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Raman Spectroscopy in Skin Research and Dermal Drug Delivery

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Book cover Confocal Raman Microscopy

Part of the book series: Springer Series in Surface Sciences ((SSSUR,volume 66))

Abstract

Raman spectroscopy represents an upcoming analytical technique in the field of skin research and dermal drug delivery. In the last few decades, significant progress in optical equipment like lasers and detectors as well as in microscopy and software development paved the way for chemically selective three-dimensional Raman imaging with high spatial resolution. Potential applications range from analysis of physiological and pathophysiological skin conditions (e.g. non-destructive cancer detection in clinics) up to surgery guidance. In the field of drug delivery and cosmetics , Raman microscopy is successfully applied for investigating interactions with skin as well as for elucidation of drug penetration kinetics within the different skin tissue layers, thus strongly supporting rational development and improving product safety of novel skin therapeutics. This chapter provides a brief introduction about skin anatomy and dermal drug delivery systems, as well as state-of-the-art analytics in skin research. Furthermore, the potential of Raman spectroscopy for application in skin research, particularly its advantages and limitations in the field, is comprehensively elaborated. Subsequently, an overview about skin research studies applying Raman spectroscopy is given comprising various in vitro as well as in vivo implementations. Finally, employment of Raman spectroscopy for advanced diagnosis and surgery guidance are discussed and a future perspective in the field of skin research is given.

Nathalie Jung and Branko Vukosavljevic are contributed equally to this work.

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References

  1. K. Myer, H. Maibach, Skin Res. Technol. 19(3), 213 (2013)

    Article  Google Scholar 

  2. L. Franzen, C. Mathes, S. Hansen, M. Windbergs, J. Biomed. Opt. 18(6), 061210 (2013)

    Article  ADS  Google Scholar 

  3. R. Vyumvuhore, A. Tfayli, H. Duplan, A. Delalleau, M. Manfait, A. Baillet-Guffroy, Analyst 138(14), 4103 (2013)

    Article  ADS  Google Scholar 

  4. M.E. Darvin, J.W. Fluhr, P. Caspers, A. Van Der Pool, H. Richter, A. Patzelt, W. Sterry, J. Lademann, Exp. Dermatol. 18(12), 1060 (2009)

    Article  Google Scholar 

  5. P. Philipsen, L. Knudsen, M. Gniadecka, M. Ravnbak, H. Wulf, Photochem. Photobiol. Sci. 12(5), 770 (2013)

    Article  Google Scholar 

  6. E. Brauchle, S. Noor, E. Holtorf, C. Garbe, K. Schenke-Layland, C. Busch, Clin. Exp. Dermatol. 39(5), 636 (2014)

    Article  Google Scholar 

  7. L. Chrit, P. Bastien, B. Biatry, J.T. Simonnet, A. Potter, A. Minondo, F. Flament, R. Bazin, G. Sockalingum, F. Leroy et al., Biopolymers 85(4), 359 (2007)

    Article  Google Scholar 

  8. M. Förster, M.A. Bolzinger, D. Ach, G. Montagnac, S. Briançon, Pharm. Res. 28(4), 858 (2011)

    Article  Google Scholar 

  9. H.C. Broding, A. van der Pol, J. de Sterke, C. Monsé, M. Fartasch, T. Brüning, JDDG: J. der Deutsch. Dermatol. Ges. 9(8), 618 (2011)

    Google Scholar 

  10. C.W. Freudiger, W. Min, B.G. Saar, S. Lu, G.R. Holtom, C. He, J.C. Tsai, J.X. Kang, X.S. Xie, Science 322(5909), 1857 (2008)

    Article  ADS  Google Scholar 

  11. A. Zumbusch, G.R. Holtom, X.S. Xie, Phys. Rev. Lett. 82(20), 4142 (1999)

    Article  ADS  Google Scholar 

  12. B. Kann, H.L. Offerhaus, M. Windbergs, C. Otto, Adv. Drug Deliv. Rev. (2015)

    Google Scholar 

  13. L. Franzen, L. Vidlářová, K.H. Kostka, U.F. Schaefer, M. Windbergs, Exp. Dermatol. 22(1), 54 (2013)

    Article  Google Scholar 

  14. R. Na, I.M. Stender, M. Henriksen, H.C. Wulf, J. Invest. Dermatol. 116(4), 536 (2001)

    Article  Google Scholar 

  15. S. Tfaili, G. Josse, C. Gobinet, J.F. Angiboust, M. Manfait, O. Piot, Analyst 137(18), 4241 (2012)

    Article  ADS  Google Scholar 

  16. T. Dai, B.M. Pikkula, L.V. Wang, B. Anvari, Phys. Med. Biol. 49(21), 4861 (2004)

    Article  Google Scholar 

  17. L. Franzen, J. Anderski, V. Planz, K.H. Kostka, M. Windbergs, Exp. Dermatol. 23(12), 942 (2014)

    Article  Google Scholar 

  18. L. Franzen, M. Windbergs, Adv. Drug Deliv. Rev. (2015)

    Google Scholar 

  19. L. Silveira Jr., B. Bodanese, R.A. Zangaro, M.T.T. Pacheco, Instrum Sci. Technol. 38(4), 268 (2010)

    Article  Google Scholar 

  20. M.G. Ramírez-Elías, J. Alda, F.J. Gonzalez, Appl. Spectrosc. 66(6), 650 (2012)

    Article  ADS  Google Scholar 

  21. H. Wang, J. Zhao, A.M. Lee, H. Lui, H. Zeng, Photodiagn. Photodyn. Ther. 9(4), 299 (2012)

    Google Scholar 

  22. F. Bonnier, S.M. Ali, P. Knief, H. Lambkin, K. Flynn, V. McDonagh, C. Healy, T. Lee, F.M. Lyng, H.J. Byrne, Vib. Spectrosc. 61, 124 (2012)

    Article  Google Scholar 

  23. N.J. Everall, Spectroscopy 19, 16 (2004)

    Google Scholar 

  24. N.J. Everall, Analyst 135(10), 2512 (2010)

    Article  ADS  Google Scholar 

  25. N.J. Everall, Appl. Spectrosc. 54(10), 1515 (2000)

    Article  ADS  Google Scholar 

  26. K. Baldwin, D. Batchelder, Appl. Spectrosc. 55(5), 517 (2001)

    Article  ADS  Google Scholar 

  27. J. Bruneel, J. Lassegues, C. Sourisseau, J. Raman Spectrosc. 33(10), 815 (2002)

    Article  ADS  Google Scholar 

  28. C. Xiao, C.R. Flach, C. Marcott, R. Mendelsohn, Appl. Spectrosc. 58(4), 382 (2004)

    Article  ADS  Google Scholar 

  29. L. Franzen, D. Selzer, J.W. Fluhr, U.F. Schaefer, M. Windbergs, Eur. J. Pharm. Biopharm. 84(2), 437 (2013)

    Article  Google Scholar 

  30. L. Franzen, J. Anderski, M. Windbergs, Eur. J. Pharm. Biopharm. (2015)

    Google Scholar 

  31. M.G. Shim, B.C. Wilson, J. Raman Spectrosc. 28(2–3), 131 (1997)

    Article  ADS  Google Scholar 

  32. M.G. Shim, B.C. Wilson, E. Marple, M. Wach, Appl. Spectrosc. 53(6), 619 (1999)

    Article  ADS  Google Scholar 

  33. P. Caspers, G. Lucassen, R. Wolthuis, H. Bruining, G. Puppels, BIOSPECTROSCOPY-NEW YORK- 4, S31 (1998)

    Article  Google Scholar 

  34. P.J. Caspers, G.W. Lucassen, E.A. Carter, H.A. Bruining, G.J. Puppels, J. Invest. Dermatol. 116(3), 434 (2001)

    Article  Google Scholar 

  35. P. Caspers, G. Lucassen, G. Puppels, Biophys. J. 85(1), 572 (2003)

    Article  Google Scholar 

  36. A. Williams, H. Edwards, B. Barry, Int. J. Pharm. 81(2), R11 (1992)

    Article  Google Scholar 

  37. B. Barry, H. Edwards, A. Williams, J. Raman Spectrosc. 23(11), 641 (1992)

    Article  ADS  Google Scholar 

  38. A.C. Williams, H.G. Edwards, B.W. Barry, Biochim. Biophys. Acta (BBA)-Protein Struct. Mol. Enzymol. 1246(1), 98 (1995)

    Article  Google Scholar 

  39. A. Williams, H. Edwards, B. Barry, J. Raman Spectrosc. 25(1), 95 (1994)

    Article  ADS  Google Scholar 

  40. S.M. Ali, F. Bonnier, A. Tfayli, H. Lambkin, K. Flynn, V. McDonagh, C. Healy, T.C. Lee, F.M. Lyng, H.J. Byrne, J. Biomed. Opt. 18(6), 061202 (2013)

    Article  ADS  Google Scholar 

  41. M. Gąsior-Głogowska, M. Komorowska, J. Hanuza, M. Mączka, A. Zając, M. Ptak, R. Będziński, M. Kobielarz, K. Maksymowicz, P. Kuropka et al., J. Mech. Behav. Biomed. Mater. 18, 240 (2013)

    Article  Google Scholar 

  42. R. Vyumvuhore, A. Tfayli, H. Duplan, A. Delalleau, M. Manfait, A. Baillet-Guffroy, J. Raman Spectrosc. 44(8), 1077 (2013)

    Article  ADS  Google Scholar 

  43. Q. Tu, C. Chang, Nanomed. Nanotechnol. Biol. Med. 8(5), 545 (2012)

    Article  MathSciNet  Google Scholar 

  44. M. Gniadecka, P.A. Philipsen, S. Sigurdsson, S. Wessel, O.F. Nielsen, D.H. Christensen, J. Hercogova, K. Rossen, H.K. Thomsen, R. Gniadecki et al., J. Invest. Dermatol. 122(2), 443 (2004)

    Article  Google Scholar 

  45. A. Nijssen, K. Maquelin, L.F. Santos, P.J. Caspers, T.C.B. Schut, J.C. den Hollander, M.H. Neumann, G.J. Puppels, J. Biomed. Opt. 12(3), 034004 (2007)

    Article  ADS  Google Scholar 

  46. A. Nijssen, T.C.B. Schut, F. Heule, P.J. Caspers, D.P. Hayes, M.H. Neumann, G.J. Puppels, J. Invest. Dermatol. 119(1), 64 (2002)

    Article  Google Scholar 

  47. C.A. Lieber, S.K. Majumder, D. Billheimer, D.L. Ellis, A. Mahadevan-Jansen, J. Biomed. Opt. 13(2), 024013 (2008)

    Article  ADS  Google Scholar 

  48. R.L. Cleek, A.L. Bunge, Pharm. Res. 10(4), 497 (1993)

    Article  Google Scholar 

  49. C. Wang, T.J. Vickers, C.K. Mann, J. Pharm. Biomed. Anal. 16(1), 87 (1997)

    Article  Google Scholar 

  50. J. Breitenbach, W. Schrof, J. Neumann, Pharm. Res. 16(7), 1109 (1999)

    Article  Google Scholar 

  51. B. Gotter, W. Faubel, S. Heißler, J. Hein, R. Neubert, in Journal of Physics: Conference Series, vol. 214 (IOP Publishing, 2010), vol. 214, p. 012129

    Google Scholar 

  52. P.J. Larkin, M. Dabros, B. Sarsfield, E. Chan, J.T. Carriere, B.C. Smith, Appl. Spectrosc. 68(7), 758 (2014)

    Article  ADS  Google Scholar 

  53. G. Zhang, D.J. Moore, K.B. Sloan, C.R. Flach, R. Mendelsohn, J. Invest. Dermatol. 127(5), 1205 (2007)

    Article  Google Scholar 

  54. G. Zhang, C.R. Flach, R. Mendelsohn, J. Control. Release 123(2), 141 (2007)

    Article  Google Scholar 

  55. A.C. Williams, B.W. Barry, Adv. Drug Deliv. Rev. 64, 128 (2012)

    Article  Google Scholar 

  56. A.N. Anigbogu, A.C. Williams, B.W. Barry, H.G. Edwards, Int. J. Pharm. 125(2), 265 (1995)

    Article  Google Scholar 

  57. A. López, F. Llinares, C. Cortell, M. Herraez, Int. J. Pharm. 202(1), 133 (2000)

    Article  Google Scholar 

  58. M. Mélot, P.D. Pudney, A.M. Williamson, P.J. Caspers, A. Van Der Pol, G.J. Puppels, J. Control. Release 138(1), 32 (2009)

    Article  Google Scholar 

  59. P.D. Pudney, M. Mélot, P.J. Caspers, A. Van Der Pol, G.J. Puppels, Appl. Spectrosc. 61(8), 804 (2007)

    Article  ADS  Google Scholar 

  60. A. Tfayli, O. Piot, F. Pitre, M. Manfait, Eur. Biophys. J. 36(8), 1049 (2007)

    Article  Google Scholar 

  61. S. Tfaili, C. Gobinet, G. Josse, J.F. Angiboust, A. Baillet, M. Manfait, O. Piot, Anal. Bioanal. Chem. 405(4), 1325 (2013)

    Article  Google Scholar 

  62. N.A. Belsey, N.L. Garrett, L.R. Contreras-Rojas, A.J. Pickup-Gerlaugh, G.J. Price, J. Moger, R.H. Guy, J. Controlled Release 174, 37 (2014)

    Article  Google Scholar 

  63. C. Xiao, D.J. Moore, C.R. Flach, R. Mendelsohn, Vib. Spectrosc. 38(1), 151 (2005)

    Article  Google Scholar 

  64. C. Xiao, D.J. Moore, M.E. Rerek, C.R. Flach, R. Mendelsohn, J. Invest. Dermatol. 124(3), 622 (2005)

    Article  Google Scholar 

  65. G. Mao, C. Flach, R. Mendelsohn, R. Walters, Pharm. Res. 29(8), 2189 (2012)

    Article  Google Scholar 

  66. C. Choe, J. Lademann, M. Darvin, Skin Pharm. Physiol. 28(6), 318 (2015)

    Article  Google Scholar 

  67. C. Choe, J. Lademann, M.E. Darvin, J. Dermatol. Sci. (2015)

    Google Scholar 

  68. P.J. Caspers, A.C. Williams, E.A. Carter, H.G. Edwards, B.W. Barry, H.A. Bruining, G.J. Puppels, Pharm. Res. 19(10), 1577 (2002)

    Article  Google Scholar 

  69. R. Mateus, H. Abdalghafor, G. Oliveira, J. Hadgraft, M. Lane, Int. J. Pharm. 444(1), 106 (2013)

    Article  Google Scholar 

  70. D. Mohammed, P. Matts, J. Hadgraft, M. Lane, Pharm. Res. 31(2), 394 (2014)

    Article  Google Scholar 

  71. M. Egawa, H. Iwaki, Skin Res. Technol. 14(4), 410 (2008)

    Article  Google Scholar 

  72. M. Egawa, J. Nomura, H. Iwaki, Photochem. Photobiol. Sci. 9(5), 730 (2010)

    Article  Google Scholar 

  73. G. Howell et al., Analyst 119(4), 563 (1994)

    Article  Google Scholar 

  74. H. Edwards, D. Hunt, M. Sibley, Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 54(5), 745 (1998)

    Article  ADS  Google Scholar 

  75. R.L. Bronaugh, R.F. Stewart, E.R. Congdon, Toxicol. Appl. Pharmacol. 62(3), 481 (1982)

    Article  Google Scholar 

  76. U. Jacobi, M. Kaiser, R. Toll, S. Mangelsdorf, H. Audring, N. Otberg, W. Sterry, J. Lademann, Skin Res. Technol. 13(1), 19 (2007)

    Article  Google Scholar 

  77. S. Tfaili, C. Gobinet, G. Josse, J.F. Angiboust, M. Manfait, O. Piot, Analyst 137(16), 3673 (2012)

    Article  ADS  Google Scholar 

  78. J. Wu, T. Polefka, Int. J. Cosmet. Sci. 30(1), 47 (2008)

    Article  Google Scholar 

  79. M. Förster, M. Bolzinger, M. Rovere, O. Damour, G. Montagnac, S. Briançon, Skin Pharmacol. Physiol. 24(2), 103 (2011)

    Article  Google Scholar 

  80. L.B. Lyndgaard, K.M. Sørensen, F. Berg, S.B. Engelsen, J. Raman Spectrosc. 43(4), 482 (2012)

    Article  ADS  Google Scholar 

  81. A. Tfayli, O. Piot, F. Draux, F. Pitre, M. Manfait, Biopolymers 87(4), 261 (2007)

    Article  Google Scholar 

  82. S. Ali, F. Bonnier, K. Ptasinski, H. Lambkin, K. Flynn, F. Lyng, H. Byrne, Analyst 138(14), 3946 (2013)

    Article  ADS  Google Scholar 

  83. M. Pudlas, S. Koch, C. Bolwien, S. Thude, N. Jenne, T. Hirth, H. Walles, K. Schenke-Layland, Tissue Eng. Part C: Methods 17(10), 1027 (2011)

    Article  Google Scholar 

  84. G. Bernard, M. Auger, J. Soucy, R. Pouliot, Biochim. Biophys. Acta (BBA)-Gen. Subj. 1770(9), 1317 (2007)

    Article  Google Scholar 

  85. G. Perna, M. Lastella, M. Lasalvia, E. Mezzenga, V. Capozzi, J. Mol. Struct. 834, 182 (2007)

    Article  ADS  Google Scholar 

  86. G. Perna, M. Lasalvia, P. D’Antonio, N. L’Abbate, V. Capozzi, J. Raman Spectrosc. 42(4), 603 (2011)

    Article  ADS  Google Scholar 

  87. P. Donfack, M. Rehders, K. Brix, P. Boukamp, A. Materny, J. Raman Spectrosc. 41(1), 16 (2010)

    Article  ADS  Google Scholar 

  88. M. Ochalek, S. Heissler, J. Wohlrab, R. Neubert, Eur. J. Pharm. Biopharm. 81(1), 113 (2012)

    Article  Google Scholar 

  89. A. Percot, M. Lafleur, Biophys. J. 81(4), 2144 (2001)

    Article  Google Scholar 

  90. B. Gotter, W. Faubel, R. Neubert, Eur. J. Pharm. Biopharm. 74(1), 14 (2010)

    Article  Google Scholar 

  91. A. Tfayli, E. Guillard, M. Manfait, A. Baillet-Guffroy, Analyst 137(21), 5002 (2012)

    Article  ADS  Google Scholar 

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Authors and Affiliations

  1. Institute of Pharmaceutical Technology and Buchmann Institute for Molecular Life Sciences, Goethe University, Frankfurt am Main, Germany

    Nathalie Jung, Branko Vukosavljevic & Maike Windbergs

  2. Department of Drug Delivery, Helmholtz Centre for Infection Research (HZI) and Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbruecken, Germany

    Nathalie Jung & Maike Windbergs

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  1. Nathalie Jung
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  2. Branko Vukosavljevic
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  3. Maike Windbergs
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Correspondence to Maike Windbergs .

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Editors and Affiliations

  1. Wissenschaftliche Instrumente und Technologie GmbH, Ulm, Germany

    Jan Toporski

  2. Ulm, Germany

    Thomas Dieing

  3. Wissenschaftliche Instrumente und Technologie GmbH, Ulm, Germany

    Olaf Hollricher

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Jung, N., Vukosavljevic, B., Windbergs, M. (2018). Raman Spectroscopy in Skin Research and Dermal Drug Delivery. In: Toporski, J., Dieing, T., Hollricher, O. (eds) Confocal Raman Microscopy. Springer Series in Surface Sciences, vol 66. Springer, Cham. https://doi.org/10.1007/978-3-319-75380-5_17

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