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Alterations of Reil’s Insula in Alzheimer’s Disease

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Book cover Island of Reil (Insula) in the Human Brain

Abstract

This chapter looks at the link between Alzheimer’s disease and the insula. This review also encompasses general histology and pathology of Alzheimer’s. It is a comprehensive review of; the first known case reports, the pillars of clinical diagnosis and its implications for treatment and further research.

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Abbreviations

AD:

Alzheimer’s disease

FTD:

Frontotemporal dementia

IC:

Insular cortex

MDD:

Major depressive disorder

NFPA:

Nonfluent progressive aphasia

NFTs:

Neurofibrillary tangles

References

  1. Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E. Alzheimer’s disease. Lancet. 2011;377(9770):1019–31.

    Article  PubMed  Google Scholar 

  2. Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991;82(4):239–59.

    Article  CAS  Google Scholar 

  3. Sandor T, Jolesz F, Tieman J, Kikinis R, Jones K, Albert M. Comparative analysis of computed tomographic and magnetic resonance imaging scans in Alzheimer patients and controls. Arch Neurol. 1992;49(4):381–4.

    Article  CAS  PubMed  Google Scholar 

  4. Braak H, Braak E. Staging of Alzheimer’s disease-related neurofibrillary changes. Neurobiol Aging. 1995;16(3):271–8; discussion 8–84.

    Article  CAS  PubMed  Google Scholar 

  5. Arnold SE, Hyman BT, Flory J, Damasio AR, Van Hoesen GW. The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer’s disease. Cereb Cortex. 1991;1(1):103–16.

    Article  CAS  PubMed  Google Scholar 

  6. Whitehouse PJ, Price DL, Clark AW, Coyle JT, DeLong MR. Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann Neurol. 1981;10(2):122–6.

    Article  CAS  PubMed  Google Scholar 

  7. Mesulam MM, Mufson EJ. Neural inputs into the nucleus basalis of the substantia innominata (Ch4) in the rhesus monkey. Brain. 1984;107(Pt 1):253–74.

    Article  PubMed  Google Scholar 

  8. Mesulam MM, Mufson EJ. Insula of the old world monkey. I. Architectonics in the insulo-orbito-temporal component of the paralimbic brain. J Comp Neurol. 1982;212(1):1–22.

    Article  CAS  PubMed  Google Scholar 

  9. Mufson EJ, Mesulam MM. Insula of the old world monkey. II: afferent cortical input and comments on the claustrum. J Comp Neurol. 1982;212(1):23–37.

    Article  CAS  PubMed  Google Scholar 

  10. Seltzer B, Pandya DN. Post-rolandic cortical projections of the superior temporal sulcus in the rhesus monkey. J Comp Neurol. 1991;312(4):625–40.

    Article  CAS  PubMed  Google Scholar 

  11. Foundas AL, Leonard CM, Mahoney SM, Agee OF, Heilman KM. Atrophy of the hippocampus, parietal cortex, and insula in Alzheimer’s disease: a volumetric magnetic resonance imaging study. Neuropsychiatry Neuropsychol Behav Neurol. 1997;10(2):81–9.

    PubMed  CAS  Google Scholar 

  12. Bonthius DJ, Solodkin A, Van Hoesen GW. Pathology of the insular cortex in Alzheimer disease depends on cortical architecture. J Neuropathol Exp Neurol. 2005;64(10):910–22.

    Article  PubMed  Google Scholar 

  13. Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Green RC, et al. The Alzheimer’s disease neuroimaging initiative: a review of papers published since its inception. Alzheimers Dement. 2013;9(5):e111–94.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Bakkour A, Morris JC, Wolk DA, Dickerson BC. The effects of aging and Alzheimer’s disease on cerebral cortical anatomy: specificity and differential relationships with cognition. NeuroImage. 2013;76:332–44.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Serrano-Pozo A, Frosch MP, Masliah E, Hyman BT. Neuropathological alterations in Alzheimer disease. Cold Spring Harb Perspect Med. 2011;1(1):a006189.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Van Dam D, Vermeiren Y. Neuropsychiatric disturbances in Alzheimer’s disease: what have we learned from neuropathological studies? Curr Alzheimer Res. 2016;13:1145–64.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Petrides FE, Mavroudis IA, Spilioti M, Chatzinikolaou FG, Costa VG, Baloyannis SJ. Spinal alterations of Reil insula in Alzheimer’s disease. Am J Alzheimers Dis Other Demen. 2017;32(4):222–9.

    Article  PubMed  Google Scholar 

  18. Sliz D, Hayley S. Major depressive disorder and alterations in insular cortical activity: a review of current functional magnetic imaging research. Front Hum Neurosci. 2012;6:323.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Lee HY, Tae WS, Yoon HK, Lee BT, Paik JW, Son KR, et al. Demonstration of decreased gray matter concentration in the midbrain encompassing the dorsal raphe nucleus and the limbic subcortical regions in major depressive disorder: an optimized voxel-based morphometry study. J Affect Disord. 2011;133(1–2):128–36.

    Article  PubMed  Google Scholar 

  20. Ossenkoppele R, Pijnenburg YA, Perry DC, Cohn-Sheehy BI, Scheltens NM, Vogel JW, et al. The behavioural/dysexecutive variant of Alzheimer’s disease: clinical, neuroimaging and pathological features. Brain. 2015;138(Pt 9):2732–49.

    Article  PubMed  PubMed Central  Google Scholar 

  21. de Araujo IE, Geha P, Small DM. Orosensory and homeostatic functions of the insular taste cortex. Chemosens Percept. 2012;5(1):64–79.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Avery JA, Powell JN, Breslin FJ, Lepping RJ, Martin LE, Patrician TM, et al. Obesity is associated with altered mid-insula functional connectivity to limbic regions underlying appetitive responses to foods. J Psychopharmacol. 2017;31(11):1475–84.

    Article  PubMed  Google Scholar 

  23. Mandelli ML, Vitali P, Santos M, Henry M, Gola K, Rosenberg L, et al. Two insular regions are differentially involved in behavioral variant FTD and nonfluent/agrammatic variant PPA. Cortex. 2016;74:149–57.

    Article  PubMed  Google Scholar 

  24. Gu Y, Scarmeas N, Cosentino S, Brandt J, Albert M, Blacker D, et al. Change in body mass index before and after Alzheimer’s disease onset. Curr Alzheimer Res. 2014;11(4):349–56.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Luchsinger JA, Cheng D, Tang MX, Schupf N, Mayeux R. Central obesity in the elderly is related to late-onset Alzheimer disease. Alzheimer Dis Assoc Disord. 2012;26(2):101–5.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Luchsinger JA, Gustafson DR. Adiposity, type 2 diabetes, and Alzheimer’s disease. J Alzheimers Dis. 2009;16(4):693–704.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Dineley KT, Jahrling JB, Denner L. Insulin resistance in Alzheimer’s disease. Neurobiol Dis. 2014;72(Pt A):92–103.

    Article  CAS  PubMed  Google Scholar 

  28. Stephani C, Fernandez-Baca Vaca G, Maciunas R, Koubeissi M, Luders HO. Functional neuroanatomy of the insular lobe. Brain Struct Funct. 2011;216(2):137–49.

    Article  CAS  PubMed  Google Scholar 

  29. de Morree HM, Rutten GJ, Szabo BM, Sitskoorn MM, Kop WJ. Effects of insula resection on autonomic nervous system activity. J Neurosurg Anesthesiol. 2016;28(2):153–8.

    Article  PubMed  Google Scholar 

  30. Colurso GJ, Kan RK, Anthony A. Microdensitometric measures of cytoplasmic RNA and total protein in pyramidal neurons of the insular cortex and midfrontal gyrus in patients with Alzheimer’s disease. Cell Biochem Funct. 1995;13(4):287–92.

    Article  CAS  PubMed  Google Scholar 

  31. Philippi N, Kemp J, Constans-Erbs M, Hamdaoui M, Monjoin L, Ehrhard E, et al. Insular cognitive impairment at the early stage of dementia with Lewy bodies: a preliminary study. Geriatr Psychol Neuropsychiatr Vieil. 2017;15(3):329–38.

    PubMed  Google Scholar 

  32. O'Doherty J, Rolls ET, Francis S, Bowtell R, McGlone F. Representation of pleasant and aversive taste in the human brain. J Neurophysiol. 2001;85(3):1315–21.

    Article  CAS  PubMed  Google Scholar 

  33. Gorno-Tempini ML, Dronkers NF, Rankin KP, Ogar JM, Phengrasamy L, Rosen HJ, et al. Cognition and anatomy in three variants of primary progressive aphasia. Ann Neurol. 2004;55(3):335–46.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Choi J, Jeong Y. Elevated emotional contagion in a mouse model of Alzheimer’s disease is associated with increased synchronization in the insula and amygdala. Sci Rep. 2017;7:46262.

    Article  PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Seattle Science Foundation, Seattle, WA, USA

    Paul Choi, Emily Simonds, Marc Vetter, Charlotte Wilson & R. Shane Tubbs

Authors
  1. Paul Choi
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  2. Emily Simonds
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  3. Marc Vetter
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  4. Charlotte Wilson
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  5. R. Shane Tubbs
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Corresponding author

Correspondence to R. Shane Tubbs .

Editor information

Editors and Affiliations

  1. Adnan Menderes University, School of Medicine , Aydın, Turkey

    Mehmet Turgut

  2. Ege University, Department of Anatomy, Izmir, Turkey

    Canan Yurttaş

  3. Seattle Science Foundation, Seattle, Washington, USA

    R. Shane Tubbs

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Choi, P., Simonds, E., Vetter, M., Wilson, C., Shane Tubbs, R. (2018). Alterations of Reil’s Insula in Alzheimer’s Disease. In: Turgut, M., Yurttaş , C., Tubbs, R. (eds) Island of Reil (Insula) in the Human Brain. Springer, Cham. https://doi.org/10.1007/978-3-319-75468-0_19

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  • DOI: https://doi.org/10.1007/978-3-319-75468-0_19

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-75467-3

  • Online ISBN: 978-3-319-75468-0

  • eBook Packages: MedicineMedicine (R0)

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