Abstract
Non-pharmacological interventions have been shown not only to reduce blood pressure and delay the appearance of hypertension but also to improve glucose and cholesterol metabolism. They also affect other aspects of metabolism and have also beneficial psychological aspects.
Thus, non-pharmacological interventions should be recommended to the entire public including healthy subjects, prehypertensive and hypertensive subjects as well as all those with increased CVD risk. Generally, the greater the risk of CVD, the greater the benefit of intervention. Lifestyle interventions remain the cornerstone of therapeutic approach with or without pharmacological treatment.
However, things are not so simple, the evidence of the beneficial effect of such interventions is proven only in RCT’s (Randomized controlled studies) and not in real life setting. Subjects that are included in a RCT are in a “laboratory” surrounding with specific support and supervision, the data may be different in “wild” unsupervised settings. These methods are associated with difficulties in compliance implementation and persistence.
Prehypertension is the gray zone between normotension and hypertension and is associated with gradual increase in blood pressure until becoming hypertensive. These subjects are at increased CVD risk and the majority of them will become eventually hypertensive. While the pharmacological treatment of prehypertension is still disputed there is no dispute regarding the justification to use the non-pharmacological approach in prehypertensive patients in order to delay transition to hypertension and to lower CVD risk.
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References
Guo X, Zhang X, Guo L, et al. Association between pre-hypertension and cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. Curr Hypertens Rep. 2013;15:703–16.
Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA. 2003;289:2560–71.
Greenlund KJ, Croft JB, Mensah GA. Prevalence of heart disease and stroke risk factors in persons with prehypertension in the United States, 1999–2000. Arch Intern Med. 2004;164:2113–8.
Nesbitt SD. Treatment options for prehypertension. Curr Opin Nephrol Hypertens. 2007;16:250–5.
Egan BM, Nesbitt SD, Julius S. Prehypertension: should we be treating with pharmacologic therapy? Ther Adv Cardiovasc Dis. 2008;2:305–14.
Rose G. Strategy of prevention: lessons from cardiovascular disease. Br Med J (Clin Res Ed). 1981;282:1847.
Huang Y, Cai X, Li Y, et al. Prehypertension and the risk of stroke a meta-analysis. Neurology. 2014;82:1153–61.
Huang Y, Su L, Cai X, et al. Association of all-cause and cardiovascular mortality with prehypertension: a meta-analysis. Am Heart J. 2014;167:160–8.
Huang Y, Wang S, Cai X, et al. Prehypertension and incidence of cardiovascular disease: a meta-analysis. BMC Med. 2013;11:177.
Guo X, Zhang X, Zheng L, et al. Prehypertension is not associated with all-cause mortality: a systematic review and meta-analysis of prospective studies. PLoS One. 2013;8:e61796.
Egan BM, Stevens-Fabry S. Prehypertension [mdash] prevalence, health risks, and management strategies. Nat Rev Cardiol. 2015;12:289–300.
Zhang Y, Lee ET, Devereux RB, et al. Prehypertension, diabetes, and cardiovascular disease risk in a population-based sample. Hypertension. 2006;47:410–4.
Blackburn H. Non-pharmacologic treatment of hypertension. Ann N Y Acad Sci. 1978;304:236–42.
Fuchs FD. Prehypertension: the rationale for early drug therapy. Cardiovasc Ther. 2010;28:339–43.
Swales JD. Non-pharmacological antihypertensive therapy. Eur Heart J. 1988;9:45–52.
Rose G, Stamler J, Stamler R, et al. Intersalt: an international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion. Br Med J. 1988;297:319–28.
Alderman MH. Non-pharmacological treatment of hypertension. Lancet. 1994;344:307–11.
Mozaffarian D, Fahimi S, Singh GM, et al. Global sodium consumption and death from cardiovascular causes. N Engl J Med. 2014;371:624–34.
Van Horn L. Dietary sodium and blood pressure: how low should we go? Prog Cardiovasc Dis. 2015;58:61–8.
McLaren L, Sumar N, Barberio AM, et al. Population-level interventions in government jurisdictions for dietary sodium reduction. Cochrane Database Syst Rev. 2016;9:CD010166.
Reisin E, Abel R, Modan M, et al. Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patients. N Engl J Med. 1978;298:1–6.
Dahl LK. Possible role of salt intake in the development of essential hypertension. Int J Epidemiol. 2005;34:967–72.
Wassertheil-Smoller S, Blaufox MD, Oberman AS, et al. The trial of antihypertensive interventions and management (TAIM) study: adequate weight loss, alone and combined with drug therapy in the treatment of mild hypertension. Arch Intern Med. 1992;152:131–6.
Lasser VI, Raczynski JM, Stevens VJ, et al. Trials of hypertension prevention, phase II structure and content of the weight loss and dietary sodium reduction interventions. Ann Epidemiol. 1995;5:156–64.
Hjermann I, et al. Smoking and diet intervention in healthy coronary high risk men. Methods and 5-year-follow-up of risk factors in a randomized trial. The Oslo Study. J Oslo City Hosp. 1980;30:3–17.
Hjermann I, Holme I, Byre KV, et al. Effect of diet and smoking intervention on the incidence of coronary heart disease: report from the Oslo Study Group of a randomised trial in healthy men. Lancet. 1981;318:1303–10.
Moser M. A decade of progress in the management of hypertension. Hypertension. 1983;5:808–13.
Mainous AG, Everett CJ, Liszka H, et al. Prehypertension and mortality in a nationally representative cohort. Am J Cardiol. 2004;94:1496–500.
Knowler WC, Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346:393–403.
Dagogo-Jack S, Egbuonu N, Edeoga C. Principles and practice of nonpharmacological interventions to reduce cardiometabolic risk. Med Princ Pract. 2010;19:167.
Reddy KS, Katan MB. Diet, nutrition and the prevention of hypertension and cardiovascular diseases. Public Health Nutr. 2004;7:167–86.
Lelong H, Galan P, Kesse-Guyot E, et al. Relationship between nutrition and blood pressure: a cross-sectional analysis from the NutriNet-sante study, a French web-based cohort study. Am J Hypertens. 2015;28:362–71.
Fung TT, Rimm EB, Spiegelman D, et al. Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk. Am J Clin Nutr. 2001;73:61–7.
Vollmer WM, Sacks FM, Ard J, et al. Effects of diet and sodium intake on blood pressure: subgroup analysis of the DASH-sodium trial. Ann Intern Med. 2001;135:1019–28.
Hinderliter AL, Sherwood A, Craighead LW, et al. The long-term effects of lifestyle change on blood pressure: one-year follow-up of the ENCORE study. Am J Hypertens. 2013;27:734–41.
Allbaugh L. Food and nutrition. In: Crete: a case study of an underdeveloped area. Princeton, NJ: Princeton University Press; 1953. p. 97–135.
Vamvakis A, Gkaliagkousi E, Triantafyllou A, et al. Beneficial effects of nonpharmacological interventions in the management of essential hypertension. JRSM Cardiovasc Dis. 2017;6:2048004016683891.
Estruch R, Martinez-González MA, Corella D, et al. Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial. Ann Intern Med. 2006;145:1–11.
Pitsavos C, Chrysohoou C, Panagiotakos DB, et al. Abdominal obesity and inflammation predicts hypertension among prehypertensive men and women: the ATTICA study. Heart Vessel. 2008;23:96–103.
Kastorini C-M, Milionis HJ, Esposito K, et al. The effect of Mediterranean diet on metabolic syndrome and its components: a meta-analysis of 50 studies and 534,906 individuals. J Am Coll Cardiol. 2011;57:1299–313.
Davy BM, Halliday TM, Davy KP. Sodium intake and blood pressure: new controversies, new labels... New guidelines? J Acad Nutr Diet. 2015;115:200–4.
Sacks FM, Svetkey LP, Vollmer WM, et al. Effects on blood pressure of reduced dietary sodium and the dietary approaches to stop hypertension (DASH) diet. N Engl J Med. 2001;344:3–10.
MacGregor GA, Sagnella GA, Markandu ND, et al. Double-blind study of three sodium intakes and long-term effects of sodium restriction in essential hypertension. Lancet. 1989;334:1244–7.
Khaw K-T, Barrett-Connor E. Dietary potassium and stroke-associated mortality. N Engl J Med. 1987;316:235–40.
Luft FC. Putative mechanism of blood pressure reduction induced by increases in dietary calcium intake. Am J Hypertens. 1990;3:156S–60S.
O’Keefe JH, Bhatti SK, Bajwa A, et al. Alcohol and cardiovascular health: the dose makes the poison… or the remedy. Mayo Clin Proc. 2014;89:382–93.
Piano MR, Mazzuco A, Kang M, et al. Cardiovascular consequences of binge drinking: an integrative review with implications for advocacy, policy, and research. Alcohol Clin Exp Res. 2017;41:487–96.
Ozemek C, Phillips SA, Popovic D, et al. Nonpharmacologic management of hypertension: a multidisciplinary approach. Curr Opin Cardiol. 2017;32:381–8.
Xue X, Jiang H, Frontini MG, et al. Effects of alcohol reduction on blood pressure: a meta-analysis of randomised controlled trials. Hypertension. 2001;38:1112–7.
Lackland DT, Voeks JH. Metabolic syndrome and hypertension: regular exercise as part of lifestyle management. Curr Hypertens Rep. 2014;16:492.
Collier SR, Landram MJ. Treatment of prehypertension: lifestyle and/or medication. Vasc Health Risk Manag. 2012;8:613.
Whelton SP, Chin A, Xin X, et al. Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trials. Ann Intern Med. 2002;136:493–503.
Kelley GA, Kelley KS. Progressive resistance exercise and resting blood pressure. Hypertension. 2000;35:838–43.
McGrady A. The effects of biofeedback in diabetes and essential hypertension. Cleve Clin J Med. 2010;77:S68–71.
Elliott WJ, Izzo JL, White WB, et al. Graded blood pressure reduction in hypertensive outpatients associated with use of a device to assist with slow breathing. J Clin Hypertens. 2004;6:553–9.
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Zimlichman, R. (2019). Non-pharmacologic Approaches for the Management of Prehypertension. In: Zimlichman, R., Julius, S., Mancia, G. (eds) Prehypertension and Cardiometabolic Syndrome. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-319-75310-2_39
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DOI: https://doi.org/10.1007/978-3-319-75310-2_39
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