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Multiscale Chemical Imaging of Complex Biological and Archaeological Materials

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Confocal Raman Microscopy

Part of the book series: Springer Series in Surface Sciences ((SSSUR,volume 66))

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Abstract

Raman chemical imaging provides powerful and general means to chemically characterize biological and synthetic materials under complex experimental conditions. For biological materials, we describe several techniques for investigating in-vivo processes spanning size ranges from single cells to complex multicellular organisms. Because these experimental approaches are non-invasive, Raman chemical imaging allows monitoring of dynamic processes in living systems including, for example, the study of the early stages of bone formation. We also describe large-scale Raman-based imaging techniques, including approaches for analyzing samples exhibiting complex shapes and irregular heterogeneous surface topographies. We further demonstrate how correlative Raman-SEM/EDS approaches can be applied to collect complementary information from complex biological and archaeological samples regarding structural complexity, elemental composition, and short-range chemical bonding parameters.

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Acknowledgements

We thank Prof. Lia Addadi, Prof. Steve Weiner, Dr. Damien Faivre, Dr. Mathieu Bennet, and Prof. Peter Fratzl for fruitful discussions. We thank Dr. Thomas Dieing for helping with TrueSurface data acquisition and processing and Dr. Karl Brommer for helpful suggestions. Part of this research was supported by a German Research Foundation (DFG) grant, within the framework of the SPP 1420.

Author information

Authors and Affiliations

  1. Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA

    James C. Weaver

  2. Department of Civil and Environmental Engineering, MIT, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA

    Admir Masic

Authors
  1. James C. Weaver
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  2. Admir Masic
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Corresponding author

Correspondence to James C. Weaver .

Editor information

Editors and Affiliations

  1. Wissenschaftliche Instrumente und Technologie GmbH, Ulm, Germany

    Jan Toporski

  2. Ulm, Germany

    Thomas Dieing

  3. Wissenschaftliche Instrumente und Technologie GmbH, Ulm, Germany

    Olaf Hollricher

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Weaver, J.C., Masic, A. (2018). Multiscale Chemical Imaging of Complex Biological and Archaeological Materials. In: Toporski, J., Dieing, T., Hollricher, O. (eds) Confocal Raman Microscopy. Springer Series in Surface Sciences, vol 66. Springer, Cham. https://doi.org/10.1007/978-3-319-75380-5_12

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