Abstract
Since release of the Seventh Joint National Committee on the Prevention, Detection, Evaluation and Treatment of Hypertension [JNC-7] report in 2003, new data provided a compelling argument for using the concept of prehypertension and focusing attention on the range of systolic blood pressure of 120–139 mmHg and diastolic BP between 80 and 89 mmHg as having clinical and public health significance. The prevalence of prehypertension and its associated risk factors has been investigated worldwide indicating that prehypertension is a common condition across age, sex, ethnicity, and geographical boundaries in countries with both developed and developing economies. Prevalence estimates in population-based samples range from 22 to 38% with only few studies reporting prevalence higher than 50%. Individuals with prehypertension are carrying a twofold to threefold higher risk of developing hypertension than those who are normotensive. The results of available meta-analyses confirm previous study and reports indicating that individuals with prehypertension free from cardiovascular disease are carrying increased relative risk of coronary heart disease, stroke, and total cardiovascular disease. Based on the available studies prehypertension increases the risk of myocardial infarction by 3.5 times and coronary artery disease by 1.7 times. In summary, prevention strategies need to be carefully considered to design and implement strategies both to reduce population-attributable risk among the majority of subjects who are at low-to-moderate risk, and to decrease adverse outcomes among individuals with prehypertension who are at high risk.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Chobanian AV. Prehypertension revisited. Hypertension. 2006;48:812–4.
Kshirsgar AV, Carpenter M, Bang H, et al. Blood pressure usually considered normal is associated with an elevated risk of cardiovascular disease. Am J Med. 2006;119:133–41.
Assadi F. Prehypertension : a warning sign of future cardiovascular risk. Int J Prev Med. 2014;special issue:S4–9.
Whaley-Connell A, Sowers JR. Is it time to target prehypertension. Cardiovasc Ther. 2010;28:337–8.
Habib GB, Virani SS, Jneid H. Is 2015 the primetime year for prehypertension ? Prehypertension: a cardiovascular risk factor or simply a risk marker? J Am Heart Assoc. 2015;4:e001792. https://doi.org/10.1161/JAHA/115.00.1792.
Egan BM, Stevens-Fabry S. Prehypertension—prevalence, health risks and management strategies. Nat Rev Cardiol. 2015;12:289–300.
Egan BM, Lackland DT, Jones DW. Prehypertension: an opportunity for a new public health paradigm. Cardiol Clin. 2010;28:561–9.
Wang Y, Wang QJ. The prevalence of prehypertension and hypertension among US adults according to the New Joint National Committee Guidelines. Arch Intern Med. 2004;164:2126–34.
Okosun IS, Boltri JM, Anochie LK, et al. Racial / ethnic differences in prehypertension in American adults: population and relative attributable risks of abdominal obesity. J Hum Hypertens. 2004;18:849–55.
Booth JN, Li J, Zhang L, et al. Trends in prehypertension and hypertension risk factors in USA adults: 1999–2012. Hypertension. 2017;70:275–84.
Rodriguez-Ramirez M, Simental-Mendia L, Gonzalez-Ortiz M, et al. Prevalence of prehypertension in Mexico and its association with hypomagnesemia. Am J Hypertens. 2015;28:1024–30.
Meng XJ, Dong GH, Wang D, et al. Epidemiology of prehypertension and associated risk factors in urban adults from 33 communities in China. Circ J. 2012;76:900–6.
Gu D, Chen J, Wu X, Duan X, et al. Prehypertension and risk of cardiovascular disease in Chinese adults. J Hypertens. 2009;27:721–9.
Wu J, Yan W, Qiu L, et al. High prevalence of coexisting prehypertension and prediabetes among healthy adults in northern and northeastern China. BMC Public Health. 2011;11:794–802.
Yang J, Lu F, Zhang C, et al. Prevalence of prehypertension and hypertension in a Chinese rural area from 1991 to 2007. Hypertens Res. 2010;33:331–7.
Zhang W-H, Zhang L, An W-F, et al. Prehypertension and clustering of cardiovascular risk factors among adults in suburban Beijing, China. J Epidemiol. 2011;21:440–6.
Ishikawa Y, Ishikawa J, Ishikawa S, et al. Prehypertension and the risk for cardiovascular disease in the Japanese general population : the Jichi Medical School Cohort Study. J Hypertens. 2010;28:1630–7.
Choi KM, Park HS, Han JH, et al. Prevalence o prehypertension and hypertension in a Korean population : Korean National Health and Nutrition Survey 2001. J Hypertens. 2006;24:1515–21.
Tsai P-S, Ke T-L, Huang C-J, et al. Prevalence and determinants of prehypertension status in the Taiwanese general population. J Hypertens. 2005;23:1355–60.
Liu L-K, Peng L-N, Chen L-K, et al. Prehypertension among middle-age and elderly people in Taiwan : a five-year follow-up. J Atheroscler Thromb. 2010;17:189–94.
Grotto I, Grossman E, Huerta M, et al. Prevalence of prehypertension and associated cardiovascular risk profiles among young Israeli adults. Hypertension. 2006;48:254–9.
Isezuo SA, Sabir AA, Ohwovorilole AE, et al. Prevalence, associated factors and relationship between prehypertension and hypertension : a study of two ethnic African populations in Northern Nigeria. J Hum Hypertens. 2011;25:224–30.
Janhorbani M, Amini M, Gouya MM, et al. Nationwide survey of prevalence and risk factors of prehypertension and hypertension in Iranian adults. J Hypertens. 2008;26:419–26.
Zhang Y, Lee ET, Devereux RB, et al. Prehypertension, diabetes and cardiovascular disease risk in a population-based sample. The Strong Heart Study. Hypertension. 2006;47:410–4.
Hsia J, Margolis KL, Eaton CB, et al. Prehypertension and cardiovascular disease risk in the Women’s Health Initiative. Circulation. 2007;115:855–60.
Glasser SP, Judd S, Basile J, et al. Prehypertension, racial prevalence and its association with risk factors: analysis of the reasons for geographic and racial differences in stroke [REGARDS] study. Am J Hypertens. 2011;24:194–9.
Guo X, Zou L, Zhang X, et al. Prehypertension. A meta-analysis of the epidemiology, risk factors, and predictors of progression. Tex Heart Inst J. 2011;38:643–52.
Huang Y, Wang S, Cai X, et al. Prehypertension and incidence of cardiovascular disease: a meta-analysis. BMC Med. 2013;11:177–86.
Vasan RS, Larson MG, Leip EP, et al. Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study: a cohort study. Lancet. 2001;358:1682–6.
Luders S, Schrader J, Berger J, et al. The PHARAO study: prevention of hypertension with the angiotensin-converting enzyme inhibitor ramipril in patients with high-normal blood pressure—a prospective, randomized, controlled prevention trial of the German Hypertension League. J Hypertens. 2008;26:1487–96.
Selassie A, Wagner CS, Laken ML, et al. Progression is accelerated from pre-hypertension to hypertension in African Americans. Hypertension. 2011;58:579–87.
Faselis C, Doumas M, Kokkinos JP, et al. Exercise capacity and progression from prehypertension to hypertension. Hypertension. 2012;60:333–8.
Suri MFK, Qureshi AI. Prehypertension as a risk factor for cardiovascular diseases. J Cardiovasc Nurs. 2006;21:478–82.
Qureshi AI, Suri MFK, Kirmani JF, et al. Is prehypertension a risk factor for cardiovascular disease? Stroke. 2005;36:1859–63.
Liszka HA, Mainous AG, King DE, et al. Prehypertension and cardiovascular morbidity. Ann Fam Med. 2005;3:294–9.
Mainous AG, Everett CJ, Liszka H, et al. Prehypertension and mortality in a nationally representative cohort. Am J Cardiol. 2004;94:1496–500.
Guo X, Zhang X, Guo L, et al. Association between pre-hypertension and cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. Curr Hypertens Res. 2013;15:703–16.
Huang Y, Su L, Cai X, et al. Association of all-cause and cardiovascular mortality with prehypertension: a meta-analysis. Am Heart J. 2014;167:160–8.
Guo X, Zhang X, Zheng L, et al. Prehypertension is not associated with all-cause mortality: a systematic review and meta-analysis of prospective studies. PLoS One. 2013;8:e61796.
Lee M, Saver JL, Chang B, et al. Presence of baseline prehypertension and risk of incident stroke. Neurology. 2011;77:1330–7.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Januszewicz, A., Prejbisz, A. (2019). Prehypertension, Statistics and Health Burden. In: Zimlichman, R., Julius, S., Mancia, G. (eds) Prehypertension and Cardiometabolic Syndrome. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-319-75310-2_7
Download citation
DOI: https://doi.org/10.1007/978-3-319-75310-2_7
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-75309-6
Online ISBN: 978-3-319-75310-2
eBook Packages: MedicineMedicine (R0)