on the claustrum. J Comp Neurol. 1982;212:23–37.
Pritchard TC, Hamilton RB, Morse JR, Norgren R. Projections of thalamic gustatory and lingual areas in the monkey, Macaca fascicularis. J Comp Neurol. 1986;244:213–28.
Cereda C, Ghika J, Maeder P, Bogousslavsky J. Strokes restricted to the insular cortex. Neurology. 2002;59:1950–5.
Fink JN, et al. Insular cortex infarction in acute middle cerebral artery territory stroke: predictor of stroke severity and vascular lesion. Arch Neurol. 2005;62:1081–5.
Kalani MY, Kalani MA, Gwinn R, Keogh B, Tse VC. Embryological development of the human insula and its implications for the spread and resection of insular gliomas. Neurosurg Focus. 2009;27:E2.
Skrap M, et al. Surgery of insular non-enhancing gliomas: volumetric analysis of tumoral resection, clinical outcome and survival in a consecutive series of 66 cases. Neurosurgery. 2011;70:1081–93.
Duffau H. A personal consecutive series of surgically treated 51 cases of insular WHO Grade II glioma: advances and limitations. J Neurosurg. 2009;110:696–708.
Sanai N, Polley MY, Berger MS. Insular glioma resection: assessment of patient morbidity, survival, and tumor progression. J Neurosurg. 2010;112:1–9.
Lang FF, Olansen NE, DeMonte F, et al. Surgical resection of intrinsic insular tumors: complication avoidance. J Neurosurg. 2001;95:638–50.
Ius T, et al. Surgery for insular low-grade glioma: predictors of postoperative seizure outcome. J Neurosurg. 2014;120:12–23.
Yasargil MG, et al. Tumours of the limbic and paralimbic systems. Acta Neurochir (Wien). 1992;118(1–2):40–52.
Schätz C, et al. Interstitial 125-iodine radiosurgery of low-grade gliomas of the insula of Reil. Acta Neurochir. 1994;130:80–9.
Vanaclocha V, Saiz-Sapena N, Garcia-Casasola C. Surgical treatment of insular gliomas. Acta Neurochir. 1997;139:1126–34.
Penfield W, Faulk ME. The insula; further observations on its function. Brain. 1955;78:445–70.
Ostrowsky K, et al. Functional mapping of the insula cortex: clinical implication in temporal lobe epilepsy. Epilepsia. 2000;41:681–6.
Ojemann GA, Whitaker HA. Language localization and variability. Brain Lang. 1978;6:239–60.
Duffau H, et al. The insular lobe: physiopathological and surgical considerations. Neurosurgery. 2000;47:801–10.
Afif A, Minotti L, Kahane P, Hoffmann D. Middle short gyrus of the insula implicated in speech production: intracerebral electric stimulation of patients with epilepsy. Epilepsia. 2010;51:206–13.
Isnard J, Guenot M, Sindou M, Mauguiere F. Clinical manifestations of insular lobe seizures: a stereo-electroencephalographic study. Epilepsia. 2004;45:1079–90.
Skrap M, Marin D, Ius T, Fabbro F, Tomasino B. Brain mapping: A novel intraoperative neuropsychological approach. J Neurosurg. 2016;5:1–11.
Capitani E, Neppi-Modona M, Bisiach E. Verbal-response and manual-response versions of the Milner Landmark task: normative data. Cortex. 2000;36:593–600.
Lang PJ, Bradley MM, Cuthbert BN. International affective picture system (IAPS): affective ratings of pictures and instruction manual. Gainesville, FL: University of Florida; 2008.
Barbarotto R, Laiacona M, Macchi V, Capitani E. Picture reality decision, semantic categories and gender. A new set of pictures, with norms and an experimental study. Neuropsychologia. 2002;40:1637–53.
Bizzozero I, Ferrari F, Pozzoli S, Saetti MC, Spinnler H. Who is who: Italian norms for visual recognition and identification of celebrities. Neurol Sci. 2005;26:296.
Prior M, Marchi S, Sartori G. Cognizione sociale e comportamento-Volume I. Domeneghini Editore UPSEL; 2003.
Antonietti A, Bartolomeo P, Colombi A, Incorpora C, Olivieri S. BIP – Batteria Immaginazione e Percezione (Test) per la valutazione della cognizione visuo-spaziale. Milano; 2017.
Crepaldi D, et al. Noun-verb dissociation in aphasia: the role of imageability and functional locus of the lesion. Neuropsychologia. 2006;44:73–89.
Ripamonti E, et al. The anatomical foundations of acquired reading disorders: A neuropsychological verification of the dual-route model of reading. Brain Lang. 2014;134C:44–67.
Miceli G, Laudanna A, Burani C, Capasso R. Batteria per l'analisi dei deficit afasici. B. A. D. A. [B. A. D. A.: A Battery for the assessment of aphasic disorders.]. Roma: CEPSAG; 1994.
Paradis M. Bilingual aphasia test (Italian version). Bologna: EMS; 1986.
Orsini A, et al. Verbal and spatial immediate memory span: normative data from 1355 adults and 1112 children. Ital J Neurol Sci. 1987;8:539–48.
Tomasino B, et al. Neuropsychological patterns following lesions of the anterior insula in a series of forty neurosurgical patients. AIMS Neurosci. 2014;1:225–44.
Duffau H, Bauchet L, Lehericy S, Cappelle L. Functional compensation of the left dominant insula for language. Neuroreport. 2001;12:2159–63.
Duffau H, Taillandier L, Gatignol P, Capelle L. The insular lobe and brain plasticity: lessons from tumor surgery. Clin Neurol Neurosurg. 2006;108:543–8.
Suggested Reading
Jones CL, Ward J, Critchley HD. The neuropsychological impact of insular cortex lesions. J Neurol Neurosurg Psychiatry. 2010;81:611–8.
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Tomasino, B., Marin, D., Ius, T., Skrap, M. (2018). Neuropsychology in Insular Lesions Prior-During and After Brain Surgery. In: Turgut, M., Yurttaş , C., Tubbs, R. (eds) Island of Reil (Insula) in the Human Brain. Springer, Cham. https://doi.org/10.1007/978-3-319-75468-0_31
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DOI: https://doi.org/10.1007/978-3-319-75468-0_31
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